LOCUS       NM_172285               4314 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus phospholipase C, gamma 2 (Plcg2), mRNA.
ACCESSION   NM_172285
VERSION     NM_172285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4314)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   2  (bases 1 to 4314)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   3  (bases 1 to 4314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4314)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4314)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4314)
  AUTHORS   Beckman,B.S., Mallia,C. and Clejan,S.
  TITLE     Molecular species of phospholipids in a murine stem-cell line
            responsive to erythropoietin
  JOURNAL   Biochem J 314 (Pt 3) (Pt 3), 861-867 (1996)
   PUBMED   8615781
REFERENCE   7  (bases 1 to 4314)
  AUTHORS   Argeson,A.C., Druck,T., Veronese,M.L., Knopf,J.L., Buchberg,A.M.,
            Huebner,K. and Siracusa,L.D.
  TITLE     Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1)
            map to distinct regions in the human and mouse genomes
  JOURNAL   Genomics 25 (1), 29-35 (1995)
   PUBMED   7774933
REFERENCE   8  (bases 1 to 4314)
  AUTHORS   Hernandez,D., Egan,S.E., Yulug,I.G. and Fisher,E.M.
  TITLE     Mapping the gene that encodes phosphatidylinositol-specific
            phospholipase C-gamma 2 in the human and the mouse
  JOURNAL   Genomics 23 (2), 504-507 (1994)
   PUBMED   7835906
REFERENCE   9  (bases 1 to 4314)
  AUTHORS   Pleiman,C.M., Clark,M.R., Gauen,L.K., Winitz,S., Coggeshall,K.M.,
            Johnson,G.L., Shaw,A.S. and Cambier,J.C.
  TITLE     Mapping of sites on the Src family protein tyrosine kinases p55blk,
            p59fyn, and p56lyn which interact with the effector molecules
            phospholipase C-gamma 2, microtubule-associated protein kinase,
            GTPase-activating protein, and phosphatidylinositol 3-kinase
  JOURNAL   Mol Cell Biol 13 (9), 5877-5887 (1993)
   PUBMED   8395016
REFERENCE   10 (bases 1 to 4314)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161193.3 and AK142173.1.
            
            On Nov 26, 2015 this sequence version replaced NM_172285.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023877.1, AK142173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC161193.3         156876-156878       c
            4-2560              AK142173.1         1-2557
            2561-2561           AC161193.3         53973-53973         c
            2562-4310           AK142173.1         2559-4307
            4311-4314           AC161193.3         20011-20014         c
FEATURES             Location/Qualifiers
     source          1..4314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 64.26 cM"
     gene            1..4314
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /note="phospholipase C, gamma 2"
                     /db_xref="GeneID:234779"
                     /db_xref="MGI:MGI:97616"
     exon            1..155
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..394
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3999
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /EC_number="3.1.4.11"
                     /note="phosphoinositide phospholipase C-gamma-2"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase gamma-2"
                     /protein_id="NP_758489.1"
                     /db_xref="CCDS:CCDS22700.1"
                     /db_xref="GeneID:234779"
                     /db_xref="MGI:MGI:97616"
                     /translation="MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQ
                     MIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGT
                     QFVLSTLSLATDSKEDAVKWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNS
                     ISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSIL
                     DEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDT
                     MRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGD
                     QLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDH
                     AFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDMLLTKPTEASADQLPSPSQLREK
                     IIIKHKKLGPKGDVDVNVEDKKDEHKPQGELYMWDSIDQKWTRHYCAIADAKLSFGDD
                     IEQAVEEEPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGTFLVRES
