LOCUS       NM_001114663            6555 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phospholipase C-like 1 (Plcl1), mRNA.
ACCESSION   NM_001114663
VERSION     NM_001114663.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6555)
  AUTHORS   Hu,Y., Ye,S., Kong,J., Zhou,Q., Wang,Z., Zhang,Y., Yan,H., Wang,Y.,
            Li,T., Xie,Y., Chen,B., Zhao,Y., Zhang,T., Zheng,X., Niu,J., Hu,B.,
            Wang,S., Chen,Z. and Zheng,C.
  TITLE     DOT1L protects against podocyte injury in diabetic kidney disease
            through phospholipase C-like 1
  JOURNAL   Cell Commun Signal 22 (1), 519 (2024)
   PUBMED   39456056
  REMARK    GeneRIF: DOT1L protects against podocyte injury in diabetic kidney
            disease through phospholipase C-like 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6555)
  AUTHORS   Luo,S., Li,X.F., Yang,Y.L., Song,B., Wu,S., Niu,X.N., Wu,Y.Y.,
            Shi,W., Huang,C. and Li,J.
  TITLE     PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3
            inflammasomes in rheumatoid arthritis
  JOURNAL   Adv Rheumatol 62 (1), 25 (2022)
   PUBMED   35820936
  REMARK    GeneRIF: PLCL1 regulates fibroblast-like synoviocytes inflammation
            via NLRP3 inflammasomes in rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6555)
  AUTHORS   Gao,J., Mizokami,A., Takeuchi,H., Li,A., Huang,F., Nagano,H.,
            Kanematsu,T., Jimi,E. and Hirata,M.
  TITLE     Phospholipase C-related but catalytically inactive protein acts as
            a positive regulator of insulin signalling in adipocytes
  JOURNAL   J Cell Sci 135 (1) (2022)
   PUBMED   34859819
REFERENCE   4  (bases 1 to 6555)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6555)
  AUTHORS   Maetani,Y., Asano,S., Mizokami,A., Yamawaki,Y., Sano,T., Hirata,M.,
            Irifune,M. and Kanematsu,T.
  TITLE     Expression of PRIP, a phosphatidylinositol 4,5-bisphosphate binding
            protein, attenuates PI3K/AKT signaling and suppresses tumor growth
            in a xenograft mouse model
  JOURNAL   Biochem Biophys Res Commun 552, 106-113 (2021)
   PUBMED   33743346
  REMARK    GeneRIF: Expression of PRIP, a phosphatidylinositol
            4,5-bisphosphate binding protein, attenuates PI3K/AKT signaling and
            suppresses tumor growth in a xenograft mouse model.
REFERENCE   6  (bases 1 to 6555)
  AUTHORS   Harada,K., Takeuchi,H., Oike,M., Matsuda,M., Kanematsu,T.,
            Yagisawa,H., Nakayama,K.I., Maeda,K., Erneux,C. and Hirata,M.
  TITLE     Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in
            Ins(1,4,5)P3-mediated Ca2+ signaling
  JOURNAL   J Cell Physiol 202 (2), 422-433 (2005)
   PUBMED   15468068
  REMARK    GeneRIF: PRIP-1 plays an important role in regulating the
            Ins(1,4,5)P3-mediated Ca2+ signaling by modulating type1 inositol
            polyphosphate 5-phosphatase activity through binding to
            Ins(1,4,5)P3.
REFERENCE   7  (bases 1 to 6555)
  AUTHORS   Yamaguchi,T., Kubota,T., Kanematsu,T., Nakayama,K., Hirata,M. and
            Yamamoto,T.
  TITLE     Hypersensitivity to pentylenetetrazol-induced convulsion in mice
            lacking the PLC-related inactive protein-1
  JOURNAL   Brain Res 1025 (1-2), 237-240 (2004)
   PUBMED   15464766
REFERENCE   8  (bases 1 to 6555)
  AUTHORS   Terunuma,M., Jang,I.S., Ha,S.H., Kittler,J.T., Kanematsu,T.,
            Jovanovic,J.N., Nakayama,K.I., Akaike,N., Ryu,S.H., Moss,S.J. and
            Hirata,M.
