LOCUS       NM_021280               4435 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phospholipase C, gamma 1 (Plcg1), mRNA.
ACCESSION   NM_021280 XM_130636 XM_355360
VERSION     NM_021280.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4435)
  AUTHORS   Hong,S., Kim,K., Shim,Y.R., Park,J., Choi,S.E., Min,H., Lee,S.,
            Song,J.J., Kang,S.J., Jeong,W.I., Seong,R.H. and Kim,S.
  TITLE     A non-catalytic role of IPMK is required for PLCgamma1 activation
            in T cell receptor signaling by stabilizing the PLCgamma1-Sam68
            complex
  JOURNAL   Cell Commun Signal 22 (1), 526 (2024)
   PUBMED   39478550
  REMARK    GeneRIF: A non-catalytic role of IPMK is required for PLCgamma1
            activation in T cell receptor signaling by stabilizing the
            PLCgamma1-Sam68 complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4435)
  AUTHORS   Zhao,Q., Chen,X., Qu,N., Qiu,J., Zhang,B. and Xia,C.
  TITLE     PLCgamma1 deficiency in chondrocytes accelerates the age-related
            changes in articular cartilage and subchondral bone
  JOURNAL   J Cell Mol Med 28 (16), e70027 (2024)
   PUBMED   39159149
  REMARK    GeneRIF: PLCgamma1 deficiency in chondrocytes accelerates the
            age-related changes in articular cartilage and subchondral bone.
REFERENCE   3  (bases 1 to 4435)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   4  (bases 1 to 4435)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4435)
  AUTHORS   Kim,H.Y., Lee,J., Kim,H.J., Lee,B.E., Jeong,J., Cho,E.J.,
            Jang,H.J., Shin,K.J., Kim,M.J., Chae,Y.C., Lee,S.E., Myung,K.,
            Baik,J.H., Suh,P.G. and Kim,J.I.
  TITLE     PLCgamma1 in dopamine neurons critically regulates striatal
            dopamine release via VMAT2 and synapsin III
  JOURNAL   Exp Mol Med 55 (11), 2357-2375 (2023)
   PUBMED   37907739
  REMARK    GeneRIF: PLCgamma1 in dopamine neurons critically regulates
            striatal dopamine release via VMAT2 and synapsin III.
REFERENCE   6  (bases 1 to 4435)
  AUTHORS   Sillman,A.L. and Monroe,J.G.
  TITLE     Association of p72syk with the src homology-2 (SH2) domains of PLC
            gamma 1 in B lymphocytes
  JOURNAL   J Biol Chem 270 (20), 11806-11811 (1995)
   PUBMED   7744830
REFERENCE   7  (bases 1 to 4435)
  AUTHORS   Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
            Skolnik,E., Ullrich,A. and Schlessinger,J.
  TITLE     High-efficiency expression/cloning of epidermal growth
            factor-receptor-binding proteins with Src homology 2 domains
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8894-8898 (1992)
   PUBMED   1409582
REFERENCE   8  (bases 1 to 4435)
  AUTHORS   Nelson,K.K., Knopf,J.L. and Siracusa,L.D.
  TITLE     Localization of phospholipase C-gamma 1 to mouse chromosome 2
  JOURNAL   Mamm Genome 3 (10), 597-600 (1992)
   PUBMED   1358284
REFERENCE   9  (bases 1 to 4435)
  AUTHORS   Reith,A.D., Ellis,C., Lyman,S.D., Anderson,D.M., Williams,D.E.,
            Bernstein,A. and Pawson,T.
  TITLE     Signal transduction by normal isoforms and W mutant variants of the
            Kit receptor tyrosine kinase
  JOURNAL   EMBO J 10 (9), 2451-2459 (1991)
   PUBMED   1714377
REFERENCE   10 (bases 1 to 4435)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL590389.8.
