LOCUS       NM_178911               1978 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus phospholipase D family member 4 (Pld4), mRNA.
ACCESSION   NM_178911
VERSION     NM_178911.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Singh,S., Dransfeld,U.E., Ambaw,Y.A., Lopez-Scarim,J., Farese,R.V.
            Jr. and Walther,T.C.
  TITLE     PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid
            degradation in lysosomes
  JOURNAL   Cell 187 (24), 6820-6834 (2024)
   PUBMED   39423811
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Gavin,A.L., Huang,D., Blane,T.R., Thinnes,T.C., Murakami,Y.,
            Fukui,R., Miyake,K. and Nemazee,D.
  TITLE     Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory
            triggering by multiple sensors
  JOURNAL   Nat Commun 12 (1), 5874 (2021)
   PUBMED   34620855
  REMARK    GeneRIF: Cleavage of DNA and RNA by PLD3 and PLD4 limits
            autoinflammatory triggering by multiple sensors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Akizuki,S., Ishigaki,K., Kochi,Y., Law,S.M., Matsuo,K., Ohmura,K.,
            Suzuki,A., Nakayama,M., Iizuka,Y., Koseki,H., Ohara,O., Hirata,J.,
            Kamatani,Y., Matsuda,F., Sumida,T., Yamamoto,K., Okada,Y.,
            Mimori,T. and Terao,C.
  TITLE     PLD4 is a genetic determinant to systemic lupus erythematosus and
            involved in murine autoimmune phenotypes
  JOURNAL   Ann Rheum Dis 78 (4), 509-518 (2019)
   PUBMED   30679154
  REMARK    GeneRIF: Pld4 mutant mice revealed autoimmune phenotypes suggesting
            functional involvement of PLD4 with the basics of systemic lupus
            erythematosus.
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Lopez-Juarez,A., Morales-Lazaro,S., Sanchez-Sanchez,R., Sunkara,M.,
            Lomeli,H., Velasco,I., Morris,A.J. and Escalante-Alcalde,D.
  TITLE     Expression of LPP3 in Bergmann glia is required for proper
            cerebellar sphingosine-1-phosphate metabolism/signaling and
            development
  JOURNAL   Glia 59 (4), 577-589 (2011)
   PUBMED   21319224
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Otani,Y., Yamaguchi,Y., Sato,Y., Furuichi,T., Ikenaka,K., Kitani,H.
            and Baba,H.
  TITLE     PLD$ is involved in phagocytosis of microglia: expression and
            localization changes of PLD4 are correlated with activation state
            of microglia
  JOURNAL   PLoS One 6 (11), e27544 (2011)
   PUBMED   22102906
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Yoshikawa,F., Banno,Y., Otani,Y., Yamaguchi,Y., Nagakura-Takagi,Y.,
            Morita,N., Sato,Y., Saruta,C., Nishibe,H., Sadakata,T., Shinoda,Y.,
            Hayashi,K., Mishima,Y., Baba,H. and Furuichi,T.
  TITLE     Phospholipase D family member 4, a transmembrane glycoprotein with
            no phospholipase D activity, expression in spleen and early
            postnatal microglia
  JOURNAL   PLoS One 5 (11), e13932 (2010)
   PUBMED   21085684
  REMARK    GeneRIF: Results showed that PLD4 is a non-PLD, HKD motif-carrying,
            transmembrane glycoprotein localized in the endoplasmic reticulum
            and Golgi apparatus.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Felkl,M. and Leube,R.E.
  TITLE     Interaction assays in yeast and cultured cells confirm known and
            identify novel partners of the synaptic vesicle protein
            synaptophysin
  JOURNAL   Neuroscience 156 (2), 344-352 (2008)
   PUBMED   18706977
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124353.5 and
            MF597757.1.