  TITLE     GABAA receptor phospho-dependent modulation is regulated by
            phospholipase C-related inactive protein type 1, a novel protein
            phosphatase 1 anchoring protein
  JOURNAL   J Neurosci 24 (32), 7074-7084 (2004)
   PUBMED   15306641
REFERENCE   9  (bases 1 to 6555)
  AUTHORS   Kanematsu,T., Jang,I.S., Yamaguchi,T., Nagahama,H., Yoshimura,K.,
            Hidaka,K., Matsuda,M., Takeuchi,H., Misumi,Y., Nakayama,K.,
            Yamamoto,T., Akaike,N., Hirata,M. and Nakayama,K.
  TITLE     Role of the PLC-related, catalytically inactive protein p130 in
            GABA(A) receptor function
  JOURNAL   EMBO J 21 (5), 1004-1011 (2002)
   PUBMED   11867528
REFERENCE   10 (bases 1 to 6555)
  AUTHORS   Otsuki,M., Fukami,K., Kohno,T., Yokota,J. and Takenawa,T.
  TITLE     Identification and characterization of a new phospholipase C-like
            protein, PLC-L(2)
  JOURNAL   Biochem Biophys Res Commun 266 (1), 97-103 (1999)
   PUBMED   10581172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK083136.1,
            BE981359.1, AK140530.1, AI644888.1 and AC145691.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140530.1, SRR10223970.307.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AK083136.1         27-521
            496-901             BE981359.1         177-582
            902-3328            AK140530.1         254-2680
            3329-3657           AI644888.1         138-466
            3658-6555           AC145691.5         95488-98385
FEATURES             Location/Qualifiers
     source          1..6555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.15 cM"
     gene            1..6555
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="phospholipase C-like 1"
                     /db_xref="GeneID:227120"
                     /db_xref="MGI:MGI:3036262"
     exon            1..685
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..3733
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="phospholipase C-related but catalytically inactive
                     protein; phospholipase C, eta 2 pseudogene"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 1"
                     /protein_id="NP_001108135.1"
                     /db_xref="CCDS:CCDS48263.1"
                     /db_xref="GeneID:227120"
                     /db_xref="MGI:MGI:3036262"
                     /translation="MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAPPPALGGRMR
                     DRRSGVALPGAAGVPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPS
                     EKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLD
                     ISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSG
                     LRYLVSRSKQPLDFIEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTL
                     KESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDAN
                     DLMLFLEAEQGVTHITEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDP
                     EQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDG
                     PDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQM
                     KKVFGEKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPSESDLLEGEVTDEDEEAEMS
                     RRMSGDYNGEQKHIWLCRELSDLVSICKSVQHRDFELSMKTQNYWEMCSFSETEASRI
