LOCUS       NM_001346515            3884 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pleckstrin homology domain containing, family A
            (phosphoinositide binding specific) member 1 (Plekha1), transcript
            variant 2, mRNA.
ACCESSION   NM_001346515 XM_006507148
VERSION     NM_001346515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Olayinka-Adefemi,F., Hou,S. and Marshall,A.J.
  TITLE     Dual inhibition of phosphoinositide 3-kinases delta and gamma
            reduces chronic B cell activation and autoantibody production in a
            mouse model of lupus
  JOURNAL   Front Immunol 14, 1115244 (2023)
   PUBMED   37234154
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   Lee,S., Sears,M.J., Zhang,Z., Li,H., Salhab,I., Krebs,P., Xing,Y.,
            Nah,H.D., Williams,T. and Carstens,R.P.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Jayachandran,N., Landego,I., Hou,S., Alessi,D.R. and Marshall,A.J.
  TITLE     B-cell-intrinsic function of TAPP adaptors in controlling germinal
            center responses and autoantibody production in mice
  JOURNAL   Eur J Immunol 47 (2), 280-290 (2017)
   PUBMED   27859053
  REMARK    GeneRIF: this study shows that TAPP1/2 double knock-out mice
            develop chronic germinal centers with age and show abnormal
            expression of B-cell activation anddevelop lupus-like
            characteristics including anti-DNA antibodies and deposition of
            immune complexes in kidneys
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   8  (bases 1 to 3884)
  AUTHORS   Lakatos,A., Prinster,S., Vicentic,A., Hall,R.A. and Kuhar,M.J.
  TITLE     Cocaine- and amphetamine-regulated transcript (CART) peptide
            activates the extracellular signal-regulated kinase (ERK) pathway
            in AtT20 cells via putative G-protein coupled receptors
  JOURNAL   Neurosci Lett 384 (1-2), 198-202 (2005)
   PUBMED   15908120
REFERENCE   9  (bases 1 to 3884)
  AUTHORS   Bouchard,M., Grote,D., Craven,S.E., Sun,Q., Steinlein,P. and
            Busslinger,M.
  TITLE     Identification of Pax2-regulated genes by expression profiling of
            the mid-hindbrain organizer region
  JOURNAL   Development 132 (11), 2633-2643 (2005)
   PUBMED   15872005
REFERENCE   10 (bases 1 to 3884)
  AUTHORS   Marker,P.C., Dahiya,R. and Cunha,G.R.
  TITLE     Spontaneous mutation in mice provides new insight into the genetic
            mechanisms that pattern the seminal vesicles and prostate gland
  JOURNAL   Dev Dyn 226 (4), 643-653 (2003)
   PUBMED   12666202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115697.19.
            
            On Oct 18, 2016 this sequence version replaced XM_006507148.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.2646.1,
                                           SRR7974084.25726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC115697.19        80437-80696         c
            261-421             AC115697.19        68526-68686         c
            422-478             AC115697.19        64034-64090         c
            479-524             AC115697.19        60972-61017         c
            525-622             AC115697.19        54142-54239         c
            623-748             AC115697.19        48970-49095         c
            749-892             AC115697.19        45760-45903         c
            893-961             AC115697.19        44175-44243         c
            962-1026            AC115697.19        41486-41550         c
            1027-1090           AC115697.19        40966-41029         c
            1091-1180           AC115697.19        37995-38084         c
            1181-1221           AC115697.19        36792-36832         c
            1222-3884           AC115697.19        32926-35588         c
