LOCUS       NM_031257               4992 bp    mRNA    linear   ROD 28-NOV-2023
DEFINITION  Mus musculus pleckstrin homology domain-containing, family A
            (phosphoinositide binding specific) member 2 (Plekha2), mRNA.
ACCESSION   NM_031257
VERSION     NM_031257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4992)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4992)
  AUTHORS   Jayachandran N, Landego I, Hou S, Alessi DR and Marshall AJ.
  TITLE     B-cell-intrinsic function of TAPP adaptors in controlling germinal
            center responses and autoantibody production in mice
  JOURNAL   Eur J Immunol 47 (2), 280-290 (2017)
   PUBMED   27859053
  REMARK    GeneRIF: this study shows that TAPP1/2 double knock-out mice
            develop chronic germinal centers with age and show abnormal
            expression of B-cell activation and develop lupus-like
            characteristics including anti-DNA antibodies and deposition of
            immune complexes in kidneys
REFERENCE   3  (bases 1 to 4992)
  AUTHORS   Landego I, Jayachandran N, Wullschleger S, Zhang TT, Gibson IW,
            Miller A, Alessi DR and Marshall AJ.
  TITLE     Interaction of TAPP adapter proteins with phosphatidylinositol
            (3,4)-bisphosphate regulates B-cell activation and autoantibody
            production
  JOURNAL   Eur J Immunol 42 (10), 2760-2770 (2012)
   PUBMED   22777911
  REMARK    GeneRIF: interacts with phosphatidylinositol (3,4)-bisphosphate
            thus regulating B-cell activation and autoantibody production
REFERENCE   4  (bases 1 to 4992)
  AUTHORS   Wullschleger S, Wasserman DH, Gray A, Sakamoto K and Alessi DR.
  TITLE     Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in
            regulating insulin sensitivity defined by knock-in analysis
  JOURNAL   Biochem J 434 (2), 265-274 (2011)
   PUBMED   21204784
REFERENCE   5  (bases 1 to 4992)
  AUTHORS   Kimber WA, Deak M, Prescott AR and Alessi DR.
  TITLE     Interaction of the protein tyrosine phosphatase PTPL1 with the
            PtdIns(3,4)P2-binding adaptor protein TAPP1
  JOURNAL   Biochem J 376 (Pt 2), 525-535 (2003)
   PUBMED   14516276
REFERENCE   6  (bases 1 to 4992)
  AUTHORS   Marshall AJ, Krahn AK, Ma K, Duronio V and Hou S.
  TITLE     TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase
            signaling in B cells: sustained plasma membrane recruitment
            triggered by the B-cell antigen receptor
  JOURNAL   Mol Cell Biol 22 (15), 5479-5491 (2002)
   PUBMED   12101241
REFERENCE   7  (bases 1 to 4992)
  AUTHORS   Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ,
            Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM and
            Alessi DR.
  TITLE     Evidence that the tandem-pleckstrin-homology-domain-containing
            protein TAPP1 interacts with Ptd(3,4)P2 and the
            multi-PDZ-domain-containing protein MUPP1 in vivo
  JOURNAL   Biochem J 361 (Pt 3), 525-536 (2002)
   PUBMED   11802782
REFERENCE   8  (bases 1 to 4992)
  AUTHORS   Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP and
            Alessi DR.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI730323.1, AK078212.1, AC156553.17 and BG143535.1.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_031257.4.
            
            On May 1, 2009 this sequence version replaced NM_031257.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010215.1, SRR9219382.113963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BI730323.1         175-274
            101-1986            AK078212.1         80-1965
            1987-4969           AC156553.17        90393-93375
            4970-4992           BG143535.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 13.7 cM"
     gene            1..4992
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /note="pleckstrin homology domain-containing, family A
                     (phosphoinositide binding specific) member 2"
                     /db_xref="GeneID:83436"
                     /db_xref="MGI:MGI:1928144"
     exon            1..152
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            153..316
