LOCUS       NM_001113360            5094 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus phospholipase C, eta 2 (Plch2), transcript variant 2,
            mRNA.
ACCESSION   NM_001113360
VERSION     NM_001113360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5094)
  AUTHORS   Popovics,P., Gray,A., Arastoo,M., Finelli,D.K., Tan,A.J. and
            Stewart,A.J.
  TITLE     Phospholipase C-eta2 is required for retinoic acid-stimulated
            neurite growth
  JOURNAL   J Neurochem 124 (5), 632-644 (2013)
   PUBMED   23237262
  REMARK    GeneRIF: The role of PLCeta2 in neuritogenesis was assessed during
            retinoic acid (RA)-induced Neuro2A cell differentiation
REFERENCE   2  (bases 1 to 5094)
  AUTHORS   Kanemaru,K., Nakahara,M., Nakamura,Y., Hashiguchi,Y., Kouchi,Z.,
            Yamaguchi,H., Oshima,N., Kiyonari,H. and Fukami,K.
  TITLE     Phospholipase C-eta2 is highly expressed in the habenula and retina
  JOURNAL   Gene Expr Patterns 10 (2-3), 119-126 (2010)
   PUBMED   20060933
  REMARK    GeneRIF: PLCeta2 exhibited a dynamic expression pattern during
            postnatal retinal development, strongly suggesting that this
            isozyme might be involved in the development and maturation of the
            retina.
REFERENCE   3  (bases 1 to 5094)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (bases 1 to 5094)
  AUTHORS   Zhou,Y., Wing,M.R., Sondek,J. and Harden,T.K.
  TITLE     Molecular cloning and characterization of PLC-eta2
  JOURNAL   Biochem J 391 (Pt 3), 667-676 (2005)
   PUBMED   16107206
  REMARK    GeneRIF: The molecular cloning and sequencing of phospholipase C
            eta2 are reported.
REFERENCE   5  (bases 1 to 5094)
  AUTHORS   Nakahara,M., Shimozawa,M., Nakamura,Y., Irino,Y., Morita,M.,
            Kudo,Y. and Fukami,K.
  TITLE     A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme
  JOURNAL   J Biol Chem 280 (32), 29128-29134 (2005)
   PUBMED   15899900
  REMARK    GeneRIF: PLC(eta)2 is a neuron-specific isozyme that may be
            important for the formation and/or maintenance of the neuronal
            network in the postnatal brain
REFERENCE   6  (bases 1 to 5094)
  AUTHORS   Stewart,A.J., Mukherjee,J., Roberts,S.J., Lester,D. and
            Farquharson,C.
  TITLE     Identification of a novel class of mammalian
            phosphoinositol-specific phospholipase C enzymes
  JOURNAL   Int J Mol Med 15 (1), 117-121 (2005)
   PUBMED   15583837
  REMARK    GeneRIF: molecular cloning of PLC-eta1 and PLC-eta2.
REFERENCE   7  (bases 1 to 5094)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831788.14 and BX004788.7.