            
            On Nov 17, 2006 this sequence version replaced NM_021280.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL590389.8         1224-1258
            36-351              AL590389.8         1632-1947
            352-504             AL590389.8         17689-17841
            505-598             AL590389.8         17948-18041
            599-646             AL590389.8         18196-18243
            647-731             AL590389.8         20877-20961
            732-815             AL590389.8         21057-21140
            816-850             AL590389.8         21350-21384
            851-923             AL590389.8         21547-21619
            924-1025            AL590389.8         21698-21799
            1026-1144           AL590389.8         22002-22120
            1145-1230           AL590389.8         22209-22294
            1231-1351           AL590389.8         22368-22488
            1352-1520           AL590389.8         23099-23267
            1521-1643           AL590389.8         23356-23478
            1644-1745           AL590389.8         23557-23658
            1746-1933           AL590389.8         23738-23925
            1934-2134           AL590389.8         24199-24399
            2135-2254           AL590389.8         24477-24596
            2255-2435           AL590389.8         24675-24855
            2436-2513           AL590389.8         25655-25732
            2514-2617           AL590389.8         26455-26558
            2618-2714           AL590389.8         26784-26880
            2715-2784           AL590389.8         27128-27197
            2785-2942           AL590389.8         27886-28043
            2943-3039           AL590389.8         29368-29464
            3040-3264           AL590389.8         29596-29820
            3265-3413           AL590389.8         29897-30045
            3414-3528           AL590389.8         30994-31108
            3529-3690           AL590389.8         31219-31380
            3691-3779           AL590389.8         31474-31562
            3780-3964           AL590389.8         31653-31837
            3965-4024           AL590389.8         44442-44501
            4025-4435           AL590389.8         45264-45674
FEATURES             Location/Qualifiers
     source          1..4435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 80.97 cM"
     gene            1..4435
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /note="phospholipase C, gamma 1"
                     /db_xref="GeneID:18803"
                     /db_xref="MGI:MGI:97615"
     exon            1..35
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            36..351
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..4043
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /EC_number="3.1.4.11"
                     /note="cell differentiation and embryonic development;
                     PLC-gamma-1; phosphoinositide phospholipase C-gamma-1"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase gamma-1"
                     /protein_id="NP_067255.2"
                     /db_xref="CCDS:CCDS16996.1"
                     /db_xref="GeneID:18803"
                     /db_xref="MGI:MGI:97615"
                     /translation="MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQ
                     RPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPD
                     QSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQ
                     FYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYR
                     SLMYSAQKTMDLPFLETNALRTGERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEF
                     MLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSS
                     HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSD
                     VLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLP
                     SPNQLRRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPH
                     YFVLTSSKIYYSEETSSDQGNEDEEEPKEASSSTELHSSEKWFHGKLGAGRDGRHIAE
                     RLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLT
                     DNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHML
