LOCUS       NM_013738               1570 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus pleckstrin 2 (Plek2), mRNA.
ACCESSION   NM_013738
VERSION     NM_013738.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1570)
  AUTHORS   Mao,D., Zhou,Z., Chen,H., Liu,X., Li,D., Chen,X., He,Y., Liu,M. and
            Zhang,C.
  TITLE     Pleckstrin-2 promotes tumour immune escape from NK cells by
            activating the MT1-MMP-MICA signalling axis in gastric cancer
  JOURNAL   Cancer Lett 572, 216351 (2023)
   PUBMED   37591356
  REMARK    GeneRIF: Pleckstrin-2 promotes tumour immune escape from NK cells
            by activating the MT1-MMP-MICA signalling axis in gastric cancer.
REFERENCE   3  (bases 1 to 1570)
  AUTHORS   Han,X., Mei,Y., Mishra,R.K., Bi,H., Jain,A.D., Schiltz,G.E.,
            Zhao,B., Sukhanova,M., Wang,P., Grigorescu,A.A., Weber,P.C.,
            Piwinski,J.J., Prado,M.A., Paulo,J.A., Stephens,L., Anderson,K.E.,
            Abrams,C.S., Yang,J. and Ji,P.
  TITLE     Targeting pleckstrin-2/Akt signaling reduces proliferation in
            myeloproliferative neoplasm models
  JOURNAL   J Clin Invest 133 (6), e159638 (2023)
   PUBMED   36719747
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1570)
  AUTHORS   Feola,M., Zamperone,A., Moskop,D., Chen,H., Casu,C., Lama,D., Di
            Martino,J., Djedaini,M., Papa,L., Martinez,M.R., Choesang,T.,
            Bravo-Cordero,J.J., MacKay,M., Zumbo,P., Brinkman,N., Abrams,C.S.,
            Rivella,S., Hattangadi,S., Mason,C.E., Hoffman,R., Ji,P.,
            Follenzi,A. and Ginzburg,Y.Z.
  TITLE     Pleckstrin-2 is essential for erythropoiesis in beta-thalassemic
            mice, reducing apoptosis and enhancing enucleation
  JOURNAL   Commun Biol 4 (1), 517 (2021)
   PUBMED   33941818
  REMARK    GeneRIF: Pleckstrin-2 is essential for erythropoiesis in
            beta-thalassemic mice, reducing apoptosis and enhancing
            enucleation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1570)
  AUTHORS   Lin,J.I., Feinstein,T.N., Jha,A., McCleary,J.T., Xu,J.,
            Arrigo,A.B., Rong,G., Maclay,L.M., Ridge,T., Xu,X. and Lo,C.W.
  TITLE     Mutation of LRP1 in cardiac neural crest cells causes congenital
            heart defects by perturbing outflow lengthening
  JOURNAL   Commun Biol 3 (1), 312 (2020)
   PUBMED   32546759
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1570)
  AUTHORS   Bach,T.L., Kerr,W.T., Wang,Y., Bauman,E.M., Kine,P., Whiteman,E.L.,
            Morgan,R.S., Williamson,E.K., Ostap,E.M., Burkhardt,J.K.,
            Koretzky,G.A., Birnbaum,M.J. and Abrams,C.S.
  TITLE     PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization
  JOURNAL   Blood 109 (3), 1147-1155 (2007)
   PUBMED   17008542
REFERENCE   7  (bases 1 to 1570)
  AUTHORS   Inazu,T., Kuroiwa,A., Matsuda,Y. and Miyamoto,K.
  TITLE     Cloning, expression and chromosomal assignment of human pleckstrin
            2
  JOURNAL   Mol Biol Rep 32 (1), 35-40 (2005)
   PUBMED   15865208
REFERENCE   8  (bases 1 to 1570)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
REFERENCE   9  (bases 1 to 1570)
  AUTHORS   Inazu,T., Yamada,K. and Miyamoto,K.
  TITLE     Cloning and expression of pleckstrin 2, a novel member of the
            pleckstrin family
  JOURNAL   Biochem Biophys Res Commun 265 (1), 87-93 (1999)
   PUBMED   10548495
REFERENCE   10 (bases 1 to 1570)
  AUTHORS   Hu,M.H., Bauman,E.M., Roll,R.L., Yeilding,N. and Abrams,C.S.
  TITLE     Pleckstrin 2, a widely expressed paralog of pleckstrin involved in
            actin rearrangement
  JOURNAL   J Biol Chem 274 (31), 21515-21518 (1999)
   PUBMED   10419454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC028902.1.