            
            On Jun 19, 2019 this sequence version replaced NM_001113360.2.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AL831788.14        12953-13339         c
            388-534             AL831788.14        11305-11451         c
            535-778             AL831788.14        9232-9475           c
            779-908             AL831788.14        8916-9045           c
            909-1079            AL831788.14        5069-5239           c
            1080-1173           AL831788.14        3118-3211           c
            1174-1377           AL831788.14        2762-2965           c
            1378-1498           AL831788.14        2379-2499           c
            1499-1670           BX004788.7         80641-80812         c
            1671-1778           BX004788.7         80243-80350         c
            1779-1937           BX004788.7         77922-78080         c
            1938-2036           BX004788.7         74715-74813         c
            2037-2119           BX004788.7         74323-74405         c
            2120-2217           BX004788.7         73075-73172         c
            2218-2400           BX004788.7         72805-72987         c
            2401-2508           BX004788.7         72479-72586         c
            2509-2633           BX004788.7         71683-71807         c
            2634-2718           BX004788.7         71520-71604         c
            2719-2865           BX004788.7         71210-71356         c
            2866-2945           BX004788.7         70908-70987         c
            2946-3243           BX004788.7         68509-68806         c
            3244-5094           BX004788.7         64905-66755         c
FEATURES             Location/Qualifiers
     source          1..5094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.13 cM"
     gene            1..5094
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /note="phospholipase C, eta 2"
                     /db_xref="GeneID:269615"
                     /db_xref="MGI:MGI:2443078"
     exon            1..387
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..4547
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /EC_number="3.1.4.11"
                     /note="isoform b is encoded by transcript variant 2;
                     phospholipase C-like protein 4; phosphoinositide
                     phospholipase C-eta-2; phosphoinositide phospholipase
                     C-like 4; 1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2 isoform b"
                     /protein_id="NP_001106831.1"
                     /db_xref="CCDS:CCDS71533.1"
                     /db_xref="GeneID:269615"
                     /db_xref="MGI:MGI:2443078"
                     /translation="MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEK
                     GIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGG
                     SVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKN
                     EKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEAR
                     TWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLN
                     VNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDA
                     SDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFN
                     PEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWD
                     GPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQY
                     LTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSA
                     DEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKL
                     GRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDE
                     TLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKA
                     HQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRML
                     QLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRD
                     SVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALV
                     RFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQT
                     LGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELAL
                     GTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIA
                     EEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGREN
