LOCUS       NM_013880               4068 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus phospholipase C-like 2 (Plcl2), mRNA.
ACCESSION   NM_013880 XM_128631
VERSION     NM_013880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4068)
  AUTHORS   Gao,J., Mizokami,A., Takeuchi,H., Li,A., Huang,F., Nagano,H.,
            Kanematsu,T., Jimi,E. and Hirata,M.
  TITLE     Phospholipase C-related but catalytically inactive protein acts as
            a positive regulator of insulin signalling in adipocytes
  JOURNAL   J Cell Sci 135 (1) (2022)
   PUBMED   34859819
REFERENCE   2  (bases 1 to 4068)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4068)
  AUTHORS   Yamawaki,Y., Shirawachi,S., Mizokami,A., Nozaki,K., Ito,H.,
            Asano,S., Oue,K., Aizawa,H., Yamawaki,S., Hirata,M. and
            Kanematsu,T.
  TITLE     Phospholipase C-related catalytically inactive protein regulates
            lipopolysaccharide-induced hypothalamic inflammation-mediated
            anorexia in mice
  JOURNAL   Neurochem Int 131, 104563 (2019)
   PUBMED   31589911
  REMARK    GeneRIF: Phospholipase C-related catalytically inactive protein
            regulates lipopolysaccharide-induced hypothalamic
            inflammation-mediated anorexia in mice.
REFERENCE   4  (bases 1 to 4068)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   5  (bases 1 to 4068)
  AUTHORS   Matsuda,M. and Hirata,M.
  TITLE     Phospholipase C-related but catalytically inactive proteins
            regulate ovarian follicle development
  JOURNAL   J Biol Chem 292 (20), 8369-8380 (2017)
   PUBMED   28360101
  REMARK    GeneRIF: These results suggest that PRIPs are positively involved
            in the development of follicles via their regulation of LH-LHR
            signaling and estradiol secretion.
REFERENCE   6  (bases 1 to 4068)
  AUTHORS   Kanematsu,T., Yasunaga,A., Mizoguchi,Y., Kuratani,A., Kittler,J.T.,
            Jovanovic,J.N., Takenaka,K., Nakayama,K.I., Fukami,K., Takenawa,T.,
            Moss,S.J., Nabekura,J. and Hirata,M.
  TITLE     Modulation of GABA(A) receptor phosphorylation and membrane
            trafficking by phospholipase C-related inactive protein/protein
            phosphatase 1 and 2A signaling complex underlying brain-derived
            neurotrophic factor-dependent regulation of GABAergic inhibition
  JOURNAL   J Biol Chem 281 (31), 22180-22189 (2006)
   PUBMED   16754670
REFERENCE   7  (bases 1 to 4068)
  AUTHORS   Takenaka,K., Fukami,K., Otsuki,M., Nakamura,Y., Kataoka,Y.,
            Wada,M., Tsuji,K., Nishikawa,S., Yoshida,N. and Takenawa,T.
  TITLE     Role of phospholipase C-L2, a novel phospholipase C-like protein
            that lacks lipase activity, in B-cell receptor signaling
  JOURNAL   Mol Cell Biol 23 (20), 7329-7338 (2003)
   PUBMED   14517301
  REMARK    GeneRIF: PLC-L2 is a novel negative regulator of BCR signaling and
            immune responses
REFERENCE   8  (bases 1 to 4068)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4068)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 4068)
  AUTHORS   Otsuki,M., Fukami,K., Kohno,T., Yokota,J. and Takenawa,T.
  TITLE     Identification and characterization of a new phospholipase C-like
            protein, PLC-L(2)
  JOURNAL   Biochem Biophys Res Commun 266 (1), 97-103 (1999)
   PUBMED   10581172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB033615.1, BY125070.1, CD553464.1, AK137821.1, AK134985.1 and
            BE983099.1.