                     ETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYYLTDNLTFNSIYALIQHYREAHLRC
                     AEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGTNSYAI
                     TFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELL
                     ERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHN
                     VSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCKGILDLN
                     TYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKMDTKE
                     NNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPV
                     DLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSL
                     NGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVE
                     ICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPN
                     FLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLR
                     RRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSNSR
                     FYS"
     exon            395..538
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..632
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..680
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..765
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..849
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..893
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            894..966
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1068
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1187
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1273
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1394
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1563
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1668
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1758
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1934
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2135
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2255
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2436
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2508
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2618
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2715
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2716..2782
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2940
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3043
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3253
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3399
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3514
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3682
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3771
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3956
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4314
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4287..4292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /note="hexamer: AATAAA"
     polyA_site      4314
                     /gene="Plcg2"
                     /gene_synonym="PLC-gamma-2; Plcg-2; PLCgamma2"
                     /note="major polyA site"
ORIGIN      
        1 aaagcagaag taaggagcgc cgctgagcaa gacctgcgct gccggactgc ccgggcccca
       61 ggcggctgct gcacgaggga cccccgagtc cccccaaccc gtggctggca ggcccaggga
      121 ttgtgcgggt ggctgcgctc cgggggtacc gccagcctcc atctttctcc tgcttctccc
      181 gtctccctgg agcggctgac aatgaccacc atggtcaacg tggacaccct tccagaatat
      241 gagaagagtc agatcaagag agcgctggag ttagggacgg tgatgaccgt gttcaacgcc
      301 cgcaaatcca ccccagagcg gaggacagta cagatgatca tggagactcg gcaggtggca
      361 tggagcaaga ccgcagacaa gattgaaggc ttcctggaca tcatggagat aaaggaaatc
      421 cgtccgggga agaactccaa ggactttgag cgagccaagg ctgtccgcca caaggcagaa
      481 tgttgcttca ccatcctcta cggcacccag tttgtcctca gcacgctcag tttggcaacg
      541 gactcaaagg aggatgcggt gaagtggctc tctggtttga agatcctaca ccaggaagcg
      601 atgagtgcat ccacccccac aatgattgag agttggctga gaaaacagat ttattcagta
      661 gatcaaaccc gaagaaacag catcagcctc cgggagctga agaccatctt gcccctggtc
      721 aacttcaaag tgagcggcat caagtttctc aaggacaagc tggtggaaat cggcgcacag
      781 aaagatgagc tcagctttga acagttccat ctcttctata agaaactcat gtttgaccag
      841 caaaaatcga tacttgacga attcaaaaaa gactcctccg tgttcatcct aggaaacaca