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 73.19 cM"
     gene            1..3884
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /note="pleckstrin homology domain containing, family A
                     (phosphoinositide binding specific) member 1"
                     /db_xref="GeneID:101476"
                     /db_xref="MGI:MGI:2442213"
     exon            1..260
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..421
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1432
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pleckstrin homology domain-containing family A member 1;
                     tandem PH domain-containing protein 1; PH
                     domain-containing family A member 1; TAPP-1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 1 isoform 2"
                     /protein_id="NP_001333444.1"
                     /db_xref="CCDS:CCDS85434.1"
                     /db_xref="GeneID:101476"
                     /db_xref="MGI:MGI:2442213"
                     /translation="MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMD
                     NPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVE
                     WVNVLNKAIKITVPKQSDSQPASDSLSRQGDCGKKQVSYRTDIVGGVPIITPTQKEEV
                     NECGESLDRNNLKRSQSHLPYFAPKPPSDSAVIKAGYCVKQGAVMKNWKRRYFQLDEN
                     TIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEE
                     MHSWIKAVSGAIVAQRGPGRSSSSMRQARRLSNPCIQRSIPAGLQNPNSLSVLPGPQP
                     PPHIPQPLAATLWSQAVPWRSEEFTNLLPRSSQGTSRSRLSLQESQLPK"
     exon            422..478
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..524
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..622
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..748
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..892
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..961
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1026
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1090
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1180
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1221
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..3884
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      3698
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /note="major polyA site"
     regulatory      3860..3865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
                     /note="hexamer: AATAAA"
     polyA_site      3882
                     /gene="Plekha1"
                     /gene_synonym="C920009D07Rik; TAPP1"
ORIGIN      
        1 agccaccacc ctggaactag gaagacgccc gattcctttg cccgccacgc cgccgggcgt
       61 gcgcggagcc tgtcgggact tgtagtgttc gcggtaggga gtgcccgctc cggaatctca
      121 gtcgctgtct ggtctggtag aggcagcgcg tgcacgcgtg cgcagtgcgc gggcgggccg
      181 tcgtgggcgc cgctcccggc agctgggtgc ctgaaggagc cgggaccgcg gtggcgcggg
      241 tgctccgggc ggaggccgcg tgtaatgttc aagcccagaa atgccttatg tggatcgaca
      301 gaatcgcatc tgtggatttc tagacattga agaaaatgag aacagtggga aatttcttcg
      361 acggtatttc atcctggata ccagagaaga cagctttgta tggtacatgg ataatccaca
      421 gaacctgcct tcaggatcgt cacgggttgg agccattaaa cttacctaca tttcaaaggt
      481 tagcgatgca actaagttaa ggccaaaggc agagttttgt tttgttatga atgcaggaat
      541 gagaaaatac tttctacaag ctaatgatca gcaggactta gtggagtggg taaatgtctt
      601 gaacaaagct ataaaaatta cagtaccaaa gcagtcagac tcacagccgg cctccgacag
      661 cctgagtcgc caaggtgact gtggtaagaa gcaagtgtct tacagaactg acattgttgg
      721 tggtgtgccc atcatcacgc cgacgcagaa agaagaagta aacgaatgtg gtgagagtct
      781 ggatagaaac aatttgaaac ggtcacagag ccatcttcct tactttgctc ctaagccacc
      841 ttcagacagt gcagttatca aagctgggta ttgtgtgaag caaggagcgg tgatgaaaaa