            
            On Apr 3, 2009 this sequence version replaced NM_013880.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033615.1, SRR1660815.140990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               AB033615.1         129-501
            374-541             BY125070.1         164-331
            542-1078            AB033615.1         670-1206
            1079-1576           CD553464.1         62-559
            1577-2763           AK137821.1         487-1673
            2764-3636           AK134985.1         1095-1967
            3637-4068           BE983099.1         1-432               c
FEATURES             Location/Qualifiers
     source          1..4068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.86 cM"
     gene            1..4068
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /note="phospholipase C-like 2"
                     /db_xref="GeneID:224860"
                     /db_xref="MGI:MGI:1352756"
     exon            1..391
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..2878
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3082
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3158
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3268
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..4051
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3612..3617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /note="hexamer: AATAAA"
     polyA_site      3637
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /note="major polyA site"
     regulatory      4016..4021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4037
                     /gene="Plcl2"
                     /gene_synonym="mKIAA1092; PLC-L2; Plce2; PRIP-2"
ORIGIN      
        1 cgaggcggcg gcggcgggga cgcggggacg cggctttgtg caggcgggtc gtggggcgcc
       61 catggcggag tgtggccggg gcgccgcagg aggggccctg cccacctccc cgagcccggc
      121 cctaggcgcc aagggcgccc tgaaagccgg agccggggaa ggcggaggtg gtggcggggg
      181 aggtcgcctc ggccacgggc gggcgcgcta tgacagcggc ggggtttcca acggagactg
      241 cagcctcggc gtgtccgggg acgaagcccg gaccagccct ggcaggggac ctctaggcgt
      301 ggcgctcgcg cggaccccta gcccagctgc cggtccggtc cccagggaca gcaaaccggg
      361 cggcctgccc cgccggagca gcatcatcaa ggatggcacg aagcagaaaa gggagcggaa
      421 gaagacggtg tcattcagca gcatgccgac agagaagaag atcagcagcg caagtgactg
      481 tatcaactca atggttgagg gctctgaact caaaaaggtt cgttctaact ccagaattta
      541 ccatcggtat tttctgctgg acgccgacat gcaaagcctg aggtgggagc catctaagaa
      601 ggattctgag aaagccaaga ttgatatcaa atctatcaag gaagtgagaa caggaaagaa
      661 cacagatata ttccgcagca atggcatttc tgagcagatc tctgaagatt gtgcattttc
      721 agtcatatat ggagaaaatt atgagtcact tgatttggtt gccaattctg cagatgttgc
      781 aaacatctgg gtgacaggac tccgctacct gatttcttat gggaaacata cacttgatat
      841 gctagaaagt agccaagaca acatgaggac ttcttggatt tcacaaatgt ttagtgaaat
      901 tgatgtagat ggtcttggac atataactct gtgtcatgct gtccagtgta tcagaaacct
      961 caatcctggt ctaaaaacaa gcaaaattga gcttaagttc aaagaattgc ataaatcaaa
     1021 ggacaaagct ggtactgaaa tcacaaagga ggaatttatt gaggtctttc atgaactttg
     1081 tactagacct gaaatttact tccttttagt tcagttttca agcaataaag aattccttga
     1141 taccaaggac cttatgatgt ttcttgaggc agaacagggt gtagcacata tcaatgagga
     1201 aataagcctg gaaattattc acaaatacga gccatccaaa gaaggccagg aaaagggctg
     1261 gctctccata gatggattca ctaactacct gatgtcacct gattgttaca tctttgatcc
     1321 ggaacataag aaggtctgtc aggatatgaa gcaacctctg tctcattact ttataaactc