      901 gaccggccgg atgcctcggc tgtctacctg caggacttcc aaaggtttct tttacatgaa
      961 cagcaggagc tatgggctca ggatctgaac aaagtccggg agcggatgac caagtttatc
     1021 gacgacacaa tgagagagac cgcagagccc ttcttatttg tggatgagtt cctcacgtat
     1081 ctgttctccc gggagaacag catctgggac gagaagtacg atgcagtgga catgcaggac
     1141 atgaacaacc ccttgtccca ctactggatc tcctcttccc acaacacgta cctcactggg
     1201 gaccagctgc gtagtgagtc ctccacggaa gcgtatatcc gctgtctgcg cgctggttgc
     1261 cgctgcattg agctggactg ctgggacggg cctgatggga agcccattat ctaccacggc
     1321 tggacacgga ccaccaagat caagtttgat gatgttgttc aggccatccg agaccacgcc
     1381 tttgttacct ccagcttccc cgtcatcttg tctatcgagg agcactgcag tgtggagcag
     1441 caacgtcaca tggccaaggt gttcaaggaa gtgttaggag acatgctgtt gacgaagccc
     1501 acagaggcca gtgctgacca gctgccctcg cccagtcagc ttcgtgagaa gatcattatc
     1561 aagcataaga agctgggtcc caagggtgat gtcgacgtca acgtggagga caagaaagat
     1621 gagcacaagc cccagggcga gctgtatatg tgggactcca tcgaccagaa atggacgcgc
     1681 cactactgtg ccattgctga cgccaagctg tccttcggtg atgacattga acaggctgtg
     1741 gaggaggagc cggtccagga cactcccccc acggagctgc attttgggga gaaatggttc
     1801 cacaagaagg tggagagtag gaccagtgcg gagaagctgc tgcaagagta ctgtgctgag
     1861 accggggcca aggacggcac cttcctggtg cgggagagcg agaccttccc caatgactac
     1921 acactctcct tctggcggtc tggccgggtg cagcactgcc ggatccggtc tactatggag
     1981 aatggggtca tgaagtacta cctgaccgac aacctcacgt tcaacagcat ctacgccctc
     2041 atccagcact accgtgaggc acacctgcgc tgcgcggagt tcgagctgcg gctcacagac
     2101 ccggtgccca accccaaccc acacgagtcc aagccgtggt actatgacag tctgagcagg
     2161 ggggaagcgg aggacatgct gatgcggatc ccccgagatg gagccttcct catccggaag
     2221 agggagggga ccaactccta cgccatcacc ttcagggcca ggggcaaggt gaaacattgt
     2281 cgcatcaacc gggacggacg ccacttcgtg ctgggcacct ctgcctactt tgagagcctg
     2341 gtggagcttg tcagctacta cgagaagcac gcgctctatc gcaagatgag gcttcgatac
     2401 cccgtgaccc cggagctcct ggagcgatat aatatggaaa gagacatcaa ctctctttat
     2461 gacgtcagca ggatgtatgt ggacccaagt gagatcaacc cttccatgcc tcagaggacc
     2521 gtgaaagcgc tctatgacta caaagccaag cgcagcgacg agctgacctt ctgccgcggt
     2581 gccctcatcc acaatgtctc caaggagccc gggggatggt ggaaagggga ctacgggacc
     2641 cggatccagc agtacttccc gtccaactat gtcgaggata tctcggcagg cgatgctgag
     2701 gagatggaaa agcagattat tgaagacaat cccctcgggt ctctctgcaa aggcatattg
     2761 gatcttaata cctacaacgt tgtgaaggcc ccccagggga aaaaccagaa agccttcgtc
     2821 tttatcctgg agcctaagaa acagggagat cctcccgtgg agttcgcgac cgaccgtgtg
     2881 gaggagctgt ttgagtggtt tcagagcata cgggagatca cttggaagat ggacaccaag
     2941 gagaacaaca tgaagtactg ggagaggaac cagtccatcg ccattgagct ctcggacttg
     3001 gttgtatact gcaagccaac tagcaaaacc aaggaccatt tggaaaatcc cgacttccga
     3061 gaaatccgct cttttgtgga gacgaaggca gacagcattg tcaggcaaaa acctgtcgat
     3121 ctattgcgat acaatcagaa gggcctgacc cgagtctacc ccaagggaca gagagttgac
     3181 tcttcgaact atgacccctt ccgtctgtgg ctgtgcggct cccagatggt ggcactcaat
     3241 ttccagactc cagacaaata catgcagatg aaccacgcgc tgttttcgct caatgggcga
     3301 acaggctacg tcctgcagcc tgagagcatg cgctctgaga agtatgatcc gatgcccctg
     3361 gagtcccaga ggaagatcct gatgacactc actgtcaagg ttcttggtgc acgccacctc
     3421 cctaaactag ggcggagtat tgcctgtcct tttgtggagg tggaaatctg cggggctgag
     3481 tatgacagca acaaattcaa gacgacggtt gtgaatgaca atggcctcag ccctgtctgg
     3541 gctccaactc aggagaaggt gacatttgag atctatgatc caaaccttgc cttcctacgc
     3601 tttgtggtct acgaagaaga catgttcagt gatcccaact tcctggctca tgccacgtac
     3661 cccattaaag gcatcaaatc cgggtttaga tcagtccctc tgaagaatgg gtacagtgaa
     3721 gacatcgagc tggcatccct cctggttttc tgtgagatga ggccagtcct ggagagtgaa
     3781 gaggaactct attcctcctg tcgccaactg cggaggcggc aagaagagct caacaaccag
     3841 ctcttccttt acgacacgca ccagaacctg cgcggagcca accgtgatgc cctggtgaag
     3901 gagttcaatg ttaacgagaa tcagctgcag ctgtaccagg agaagtgcaa ccggaggctg
     3961 agagagaaga gagtaagcaa cagcaggttc tactcctaga agccgtgtgt gcgtgcgcgc
     4021 atgcgcacgg tgttcacgag cgcatctggg tacgggagag ccttataaac agcccccagg
     4081 aagagattca tctgtgacat tcatcgtcct ctctccgagc cactcaccat agagatgaca
     4141 gttctgaaga cgcccccgtg ggcaggaggc gttgagacct tcctgctatt tttccacctt
     4201 ggacaacttt cttaacttat actacccctg atagaggatc cccccaactg tgtgcctttt
     4261 gaacttccct gttctcagcc tcattgaata aagacaacag tttcatgccg ttaa
//