      901 ctggaagaga agatattttc aattggatga aaacacaata ggctacttca aatctgaact
      961 ggagaaggaa cctctgcggg tgataccact taaagaagtg cacaaagtcc aggagtgcaa
     1021 acagagtgac ataatgatga gggacaacct gtttgaaatc gtgacgacat ctcggacttt
     1081 ctatgtgcag gctgatagcc ctgaagagat gcacagttgg attaaagcag tctctggcgc
     1141 catcgtagca cagcggggac ctggcaggtc atcctcttct atgcggcagg ccagaaggct
     1201 gtcgaaccct tgtatacaga ggagcattcc ggctggcctt cagaacccaa attcactgtc
     1261 cgtcctgccg gggccgcagc caccgcctca cattccccag cctctcgcag ccactctctg
     1321 gtctcaggct gtgccatgga gaagcgagga gtttaccaat ctcttgccaa ggtcaagcca
     1381 gggaacttca aggtccagac tgtctctcca agagagccag cttccaaagt gactgaacag
     1441 gctttgctca gacctcagag taaaaacggc cctcagggag aagatggcga gccagtggac
     1501 ttagatgacg ccagcctgcc agtcagcgat gtgtgaggag gctctcgtgg gctgcctgcg
     1561 ccactcaccc tcagtgtcct tccgtgaggc ttctcgccaa agatgataga gggtgaatga
     1621 tctcagtgca tatgtcatac tgccttgtgg gtggactcta agttggcaaa ccaaggattt
     1681 agggagtggc ctagtcaaca taattcttta agaaaggaag gagaaaagct gtgtccatag
     1741 tgactgtttg aagctttata tgtttgggtg gtgaaaatgt gtgtgtgttt ttttttttct
     1801 taagtgactt tgaaatttta aataacaatt taaaacatta aaatttctta ttatcttggt
     1861 catttaaacc tgctaatatg actccctttg aaatattcaa tatttacaca ttcttatcag
     1921 ctaaaattat caagtgggcc attcccagat gaaaatttct aatctcatga ggtctgtggt
     1981 gctgcagaat ttatactgca atgtggactg tttagaattc taaccattta tgatattctg
     2041 gctgtccagg tgagtggaaa tttttgcata gatttgacta gatgattggt gtaggtggca
     2101 gtggaacagg gcaagcagaa gtggggagac tggaggtcag ctatagctaa aattgttatt
     2161 tctctgggga ggggactttt tttatcttta tttttatttt ggagattgga tttttctatg
     2221 tagctatggc tgtccttgaa ttctctctgt aaaccaggct gcccttgaac ttgtgatcct
     2281 tctgcctcag ttgcctccca aattataggg ttatgtcacc aacttgcagc ctgagacact
     2341 tgttttaaaa agctcagtgt tttatttcag taaaaattat ttggtcataa attttgggaa
     2401 gaactgattt ctttttttaa atcaaagttt tgtaaataga tcttacttct gaatttgaat
     2461 cggtggaaga cctcagttca catgctaagt caaaacggcc cttagtcacg accttgttgt
     2521 ggcccctccc ttgtcatcag tagtaaccta tactcaagtg cctgtgtctt ctcatctcac
     2581 ttaggattgt accccaaagt cctacatgat tggctttaaa tgtccgggaa aactaatttc
     2641 agtagcgtag tttgataggt taaatgagat agcattttta tatcagagac accagaatgt
     2701 tggtggtcaa ctacctgtgc aatatttatg tcttgaaaac cagatctgag tatgcattga
     2761 acagtgggga tattataaac agaagcgcct ctctgaagaa cccggtttcc ggtgttgagt
     2821 gatagactgg tttgagcgag tactgttttg tggtgacatc ttaggtgttt cctttctccc
     2881 aggctgctgc tctgtggtat ttccagtctc agacttgtgt tgtggagtca tggtgttagt
     2941 gttctgcctt tttatgttct aagactactt gttagaggac ggaagatttg ctacagtggt
     3001 ctagagttaa aatgtgctct ttagttgccc agcacaagaa cgtaccactc accttttgta
     3061 ttcataagct aatatgttag agttctatgt agttttctct tgtgcacctg catcagaaaa
     3121 ccataggaca acaaggtggc taggcagtta tcacccctct gctgccgtat tcatcaccca
     3181 ggctctctta caagttcctt gttaatgcac aagcgtaggg acccttgtac agactctggc
     3241 agtattgatg agcctggcgc tgtttgcttt ggtgcagcct ccacagtgcg cgttcatttt
     3301 atcatatttt ggtatcggta atttgatata tttcatggtg gcaaaatatt agctctattt
     3361 tgggactttt tctagactta catttattca aatgcatagg aatatgtcct tgtgattatc
     3421 aggatctcct aatatttatc tcaattcttt tgtaagcttg tggaaattat ttaagtattt
     3481 taaagcatat tttcttgtaa atatatccta tccgaagtgt cagcagttac gttagttaat
     3541 accgtgttat ctgctgtatt ttccctgtgt gtataatgta tctcctttca gaacaggaat
     3601 gtgcctccta atgtttactg ttaccctgct gtctctgtat gtccagtcgg tggaacactg
     3661 taatgacttg agaataaact gcccagagtt cattttcact cacgtcccct tttatttggt
     3721 tcagtgttca tgtgaacaaa tcagtagaac tggtaaaaaa catttttggt tagttcattt
     3781 acttaccttt cagtaaacag atttcatttc caggacagcc agggttaaaa cagagaaact
     3841 ctgtcttgaa aagccaaaaa ataaaaataa ttttaaaaag tttc
//
