LOCUS       NM_019676               2657 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phospholipase C, delta 1 (Plcd1), transcript variant
            2, mRNA.
ACCESSION   NM_019676
VERSION     NM_019676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Haan,K.D., Park,S.J., Nakamura,Y., Fukami,K. and Fisher,T.E.
  TITLE     Osmotically evoked PLCdelta1-dependent translocation of
            DeltaN-TRPV1 channels in rat supraoptic neurons
  JOURNAL   iScience 26 (3), 106258 (2023)
   PUBMED   36926650
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Liang,S., Zhao,J., Wang,Q., Yang,M., Wang,X., Chen,S., Chen,M. and
            Sun,C.
  TITLE     Carbon monoxide enhances calcium transients and glucose-stimulated
            insulin secretion from pancreatic beta-cells by activating
            Phospholipase C signal pathway in diabetic mice
  JOURNAL   Biochem Biophys Res Commun 582, 1-7 (2021)
   PUBMED   34678590
  REMARK    GeneRIF: Carbon monoxide enhances calcium transients and
            glucose-stimulated insulin secretion from pancreatic beta-cells by
            activating Phospholipase C signal pathway in diabetic mice.
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Park,S.J., Haan,K.D., Nakamura,Y., Fukami,K. and Fisher,T.E.
  TITLE     PLCdelta1 Plays Central Roles in the Osmotic Activation of
            DeltaN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine
            Osmoregulation
  JOURNAL   J Neurosci 41 (16), 3579-3587 (2021)
   PUBMED   33707294
  REMARK    GeneRIF: PLCdelta1 Plays Central Roles in the Osmotic Activation of
            DeltaN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine
            Osmoregulation.
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Liu,K., Luo,J., Ma,T., Fang,M., Xu,Z., Wang,L., Zhang,X.Y., Wen,J.,
            Liu,C., Cao,Y., Li,X., Zhang,L., Guo,A., Wang,N., Yi,P. and
            Liu,J.Y.
  TITLE     Germline Mutation of PLCD1 Contributes to Human Multiple
            Pilomatricomas through Protein Kinase D/Extracellular
            Signal-Regulated Kinase1/2 Cascade and TRPV6
  JOURNAL   J Invest Dermatol 141 (3), 533-544 (2021)
   PUBMED   32795530
REFERENCE   5  (bases 1 to 2657)
  AUTHORS   Thakur,D.P., Wang,Q., Jeon,J., Tian,J.B. and Zhu,M.X.
  TITLE     Intracellular acidification facilitates receptor-operated TRPC4
            activation through PLCdelta1 in a Ca2+ -dependent manner
  JOURNAL   J Physiol 598 (13), 2651-2667 (2020)
   PUBMED   32338378
  REMARK    GeneRIF: Intracellular acidification facilitates receptor-operated
            TRPC4 activation through PLCdelta1 in a Ca(2+) -dependent manner.
REFERENCE   6  (bases 1 to 2657)
  AUTHORS   Lee,W.K., Kim,J.K., Seo,M.S., Cha,J.H., Lee,K.J., Rha,H.K.,
            Min,D.S., Jo,Y.H. and Lee,K.H.
  TITLE     Molecular cloning and expression analysis of a mouse phospholipase
            C-delta1
  JOURNAL   Biochem Biophys Res Commun 261 (2), 393-399 (1999)
   PUBMED   10425196
REFERENCE   7  (bases 1 to 2657)
  AUTHORS   Huttner,K.M., Kozak,C.A. and Bevins,C.L.
  TITLE     The mouse genome encodes a single homolog of the antimicrobial
            peptide human beta-defensin 1
  JOURNAL   FEBS Lett 413 (1), 45-49 (1997)
   PUBMED   9287114
REFERENCE   8  (bases 1 to 2657)
  AUTHORS   Lyu,M.S., Park,D.J., Rhee,S.G. and Kozak,C.A.
  TITLE     Genetic mapping of the human and mouse phospholipase C genes
  JOURNAL   Mamm Genome 7 (7), 501-504 (1996)
   PUBMED   8672127
REFERENCE   9  (bases 1 to 2657)
  AUTHORS   Kozawa,O., Suzuki,A., Watanabe,Y., Shinoda,J. and Oiso,Y.
  TITLE     Effect of platelet-derived growth factor on
            phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like
            cells
  JOURNAL   Endocrinology 136 (10), 4473-4478 (1995)
   PUBMED   7664667
REFERENCE   10 (bases 1 to 2657)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028749.1 and BY383308.1.