                     MRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISY
                     YEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
                     LFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAVLE
                     PEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAAD
                     SQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGT
                     ERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWI
                     CGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPC
                     VICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFH
                     FQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELAS
                     LLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDFRI
                     SQEHLADHFDSRERSTSDGPSSATNLIEDPLHDKLWKCSL"
     exon            352..504
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..598
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..646
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..731
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..815
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..850
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..923
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1025
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1144
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1230
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1351
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1520
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1643
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1745
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1933
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2134
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2254
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2435
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2513
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2617
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2714
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2784
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2942
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3039
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3264
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3413
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3414..3528
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3690
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3779
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3964
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3965..4024
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4435
                     /gene="Plcg1"
                     /gene_synonym="Cded; Plc-1; Plc-gamma1; Plcg-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcgcggc tccctccgcc cggcagcctt gccaggagct gccaccgggt cccgctcgcc
       61 tccccggccg ccgccaccgc ctccgcctcc gccgctccgg gcccgccggc ttgcgtcgcc
      121 gaggtcgctg cagcatggcg ggcgtcgcga ccccctgcgc caacggctgc gggcctggcg
      181 caccctccga agccgaggtg ctgcacctct gccgcagcct cgaggtgggc accgtcatga
      241 ctttgttcta ctccaagaag tcgcagcggc cagaacggaa gaccttccag gtcaagttgg
      301 agacgcgcca gatcacatgg agccgcggcg cggacaaaat cgaggggtcc attgatatcc
      361 gagaaatcaa ggagatccgt ccagggaaga cttctcggga ctttgaccgc taccaagaag
      421 accctgcctt ccggccagat caatcacact gctttgtcat cctctatgga atggaattcc
      481 gcttgaagac cctgagcctg caagccacat ctgaggatga agtgaacatg tggatcaagg
      541 gcttaacttg gctaatggag gatacactgc aggcagccac acccctgcaa attgagaggt
      601 ggctccggaa gcagttctac tcagtggatc gtaaccgaga ggatcgtata tcagccaagg
      661 acttgaagaa catgctgtct caggtcaact accgagtccc caatatgcgc ttcctccgag
      721 agcggctgac ggaccttgaa cagcgcagcg gggacatcac ctacgggcag tttgctcagc
      781 tgtaccgcag cctcatgtac agcgcccaga agacgatgga ccttcccttc ttggaaacca
      841 acgctttgag gactggagag cgtccggagc attgccaggt gtccctttct gagttccagc
      901 agttcctcct tgaataccag ggggagctgt gggctgtcga ccggctccag gtgcaggaat
      961 tcatgctcag cttccttcga gaccccttgc gagagattga ggagccatac ttcttcttgg
     1021 atgagcttgt caccttcctg ttctccaaag agaacagcgt gtggaactca cagctggatg
