LOCUS       NM_001290349            4273 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus phospholipase C, beta 3 (Plcb3), transcript variant 1,
            mRNA.
ACCESSION   NM_001290349 XM_006526765
VERSION     NM_001290349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4273)
  AUTHORS   Jin,S.Y., Ha,J.M., Kum,H.J., Ma,J.S., Ha,H.K., Song,S.H.,
            Yang,Y.R., Lee,H., Bae,Y.S., Yamamoto,M., Suh,P.G. and Bae,S.S.
  TITLE     Phospholipase C-beta3 is dispensable for vascular constriction but
            indispensable for vascular hyperplasia
  JOURNAL   Exp Mol Med 56 (7), 1620-1630 (2024)
   PUBMED   38945956
  REMARK    GeneRIF: Phospholipase C-beta3 is dispensable for vascular
            constriction but indispensable for vascular hyperplasia.
REFERENCE   2  (bases 1 to 4273)
  AUTHORS   Ando,T., Takazawa,I., Spencer,Z.T., Ito,R., Tomimori,Y.,
            Mikulski,Z., Matsumoto,K., Ishitani,T., Denson,L.A., Kawakami,Y.,
            Kawakami,Y., Kitaura,J., Ahmed,Y. and Kawakami,T.
  TITLE     Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase
            C-beta3-Dependent Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Cells 13 (11), 986 (2024)
   PUBMED   38891118
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4273)
  AUTHORS   Ascencio Gutierrez,V., Martin,L.E., Simental-Ramos,A., James,K.F.,
            Medler,K.F., Schier,L.A. and Torregrossa,A.M.
  TITLE     TRPM4 and PLCbeta3 contribute to normal behavioral responses to an
            array of sweeteners and carbohydrates but PLCbeta3 is not needed
            for taste-driven licking for glucose
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   38183495
  REMARK    GeneRIF: TRPM4 and PLCbeta3 contribute to normal behavioral
            responses to an array of sweeteners and carbohydrates but PLCbeta3
            is not needed for taste-driven licking for glucose.
REFERENCE   4  (bases 1 to 4273)
  AUTHORS   Gupta,S., Cooper,M., Zhao,X., Yarman,Y., Thomson,H., DeHelian,D.,
            Brass,L.F. and Ma,P.
  TITLE     A regulatory node involving Galphaq, PLCbeta, and RGS proteins
            modulates platelet reactivity to critical agonists
  JOURNAL   J Thromb Haemost 21 (12), 3633-3639 (2023)
   PUBMED   37657560
  REMARK    GeneRIF: A regulatory node involving Galphaq, PLCbeta, and RGS
            proteins modulates platelet reactivity to critical agonists.
REFERENCE   5  (bases 1 to 4273)
  AUTHORS   Kumar,R. and Rao,G.N.
  TITLE     Novel Role of Prereplication Complex Component Cell Division Cycle
            6 in Retinal Neovascularization
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (4), 407-427 (2022)
   PUBMED   35236105
REFERENCE   6  (bases 1 to 4273)
  AUTHORS   Lyu,M.S., Park,D.J., Rhee,S.G. and Kozak,C.A.
  TITLE     Genetic mapping of the human and mouse phospholipase C genes
  JOURNAL   Mamm Genome 7 (7), 501-504 (1996)
   PUBMED   8672127
REFERENCE   7  (bases 1 to 4273)
  AUTHORS   Dupont,G., McGuinness,O.M., Johnson,M.H., Berridge,M.J. and
            Borgese,F.
  TITLE     Phospholipase C in mouse oocytes: characterization of beta and
            gamma isoforms and their possible involvement in sperm-induced Ca2+
            spiking
  JOURNAL   Biochem J 316 (Pt 2) (Pt 2), 583-591 (1996)
   PUBMED   8687404
REFERENCE   8  (bases 1 to 4273)
  AUTHORS   Martelli,A.M., Lach,S., Grill,V., Gilmour,R.S., Cocco,L.,
            Narducci,P. and Bareggi,R.
  TITLE     Expression and immunohistochemical localization of eight
            phospholipase C isoforms in adult male mouse cerebellar cortex
  JOURNAL   Acta Histochem 98 (2), 131-141 (1996)
   PUBMED   8739298
REFERENCE   9  (bases 1 to 4273)
  AUTHORS   Gobl,A.E., Chowdhary,B.P., Shu,W., Eriksson,L., Larsson,C.,
            Weber,G., Oberg,K. and Skogseid,B.