                     ANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLH
                     TGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGA
                     CAKGDVIDPYVCVEIHGIPADCCEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFV
                     ILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGK
                     PQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKE
                     LCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGAIPDVQKRMLAAY
                     DLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAW
                     NITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGGGSEAKGKRSLEAIEEKE
                     SSEENGKL"
     exon            686..3160
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3364
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3440
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3550
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..6555
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3850..3855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="hexamer: CATAAA"
     polyA_site      3875
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="major polyA site"
     regulatory      5204..5209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="hexamer: AGTAAA"
     polyA_site      5232
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="major polyA site"
     regulatory      6346..6351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
                     /note="hexamer: AATAAA"
     polyA_site      6366
                     /gene="Plcl1"
                     /gene_synonym="C230017K02Rik; PLC-L; PLC-L1; PLCE; PLCL;
                     PLDL1; PRIP; PRIP-1"
ORIGIN      
        1 acttcctggg gccgccgtgc tgcggtcggc gggcaggtgg ctggtggccg atccgcagtc
       61 gccgctccgg ccgcgcacgt cccggctccg aggctcctgg ctccggcgcc cactgccttt
      121 tgtctgcaca gagccggcgc tcgcctcgcg tctccagtac ctcccgctgc ttttcgcctg
      181 cttctccctc ccgctcacat cttctccccg cccccgccgc ccgtccgcgc cggcccgctg
      241 acctcctgga ccacagcccg aggacgcctc tgccggagcg atgtctcctt tctacaaagt
      301 tgtggctgcc actgcagcgg ccgtggcgcg ctaaaacaaa gtctagcggg gtttccttct
      361 ggtgcctgag cgcacccgtg cccggggctg gacgccgctg gcggtcgtgc tgtctcgccg
      421 ggagcctaaa acgtgcttgg ctatggctga gggcgcggct agcagggagg ctccggcgcc
      481 tctcgacgtt gccgggggcg aagacgaccc ccgagccggc gccgacgctg cctcagggga
      541 cgccccaccc ccggccttgg ggggccggat gagggaccgt cgcagtgggg tcgcgctgcc
      601 gggcgctgcg ggggtccccg cggatagcga ggccggcctc ctggaggctg cacgagcgac
      661 cccccggcgt agcagcatca tcaaggatcc ttcaaaccaa aaatgtggtg gcagaaagaa
      721 aacagtgtct ttcagtagca tgccatcgga gaagaagatt agcagtgccc acgactgcat
      781 tagcttcatg caggctggct gcgagctgaa gaaagtgcgc ccgaactctc gcatctacaa
      841 ccgatttttc accctagata ccgacctcca ggctctacgc tgggaacctt ccaagaaaga
      901 ccttgaaaaa gccaagctgg acatttctgc catcaaagag atcaggctgg ggaagaacac
      961 agagacattc agaaacaatg gccttgctga ccagatctgt gaagactgtg ccttctccat
     1021 actccatggg gaaaattacg agtctctgga cctagttgcc aattcagcag atgtggcaaa
     1081 catctgggtg tcggggttac ggtacctggt ctctcgtagt aagcaaccgc ttgattttat
     1141 agagggtaac cagaacacac cacggttcat gtggctgaaa acggtgtttg aagcagcaga
     1201 tgttgatgga aatgggatta tgttagaaga cacttcagtg gagttaataa aacaactcaa
     1261 ccctactctg aaggaatcta agatcaggtt aaaatttaaa gaaatccaga agagcaaaga
