LOCUS       NP_001404025             488 aa            linear   ROD 16-FEB-2025
DEFINITION  5'-3' exonuclease PLD3 isoform a [Mus musculus].
ACCESSION   NP_001404025 XP_006539705
VERSION     NP_001404025.1
DBSOURCE    REFSEQ: accession NM_001417096.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Singh,S., Dransfeld,U.E., Ambaw,Y.A., Lopez-Scarim,J., Farese,R.V.
            Jr. and Walther,T.C.
  TITLE     PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid
            degradation in lysosomes
  JOURNAL   Cell 187 (24), 6820-6834 (2024)
   PUBMED   39423811
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Yuan,P., Zhang,M., Tong,L., Morse,T.M., McDougal,R.A., Ding,H.,
            Chan,D., Cai,Y. and Grutzendler,J.
  TITLE     PLD3 affects axonal spheroids and network defects in Alzheimer's
            disease
  JOURNAL   Nature 612 (7939), 328-337 (2022)
   PUBMED   36450991
  REMARK    GeneRIF: PLD3 affects axonal spheroids and network defects in
            Alzheimer's disease.
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Gavin,A.L., Huang,D., Blane,T.R., Thinnes,T.C., Murakami,Y.,
            Fukui,R., Miyake,K. and Nemazee,D.
  TITLE     Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory
            triggering by multiple sensors
  JOURNAL   Nat Commun 12 (1), 5874 (2021)
   PUBMED   34620855
  REMARK    GeneRIF: Cleavage of DNA and RNA by PLD3 and PLD4 limits
            autoinflammatory triggering by multiple sensors.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Kent,D.G., Copley,M.R., Benz,C., Wohrer,S., Dykstra,B.J., Ma,E.,
            Cheyne,J., Zhao,Y., Bowie,M.B., Zhao,Y., Gasparetto,M., Delaney,A.,
            Smith,C., Marra,M. and Eaves,C.J.
  TITLE     Prospective isolation and molecular characterization of
            hematopoietic stem cells with durable self-renewal potential
  JOURNAL   Blood 113 (25), 6342-6350 (2009)
   PUBMED   19377048
  REMARK    GeneRIF: Pld3 expression is associated with hematopoietic stem
            cells that have durable self-renewal potential.
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Tanaka,K., Tamura,H., Tanaka,H., Katoh,M., Futamata,Y., Seki,N.,
            Nishimune,Y. and Hara,T.
  TITLE     Spermatogonia-dependent expression of testicular genes in mice
  JOURNAL   Dev Biol 246 (2), 466-479 (2002)
   PUBMED   12051830
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     Expression of a novel murine phospholipase D homolog coincides with
            late neuronal development in the forebrain
  JOURNAL   J Biol Chem 273 (47), 31494-31504 (1998)
   PUBMED   9813063
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Roy,I.L., Perez-Diaz,F. and Roubertoux,P.
  TITLE     Quantitative trait loci implicated in corpus callosum midsagittal
            area in mice
  JOURNAL   Brain Res 811 (1-2), 173-176 (1998)
   PUBMED   9804947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158304.11.
            
            On Feb 24, 2023 this sequence version replaced XP_006539705.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.7020637.1,
                                           SRR17784651.458921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.92 cM"
     Protein         1..488
                     /product="5'-3' exonuclease PLD3 isoform a"
                     /EC_number="3.1.16.1"
                     /note="phospholipase D3; PLD 3; choline phosphatase 3;
                     schwannoma-associated protein 9;
                     phosphatidylcholine-hydrolyzing phospholipase D3; 5'-3'
                     exonuclease PLD3; (S,S)-bis(monoacylglycero)phosphate
                     synthase PLD3"
                     /calculated_mol_wt=54258
     Site            39..59
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35405.1)"
     Site            71..72
                     /site_type="cleavage"
                     /note="Cleavage, by lysosomal cysteine proteases.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (O35405.1)"
     Region          77..488
                     /region_name="PHA02820"
                     /note="phospholipase-D-like protein; Provisional"
                     /db_xref="CDD:222934"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:38537643,
                     ECO:0007744|PDB:8V05; propagated from UniProtKB/Swiss-Prot
                     (O35405.1)"
     Site            132
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35405.1)"
     Site            234
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:38537643,
                     ECO:0007744|PDB:8V05; propagated from UniProtKB/Swiss-Prot
                     (O35405.1)"
     Site            282
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (O35405.1)"
     Site            385
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (O35405.1)"
     CDS             1..488
                     /gene="Pld3"
                     /gene_synonym="Sam-9"
                     /coded_by="NM_001417096.1:368..1834"
                     /note="isoform a is encoded by transcript variant 3"
                     /db_xref="GeneID:18807"
                     /db_xref="MGI:MGI:1333782"
ORIGIN      
        1 mkpklmyqel kvpveepage lplneieawk aaekkarwvl lvlilavvgf galmtqlflw
       61 eygdlhlfgp nqrpapcydp ceavlvesip eglefpnatt snpstsqawl gllagahssl
      121 diasfywtlt nndthtqeps aqqgeevlqq lqalaprgvk vriavskpng pladlqsllq
      181 sgaqvrmvdm qklthgvlht kfwvvdqthf ylgsanmdwr sltqvkelgv vmyncsclar
      241 dltkifeayw flgqagssip stwprsfdtr ynqetpmeic lngtpalayl asappplcps
      301 grtpdlkall nvvdsarsfi yiavmnylpt mefshprrfw paiddglrra ayergvkvrl
      361 liscwghsdp smrsfllsla alhdnhthsd iqvklfvvpt desqaripya rvnhnkymvt
      421 erasyigtsn wsgsyfteta gtsllvtqng hgglrsqlea vflrdwespy shdldtsans
      481 vgnacrll
//