            
            On May 2, 2007 this sequence version replaced NM_178911.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079878.1, AK170362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC124353.5         109348-109476
            130-213             AC124353.5         111219-111302
            214-380             AC124353.5         112090-112256
            381-564             AC124353.5         112656-112839
            565-685             AC124353.5         113141-113261
            686-813             AC124353.5         113691-113818
            814-1014            AC124353.5         115396-115596
            1015-1154           AC124353.5         116191-116330
            1155-1320           AC124353.5         116447-116612
            1321-1417           AC124353.5         116718-116814
            1418-1502           AC124353.5         117119-117203
            1503-1978           MF597757.1         1-476
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..1978
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /note="phospholipase D family member 4"
                     /db_xref="GeneID:104759"
                     /db_xref="MGI:MGI:2144765"
     exon            1..129
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1614
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /EC_number="3.1.16.1"
                     /note="phospholipase D4; PLD 4; choline phosphatase 4;
                     phosphatidylcholine-hydrolyzing phospholipase D4;
                     (S,S)-bis(monoacylglycero)phosphate synthase PLD4"
                     /codon_start=1
                     /product="5'-3' exonuclease PLD4"
                     /protein_id="NP_849242.1"
                     /db_xref="CCDS:CCDS26195.1"
                     /db_xref="GeneID:104759"
                     /db_xref="MGI:MGI:2144765"
                     /translation="MDKKKEHPEMRIPLQTAVEVSDWPCSTSHDPHSGLGMVLGMLAV
                     LGLSSVTLILFLWQGATSFTSHRMFPEEVPSWSWETLKGDAEQQNNSCQLILVESIPE
                     DLPFAAGSPTAQPLAQAWLQLLDTARESVHIASYYWSLTGLDIGVNDSSSRQGEALLQ
                     KFQQLLLRNISVVVATHSPTLAKTSTDLQVLAAHGAQIRQVPMKQLTGGVLHSKFWVV
                     DGRHIYVGSANMDWRSLTQVKELGAIIYNCSNLAQDLEKTFQTYWVLGTPQAVLPKTW
                     PRNFSSHINRFHPLRGPFDGVPTTAYFSASPPSLCPHGRTRDLDAVLGVMEGARQFIY
                     VSVMEYFPTTRFTHHARYWPVLDNALRAAALNKGVHVRLLVSCWFNTDPTMFAYLRSL
                     QAFSNPSAGISVDVKVFIVPVGNHSNIPFSRVNHSKFMVTDKTAYVGTSNWSEDYFSH
                     TAGVGLIVSQKTPRAQPGATTVQEQLRQLFERDWSSHYAMDLDRQVPSQDCVW"
     exon            130..213
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            214..380
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            381..564
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            565..685
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            686..813
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            814..1014
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1154
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1320
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1417
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1978
                     /gene="Pld4"
                     /gene_synonym="thss"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaacaaag aggaagtgaa tggaaggggg aagcagcagg ccagagagga ggcaggtgcc
       61 tgcctgcaca ggcaaagcct gcagacagtg gctggaacca ggatggacaa gaagaaagag
      121 cacccagaga tgcggatacc actccagaca gcagtggagg tctctgattg gccctgctcc
      181 acatctcatg atccacatag cggacttggc atggtactgg ggatgctagc tgtactggga
      241 ctcagctctg tgactctcat cttgttcctg tggcaagggg ccacttcttt caccagtcat
      301 cggatgttcc ctgaggaagt gccctcctgg tcctgggaga ccctgaaagg agacgctgag
      361 cagcagaata actcctgtca gctcatcctt gtggaaagca tccctgagga cttgccattt
      421 gcagctggca gccccactgc ccagcccctg gcccaggctt ggctgcagct tcttgacact
      481 gctcgggaga gcgtccacat tgcctcgtac tactggtccc tcactggact ggacattgga
      541 gtcaatgact cgtcttctcg gcagggagag gcccttctac agaagttcca acagcttctt
      601 ctcaggaaca tctctgtggt ggtggccacc cacagcccaa cattggccaa gacatccact
      661 gacctccagg tcttggctgc ccatggtgcc cagatacgac aagtgcccat gaaacagctt
      721 actgggggtg ttctacactc caaattctgg gttgtggatg ggcgacacat ctacgtgggc
      781 agtgccaaca tggactggcg gtccctgact caggtgaagg aacttggtgc aatcatctac
      841 aactgcagca acctggctca agaccttgag aaaacattcc agacctactg ggtgctaggg
      901 actccccaag ctgttctccc taaaacctgg cctcggaact tctcatccca catcaaccgc
      961 ttccatccct tgcggggtcc ctttgatggg gttcccacca cggcctattt ctcggcctcc
     1021 cctccctccc tctgcccgca tggccggacc cgggatctgg acgcagtgtt gggagtgatg
     1081 gagggtgctc gccagttcat ctatgtctcg gtgatggagt atttccctac cacgcgcttc
     1141 acccaccatg ccaggtactg gcccgtgctg gacaatgcgc tacgggcagc ggccctcaat
     1201 aagggtgtgc atgtgcgctt actggtcagc tgctggttca acacagaccc caccatgttc
     1261 gcttatctga ggtccctgca ggctttcagt aacccctcgg ctggcatctc agtggatgtg
     1321 aaagtcttca tcgtgcctgt gggaaatcat tccaacatcc cgttcagccg cgtgaaccac
     1381 agcaagttca tggtcacaga caagacagcc tatgtaggca cctctaactg gtcagaagac
     1441 tacttcagcc acaccgctgg tgtgggcctg attgtcagcc agaagacccc cagagcccag
     1501 ccaggcgcaa ccaccgtgca ggagcagctg aggcaactct ttgaacgaga ctggagttcc
     1561 cactatgcta tggacctaga cagacaagtc ccgagccagg actgtgtctg gtagggctga
     1621 gggttgatcc ctttgattct ggcctacagc tctagatgga cactgatgct ccccagactt
     1681 ccatctgccc aagctcagaa accaagcaag caaaggatca ccactgaggg cccgagattg
     1741 tcatcagaca aacagcttcc ggcagagctc tcaacggctt ttaaacgaag aagaggctaa
     1801 agcagaggga ggcaccacgg tgacatggga agacagcaac tacatataag tgacccccag
     1861 aaccctccct ggtctaccta tgatgagttg ctagggccat tcccagatgt aatgttggtg
     1921 ctgtccagcc acaataaaac cctgccacca gctactgacc tgacccaggt caaaagtg
//
