LOCUS       NM_152813               3031 bp    mRNA    linear   ROD 16-DEC-2024
DEFINITION  Mus musculus phospholipase C, delta 3 (Plcd3), transcript variant
            1, mRNA.
ACCESSION   NM_152813 XM_985682
VERSION     NM_152813.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Nakamura,Y., Kanemaru,K., Kojima,R., Hashimoto,Y., Marunouchi,T.,
            Oka,N., Ogura,T., Tanonaka,K. and Fukami,K.
  TITLE     Simultaneous loss of phospholipase Cdelta1 and phospholipase
            Cdelta3 causes cardiomyocyte apoptosis and cardiomyopathy
  JOURNAL   Cell Death Dis 5 (5), e1215 (2014)
   PUBMED   24810051
  REMARK    GeneRIF: Results indicate that PLCdelta1 and PLCdelta3 are required
            for cardiomyocyte survival and normal cardiac function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Runkel,F., Hintze,M., Griesing,S., Michels,M., Blanck,B.,
            Fukami,K., Guenet,J.L. and Franz,T.
  TITLE     Alopecia in a viable phospholipase C delta 1 and phospholipase C
            delta 3 double mutant
  JOURNAL   PLoS One 7 (6), e39203 (2012)
   PUBMED   22723964
  REMARK    GeneRIF: Plcd1 and Plcd3 have synergistic effects on the murine
            hair follicle in specific regions of the body surface.
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Kouchi,Z., Igarashi,T., Shibayama,N., Inanobe,S., Sakurai,K.,
            Yamaguchi,H., Fukuda,T., Yanagi,S., Nakamura,Y. and Fukami,K.
  TITLE     Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and
            neurite outgrowth
  JOURNAL   J Biol Chem 286 (10), 8459-8471 (2011)
   PUBMED   21187285
  REMARK    GeneRIF: PLCdelta3 negatively regulates RhoA expression, inhibits
            RhoA/Rho kinase signaling, and thereby promotes neurite extension.
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Sakurai,K., Hirata,M., Yamaguchi,H., Nakamura,Y. and Fukami,K.
  TITLE     Phospholipase Cdelta3 is a novel binding partner of myosin VI and
            functions as anchoring of myosin VI on plasma membrane
  JOURNAL   Adv Enzyme Regul 51 (1), 171-181 (2011)
   PUBMED   21035487
  REMARK    GeneRIF: These results indicate that PLCdelta3 could participate in
            stability of microvilli structure via regulating and anchoring of
            Myo6 to plasma membrane.
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Fukami,K., Ichinohe,M., Hirata,M. and Nakamura,Y.
  TITLE     Physiological functions of phospholipase C delta-type
  JOURNAL   Adv Enzyme Regul 48, 261-273 (2008)
   PUBMED   18177742
  REMARK    GeneRIF: double disruption of PLCd1 and PLCd3 results in embryonic
            lethality because of insufficient vasculariztion of the placenta.
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Nakamura,Y., Hamada,Y., Fujiwara,T., Enomoto,H., Hiroe,T.,
            Tanaka,S., Nose,M., Nakahara,M., Yoshida,N., Takenawa,T. and
            Fukami,K.
  TITLE     Phospholipase C-delta1 and -delta3 are essential in the trophoblast
            for placental development
  JOURNAL   Mol Cell Biol 25 (24), 10979-10988 (2005)
   PUBMED   16314520
  REMARK    GeneRIF: PLCdelta1 and PLCdelta3 are essential in trophoblasts for
            placental development.
REFERENCE   7  (bases 1 to 3031)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 3031)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 3031)
  AUTHORS   Lyu,M.S., Park,D.J., Rhee,S.G. and Kozak,C.A.
  TITLE     Genetic mapping of the human and mouse phospholipase C genes
  JOURNAL   Mamm Genome 7 (7), 501-504 (1996)
   PUBMED   8672127
REFERENCE   10 (bases 1 to 3031)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY011789.1, AL731805.8, AK046669.1, AK011892.1 and BY589869.1.
