LOCUS       NM_054066               2182 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus phospholipase C, zeta 1 (Plcz1), mRNA.
ACCESSION   NM_054066
VERSION     NM_054066.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Hirose,N., Kikuchi,Y., Kageyama,A., Sugita,H., Sakurai,M.,
            Kawata,Y., Terakawa,J., Wakayama,T., Ito,J. and Kashiwazaki,N.
  TITLE     Successful Production of Offspring Derived from Phospholipase C
            Zeta-Deficient Sperm by Additional Artificial Activation
  JOURNAL   Life (Basel) 13 (4), 980 (2023)
   PUBMED   37109509
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Wang,T., Cao,B., Cai,Y., Chen,S., Wang,B., Yuan,Y. and Zhang,Q.
  TITLE     Plcz1 Deficiency Decreased Fertility in Male Mice Which Is
            Associated with Sperm Quality Decline and Abnormal Cytoskeleton in
            Epididymis
  JOURNAL   Int J Mol Sci 24 (1), 314 (2022)
   PUBMED   36613757
  REMARK    GeneRIF: Plcz1 Deficiency Decreased Fertility in Male Mice Which Is
            Associated with Sperm Quality Decline and Abnormal Cytoskeleton in
            Epididymis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Kashir,J., Mistry,B.V., Gumssani,M.A., Rajab,M., Abu-Dawas,R.,
            AlMohanna,F., Nomikos,M., Jones,C., Abu-Dawud,R., Al-Yacoub,N.,
            Coward,K., Lai,F.A. and Assiri,A.M.
  TITLE     Advancing male age differentially alters levels and localization
            patterns of PLCzeta in sperm and testes from different mouse
            strains
  JOURNAL   Asian J Androl 23 (2), 178-187 (2021)
   PUBMED   33208563
  REMARK    GeneRIF: Advancing male age differentially alters levels and
            localization patterns of PLCzeta in sperm and testes from different
            mouse strains.
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Ferrer-Buitrago,M., Tilleman,L., Thys,V., Hachem,A., Boel,A., Van
            Nieuwerburgh,F., Deforce,D., Leybaert,L., De Sutter,P.,
            Parrington,J. and Heindryckx,B.
  TITLE     Comparative study of preimplantation development following distinct
            assisted oocyte activation protocols in a PLC-zeta knockout mouse
            model
  JOURNAL   Mol Hum Reprod 26 (11), 801-815 (2020)
   PUBMED   32898251
  REMARK    GeneRIF: Comparative study of preimplantation development following
            distinct assisted oocyte activation protocols in a PLC-zeta
            knockout mouse model.
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Fujimoto,S., Yoshida,N., Fukui,T., Amanai,M., Isobe,T., Itagaki,C.,
            Izumi,T. and Perry,A.C.
  TITLE     Mammalian phospholipase Czeta induces oocyte activation from the
            sperm perinuclear matrix
  JOURNAL   Dev Biol 274 (2), 370-383 (2004)
   PUBMED   15385165
  REMARK    GeneRIF: Results suggest a mechanism by which phospholipase C zeta
            originates from an oocyte-penetrating assembly--the sperm
            perinuclear matrix--to induce mammalian oocyte activation at
            fertilization.
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Larman,M.G., Saunders,C.M., Carroll,J., Lai,F.A. and Swann,K.
  TITLE     Cell cycle-dependent Ca2+ oscillations in mouse embryos are
            regulated by nuclear targeting of PLCzeta
  JOURNAL   J Cell Sci 117 (Pt 12), 2513-2521 (2004)
   PUBMED   15159452
  REMARK    GeneRIF: Cell cycle-dependent Ca2+ oscillations are regulated by
            nuclear targeting of PlCzeta.
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Kouchi,Z., Fukami,K., Shikano,T., Oda,S., Nakamura,Y., Takenawa,T.
            and Miyazaki,S.
  TITLE     Recombinant phospholipase Czeta has high Ca2+ sensitivity and
            induces Ca2+ oscillations in mouse eggs
  JOURNAL   J Biol Chem 279 (11), 10408-10412 (2004)
   PUBMED   14701816
  REMARK    GeneRIF: purified PLCzeta protein induces Ca(2+) oscillations,
            indicating that PLCzeta is a proper candidate of the mammalian
            egg-activating sperm factor
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Cox,L.J., Larman,M.G., Saunders,C.M., Hashimoto,K., Swann,K. and
            Lai,F.A.
