LOCUS       NM_001081456            2734 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phospholipase C, delta 4 (Plcd4), transcript variant
            1, mRNA.
ACCESSION   NM_001081456
VERSION     NM_001081456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Yudin,Y., Lutz,B., Tao,Y.X. and Rohacs,T.
  TITLE     Phospholipase C delta4 regulates cold sensitivity in mice
  JOURNAL   J Physiol 594 (13), 3609-3628 (2016)
   PUBMED   27062607
  REMARK    GeneRIF: We identify PLCdelta4 as a PLC isoform important in the
            regulation of TRPM8 both at the cellular level and in vivo
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Fiume,R., Ramazzotti,G., Faenza,I., Piazzi,M., Bavelloni,A.,
            Billi,A.M. and Cocco,L.
  TITLE     Nuclear PLCs affect insulin secretion by targeting PPARgamma in
            pancreatic beta cells
  JOURNAL   FASEB J 26 (1), 203-210 (2012)
   PUBMED   21974932
  REMARK    GeneRIF: These findings highlight a novel pathway by which nuclear
            PLCs affect insulin secretion and identify PPARgamma as a novel
            molecular target of nuclear PLCs.
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Yamashita,M., Honda,A., Ogura,A., Kashiwabara,S., Fukami,K. and
            Baba,T.
  TITLE     Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is
            rescued by sperm exposure to uterine microenvironment
  JOURNAL   Genes Cells 13 (10), 1001-1013 (2008)
   PUBMED   18754795
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Fukami,K., Nakao,K., Inoue,T., Kataoka,Y., Kurokawa,M.,
            Fissore,R.A., Nakamura,K., Katsuki,M., Mikoshiba,K., Yoshida,N. and
            Takenawa,T.
  TITLE     Requirement of phospholipase Cdelta4 for the zona pellucida-induced
            acrosome reaction
  JOURNAL   Science 292 (5518), 920-923 (2001)
   PUBMED   11340203
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Fukami,K., Takenaka,K., Nagano,K. and Takenawa,T.
  TITLE     Growth factor-induced promoter activation of murine phospholipase C
            delta4 gene
  JOURNAL   Eur J Biochem 267 (1), 28-36 (2000)
   PUBMED   10601847
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Filie,J.D., Buckler,C.E. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse ferritin light chain gene and 11
            pseudogenes on 11 mouse chromosomes
  JOURNAL   Mamm Genome 9 (2), 111-113 (1998)
   PUBMED   9457670
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Lyu,M.S., Park,D.J., Rhee,S.G. and Kozak,C.A.
  TITLE     Genetic mapping of the human and mouse phospholipase C genes
  JOURNAL   Mamm Genome 7 (7), 501-504 (1996)
   PUBMED   8672127
REFERENCE   10 (bases 1 to 2734)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117610.7.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066156.1, SRR1660819.40930.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AC117610.7         95906-96045
            141-196             AC117610.7         100930-100985
            197-355             AC117610.7         101122-101280
            356-584             AC117610.7         102192-102420
            585-714             AC117610.7         104037-104166
            715-946             AC117610.7         105005-105236
            947-1148            AC117610.7         107507-107708
            1149-1293           AC117610.7         108960-109104
            1294-1446           AC117610.7         110737-110889
            1447-1650           AC117610.7         113307-113510
            1651-1819           AC117610.7         115072-115240
            1820-1936           AC117610.7         115731-115847
            1937-2109           AC117610.7         116468-116640
            2110-2245           AC117610.7         117394-117529
            2246-2395           AC117610.7         118049-118198
            2396-2503           AC117610.7         118277-118384
            2504-2734           AC117610.7         118764-118994
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..2734
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /note="phospholipase C, delta 4"
                     /db_xref="GeneID:18802"
                     /db_xref="MGI:MGI:107469"
     exon            1..140
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            141..196
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2502
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /EC_number="3.1.4.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PLC-delta-4; phosphoinositide phospholipase C-delta-4;
                     1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
                     delta-4"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-4 isoform 1"
                     /protein_id="NP_001074925.1"
                     /db_xref="CCDS:CCDS35617.1"
                     /db_xref="GeneID:18802"
                     /db_xref="MGI:MGI:107469"
                     /translation="MTSQIQDLLATDQDLLLMQEGTMMRKVRTKSWKKLRYFRLQNDG
                     MTVWHGSQPESMPKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTVVFHGRRPNL
                     DLVANSVEEAQIWMRGLQLLVDLVASMDHQEQMDQMLNEWFQQADRNQDGRMSFREAQ
                     RLLLLMNVEMDEEYAFSLFQEADVTQSDDLGSEEFVQFYKALTKRTEIEEIFEDFSSD
                     KQKLTLLEFVDFLRKEQKEKDHAPDLALELIDRYEPSENGRLLHVLSKDGFLKYLCSK