            
            On Sep 18, 2009 this sequence version replaced NM_152813.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046669.1, BC031392.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY011789.1         2-33
            33-34               AL731805.8         76143-76144         c
            35-2686             AK046669.1         1-2652
            2687-2808           AK011892.1         1618-1739
            2809-3031           BY589869.1         228-450
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.71 cM"
     gene            1..3031
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /note="phospholipase C, delta 3"
                     /db_xref="GeneID:72469"
                     /db_xref="MGI:MGI:107451"
     exon            1..279
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2486
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /EC_number="3.1.4.11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     PLC-delta-3; phosphoinositide phospholipase C-delta-3;
                     1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
                     delta-3; phospholipase C delta 3 varioant mNab"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-3 isoform 1"
                     /protein_id="NP_690026.2"
                     /db_xref="CCDS:CCDS25512.1"
                     /db_xref="GeneID:72469"
                     /db_xref="MGI:MGI:107451"
                     /translation="MLCGGWKRSRRSPEESRVSAQVAAPLAFPPSPASSDSSTKRPGL
                     RALKKMGLTEDEDVQAMLRGSRLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASK
                     HIFFVQHIEAVREGHQSEGLRRFGGAFAPACCLTIAFKGRRKNLDLAAPTAEEAQRWV
                     RGLAKLRARLDAMSQRERLDHWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMY
                     AYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLE
                     DQGEDGATLACAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQD
                     MGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFAQGCRCVELDCWEGPGGEPVIY
                     HGHTLTSKILFRDVIQAVRDHAFTSSPYPVILSLENHCGLEQQAVMARHLRSILGDML
                     VTQALDSQNPEELPSPEQLKGRILVKGKKLPAARSEDGRILSDREEEEEEEEEAEEAL
                     EAAEQRSRAKQISPELSALAVYCCATRLRTLDPSPGPPQSCTVGSLSERKARKFTREA
                     GTSFVRHNTQQLTRVYPLGLRMNSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRF
                     LINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLAIQVLTAQQLPKLNAEKPSSIVDP
                     LVRVEIHGVPEDCAQKETDYVLNNGFNPCWEQTLQFRLRAPELVLVRFVVEDYDTTSP
                     NDFVGQSTLPLSSLKQGYRHIHLLSKDGASLAPATLFVHIRIQNS"
     exon            280..441
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            442..670
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            671..800
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1029
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1231
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1376
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1529
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1676
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1827
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1944
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2111
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2247
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2397
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..3031
                     /gene="Plcd3"
                     /gene_synonym="2610205J15Rik; mKIAA1964"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggtctcct cctcctgact cctagggcgc cgctaagttt cttagctccg gaccgcgccg
       61 cgggctgtgt tcccgttgcc cggttctcac gcacagatcc cgggcctggc cctgggccct