     1321 aaaactaact acccgggtga cagaagagga attttgtgaa gcattttgcg aactgtgcac
     1381 caggccagaa gtgtacttct tacttgtcca gatatctaag aacaaagagt acctggatgc
     1441 caatgacctc atgctcttct tagaagctga gcaaggtgtc acccacatca ctgaggatat
     1501 gtgtttagac atcattagga gatatgagct ctctgaagat ggccgccaga aaggcttcct
     1561 tgcaattgat gggtttaccc agtatttatt gtctccagaa tgtgacattt ttgatccaga
     1621 gcaaaaaaaa gttgcccaag atatgaccca acccttatct cactactata tcaatgcgtc
     1681 tcataatacc tacctgatag aagatcagtt caggggacca gcagatatca atgggtatgt
     1741 gagagcattg aagatgggct gtagaagcat tgagctcgat gtgagtgatg gtccggataa
     1801 tgagcccatc ctttgtaata ggaacaacat ggccatgcac ctttcctttc gaagtgttct
     1861 ggaggtgata aataagtttg cctttgttgc ttcagagtac ccactcattc tctgcttggg
     1921 gaatcactgc tctctgcctc agcagaaagt catggcacag cagatgaaaa aggtgtttgg
     1981 cgagaaactt tatacagaag cacctttgtc ttcagaatcc tacctcccat cacctgaaaa
     2041 actaaaaaat atgattattg tgaaaggaaa gaaattgcct tcggaatcag atctgttaga
     2101 aggagaagtg accgacgagg acgaagaagc cgagatgtcg cggaggatgt caggggatta
     2161 caacggtgag cagaaacata tctggctctg ccgagagctc tctgacttgg tatccatctg
     2221 caaatctgtt cagcacaggg attttgaact gtctatgaaa acccaaaact actgggaaat
     2281 gtgttcattt agtgaaacag aggccagccg gattgccaat gaatacccag aggacttcgt
     2341 gaattataac aagaagttct tatcaagggt ctaccctagt gccatgcgga tagattccag
     2401 taatttgaac ccacaggact tctggaactg tggctgtcag attgtggcga tgaattttca
     2461 aactcccggt ccaatgatgg acctccacac tggctggttt cttcaaaatg gaggatgtgg
     2521 ctacgtcctc aggccatcta tcatgcgaga tgaagtttcg tacttcagcg caaatacaaa
     2581 gggcattgtc cctggcgtgt ctcccctggt tcttcacatc aagatcatca gtggtcagaa
     2641 cttcccaaag cccaaaggag cctgtgccaa aggggatgtc atagacccct atgtttgtgt
     2701 ggagattcac ggaattccag ctgattgctg cgagcaaaga actaaaactg tacaacagaa
     2761 cagcgataat ccaatttttg atgaaacttt cgagtttcaa gtcaaccttc ccgagctgac
     2821 catggtccgt tttgtcattt tggatgatga ttatattggg gatgagttca ttgggcagta
     2881 tacgatccca tttgaatgtc tgcagcccgg gtaccggcac gttcccttgc gctcctttgt
     2941 tggggatatc atggagcacg tgaccctttt cgttcacata gcaataacca atcgcagtgg
     3001 aggaggaaaa ccacagaagc gaagcctttc tgtgagaatg gggaagaaag ttcgagaata
     3061 caccatgctc aggaatattg gtcttaaaac catagatgat atcttcaaaa tagcagttca
     3121 tcccttacga gaagccatag atatgagaga aaacatgcag aacgccatag tgtctgttaa
     3181 ggagctgtgt ggactcccgc cgattgccag tctgaaacag tgcctgttaa ccctgtcctc
     3241 tcgtctcatc accagtgaca gtactccctc tgtgtctctg gtgatgaagg actgctttcc
     3301 ttacctggag cctctgggtg ccattccaga tgtgcagaag aggatgctgg ctgcatatga
     3361 tctgatgatt caagagagcc gggtcctcat agaaatggct gacacagttc aggaaaagat
     3421 tgtacagtgt cagaaagcag ggatggaatt ccatgaggaa cttcataatc tgggggcaaa
     3481 ggaaggcttg aagggaagaa aactcaacaa ggccattgag agcttcgctt ggaatattac
     3541 ggtattgaag ggacaaggag acctgctgaa gaatgccaag aatgaagccg tggagaacat
     3601 aaagcaaatc cagctggcct gcttgtcttg tggactgagt aaaggccctg gcggtggctc
     3661 agaggccaag ggcaagcgca gcttggaagc gatagaggag aaagaaagta gtgaggagaa
     3721 cgggaagctg tgagctgggc agtgcgcatg acctcgtcga gcaccgcggc ttctcattct
     3781 tgtctttttg ttttgttttt acattcttca gatgttcaca gaaatgatcc ccccccgtgg
     3841 ggtgttgtac ataaacatat attttcacag tgtcagtatt ttactgtagt taatttatct
     3901 aagttaaaac ttttagtagc agtattttaa actctaagct gtgagtatat acttacatgt