                     DGNIFNSDCLPIYQDMTQPLSHYYINSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCV
                     EVDTWDGPDGEPVVYHGHTLTSRILFKDVLATLAQYAFQSSDYPLILSLENHCTWEQQ
                     RTMAHHLTEILGEQLLRNTLEGLLVDSMPSPEQLRGKILVKGKKLRTIEVDKEEEEEE
                     EEEELEKDEGPDLDPASPELDTQPQPETQGQAAGNKKERKKKFLLLSSTTIMCPDLSA
                     LVVYLRTVPFCSFTHSKENYHIYDISSFSESKAKNLIKEAGNEFVQHNARQLCRVYPS
                     GLRTDSSNFNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDT
                     QSSFNPERPISLYKAQILVVQVISGQQLPKVDKTKETTVVDPLVKVELYGVPEDTKEQ
                     ETSHVENNGINPYWGETFYFRLQVPELAMLRFVVKDYSRKSRNNFIGQYTLPWTCMKQ
                     GYRHVSLLSRDGTSLNPASIFVYTCMQEDLDMDEP"
     exon            197..355
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..584
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            585..714
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            715..946
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1148
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1293
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1446
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1650
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1819
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1936
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2109
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2245
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2395
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2503
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2734
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2715..2720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /note="hexamer: AATAGA"
     polyA_site      2734
                     /gene="Plcd4"
                     /gene_synonym="4921507K24Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgccagttta cagcagcaaa ctgcagtgga gggtggaagc agtcaagtgc aaaggagaaa
       61 aggagtcttg ttctcagcgg agagcactgc ggagctcggg aggcgaccct cgcagacaca
      121 agattactat cctacctacg gtgactctgg caccagctgg tggagcagtg ggtgatgaca
      181 tctcagattc aagacctact agccactgat caggacctgc tgctgatgca agaaggcaca
      241 atgatgcgca aggtgaggac caaaagctgg aagaagctaa gatacttcag acttcagaat
      301 gacggcatga cagtctggca tggaagtcaa ccagaaagca tgcccaagcc cactttttcg
      361 atctctgatg tggagaggat acgtaagggg caggattctg agttgttgcg ctatctggtg
      421 gaggagtttc ccctggagca agggttcacc gttgtctttc atgggcgccg ccccaacctg
      481 gacctagtgg ccaacagtgt tgaagaggcc cagatttgga tgcgaggact ccagctgttg
      541 gtggatcttg ttgccagcat ggaccaccag gagcaaatgg atcaaatgtt gaatgagtgg
      601 ttccagcaag cagacagaaa ccaggatggc cggatgagtt tcagagaagc tcaacggctg
      661 ctgcttctga tgaacgtgga aatggatgaa gagtacgcct tcagtctttt ccaggaggca
      721 gatgttaccc agtctgatga tctggggtcg gaagaatttg tacagttcta taaggccctg
      781 actaagcgca ctgagattga agaaatattt gaggacttct catctgacaa acagaagctg
      841 accttgctgg aatttgtgga tttccttaga aaggaacaga aagaaaaaga ccatgctcct
      901 gacctcgctc tggaactcat tgaccgctat gagccttctg agaatggccg attgctgcat
      961 gtgctgagca aggatggctt cctcaagtac ctctgctcga aggatggaaa catcttcaac
     1021 agtgactgcc tccctatcta ccaggatatg actcagcctc tgagccacta ctacattaac
     1081 tcttctcaca acacctacct agtgggggac cagctttgcg gccagagcag cgttgaagga
     1141 tacatacggg ccttgaaacg ggggtgccgc tgtgtggagg tggacacgtg ggatggacct
     1201 gatggagagc ctgttgttta tcatgggcat accctgacct ctcgcatcct attcaaagat
     1261 gtgttggcaa ctctcgcgca atatgccttc cagtcatcag actaccctct catcttgtct
     1321 ctggaaaacc actgcacctg ggaacagcag aggaccatgg cacaccatct gaccgagatc
     1381 ctgggagagc agctgctgag gaacacccta gagggattgc tggttgacag catgccctcg
     1441 ccagagcagc ttcgggggaa gatcttggtg aaaggaaaga agttaagaac aattgaagtt
     1501 gacaaggaag aagaagaaga agaagaagaa gaagagctgg agaaagatga ggggccagat
     1561 ctggacccag cctcccctga gttggacact caacctcagc ctgagaccca ggggcaggcc
     1621 gctgggaaca agaaggagag gaagaagaag tttcttctcc tgagttccac aaccatcatg
     1681 tgcccagacc tatctgccct ggttgtctac ttgaggactg tccccttctg cagcttcact
     1741 cattccaaag aaaactacca catctatgac atttcatcct tttctgagtc caaggccaag
     1801 aacctcatca aggaggcagg caacgagttt gtacagcaca atgccagaca gttatgccgc
     1861 gtgtatccca gtggtctgag gacagattca tccaacttta acccccagga acactggaat
     1921 gtaggctgcc agatggtggc tatgaatatg cagactgcag gaagtgcaat ggatatctgt
     1981 gatgggctct tccgccagaa tggtggctct ggctatgtgc tgaagccaga attcctgaga
     2041 gatacccaga gttcattcaa tcctgagagg ccaattagtc tttataaggc ccagatcctt
     2101 gtagtccagg tgatcagtgg ccaacaactc cccaaagtgg ataaaaccaa agagacaacc
     2161 gttgtggatc cactggtgaa agtagagctc tatggtgttc ctgaagacac aaaggagcaa
     2221 gagaccagcc atgtggagaa caatggtatt aatccatact ggggggagac tttctatttc
     2281 cggctccagg tacctgaact tgctatgttg cgttttgtgg taaaggatta tagcaggaaa
     2341 tcccgaaata actttattgg ccaatacacc ctaccttgga cctgtatgaa acaaggctac
     2401 cgacatgtat ccttgctctc cagagatggc actagcctca atccagcttc catctttgta
     2461 tacacctgca tgcaggaaga cctggatatg gatgagccct gagaaacaca gggagggcct
     2521 tgaagaacaa tctacagatg cacaatcctt tccaacctac aacttcctca aaatccagag
     2581 ccagccaaag gatcaatgaa ggatcaaggt tgccaggcaa aggttgagga agaatgcctg
     2641 actcaaaact gtgactctag agaacaatgc acagccctga gaccccactg gactgctgct
     2701 ccttagctgg tctaaataga gcttctctgt ccga
//