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1453
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /note="pleckstrin homology domain-containing, family A
                     (phosphoinositide binding specific) member 2andem PH
                     Domain containing protein 2; PH domain-containing adaptor
                     PHAD47; tandem PH domain-containing protein 2; PH
                     domain-containing family A member 2; TAPP-2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 2"
                     /protein_id="NP_112547.1"
                     /db_xref="CCDS:CCDS22198.1"
                     /db_xref="GeneID:83436"
                     /db_xref="MGI:MGI:1928144"
                     /translation="MPYVDRQNRICGFLDIEDNENSGKFLRRYFILDTQANCLLWYMD
                     NPQNLAVGAGAVGSLQLTYISKVSIATPKQKPKTPFCFVINALSQRYFLQANDQKDLK
                     DWVEALNQASKITVPKAGTVPLATEVLKNLTAPPTLEKKPQVAYKTEIIGGVVVQTPI
                     SQNGGDGQEGCEPGTHAFLRRSQSYIPTSGCRPSTGPPLIKSGYCVKQGNVRKSWKRR
                     FFALDDFTICYFKCEQDREPLRTIPLKDVLKTHECLVKSGDLLMRDNLFEIITTSRTF
                     YVQADSPEDMHSWIEGIGAAVQALKCHPREPSFSRSISLTRPGSSTLTSAPNSILSRR
                     RPPAEEKRGLCKAPSVASSWQPWTPVPQAEEKPLSVEHAPEDSLFMPNPGESTATGVL
                     ASSRVRHRSEPQHPKEKPFVFNLDDENIRTSDV"
     exon            317..373
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..422
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..520
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..661
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..808
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..877
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..948
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1012
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1090
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..4985
                     /gene="Plekha2"
                     /gene_synonym="6430512N22Rik; TAPP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggggtggg gcgtgtgggg gcggtgtcct gtggagctgc agattctcac gtttgcagcg
       61 gcgaaacttc tccgaggttc aagcacaggg gtggtagccc ctcaaggact gcccgggcag
      121 cgggtagggg aggagcgcag agaacgtccc agggtgatgt gaacagagcc caggaatgcc
      181 ttatgtggat cggcagaacc gaatctgtgg gtttctggat attgaagaca atgagaacag
      241 tggcaaattc ctccggagat actttatcct ggatacccag gccaactgcc tcctctggta
      301 catggacaat ccccagaacc tggccgttgg ggcaggagct gtcggatctc tgcagctgac
      361 ctacatctcg aaggtgagca tagctacccc aaagcagaaa cctaaaacgc cattctgctt
      421 cgttatcaat gccctgtctc agagatattt tcttcaagcc aatgaccaga aagatctgaa
      481 ggactgggta gaagccttga accaagccag caagatcact gtacccaaag ctgggacagt
      541 acccttggcc acagaagttc tcaaaaactt aacagctcct cccaccctag agaagaagcc
      601 gcaggtggcc tacaagactg agatcatcgg gggtgtggtg gtacaaacgc ctatcagcca
      661 gaacggtggg gatgggcagg aagggtgcga gccagggact cacgccttcc tgcgaaggtc
      721 tcagagctac atccccacgt caggctgccg cccttccact gggcctcccc tcattaagag
      781 tggctactgt gtgaagcaag ggaatgtgcg gaagagttgg aaacgacgct tctttgccct
      841 cgatgacttt accatctgct acttcaagtg tgagcaggac agagagcctc tgcgtaccat
      901 accgctcaag gatgttctca agactcacga gtgtctggtc aagtctggtg atctcttaat
      961 gagggacaac ctgtttgaaa tcataaccac ctccaggacg ttctacgtac aggcggacag
     1021 ccctgaggac atgcacagct ggatcgaggg gattggagca gctgtccagg ctctgaagtg
     1081 ccaccctagg gagccgtcct tttcaaggtc catttctttg actcgacctg gaagttctac
     1141 ccttacaagc gcgcctaact ccatcttgtc aagaaggcgg ccaccagcag aagagaaaag
     1201 aggtctctgt aaggcccctt cggtggcctc ctcctggcaa ccctggacac ctgtccccca
     1261 ggctgaggaa aagccgttgt cggtggagca tgctccagag gactctctat tcatgcctaa
     1321 ccctggggag agcacagcta caggggtgct ggcaagttct cgagtcaggc acaggtcgga
     1381 gccccagcac cccaaggaga agccatttgt attcaacctt gatgacgaaa acatacgaac
     1441 ctctgatgtg tgatatgcag tgcccgttgc gtgcaggaga gccaggggct gtgacttatt
     1501 ttctctgcca tggtagagga cagagtctaa tggcactcac agtggagggg ctcgtctagc
     1561 tggctttggt tttgctatta ttgacaccat ttatttaact ggggaaagcc actaggttag
     1621 acccacaggc atactctatt acctcttgaa tgtccccatt tccccaggtt tcctagtgag
     1681 gggttagttt tcatacttcc tgtctggagg aggctagagt ccagtttcac ccataagctt