                     EEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPA
                     VYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSL
                     GRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRP
                     PWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPG
                     IRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIAS
                     RARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAAD
                     GQLLLRL"
     exon            388..534
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            535..778
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            779..908
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1079
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1173
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1377
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1498
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1670
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1778
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1937
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2036
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2119
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2217
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2400
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2508
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2633
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2718
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2719..2865
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2945
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3243
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..5094
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4808..4813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /note="hexamer: AATAGA"
     polyA_site      4836
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /note="major polyA site"
     regulatory      5062..5067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /note="hexamer: AATAAA"
     polyA_site      5083
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
ORIGIN      
        1 tggcattcat cttcttcaaa taggcctgga ggttctagag gatgggcgga ctggcctggg
       61 gaccatccag ggccgcaggc agcagttggg tcaatgccag tgggacctgg gaacagccct
      121 tgcggggctt cagtgggctc caaggaggaa gacgaagagg tagaggagag aaggggatcc
      181 ctgaggagcc cctgtgccag ctgacacctc agcttggcct gtcgctgagg gtcccttttg
      241 gcttggggga ctacggcttg gatatgcctg gtccccagcc gtctgctgcc agccagacca
      301 caggagccgt ggcttgcctg gcagaggtac tcctctgggt tggagggagc gtggtagtgt
      361 caccaagatg gcagctcagc cttgtagtgg agcgatgcat gagtgccatg caagagggga
      421 cccagatggt gaagctccgt ggcagctcca agggattggt ccgcttctac tacctggatg
      481 agcaccgctc ctgcctccga tggcgtccct cccgcaagaa cgagaaagcc aagatttcca
      541 tcgactccat ccaggaggtg agtgagggcc ggcagtctga aatcttccag cgctacccgg
      601 acagcagctt tgaccccaac tgctgcttca gcatctacca tggcagccac agagagtcgc
      661 tggacttggt ctcacccagc agtgaagagg cacgtacctg ggtcaccggc cttcgctacc
      721 tcatggctgg catcagcgat gaagacagcc tagcccgtcg ccagcgtacc agggaccagt
      781 ggctgaagca gacgtttgat gaggctgaca agaacgggga cggcagcctg agcatcagtg
      841 aggttctgca gctgctacat aaactcaacg tgaacctgcc ccggcagagg gtgaaacaga
      901 tgttcaggga ggcggacaca gatgaccatc aggggacatt aggctttgag gaattctgcg
      961 ccttctacaa gatgatgtct acccgccgag acctctacct gctcatgctg acctacagca
     1021 accataagga ccacttggat gcctccgacc tgcagcgctt tctggaggtg gagcagaaga
     1081 tgaacggtgt gaccctggag agctgtcaga acatcattga gcagtttgag ccttgcctgg
     1141 aaaataagag caaggggatg ctggggattg atggctttac caactacacc cggagccccg
     1201 ccggtgacat cttcaaccct gagcacaaca gagtgcacca agacatgacg cagccgctga
     1261 gtcactactt catcacctcg tcccacaaca cctacctcgt gggtgaccag ctcatgtccc
     1321 agtctcgggt ggacatgtat gcctgggtcc tgcaggccgg ctgccgctgt gtggaggtgg
     1381 actgctggga cgggcccgat ggagaaccca ttgtccatca tggctacact ctgacctcca
     1441 agatcctttt caaagatgtc atcgaaacca tcaacaaata cgccttcatc aagaatgagt
     1501 acccagtgat cctgtccatt gagaaccact gtagtgttgt tcagcagaag aagatggccc
     1561 agtatctgac tgacatcctc ggggacaagc tggacctctc ctcagtgagc agcgaagatg
     1621 ccaccatgct tccatctcca cagatgctca agggcaagat cctggtgaag gggaagaagc