      121 tcgagaccat gctgtgcggt ggctggaaaa ggagtcgccg ctcgccggag gaatcccggg
      181 tgtccgccca ggtcgcagcg cccctcgcgt tcccgccctc gcccgcgtcg tcggacagca
      241 gcaccaaaag gcctgggcta cgggcactga agaagatggg cctgacggag gatgaggatg
      301 tccaagccat gctgcggggc tcccgactcc tcaagatccg ctcacgcacg tggcacaagg
      361 agcggctgta ccggctgcag gaggacggcc tgagcgtgtg gtttcagcgg cgcatccctc
      421 gcgcagcttc taagcacata ttcttcgtgc agcacatcga ggctgtccgg gagggtcatc
      481 agtcggaggg cctgcggcgc ttcgggggcg ccttcgcgcc agcgtgctgc ctcaccatcg
      541 ccttcaaggg ccgccgcaag aacctggacc tggcagcgcc cactgcggag gaggcacagc
      601 gctgggtgcg aggactggcc aagctgcggg cgcgcctgga tgccatgagc cagcgggagc
      661 gcctagacca ttggatccat tcctatctgc accgggccga ctccgaccaa gacagtaaga
      721 tgagcttcaa ggagatcaag agcctgctga ggatggtgaa cgtggacatg aacgacatgt
      781 acgcttaccg cctcttcaag gagtgtgacc attccaacaa cgagcgtcta gagggggccg
      841 agatagaggc gttcctgcgg aggctgctaa agcggcctga gctggaggag atcttccgcc
      901 ggtactccgg tgaggaccgg gtgctgagtg cctctgagct gctggagttc ctggaagacc
      961 agggcgagga tggtgccacc ctggcctgtg cccagcagct tatccagact tatgagctca
     1021 atgagacagc caagcagcac gaactgatga cgctggatgg cttcatgatg tatctgttgt
     1081 cgcctgaggg ggccgccctg aacgtggccc acacgtgtgt gttccaggac atgggtcagc
     1141 ccctcgccca ctactttatc tcgtcctctc acaataccta cctgacggac tctcagatcg
     1201 gagggaccag cagcacagag gcttatatta gggcctttgc ccagggatgc cgctgtgtgg
     1261 aacttgactg ctgggagggg ccgggagggg aacctgtcat ctaccatggc cacacgctca
     1321 cctccaagat cctctttcga gatgtgatcc aggctgtgcg tgaccacgct ttcacgtcgt
     1381 ccccatatcc tgtaatccta tccctcgaga accactgcgg gctggaacag caggctgtca
     1441 tggctcgcca ccttcgaagc atcctgggag acatgctggt gacacaggcc ctggactccc
     1501 agaaccccga ggagctgcca tctcctgagc agctcaaggg ccggatcttg gtgaagggga
     1561 agaagctgcc agctgctcgg agtgaggatg gtcgaattct gtcagacagg gaggaggaag
     1621 aggaggagga agaggaggcg gaagaggcct tggaagctgc agagcagagg agtcgagcca
     1681 agcagatctc cccagagctc tcagcgctgg ctgtgtattg ctgtgctacc cgcctgcgga
     1741 ccctggatcc cagtcctggc ccgcctcagt cttgcacggt tggctccctc agcgagcgca
     1801 aggccaggaa gttcaccagg gaggcaggga ccagctttgt caggcacaac actcagcaac
     1861 tgacccgagt gtacccactg gggctgcgga tgaactcagc caactataac ccccaggaga
     1921 tgtggaactc cggctgtcag ctggtggctc tgaactttca gactcctggt tatgagatgg
     1981 acctcaacac agggcgcttc ctcataaacg ggcaatgtgg ctacgtcctc aaacctgctt
     2041 acctcaggca actcaacacc acctttgacc ctgagtgccc tggacccccc agaactactc
     2101 tggcaatcca ggtgttaacg gcccagcagc tacccaagct gaacgcagag aagcccagct
     2161 ccattgtgga tcctctggtg cgcgtggaga tccacggggt gcccgaagac tgtgcccaga
     2221 aggagacaga ctacgtcctc aacaatggct tcaacccctg ctgggagcag actctgcagt
     2281 tccgactgcg ggccccagag ctggtgctgg tcaggtttgt ggtagaagat tatgacacca
     2341 cctctcccaa tgattttgtg ggccagtcta cactgcctct cagcagcctg aagcaagggt
     2401 accgccacat ccacctgctg tccaaggatg gagcctcgct cgctccagcc acgctcttcg
     2461 tgcacatccg cattcagaac tcttgagggc gtcactgact taaccctaac atcagcaggg
     2521 ctggcgtcgt ggcacggagc cctctctgga gcacaagacc atgggagtcc cagcccctca
     2581 caccaggtcc ctgtctgggt caccaggtgc tgtgcacacc tgggtgctag gagctgtttg
     2641 gttgctcagt gagagagagg accatgattg gtgtcctgac cagtggattt caggggcctc
     2701 caaccttggg gctctgaggt ggtctcagat tccctggtca acttgaggag caggacacgt
     2761 gtccttctgc cctccagcgg ggccatcgta accttcatcc ctgagaaggg cacagccacc
     2821 ttcactgcct cctttcaggg tgagcagaac cccagagcct ccttcccctt agaagggact
     2881 tttctggctt ctccttccct ttctgtctca ggcaggtggg gagcagctga gccctgggag
     2941 aaacctggca gtaggtttgt aacttgtgtt atagaagagc ccaagagggc agaagagtaa
     3001 ctatttaaaa aaaaaaagta aagaaaaagt g
//
