LOCUS       NP_001106831            1501 aa            linear   ROD 09-JUN-2024
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2
            isoform b [Mus musculus].
ACCESSION   NP_001106831
VERSION     NP_001106831.1
DBSOURCE    REFSEQ: accession NM_001113360.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1501)
  AUTHORS   Popovics,P., Gray,A., Arastoo,M., Finelli,D.K., Tan,A.J. and
            Stewart,A.J.
  TITLE     Phospholipase C-eta2 is required for retinoic acid-stimulated
            neurite growth
  JOURNAL   J Neurochem 124 (5), 632-644 (2013)
   PUBMED   23237262
  REMARK    GeneRIF: The role of PLCeta2 in neuritogenesis was assessed during
            retinoic acid (RA)-induced Neuro2A cell differentiation
REFERENCE   2  (residues 1 to 1501)
  AUTHORS   Kanemaru,K., Nakahara,M., Nakamura,Y., Hashiguchi,Y., Kouchi,Z.,
            Yamaguchi,H., Oshima,N., Kiyonari,H. and Fukami,K.
  TITLE     Phospholipase C-eta2 is highly expressed in the habenula and retina
  JOURNAL   Gene Expr Patterns 10 (2-3), 119-126 (2010)
   PUBMED   20060933
  REMARK    GeneRIF: PLCeta2 exhibited a dynamic expression pattern during
            postnatal retinal development, strongly suggesting that this
            isozyme might be involved in the development and maturation of the
            retina.
REFERENCE   3  (residues 1 to 1501)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (residues 1 to 1501)
  AUTHORS   Zhou,Y., Wing,M.R., Sondek,J. and Harden,T.K.
  TITLE     Molecular cloning and characterization of PLC-eta2
  JOURNAL   Biochem J 391 (Pt 3), 667-676 (2005)
   PUBMED   16107206
  REMARK    GeneRIF: The molecular cloning and sequencing of phospholipase C
            eta2 are reported.
REFERENCE   5  (residues 1 to 1501)
  AUTHORS   Nakahara,M., Shimozawa,M., Nakamura,Y., Irino,Y., Morita,M.,
            Kudo,Y. and Fukami,K.
  TITLE     A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme
  JOURNAL   J Biol Chem 280 (32), 29128-29134 (2005)
   PUBMED   15899900
  REMARK    GeneRIF: PLC(eta)2 is a neuron-specific isozyme that may be
            important for the formation and/or maintenance of the neuronal
            network in the postnatal brain
REFERENCE   6  (residues 1 to 1501)
  AUTHORS   Stewart,A.J., Mukherjee,J., Roberts,S.J., Lester,D. and
            Farquharson,C.
  TITLE     Identification of a novel class of mammalian
            phosphoinositol-specific phospholipase C enzymes
  JOURNAL   Int J Mol Med 15 (1), 117-121 (2005)
   PUBMED   15583837
  REMARK    GeneRIF: molecular cloning of PLC-eta1 and PLC-eta2.
REFERENCE   7  (residues 1 to 1501)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831788.14 and BX004788.7.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.13 cM"
     Protein         1..1501
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2 isoform b"
                     /EC_number="3.1.4.11"
                     /note="phospholipase C-like protein 4; phosphoinositide
                     phospholipase C-eta-2; phosphoinositide phospholipase
                     C-like 4; 1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-2"
                     /calculated_mol_wt=164167
     Region          28..47
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          75..229
                     /region_name="Necessary for plasma membrane localization"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          123..229
                     /region_name="PH_PLC_eta"
                     /note="Phospholipase C-eta (PLC-eta) pleckstrin homology
                     (PH) domain; cd13364"
                     /db_xref="CDD:270170"
     Site            order(128,130,140,157,212)
                     /site_type="other"
                     /note="putative Rac1 binding site [polypeptide binding]"
                     /db_xref="CDD:270170"
     Site            order(131,133,137,139,141,156..157)
                     /site_type="other"
                     /note="putative phosphoinositide binding site [chemical
                     binding]"
                     /db_xref="CDD:270170"
     Region          247..387
                     /region_name="EFh_PI-PLCeta2"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C eta 2 (PI-PLC-eta2); cd16221"
                     /db_xref="CDD:320051"