     1681 tccctgccaa tatcagtgag gatgcagaag aaggcgaagt atctgatgag gacagtgctg
     1741 atgagatgga ggatgactgc aagctcctca atggggatgc ctccaccaat cggaagcgtg
     1801 tggaaaacat tgcaaagaag aagctggatt ctctgatcaa ggagtcaaag atccgtgact
     1861 gtgaagaccc caatgacttc tctgtgtcca cactatcccc ctctggaaag cttgggcgca
     1921 aagcagaggc caagaagggt cagagcaagg ttgaggaaga cgtggaggcc ggggaagaca
     1981 gcggggtgag caggcagaat agccgcctct tcatgagcag cttctccaag cgcaagaaaa
     2041 aaggcagcaa gataaagaag gtggccagcg tggaagaggg ggacgagacc ctggactccc
     2101 caggaagcca gagccgaggg actgcccggc aaaagaagac catgaagctg tcacgagccc
     2161 tctcggacct agtgaaatat accaagtctg tggggaccca tgacgtggag atagaggtgg
     2221 tatctagctg gcaggtgtcg tccttcagtg agaccaaggc ccatcagatc ctgcagcaga
     2281 agcccaccca gtacctgcgc ttcaaccagc accagctctc gcgcatatac ccctcctcct
     2341 accgtgtgga ctccagcaac tacaatccac aacccttctg gaacgctggt tgccagatgg
     2401 ttgccctgaa ctaccagtca gaggggcgga tgctacagct gaacagggcc aagttcagcg
     2461 ccaacggtga ctgtggctac gtgctcaaac cccagtgcat gtgccagggt gtcttcaacc
     2521 ccaactcgga ggatcccctg ccggggcagc tcaagaagca gctggccctg aggatcatca
     2581 gtggccagca gctgcccaaa ccacgggact cggtgctggg cgaccgtggg gagatcatcg
     2641 accccttcgt ggaggtggag gtcattgggc tccccgtgga ctgcagcaag gagcagaccc
     2701 gagtggtgga cgacaacgga ttcaacccca tgtgggagga gacactggtg ttcaccgtgc
     2761 acatgccaga gattgcgctt gtacgcttcc tggtctggga ccatgacccc attggacgtg
     2821 acttcatcgg ccagaggaca ctagccttca gcagcataat gccaggctac cggcatgtgt
     2881 acctagaagg gatggaagag gcctctatct ttgttcatgt ggctgtcagt gacattagtg
     2941 gtaaggtcaa gcagactctg ggtctaaaag gtctcttcct ccgaggcaca aagccaggct
     3001 cgctggacag tcatgctgct ggacagcccc tcccccggcc ctccgttagc cagaggctcc
     3061 tgcggcgcac ggccagtgcc ccgaccaaaa gccagaagcc aagtcgcaag ggcttcccag
     3121 agctggccct gggcacacag gacgcaggct ccgagggggc agctgatgac gtggcaccct
     3181 ctagccccaa cccagctctg gaggccccta ctcaagagag gtcaggcagc agcagccccc
     3241 gagatactcg cctcttcccc ctgcagcggc ccatctcccc cctgtgcagc ctggaaccca
     3301 ttgccgagga accagccctg ggccctggcc tcccgttaca ggcagctgcc cccacaggtc
     3361 catctcagga agggtcccag tgccctgtag gcctgggagc caaagtgacc agctcccagc
     3421 agacatctct gggagctttt ggaaccctcc agctcaggat tgggggcggt agggaaaacg
     3481 aagagccacc cctcaggcca cacaatggtg ggatctccag cgggccacgt gaggggactt
     3541 ctggaagaca gacagacagc aagagccgct cccgggtccc gggccacttg ccagtggtta
     3601 ggagggccaa gagtgagggc caggtgctct cggagctctc tcccacacct gcagtgtact
     3661 cggatgccac gggcactgac aggttatggc agcggctgga gcctgggagc cacagggaca
     3721 gtgtctcctc atcctccagc atgtcctcca acgacaccgt catagaccta tcactgccca
     3781 gcctcggcct ctgccgcagc cgagagagca ttccaggggt ctctcttgga cgcctaacct
     3841 cacggccctg cttagcctca gctgcccgtc ctgacctgcc tcctgtgacc aagagcaaat
     3901 cgaaccccaa cctgcgggtt gcgggtgggc tgcctactgc acccgacgag ctgcagcccc
     3961 ggcctcttgc cccgcggctg accggccacc atccacggcc accgtggcat cacctcaccc
     4021 tggtgggcct gcgggactgc ccagtgtctg ctaagtccaa gagtctggga gacctgacag
     4081 ctgacgactt tgctcccagc tttcagggca gcaccagcag cctgagctgc ggcctaggct
     4141 ccctgggtgt ggcgcatcag gtgctggagc cgggaatacg gcgagatgct ctcacggagc
     4201 agctacgctg gctcaccggc ttccagcagg ctggggacat cacgtcgccc accagcttgg
     4261 gcccagctgg ggacgggtct gtagggggcc ccagcttcct gaggcgttcc tcctctcgga
     4321 gccagagccg cgtgcgcgct attgccagcc gagcccgcca agcgcaggag cgccagcaga
     4381 ggctgagagg ccaggactca cggggtcccc cagaggagga gcggggcacc cctgagggtg
     4441 cctgttctgt aggccatgag ggctgtgtgg atgtgccaat gcctgccaag ggagcccctg
     4501 agcaggtgtg tggtgctgct gatggccagc tgctgctcag gctctgaccc tgcctgatga
     4561 ttccaactct gtaccttccc tgagactgcc tgcagggggg agggggtggg ggctggcctc
     4621 aacccgacct ttgctcagga aatgaagcca ctgggtcccc aaagctgtta cgcccattct
     4681 tctgtctgtg gaagacccag tagcctcccc ttcaacctta gctgtcctct tgtctctgat
     4741 cttgggaagc aagaaacagc attgtccacc tgtccttctg ggtggttccc acgttttaag
     4801 atacataaat agatatttaa ctttttagaa ccaaaactta cagtcaaatg gctctgcgtc
     4861 cttccccact ggtctgcctg gtgtctggcc ctgtggtgtg tgctgagtgt tttcttctac
     4921 ctgctgtgtg cttgtatccc ggaatgcctg tgacacaccc acaactgcta ggatgtttgt
     4981 ccctgtcccc tactccactg tgcaccgggc ttgttttgaa caaaccacac agcaattgtg
     5041 taaatttggg aacacaactc caataaacgc atcaggcctg ttctgtgtgg ctca
//