  TITLE     Sperm phospholipase Czeta from humans and cynomolgus monkeys
            triggers Ca2+ oscillations, activation and development of mouse
            oocytes
  JOURNAL   Reproduction 124 (5), 611-623 (2002)
   PUBMED   12416999
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Saunders,C.M., Larman,M.G., Parrington,J., Cox,L.J., Royse,J.,
            Blayney,L.M., Swann,K. and Lai,F.A.
  TITLE     PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs
            and embryo development
  JOURNAL   Development 129 (15), 3533-3544 (2002)
   PUBMED   12117804
  REMARK    GeneRIF: results are consistent with sperm phospholipse C zeta as
            the molecular trigger for development of a fertilised egg into an
            embryo
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC158625.9.
            
            On May 1, 2007 this sequence version replaced NM_054066.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF435950.1, BC106767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC158625.9         108907-108973       c
            68-224              AC158625.9         108127-108283       c
            225-348             AC158625.9         107211-107334       c
            349-580             AC158625.9         95880-96111         c
            581-782             AC158625.9         90674-90875         c
            783-927             AC158625.9         83642-83786         c
            928-1077            AC158625.9         81098-81247         c
            1078-1317           AC158625.9         77970-78209         c
            1318-1474           AC158625.9         75161-75317         c
            1475-1591           AC158625.9         71422-71538         c
            1592-1764           AC158625.9         69636-69808         c
            1765-1891           AC158625.9         60479-60605         c
            1892-2044           AC158625.9         58203-58355         c
            2045-2182           AC158625.9         57278-57415         c
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 69.77 cM"
     gene            1..2182
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /note="phospholipase C, zeta 1"
                     /db_xref="GeneID:114875"
                     /db_xref="MGI:MGI:2150308"
     exon            1..67
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            68..224
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2133
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /EC_number="3.1.4.11"
                     /note="phospholipase C zeta; PLC-zeta-1; phosphoinositide
                     phospholipase C-zeta-1"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase zeta-1"
                     /protein_id="NP_473407.2"
                     /db_xref="CCDS:CCDS20671.1"
                     /db_xref="GeneID:114875"
                     /db_xref="MGI:MGI:2150308"
                     /translation="MESQLHELAEARWFLSKVQDDFRGGKINVEITHKLLEKLDFPCH
                     FAHVKHIFKENDRQNQGRITIEEFRAIYRCIVHREEITEIFNTYTENRKILSENSLIE
                     FLTQEQYEMEIDHSDSVEIINKYEPIEEVKGERQMSIEGFARYMFSSECLLFKENCKT
                     VYQDMNHPLSDYFISSSHNTYLISDQILGPSDIWGYVSALVKGCRCLEIDCWDGSQNE
                     PIVYHGYTFTSKLLFKTVVQAINKYAFVTSDYPVVLSLENHCSPGQQEVMASILQSTF
                     GDFLLSDMLEEFPDTLPSPEALKFKILVKNRKVGTLSETHERIGTDKSGQVLEWKEVI
                     YEDGDEDSGMDPETWDVFLSRIKEEREADPSTLSGIAGVKKRKRKMKIAMALSDLVIY
                     TKAEKFRNFQYSRVYQQFNETNSIGESRARKLSKLRVHEFIFHTAAFITRVYPKMMRA
                     DSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPDILRDTTLGF
                     NPNEPEYDDHPVTLTIRIISGIQLPVSSSSNTPDIVVIIEVYGVPNDHVKQQTRVVKN