     1081 ctgtgtgccc ggacaccatg aacaacccac tctctcacta ttggatctcc tcctcacata
     1141 atacgtacct gactggggac cagttctcca gtgagtcctc cctggaagcc tatgctcgct
     1201 gcctgaggat gggctgtcgc tgcattgagt tggactgctg ggatgggcca gatgggatgc
     1261 cagtcattta ccatgggcac actctcacca ccaagatcaa gttctctgac gtcctgcaca
     1321 ccatcaagga gcatgctttc gtagcctcag agtacccagt catcctgtcc atcgaggacc
     1381 actgcagcat tgcccagcag agaaacatgg ctcagcactt cagaaaggtg cttggcgaca
     1441 cactccttac caagcctgtg gacattgctg ctgatggcct tccttctccc aaccagctca
     1501 ggaggaagat ccttattaag cacaagaagc tggctgaggg cagtgcctat gaggaggtgc
     1561 ctacctctgt gatgtactcc gagaatgaca tcagtaactc catcaagaat ggtatcctct
     1621 acttggagga ccccgtgaat catgagtggt atccccacta cttcgttctg actagcagca
     1681 agatctacta ctctgaggag accagcagtg accagggcaa tgaggatgaa gaggagccga
     1741 aggaggccag cagcagcaca gagctgcact cgagtgagaa gtggttccac gggaagctcg
     1801 gggctggacg tgacgggcgg cacattgctg agcgcctgct cactgagtac tgcatagaga
     1861 ctggggctcc tgatggctcc ttcctagtgc gagaaagtga gaccttcgtg ggtgactaca
     1921 cgctgtcttt ctggcggaat gggaaagtcc agcactgccg catccactcc cggcaggatg
     1981 ctgggactcc taagttcttc ttgacagata accttgtctt tgactctctc tatgacctca
     2041 tcacacatta tcagcaagta cccctgcgct gcaatgagtt tgagatgcgc ctttcagagc
     2101 ctgttccaca gacgaatgcc catgagagca aagagtggta ccacgcaagc ctgactagag
     2161 ctcaggctga acatatgctg atgcgagtgc cccgggatgg ggccttcctg gtgcggaaac
     2221 gcaatgagcc taactcatat gccatctctt tccgggctga gggaaagatc aagcactgcc
     2281 gagtacagca ggaaggccag acagtgatgc tggggaactc tgagtttgac agcctggttg
     2341 acctcatcag ctactatgag aagcaccccc tgtaccgcaa aatgaagcta cgctacccca
     2401 tcaacgagga ggcactggag aagatcggga cagctgaacc cgattatggg gcactatacg
     2461 agggccgcaa ccctggtttc tatgtggagg caaaccctat gccaactttc aagtgtgcag
     2521 taaaagccct cttcgactac aaggcccaga gagaggatga gctgaccttc accaagagtg
     2581 ccatcatcca gaatgtggaa aagcaagatg gtggctggtg gcgaggggac tatggtggga
     2641 agaagcagct gtggttcccc tcaaactatg tggaagagat gatcaatcca gcagtcctag
     2701 agcctgagag ggagcacctg gatgagaaca gcccactggg ggacttgctg cgaggggtct
     2761 tagatgtgcc agcttgtcag atcgccatcc gtcctgaggg caaaaacaac cggctcttcg
     2821 tcttctccat cagcatgcca tcagtggctc agtggtccct ggatgttgca gctgactcac
     2881 aggaggagtt acaggactgg gtgaaaaaga tccgtgaagt tgcccagact gcagatgcca
     2941 ggctcactga gggaaagatg atggagagga ggaagaagat cgccttggag ctctccgagc
     3001 ttgtggtcta ctgccggccc gttccctttg atgaagagaa gattggcaca gaacgtgctt
     3061 gttaccggga catgtcctcc tttccggaaa ccaaggctga gaagtatgtg aacaaggcca
     3121 aaggcaagaa gttcctccag tacaaccggc tgcagctctc gcgcatctac cctaagggcc
     3181 agaggctaga ctcctccaat tatgaccctc tgcccatgtg gatctgcggt agccagcttg
     3241 tagcactcaa tttccagacc ccagacaagc ctatgcagat gaaccaggcc ctcttcatgg
     3301 ctggtgggca ttgtggctat gtgctgcagc caagcaccat gagagacgaa gcctttgacc
     3361 cctttgataa gagcagtctc cgaggtctgg aaccctgtgt catttgcatt gaggtgctgg
     3421 gggccaggca tctgccgaag aatggccggg gtattgtgtg tccttttgtg gagattgagg
     3481 tggctggggc tgagtacgac agcaccaagc aaaagacgga gtttgtagtg gacaacggac
     3541 tgaaccctgt gtggcctgct aagcccttcc acttccagat cagtaaccca gagtttgcct
     3601 ttctgcgctt tgtggtgtat gaggaagaca tgtttagtga ccagaacttc ttggctcagg
     3661 ctactttccc agtaaaaggc ctgaagacag gatatagagc agtgcctttg aagaacaact
     3721 acagtgaaga cctggagttg gcctccctgc tcatcaagat tgacattttc cctgctaagg
     3781 agaacggtga cctcagtcct ttcagtggca tatccctaag ggaacgggcc tcagatgcct
     3841 ccagccagct gttccatgtc cgggcccggg aagggtcctt tgaagccaga taccagcagc
     3901 catttgaaga tttccgcatc tcgcaggagc atctagcaga ccattttgac agtcgggaac
     3961 gaagtacttc agatggtcct tcctcagcca ctaaccttat tgaggatccc ttacatgaca
     4021 agctgtggaa gtgctctctt taaataccca gtggctaaga agatgctggc ctctatgatg
     4081 gcaaaaatgc ggcaagctgc aagttttgga ggacaaagtc attactaccc tctggcaaaa
     4141 ataagccaca ccagcaacct gggccatagt tcccaggctg cctgctgtgt tgaaagagga
     4201 ctgctgcaca gaaagcagac atttaccaaa ccaggaaagc ctcttcatgc tcacctcagg
     4261 atgctgtgaa tgttcagcag gatgctttgc tagttttttg tttggttgtt tttgtttttt
     4321 gtttttttgt tttggtgagg ccaaatgtga gataatgcct tatgagttgt tggtcataga
     4381 gccagagatg tgcacaaaaa tacaagccac tgtcattcct cttggttgcc catca
//