  TITLE     Assignment of the mouse homologue of a human MEN1 candidate gene,
            phospholipase C-beta 3 (Plcb3), to chromosome region 19B by FISH
  JOURNAL   Cytogenet Cell Genet 71 (3), 257-259 (1995)
   PUBMED   7587389
REFERENCE   10 (bases 1 to 4273)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120557.12, AK146793.1 and AI851116.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006526765.1.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43144.1, AK146793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC120557.12        29164-29188
            26-3930             AK146793.1         2-3906
            3931-4273           AI851116.1         1-343               c
FEATURES             Location/Qualifiers
     source          1..4273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.1 cM"
     gene            1..4273
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /note="phospholipase C, beta 3"
                     /db_xref="GeneID:18797"
                     /db_xref="MGI:MGI:104778"
     exon            1..268
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            269..346
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            347..415
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            416..556
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            557..636
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            637..690
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            691..766
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            767..867
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1034
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1181
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1422
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1507
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1694
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1903
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2000
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2085
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2210
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2365
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2527
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2627
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2732
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2824
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2978
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3014
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3207
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3358
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3435
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3525
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3583
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3670
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..4257
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /note="hexamer: AATAAA"
     polyA_site      4257
                     /gene="Plcb3"
                     /gene_synonym="mKIAA4098"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggcc gggcgccgag tctccggtcc gtccgggaca gactggctgg cgggcgggcg
       61 ctgacgccgc ggggccagag cgggccgcgc gggagcgtgt ggagagagca gtggcaccgt
      121 cggttcccgt cggggctccg taggtccccg agccgcccct ggcttagcca tggcgggcgc
      181 gaggcccggc gtccacgcgc tgcagctgga gccgcccacc gtggtggaga ccctgcggcg
      241 cgggagtaag ttcatcaaat gggacgagga ggcctccagt cggaacctgg tgaccctgcg
      301 tgtggaccct aatggcttct tcttgtactg gacaggaccc aacatggagg tggacacact
      361 ggacatcagc tccatcaggg acacaaggac aggtcgttat gcccgcctgc ccaaggaccc
      421 taagattcga gaagtactgg gctttggagg tcctgacacc cggctggagg agaaactgat
      481 gacagtggtg gccgggccag atccagtaaa taccacattc ttgaacttca tggccgtgca
      541 agatgacaca gtcaaggtct ggtcagagga gttgtttaaa ctggccatga acatattggc
      601 tcagaacgcc tcccggaaca ccttcctgcg gaaagcatac acgaagctga agctgcaggt
      661 gaaccaggat ggacggattc cggtcaagaa cattctgaag atgttctcgg cggacaagaa
      721 gcgggtggag acggcgctgg agtcctgtgg cctcaacttc aaccgaagtg agtccattcg
      781 ccctgatgag tttcccttgg aaatttttga gcggttcttg aataaactgt gtctgcgccc