                     NAFSPKWNETFTFLIQVPELALIRFVVETQQGLLSGNELLGQYTLPVLCMNKGYRRVP
                     LFSKSGANLEPSSLFIYVWYFRE"
     exon            225..348
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            349..580
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            581..782
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            783..927
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1077
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1317
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1474
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1591
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1764
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1891
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2044
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2182
                     /gene="Plcz1"
                     /gene_synonym="1700041H07Rik; PLCzeta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcaagcc atgccaactg tgaaggtttt aagaacttag cttctggaca agttttcttc
       61 gaaagtgaaa agcggtagca gcgagaacag ctgatgacgg tcacaaaaag acagtgttac
      121 ttctaagaca agtgacacct tagacgaaga gccctctatg ggaggacaag cggcccagat
      181 catgaaatca tggaaagcca acttcatgag ctcgcagaag caagatggtt tttgtcaaag
      241 gttcaggatg attttagagg tggaaaaatc aacgttgaaa ttactcacaa actgcttgag
      301 aaacttgatt tcccatgcca ctttgctcat gtgaaacata tttttaagga aaatgacaga
      361 cagaaccaag gaagaatcac cattgaagag tttagagcca tttaccggtg tattgtacat
      421 agagaagaaa tcacggagat tttcaacacg tatactgaaa ataggaaaat tctttctgag
      481 aacagtctga ttgagtttct aacccaagag cagtatgaaa tggagatcga tcactctgat
      541 tcagtagaga tcatcaataa gtatgagccc attgaagaag taaagggtga gcgacagatg
      601 tcaattgaag gtttcgcaag atacatgttt tcatcagaat gtctactgtt taaagagaac
      661 tgtaaaaccg tgtaccaaga tatgaatcat ccattaagtg attattttat ttcatcatct
      721 cacaacacat atttgatatc cgatcaaata ttgggaccga gtgacatttg gggatatgta
      781 agtgctcttg tgaaaggctg ccgctgtctg gaaattgact gctgggatgg atcccaaaat
      841 gaacccattg tgtaccatgg ttacacattc accagcaagc ttctcttcaa aactgtggtc
      901 caagcaataa acaagtatgc ctttgtgaca tctgattacc cagtagtgct gtccttagaa
      961 aatcactgct cccctggtca gcaggaagtg atggctagca ttctgcagag cacctttgga
     1021 gacttcctgc tttcggacat gcttgaggag tttccagata cactaccgtc tccagaggca
     1081 ctaaaattca aaatattagt gaaaaacagg aaagtgggaa ccttatctga aacccacgag
     1141 aggataggaa ccgacaaaag tggccaagtg ctagaatgga aagaagtcat ctatgaagat
     1201 ggtgatgaag actcaggaat ggatccagaa acatgggatg tcttcctatc acggatcaag
     1261 gaggagaggg aagcagatcc ctcgacattg agtggaatag caggcgtcaa gaaaaggaag
     1321 aggaagatga aaatagccat ggccttatct gatcttgtca tttatactaa ggctgagaag
     1381 ttccgaaact tccaatattc aagagtctat cagcaattta atgagaccaa ttcgattgga
     1441 gagtctcgag ctcgaaaact ttccaaattg agagtccatg agtttatttt ccacaccgcg
     1501 gcattcatca ccagagtata ccccaaaatg atgagagcag actcttctaa ctttaaccct
     1561 caagagtttt ggaatgtagg atgtcagatg gtggccttga actttcaaac ccctggactg
     1621 cctatggatt tgcaaaacgg gaaatttttg gataatggag gctctggata tattttgaag
     1681 ccagacatcc ttagagatac aaccctgggc tttaacccaa atgaaccaga atatgacgac
     1741 catccagtta ccctcacaat ccgaatcatc agtgggatcc agttgcctgt tagctcatcc
     1801 tctaacacgc ctgacatagt agtgatcata gaagtctacg gtgttccaaa cgaccacgtg
     1861 aagcagcaga ctcgtgttgt taagaataat gcttttagtc caaagtggaa tgaaacattt
     1921 acatttctta ttcaagtgcc agaactggca ttgatacgtt ttgttgttga aactcaacaa
     1981 ggcttattat caggaaatga attactcggg cagtacactt taccagttct ttgcatgaac
     2041 aaaggttatc gtcgtgttcc tctgttttcc aaatccggtg cgaaccttga accttcctca
     2101 ctgtttattt atgtttggta cttcagagag tgacgcatgt aactgacgcg ttagctacac
     2161 atcacagtaa acagtccaaa gg
//