            
            On Jun 12, 2014 this sequence version replaced NM_019676.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            initiates translation at an alternate start codon, compared to
            variant 1. The encoded protein (isoform 2) has a distinct and
            shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85711.1, AK028749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2654              AK028749.1         2-2655
            2655-2657           BY383308.1         439-441
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.32 cM"
     gene            1..2657
                     /gene="Plcd1"
                     /note="phospholipase C, delta 1"
                     /db_xref="GeneID:18799"
                     /db_xref="MGI:MGI:97614"
     exon            1..145
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2382
                     /gene="Plcd1"
                     /EC_number="3.1.4.11"
                     /note="isoform 2 is encoded by transcript variant 2;
                     phosphoinositide phospholipase C-delta-1; PLC-delta 1;
                     phospholipase C delta 1 Lf; 1-phosphatidylinositol
                     4,5-bisphosphate phosphodiesterase delta-1"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-1 isoform 2"
                     /protein_id="NP_062650.1"
                     /db_xref="CCDS:CCDS23607.1"
                     /db_xref="GeneID:18799"
                     /db_xref="MGI:MGI:97614"
                     /translation="MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKL
                     QEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFK
                     DQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKM
                     NFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAF
                     AEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFL
                     MYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALC
                     KGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENH
                     CSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGG
                     ENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFS
                     SPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVE
                     MWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGP
                     WWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNP
                     RWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNG
                     DLHPSATLFVKISIQD"
     exon            146..310
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            311..539
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..669
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..901
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1103
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1248
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1398
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1557
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1717
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1834
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..2013
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2146
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2296
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2657
                     /gene="Plcd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcd1"
                     /note="hexamer: TATAAA"
     regulatory      2641..2646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcd1"
                     /note="hexamer: AATAAT"
     polyA_site      2651
                     /gene="Plcd1"
                     /note="major polyA site"
     polyA_site      2657
                     /gene="Plcd1"
                     /note="major polyA site"
ORIGIN      
        1 atctcagttc agttgggtcc ctgcaccgga ctgcgcaagg accccaggcc gcttggtgat
       61 tttgctcaag tgaatcacgc cgcgtcccct cctccgcgcg ccccgaccgg catggactcc
      121 ggtcgggact tcctgacctt gcacgggctg caggatgacc cggaccttca ggccctcctg
      181 aagggcagcc agcttctgaa ggtgaagtcc agctcgtggc gtagagaacg cttctacaag
      241 ctacaggagg actgcaagac catctggcag gaatctcgca aggtcatgag gtccccggag
      301 tcgcagctgt tctccatcga ggacattcag gaggtgcgga tgggacaccg cacagaaggc
      361 ctggagaaat ttgccagaga catacccgag gaccgatgct tctccatcgt cttcaaggac
      421 cagcgcaata ccctagacct catcgccccg tctccagctg acgtccagca ttgggtgcag
      481 ggcctgcgca agatcatcga ccgctcgggc tccatggacc agcggcagaa gctgcagcac
      541 tggattcact cctgcttgcg aaaggctgat aaaaacaagg ataacaagat gaacttcaag
      601 gaggtgaagg acttcctgaa ggagctcaac gtacaggtgg atgacagcta cgccaggaag
      661 atcttcaggg aatgtgacca ctcccagaca gactcgctgg aggatgagga gattgagacc
      721 ttctacagga tgctgaccca gcgggcagag atcgaccgtg cctttgcaga ggccgcaggt
      781 tctgcggaga ccctgtcggt ggagaagcta gtgacgttcc tgcagcatca gcagcgggag
      841 gaggaggcgg ggccagcctt ggccctctct ctcattgagc gctacgagcc cagtgagact
      901 gccaaagccc agcggcagat gaccaaggat ggcttcctca tgtacctgct gtctgctgac
      961 ggtaacgcct tcagcctggc gcaccgccgt gtctaccagg acatgaacca gccgctcagc
     1021 cactacttag tgtcttcttc ccacaacacc tacctactgg aggaccagct cacagggccc
     1081 agcagcacgg aggcctacat ccgggctctg tgcaaaggct gccggtgtct ggagctggac
     1141 tgctgggacg gccccaacca ggaacccatc atctaccatg gctacacttt tacctctaag
     1201 atacttttct gcgacgtgct cagggccatc cgggactacg ccttcaaggc atccccctac
     1261 ccagttatcc tgtccctgga gaaccactgc agcctggagc aacaacgagt catggctcat
     1321 cacctgaggg ccatcctggg gcccatgctg ttggaccagc cgctggatgg ggttaccacg
     1381 agcctgcctt cgcctgagca actgaaggaa aagattctgt tgaaagggaa gaaactgggc
     1441 gggctgctac ctgctggagg ggaaaacggg cctgaagcca ccgatgtgtc tgacgaagat
     1501 gaggctgctg aaatggaaga tgaggccgtg cgcagccaag tgcaacacaa gcccaaggag
     1561 gataagctaa agctggtgcc ggagctctcc gacatggtca tttactgcaa gagtgtccac
     1621 tttggtggct tctccagtcc tagcacctct gggcaggcat tctatgagat ggcttccttc
     1681 tccgagagcc gtgccctgcg gctgctgcaa gaatcaggaa atagttttgt ccgccataac
     1741 gtgggccatc tgagcaggat ctacccagct gggtggagga cagattcctc caactacagt
     1801 cccgtggaga tgtggaatgg aggctgccag attgtggctc tgaacttcca aacccctggg
     1861 ccagaaatgg atgtttacct tggctgcttc caggacaatg gaggttgtgg gtatgtgctg
     1921 aaaccggcct tcctgagaga ccctgacacc accttcaact cacgggccct gactcagggg
     1981 ccctggtggg ccccgaagaa gctccgagtc tggatcatct ctggacagca gctgccgaag
     2041 gtcaataaga ataagaattc tatcgtggac cccaaggtga tagtggagat ccacggtgtg
     2101 ggccaggatg tggccagccg tcagacagca gttattacca ataatggttt caacccacgg
     2161 tgggacacgg agtttgagtt tgtggtagca gtgcctgacc ttgcccttgt acgtttcatg
     2221 gtagaggatt atgactcctc ctctaagaac gactttatcg gccagagtac tatcccctgg
     2281 aacagcctca agcaggggta ccgccatgtc cacctcttgt ctaagaatgg agacctgcat
     2341 ccatcagcca ctctctttgt gaagatctcc atccaggact aagcctgggg gactgacgca
     2401 gtccgccctg agtgggcgga gctgtgtcca cacctgtctg gcaatgttgc acctctggcg
     2461 cggagcttga ggccactgaa ctgccttcag ctctaacaca tcgcctgagc ttctacttct
     2521 ctgggggtcc aggagcagtc cagtccccgg agtggtctaa aattccgtta ggaacaacac
     2581 tgcatctctc tccctacccc tagttgactt taggttgtga gtttttatat aaaaaaaaat
     2641 aataatcaca agataaa
//