            
            On Feb 2, 2008 this sequence version replaced NM_013738.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028902.1, AF170564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..1570
                     /gene="Plek2"
                     /note="pleckstrin 2"
                     /db_xref="GeneID:27260"
                     /db_xref="MGI:MGI:1351466"
     exon            1..48
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1068
                     /gene="Plek2"
                     /codon_start=1
                     /product="pleckstrin-2"
                     /protein_id="NP_038766.1"
                     /db_xref="CCDS:CCDS26004.1"
                     /db_xref="GeneID:27260"
                     /db_xref="MGI:MGI:1351466"
                     /translation="MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLLYYKLEGGRRV
                     TPPKGRIVLDGCTITCPCLEYENRPLLIKLKTRTSTEYFLEACSREERDSWAFEITGA
                     IHAGQPGKIQQLHILKNSFKLPPHISLHRIVDKMHDTSTGIRPSPNMEQGSTYKKTFL
                     GSSLVDWLISSNFAASRLEAVTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDST
                     ALYTFAESYKKKVSSKEEISLSTMELSGTVVKQGYLSKQGHKRKNWKVRRFVLRKDPA
                     FLHYYDPSKEENRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYI
                     QASSKAERAEWIEAIKKLT"
     exon            49..213
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..395
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            396..487
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..675
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..777
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..861
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..940
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1551
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1217..1222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plek2"
                     /note="hexamer: AACAAA"
     polyA_site      1237
                     /gene="Plek2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgacatgg aggacggcgt gctcaaggaa ggcttcctcg tcaagagggg ccacattgtc
       61 cacaactgga aggcacgatg gttcatcctt cggcagaaca cgctcctgta ttacaagcta
      121 gagggtggcc ggcgagtaac cccgcccaag gggaggattg tccttgatgg ctgcaccatc
      181 acctgcccct gcctggagta tgaaaaccgg ccgctcctca ttaaactgaa gacccgaact
      241 tccactgagt acttcctgga agcctgttct cgagaggaga gagactcctg ggcctttgag
      301 ataacagggg ctatccatgc agggcagcca gggaagatcc aacaactcca catactgaag
      361 aactccttca agttgccccc acacatcagc ctgcatcgaa ttgtggacaa gatgcatgac
      421 accagcactg gaatccggcc aagccccaac atggagcaag gaagcaccta caaaaagacc
      481 tttctgggct cctccctggt ggactggctc atctccagca actttgcagc cagccgtctg
      541 gaggcagtga ccctggcctc catgcttatg gaagagaact ttctcaggcc agtaggggtc
      601 cggagcatgg gagctattcg ctctggcgat ctggctgagc agtttctgga tgactccaca
      661 gccctgtata cttttgctga aagctacaag aagaaggtaa gctccaagga ggaaatcagt
      721 ctcagcacca tggagttaag tggcacagtg gtcaaacaag gctacctatc caagcagggg
      781 cacaagagga aaaactggaa ggtgcgcaga tttgttctga ggaaggaccc agctttcctg
      841 cactactatg acccttccaa agaagagaac aggccagtag gtgggttttc tcttcgtggt
      901 tcccttgtgt ctgctctgga ggataatggt gttcctactg gagttaaagg gaatgtccaa
      961 ggaaatctct tcaaagtgat tacgaaggat gacacacact attatatcca ggccagcagc
     1021 aaggctgagc gagcagaatg gattgaagct atcaagaagc taacatgatc taaaggagcg
     1081 ggaccagggt tctcatcatt ggatacagat aagacttcct ggagaactgg agtacaagat
     1141 actgggctgg ggatgtggct cagtggtgga ggacttgcct ggccatcctg agttcaattc
     1201 ttggtactgt taaaaaaaca aaacaacaac aaaaaaacct tatcattata aatgttgcat
     1261 ggctttggag taagactgcc caaagtggct cctcagatga cagcggggat gcgatgattt
     1321 ccttctgcct tcctatgacc aactttaaaa gatggaccag ctgttaggtg ggcagcatct
     1381 tgactttgct cttcaggaca gaaatctgtc tttggggaca atagtagtac ctctttctct
     1441 gttggaacac taactccggt tttctgtatt aaatactcta gtctcaagac tctctctcaa
     1501 ctgatttcaa caactcagta tctctgggat taataaagaa tgacatctgt caaaaaaaaa
     1561 aaaaaaaaaa
//