     1741 ttccctcttg tatttctttt atagtcttgg ttttgcacag gatctctggc taagaactgc
     1801 tttcatctac ccctgtttat tgactgaagt ctggggatca gtcagaccat tagcatccag
     1861 actgacaggc atcgggtgag actcaggtta tacagttccg attgggatct atctgagagc
     1921 ggtcgtaaga gtctggggag tgaaaggtga atttttggga tatctccccc aggcagttct
     1981 ttcaggatac ctcccagggg agcagacagg acctcttgtg agtcatgagg gctaattaaa
     2041 ctgctataac cacttgtagg aatcatgtcg tcctcttgat gctccatgac cccaaatgac
     2101 atagaactga gtgacagagc caccagtcta ttttccgtgt catgtcccga ggatatgcgg
     2161 ttatcagggt caaatgttat gattgcagag accagaacag agacttccct tgaaactgag
     2221 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gaaagagaga gaaagagaga gagagagaga
     2281 gagagagaga gagagagaga gagagagaaa accactcatg ttaggacaat ctctctctca
     2341 gaggcttaca ttaatataaa gcagctactg agaagagatg gatggttgtt tattgcaata
     2401 agcatctttg atccatgttt tccagacagg agaatgactc tttcttggca cagtgaatct
     2461 tgaattcctg tctcacagct cttttatagc cagtcgactt ttgtgtaatg ctaagtgctt
     2521 gtatactgtg cagcctgctg gcccacttgc tctttgcttt attgcactgc ctgttaaatg
     2581 aagtcatgca cacaccaggt ggaactctag cgtctgataa gagcctatac actcactagt
     2641 gaagagactt aaatgtgatt tttcccccca gtacttacat ttttcatgga atagaaactg
     2701 ggaataaaga aattgaatca gaggatgaat tgttggctag gaatttccta ggttctagaa
     2761 gagtttagaa gattagattt ccacccaaaa tttagggtat ggcttttcca ctgggcaaga
     2821 tactatttcc agtgcctttg gggtcatttc tatcagcctt caatgaactg tgctaccaga
     2881 aaattatggc catttcctac agggagagag gtcatggctc attcctatct gtgtaacttt
     2941 tatctgctag gtaaattaac cctgttttta attagaaatt tgtagctcta agagactagg
     3001 aggcattttt tatttaagct agttagcact ctgtgtccat agttaatgca aaagcaaaaa
     3061 caggcataaa gctctccggg tgagaggaag catgctcttt caaatgtgac tgtgaccctg
     3121 aatctggtgc cacactgaag acttctgggc tccgtgtgtg ggagctgtcc cccgactttg
     3181 tctggccttg tgatcctgat gaaaagaaaa ccaaacaaaa atcagtgggc ttctttctct
     3241 ttctgttcat gatcttgtgt gtctcccatc ccctaaaaaa aaaaaaaaaa aaaaaacttt
     3301 tgtgtgtttt ggtttttcag ggttcgggga ttatttattt aggagcgaat aaggttacaa
     3361 cctacttcaa aagtcagtgc cctttgtctc tggtttcagc ttaaaatctt cccctagaaa
     3421 attctttggc tgctcaacag aattgctcaa tgtgaagatg aggaacgaat gaaaaataaa
     3481 tcaggaactc ctgaagggcc tcgaacatgc cctggctcaa ggaaatgagg tcatcttttg
     3541 gcgtttaaat tgcaaaatct gtctgtccct ctcttagaaa ctgttggctt ggttattagt
     3601 gctgcatcaa cgggtcctta cagaaagttg agaggtttcg gtacacactc tgagatcatg
     3661 ttaaacacaa tgcggtgtat attatgcaaa caaaggaaaa gtacagtttc agtgatccta
     3721 accagcccat acatgagact tgcaagttag aacattgtta atagcggtgc ccagaaaata
     3781 taattatctt tgtgaagcct caaaacattt aaagtctcaa ttcttgtttc agaattcccc
     3841 ttctgtctgt atttacacac atacacacac cctttaaatt tgttttttgc tagagtcttg
     3901 ctacggagtc caggctggct ttgaactgat aatcctcctg cctcagcctc ctgagtgctt
     3961 ggattacaag tctatgccac catatccagc ctaggacagt attttaatgt gagccaaaga
     4021 tggtgcataa acctttagtt ttcaaggtgt gatggcgtgt gggtttgtgg ttaagcatag
     4081 attgtggata aatccgaagg gatttctgga ttataaaaga tactgcattt cctgtgtgga
     4141 ataaaagcag tctctggggt tgggtccttc tataaagctt cgaaggtatt gttctctgta
     4201 gctgaagtat gtcctatcca ttactcttca atgctttggt ggacttgctt actcgggtca
     4261 ggtgataatc aggggaaaaa aaaaaaaaag aagcgtgtgt ttttcattct ccgaaccaca
     4321 ccgaggatat gggagaccgc aaactaaagt ggcacctctg gtcaaagtgg cggagtgaca
     4381 gctctacttc caagtagaag gctgcccctc cgggaagatt taaggtccat cgtcctagtt
     4441 tactggaagc aaactggttt ggtttggttt tcccctttct acacaggact tatatgaccc
     4501 tctgagtaag cagtggactg gtaattgagc ggtagacttg atacttgttt tcagtgtcaa
     4561 ccaaataaac agctatctgg tagcagacgg cagtgttttt gaaattaggc ttcccatgtc
     4621 gcctgtttaa cctcctcccc cacccccacc ccccaaaatc tgttttcctc agtccctcgt
     4681 tctctctctg tgttattgcc tgcctgagtc aattatagtc acttatacca ggtaggcgtt
     4741 gaatcaagtg aatatttggc aaaaacacac agtgtgactg ctgggccctc tgtttatgaa
     4801 ggtgtggcat gccccgtttg agccagtgtt tgagccgtga aacacctcct gcaagcactg
     4861 agcttagtgc atggaaactc cagcttctta cgttgtgtga gctcctaatt ggtatgtagc
     4921 aaaacgtcat tttctaaaaa ctggttggtt gcttgttttg taataaaaac atgtgaaata
     4981 ggaaaaaaaa aa
//