     1381 atctcataat acatacttaa tagaggatca gttccggggt ccctctgaca tcacgggata
     1441 tatccgcgct ctgaaaatgg gttgcaggag cgttgaatta gatgtgtggg atgggccaga
     1501 taatgagcct gtgatttaca caggccacac catgacctct cagatagtct tccgcagcgt
     1561 catcgacatc attaacaagt acgcgttctt tgcttctgag tatcctctca tcttatgttt
     1621 agaaaaccac tgctctatta aacaacagaa ggtgatggtt caacacatga agaaaatttt
     1681 aggagacaag ctgtatacga catcacccaa catggaggaa tcttatctac catccccaga
     1741 tgtcctgaaa gggaaaatac taatcaaagc aaagaagctg tcttcaaatt gctccggcgt
     1801 ggaaggggat gttactgatg aggatgaagg agcagaaatg tctcagagga tggggaaaga
     1861 gaatgtggaa caacccaacc atgtgcctgt gaagcggttt cagctttgca aagaactgtc
     1921 cgagctggtc agcatctgta aatccgtcca gttcaaggag tttcaggtgt cgtttcaggt
     1981 gcagaagtac tgggaagtgt gctcctttaa tgaagtactt gcgagtaaat acgccaatga
     2041 gaaccccggg gactttgtga attacaataa gcgtttcctc gccagggtct tccctagtcc
     2101 aatgagaatt gactcaagca acatgaaccc tcaggatttt tggaaatgtg gctgtcagat
     2161 tgtagccatg aacttccaga ctccagggct gatgatggac ctaaacgttg gctggtttag
     2221 gcagaatgga aactgtggct atgttcttcg accagccatc atgagggaag aagtctcctt
     2281 cttcagtgcc aacaccaagg actctgtccc aggagtttca cctcagttgc ttcacatcaa
     2341 aatcatcagc ggccagaact ttcccaaacc caaagggtcg ggtgccaaag gtgacgtggt
     2401 ggacccttat gtctatgtgg aaatccacgg aattcctgcc gactgcgcgg agcaaaggac
     2461 aaaaacggtg aaccagaatg gagatgctcc tatttttgac gagagctttg agtttcagat
     2521 taacctccct gaactagcca tggtgcgctt tgtcgtgctg gacgacgact acatcggcga
     2581 tgagttcatc ggccagtaca ccattccctt cgagtgttta cagacgggct accgccatgt
     2641 gcctctgcag tccctgactg gagaggtcct cgcccacgct tctctgttcg tccacgtggc
     2701 tattactaac aggagagggg gagggaagcc tcacaaacgg ggcctttccg tgaggaaagg
     2761 aaaaaagtcc cgggaatatg cctctctgag aacactgtgg attaaaactg tagacgaggt
     2821 gttcaagaac gcccagcccc ccatacggga tgccacggac ctgagagaga acatgcagaa
     2881 tgcagtggtg tcgttcaaag agttgtgtgg cctctcctcc gtggccaacc tcatgcagtg
     2941 catgcttgcc gtgtctcctc gattcctggg gcctgacaat aaccccctgg tggtcttgaa
     3001 ccttagtgag ccctacccca ccatggagct gcaagccatc gtgcctgagg tgctgaagaa
     3061 gattgtaaca acttatgaca tgatgatgca gtccctcaag gcactgattg aaaatgcaga
     3121 cgctgtgtat gaaaagatcg tgcactgtca gaaggcagcc atggaatttc atgaacactt
     3181 gcacagcata ggcaccaagg aggggctgaa ggaacggaaa ctacagaagg cagtggagag
     3241 ctttacctgg aatattacaa tcttaaaggg gcaagcggat cttctgaaat atgctaagaa
     3301 tgagaccctg gagaacctga agcagatcca ctttgcagct gtttcctgtg gactgaacaa
     3361 accaggcact gaaaactccg aggcccagaa gccacgccgg agcctagaag ccatccccga
     3421 gaaagccagt gatgaaaatg gagactaagg gtcctcccag tcactgtgga cttcccaccg
     3481 agaaccagtc agcaggcgca ctggctcact gatcaggatg agagctggga tgtctgtcgg
     3541 agcacaactg gaatacccaa ctgcagccca tcactgctgt gaatgtatgt agcaacccac
     3601 gtgtgaaggc aaataaactc tttaacaaga aactctatcc tggcccaaac atgctgtctt
     3661 tgtatacaaa acgccctgag tcccactgtg aagagcagtg ctttgccgta ttccagcaga
     3721 aacaggcagt tccctcactc gggggaactg gattggattg ctgagtttgt atttattggt
     3781 gaaatggtga atgtgcacac ctcactgtgt gtgcttgcca gtcttggcgc tgcagaggat
     3841 ttgttggcgt gcttgctgag ccatatttac taagcagaat gtaagaaccc aggagctgag
     3901 ggcaatgtgc agtgtgacta aggctgcctg gctgaagatg tgctgtgtca gcatgggcag
     3961 ccgggtggaa gccgcacctt gtacatagat tttcactgta tgttgtagtg gtcacattaa
     4021 agatatcttt tatgatattt ctccaatagc aaaaaaaaaa aaaaaaaa
//