     Region          247..276
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320051"
     Region          283..313
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320051"
     Region          317..345
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320051"
     Region          321..948
                     /region_name="PLN02228"
                     /note="Phosphoinositide phospholipase C"
                     /db_xref="CDD:177873"
     Region          354..387
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320051"
     Region          399..808
                     /region_name="PI-PLCc_eta2"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-eta2; cd08633"
                     /db_xref="CDD:176570"
     Site            order(415..416,445,447,460,494,543,545,734,761,763)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176570"
     Site            order(415,460)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176570"
     Site            order(416,445,447,494)
                     /site_type="other"
                     /note="putative Ca binding site [ion binding]"
                     /db_xref="CDD:176570"
     Region          551..570
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Site            561
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AP18.2)"
     Site            565
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          609..700
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Site            676
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AP18.2)"
     Site            686
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          986..1073
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          <995..1321
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1089..1238
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          1273..1305
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     Region          1398..1469
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2AP18.2)"
     CDS             1..1501
                     /gene="Plch2"
                     /gene_synonym="A930027K05Rik; Plc-eta2; PLCeta2; Plcl4"
                     /coded_by="NM_001113360.3:42..4547"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS71533.1"
                     /db_xref="GeneID:269615"
                     /db_xref="MGI:MGI:2443078"
ORIGIN      
        1 mgglawgpsr aagsswvnas gtweqplrgf sglqggrrrg rgekgipeep lcqltpqlgl
       61 slrvpfglgd ygldmpgpqp saasqttgav aclaevllwv ggsvvvsprw qlslvvercm
      121 samqegtqmv klrgsskglv rfyyldehrs clrwrpsrkn ekakisidsi qevsegrqse
      181 ifqrypdssf dpnccfsiyh gshresldlv spsseeartw vtglrylmag isdedslarr
      241 qrtrdqwlkq tfdeadkngd gslsisevlq llhklnvnlp rqrvkqmfre adtddhqgtl
      301 gfeefcafyk mmstrrdlyl lmltysnhkd hldasdlqrf leveqkmngv tlescqniie
      361 qfepclenks kgmlgidgft nytrspagdi fnpehnrvhq dmtqplshyf itsshntylv
      421 gdqlmsqsrv dmyawvlqag crcvevdcwd gpdgepivhh gytltskilf kdvietinky
      481 afikneypvi lsienhcsvv qqkkmaqylt dilgdkldls svssedatml pspqmlkgki
      541 lvkgkklpan isedaeegev sdedsademe ddckllngda stnrkrveni akkkldslik
      601 eskirdcedp ndfsvstlsp sgklgrkaea kkgqskveed veagedsgvs rqnsrlfmss
      661 fskrkkkgsk ikkvasveeg detldspgsq srgtarqkkt mklsralsdl vkytksvgth
      721 dveievvssw qvssfsetka hqilqqkptq ylrfnqhqls riypssyrvd ssnynpqpfw
      781 nagcqmvaln yqsegrmlql nrakfsangd cgyvlkpqcm cqgvfnpnse dplpgqlkkq
      841 lalriisgqq lpkprdsvlg drgeiidpfv eveviglpvd cskeqtrvvd dngfnpmwee
      901 tlvftvhmpe ialvrflvwd hdpigrdfig qrtlafssim pgyrhvyleg meeasifvhv
      961 avsdisgkvk qtlglkglfl rgtkpgslds haagqplprp svsqrllrrt asaptksqkp
     1021 srkgfpelal gtqdagsega addvapsspn paleaptqer sgsssprdtr lfplqrpisp
     1081 lcslepiaee palgpglplq aaaptgpsqe gsqcpvglga kvtssqqtsl gafgtlqlri
     1141 gggreneepp lrphnggiss gpregtsgrq tdsksrsrvp ghlpvvrrak segqvlsels
     1201 ptpavysdat gtdrlwqrle pgshrdsvss sssmssndtv idlslpslgl crsresipgv
     1261 slgrltsrpc lasaarpdlp pvtksksnpn lrvagglpta pdelqprpla prltghhprp
     1321 pwhhltlvgl rdcpvsaksk slgdltaddf apsfqgstss lscglgslgv ahqvlepgir
     1381 rdalteqlrw ltgfqqagdi tsptslgpag dgsvggpsfl rrsssrsqsr vraiasrarq
     1441 aqerqqrlrg qdsrgppeee rgtpegacsv ghegcvdvpm pakgapeqvc gaadgqlllr
     1501 l
//
