LOCUS       NM_177355               1905 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus phosphatidylinositol-specific phospholipase C, X
            domain containing 3 (Plcxd3), mRNA.
ACCESSION   NM_177355
VERSION     NM_177355.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1905)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   2  (bases 1 to 1905)
  AUTHORS   Mattiske,T., Lee,K., Gecz,J., Friocourt,G. and Shoubridge,C.
  TITLE     Embryonic forebrain transcriptome of mice with polyalanine
            expansion mutations in the ARX homeobox gene
  JOURNAL   Hum Mol Genet 25 (24), 5433-5443 (2016)
   PUBMED   27798109
REFERENCE   3  (bases 1 to 1905)
  AUTHORS   Fischl,A.M., Heron,P.M., Stromberg,A.J. and McClintock,T.S.
  TITLE     Activity-dependent genes in mouse olfactory sensory neurons
  JOURNAL   Chem Senses 39 (5), 439-449 (2014)
   PUBMED   24692514
  REMARK    GeneRIF: Plcxd3 is an activity dependent gene in mouse olfactory
            sensory neurons.
REFERENCE   4  (bases 1 to 1905)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   5  (bases 1 to 1905)
  AUTHORS   Bishop,M.T., Sanchez-Juan,P. and Knight,R.S.
  TITLE     Splice site SNPs of phospholipase PLCXD3 are significantly
            associated with variant and sporadic Creutzfeldt-Jakob disease
  JOURNAL   BMC Med Genet 14, 91 (2013)
   PUBMED   24028506
  REMARK    GeneRIF: Three intronic SNPs in the PLCXD3 gene (rs319013,
            rs76547469, and rs545358) are associated with increased risk of CJD
            compared with published healthy control data and represent the
            first major association of a non- PRNP candidate gene.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113957.8, AK044972.1, AK038575.1 and BE945500.1.
            
            On Mar 1, 2008 this sequence version replaced NM_177355.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.287044.1,
                                           SRR1660811.18707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC113957.8         26490-26643         c
            155-711             AK044972.1         2-558
            712-1034            AK038575.1         803-1125
            1035-1888           AK044972.1         882-1735
            1889-1905           BE945500.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.96 cM"
     gene            1..1905
                     /gene="Plcxd3"
                     /gene_synonym="B130016O10Rik"
                     /note="phosphatidylinositol-specific phospholipase C, X
                     domain containing 3"
                     /db_xref="GeneID:239318"
                     /db_xref="MGI:MGI:2442605"
     exon            1..325
                     /gene="Plcxd3"
                     /gene_synonym="B130016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1188
                     /gene="Plcxd3"
                     /gene_synonym="B130016O10Rik"
                     /codon_start=1
                     /product="PI-PLC X domain-containing protein 3"
                     /protein_id="NP_796329.2"
                     /db_xref="CCDS:CCDS27362.2"
                     /db_xref="GeneID:239318"
                     /db_xref="MGI:MGI:2442605"
                     /translation="MASSQGKNELKFADWMATLPESIHSIPLTNLAIPGSHDSFSFYI
                     DEASPVGPEQPETVQNFVSVFGTVAKKLMRKWLATQTMSFTGQLGAGIRYFDLRISTK
                     PRDPDNELYFAHGLFSAKVNEGLEEINAFLTDHHKEVVFLDFNHFYGMQKYHHEKLVQ
                     MLKDIYGNKMCPAIFAQEVSLKYLWEKDYQVLVFYHSPVALEVPFLWPGQMMPAPWAN
                     TTDPEKLIQFLQASITERRKKGSFFISQVVLTPKASTVVKGVASGLRETITERALPAM
                     MQWIRTQKPGESGINIVTADFVELGDFISTVIKLNYVFNEGEANT"
     exon            326..1034
                     /gene="Plcxd3"
                     /gene_synonym="B130016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1896
                     /gene="Plcxd3"
                     /gene_synonym="B130016O10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaaaagc cccggcagtg gagtctggca aggcaaggag ggagcatggg gtgtttttga
       61 ataattatta aaatgagcat gtgtctgcgc catcctgtgg gtgtggcgca gagcggagtg
      121 taaactctag cggggccgaa gcaaacattg gcttaacggc agcagctgcc agcctgtgcc
      181 taggagtgtg gcgactagcg cggcggcaag cagaccggca ccatggcctc atctcagggg
      241 aaaaacgagc tgaaattcgc cgactggatg gcaactctgc ctgagagcat ccacagcatc
      301 cccctcacca atttagccat cccagggtcc catgattcct tcagcttcta cattgatgaa
      361 gcttctccag taggcccgga gcagccagaa acagttcaaa actttgtctc tgtgttcgga
      421 actgtagcca agaagttgat gcggaaatgg ttagccactc agacgatgag cttcactggt
      481 cagctgggag ctggaatccg ttacttcgac cttcgaattt ccaccaagcc cagagaccca
      541 gacaatgaac tgtattttgc tcacggctta ttcagtgcca aagtcaacga gggtctcgaa
      601 gagatcaatg catttctcac agaccaccac aaagaggtag tattcttgga cttcaaccat
      661 ttttatggga tgcaaaaata tcaccatgaa aaactggtcc aaatgctgaa agacatctat
      721 ggaaacaaga tgtgcccagc catttttgcc caggaagtga gtctaaagta cctatgggag
      781 aaggactatc aagtactggt cttctaccac agtccagtgg cactggaagt gcccttcctc
      841 tggcctggac agatgatgcc agcaccctgg gcaaacacga cagacccaga gaaattgatc
      901 cagtttcttc aggcatccat caccgagaga agaaagaagg gctcattttt tatatctcag
      961 gtggtgctga cacccaaagc aagcactgtg gtcaagggtg tggcaagtgg actcagagaa
     1021 acaatcacag agagagctct tcccgccatg atgcagtgga tccgtaccca aaagccagga
     1081 gagagcggca tcaatattgt cactgccgat tttgtagaac ttggtgactt tatcagcact
     1141 gtcataaaac tcaactatgt cttcaatgaa ggagaggcca acacttgata ttactcttct
     1201 gggtgtccat gaggaagata gagaagcctc attgtattag acatattatc aataagccct
     1261 ctgattttcc tgttccactg agtctctgaa ggaactgggg cttagaagtg ggtgggaaat
     1321 gagggtaaac catgtcttca gtgattgtaa ccatattctg cattgctata aatatgtcat
     1381 ttccaatttg gtgaccaaaa tctacttcta gtgttaggaa tagaaaagaa cagtgaattt
     1441 catttttcaa aattaatgtt tgtgcagtgt aactcatgag tgtttactag attgcatttt
     1501 ctgatttcaa cctcaggccc ctgtattatt catagtctct accctttcca ctccctctct
     1561 cttgcttgct cttcctaatt agatgctata tgggtgtcaa aacaattgaa tgcccgacat
     1621 aatgtgtatt tcattgttgt gccgaaatgt gtttgttttg tgagacttgg taaaaatatt
     1681 ccatagtcat ctgcaattgg gcaatcatag ctaattcttg gtcgtagaaa atatgcatca
     1741 aatcagtctc cctgcatcag taatattggc agtcaggagt gattttgtgt tttatgaaaa
     1801 caacagcatt tcacagcggc tgtgtgcgag gcagctatgg ctttcatgca aaaagactct
     1861 tggaaagact gagtgtcaac ttcacagtaa aaaaaaaaaa aaaaa
//