     3961 gactgccttg tgcctgtgtg tatccgtgca tgtgtgtgtg cgtgtgtgcg tacgtgcgtg
     4021 tgtgtataca tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgagagagag
     4081 agagagagag agagagagag agagaagagt tcctattaaa acattctctg tcgcattgtt
     4141 ggttttagta agttattctt ttatctttat gatcatttgg ggacagctga taatctgaat
     4201 tttaatgagc agttattata acccattgct gtggttagtt ttacccctct gcttttgtca
     4261 tataattttg agatcttagc acagcttatt gaagaaaacc aaatttataa aagcaaaggt
     4321 gttttataga ttacatatta catatagatt taaaaattcc taaaaatttc atcagaaatg
     4381 aaagtgaata gaaatctttt aaaatcagaa ttctggaaag ataaattcat ttcttcatta
     4441 gcagaatctt taaaatattt attaaataaa atcaaattta ggaagtttct gtagatgttt
     4501 actaagcatg tggtttttgg tagaaaagct gtggacagtg aatttgtagc cactgggcag
     4561 tactttgaaa cacactaaat gccctgttgt aactagcact gttgtgacag gaacatccaa
     4621 ttgtgaaatt tcaaggtttg cagaaagacc tcattctcct gagattggag tatggaattc
     4681 attttctatt accagttggg gcagatacag tgcttggcaa ggactggatt tagtgtagag
     4741 tactaaattt aaatgcaaag acattgttaa aataatatat catcattttg agctggcata
     4801 aattctgtaa gtcagataac atctttatga tgatttgaaa actaactaat tagacagcat
     4861 gtattttaaa acatacagta aaaaccacaa gcaaatggct aattagggta catttataat
     4921 tatatttaga taattttacc ctaatgtctt cacaaacttc ttaaatgtga tgttcattca
     4981 ttaccaccaa cagaactaaa tgttctatgg ttatggaaga atatatttat ttaaaacatt
     5041 gcttttattt tgaaaagctt cgtaattaat ttgattaaca aatatgctaa ttggggggac
     5101 ctggagaaga tgaaactttg caaacttaat catcctctac agctaccgcg ttagtgctga
     5161 ctgctcttaa tgccactctg gtcttgttgc acattaccaa aagagtaaag atgctgaaaa
     5221 cagagttctt gatcttgttt cttgtaaatt tattgggggg ggggggcgga tggggacaaa
     5281 gttcttttgt tatataaaag tgatagaggg ttcactggtt tcacagacca gatatcataa
     5341 aattatccga ggcatgtgga ggaagtgact gggttcactt gaagacaaat ttccaacagt
     5401 gcaatgacct gaaagtatcc ctctaccctc cgttcctctt accctgctga gagagggata
     5461 gtgaagaaga gttgccatga gtccctagga cagaaaggtc agtgctattg gcagaagcaa
     5521 tctgcctgct ggaggcttcc tgggcatctc agattccatt tggaccaatc catgccttac
     5581 aggtgataaa gccgggtggc aaaatcacaa aggatattta tttttgcttt gctttggtgt
     5641 caaacttagt ctttaggcat ggtgcctggt tcaatccacc catctttaag ctcctttcat
     5701 actcggtata atatgtgcat cttctggaga atgtgctgtg cgcttgctct gccttctctg
     5761 agtctcttcc agcagttgtc agtacccttc tatccaatct ctgagcatct ctgccagcgg
     5821 agaagtagga cacagcccag gatagagctt tagagatgct gagaaggtgc ccctatgaca
     5881 gtgttgcctt tggatagact agcaaaagta caatgacaga caaatgtgtt tggtatccat
     5941 gcaacacagt ttttacagtc tacagtttat ctccattgta gtcttgaact actttatgga
     6001 aagtcacttc ttccattatt cttggtgatg caagtcagtt attatatatt agttattatt
     6061 ctatttttat ttttatatca ctattggaat ttgaggcagg agtggtaaga ataaccactg
     6121 acatttatag atgagaagtc agtcactgaa atagcaaatg aaaaactaca tttgaactca
     6181 cgtctgcctg atgttatatg tacaagggtg ttcagtgatt tttattttaa ttttattctc
     6241 aaaaatttaa ctacatttgt aactctcttg tcaccacaaa aaatatattg tctttcttct
     6301 gaaaacatta atgatattga agttcaaaaa cagacaaatc tataaaataa aaataagata
     6361 aaattatcac atagtaacat tttgattttt tatttcctca gacattagat gtaactgtgc
     6421 atggtatttt aagaaaattg atgtatttta tttgaatgtt tttcaaaaaa caggtaaaca
     6481 tagttttgag agatgaagaa atttcatatt taattcaatt tattattttc attaaaagtt
     6541 tggaggtttt aatta
//