      841 ggatattgac aagatcctgc tggagatagg tgccaagggc aagccgtacc tcactctgga
      901 gcagctcatg gactttatca accagaagca gagagacccg agactcaacg aagtgctgta
      961 cccgccactt cggtcctcac aggctcggct gctcattgag aagtacgaga cgaacaaaca
     1021 gttcctggag cgcgaccaga tgtctatgga gggcttcagc cgctacctgg gaggggagga
     1081 gaatggtatc ctgcctctgg aggccctgga tctgagcatg gacatgaccc agccactgag
     1141 cgcatatttt atcaactcct cacacaacac ctatctcact gcgggccagc tggctggacc
     1201 atcatcggtg gagatgtacc gccaggcact gctgtggggc tgccgctgtg tggagctgga
     1261 tgtatggaag ggacggccac cggaggaaga gcctttcatc actcatggtt tcaccatgac
     1321 cactgaggtg ccattgcgtg atgtgctaga ggccatcgct gaggcagcct tcaagacctc
     1381 gccctaccct gtcatcctct cctttgagaa ccatgtcgac tcggcaaagc agcaggccaa
     1441 gatggctgag tactgccgct ctatctttgg ggatgcgctg ctcattgacc ctctcgacaa
     1501 atacccgcta tctgcgggca tccccctgcc tagtccacag gacctgatgg gccgtatcct
     1561 ggtgaagaat aagaagcgac atcggcccag cacaggtgtc cctgacagct cagtgcgcaa
     1621 gcggcctctg gaacagagca actcggcctt gagtgagagc tcggccgcca cagagccctc
     1681 ctcacctcag cttgggtccc ccagctccga cagctgccct ggcctaagca atggggagga
     1741 ggtgggactc gagaagacca gcctggagcc tcagaagtct ctaggtgagg agagcctcag
     1801 ccgggaacct aatgtgccca tgcctgaccg tgaccgagag gatgaggagg aagatgaaga
     1861 agaagaggaa acaacggatc caaaaaagcc caccactgat gagggcacag ccagcagtga
     1921 ggtcaatgcc acggaggaga tgtcaacgct cgtcaactac gttgagcccg tcaagttcaa
     1981 gtccttcgag gctgctcgaa aaaggaacaa gtgcttcgag atgtcatcct tcgtggagac
     2041 caaggcaatg gagcaactga ccaagagtcc tatggagttt gtggaataca acaaacagca
     2101 gctcagccgc atctacccta agggcacacg agtggactcc tccaactaca tgcctcagct
     2161 cttctggaac gtgggttgcc agcttgttgc cctcaacttc cagaccttgg atttgccaat
     2221 gcagctcaac gcaggcgtgt ttgagtacaa tgggcgcagc gggtacttgc tcaagcccga
     2281 gtttatgcgg cggccggaca agtcttttga tcccttcact gaggtcatcg tagatggcat
     2341 agtggccaac gccttgcggg tcaaggtgat ttcggggcag ttcctgtctg acaagaaggt
     2401 gggcatctac gtcgaggtgg acatgtttgg cctcccagtt gacacaagac gcaaatatcg
     2461 tacccggaca tcccagggga actcattcaa ccctgtgtgg gacgaggaac cctttgactt
     2521 ccccaaggtt gtgctgccca cgctggcctc acttcgcatc gcagcctttg aggagggtgg
     2581 caaatttgtt gggcaccgta tcctgcctgt ctctgctatc cgctcaggat accactatgt
     2641 ctgcctgcga aacgaggcca accaaccttt gtgcctgcct gccctgctta tctacactga
     2701 agcttctgac tacatcccag atgaccacca ggactatgcg gaggccttga ttaaccccat
     2761 caagcacgta agcctaatgg accagcgggc caagcaacta gccgctctca ttggggagag
     2821 tgaggctcag gccagcacag agacatatca ggagaccccg tgtcaacagc cagggtcaca
     2881 gctcccctcc aaccccacac ctaacccact ggatgcctca cctcgctggc cccccggtcc
     2941 taccacttcc tccactagct cctccctcag tagcccaggg cagcgagatg atttgattgc
     3001 cagcatcctc tctgaggtga cccctacacc tctagaggag ctcagaagcc acaaggctat
     3061 ggtgaagcta cggagccggc aggatcgaga cctgcgggag ttgcataaga agcaccagcg
     3121 caaggctgtg gccctcaccc gccgccttct ggatggcctg gcccaggcca gggctgaggg
     3181 gaagtgccgg ccctccccca gtgccctggg caaggccacc aactcggagg acgtgaagga
     3241 ggaagaggag gccaaacagt atcgagagtt ccagaaccga caagtacaga gcctgttgga
     3301 gctgagggaa gcccaggcag atgtggagac caagcggaag ctggagcatc tacgacaggc
     3361 tcatcagcgg ctcaaggagg ttgtcctgga tacacacaca acacagttca agaggctgaa
     3421 ggagctgaat gaaagggaga agaaggaact ccagaagatc ctggacagga agcgcaacaa
     3481 cagcatctca gaggccaaga caagggagaa acacaagaag gaggtggaac tgacagagat
     3541 taatcggcgg cacatcactg agtcggtaaa ctccatcaga cggctggaag aggcccagaa
     3601 gcagcgccat gaacgcctgg tggcagggca acagcaagtc ctccagcagc tagaggaaga
     3661 ggaacccaag ctgctggccc agctgaccca ggagtgtcag gaacagcgag agaggttgcc
     3721 ccaggagatc cgtcggtgcc tgctgggcga gacagcagag ggactggggg acggccccct
     3781 ggtggcctgt gccagcaatg gtcatgcacc tgggagtggt gggcacctgt ccagcgctga
     3841 ctcggagagc caggaggaga acacccagct ttgaactggc tgagcaagag gtggccacaa
     3901 gtctgggtgg gcactgggct atgggtagaa gacactaata ctttgggttt tttttaacct
     3961 tttatcttta gaaattttat ttttttaaaa tctgaggcaa atgcctcaca ctaactctaa
     4021 ctccctgcat cttcctggga cctcttggtc ctcagcctcc ccttctaact tcaggcctag
     4081 ggaaagggct agggcttgta ccccataaca ttcacctaag ataggtactc cccgattccc
     4141 aaggagcagc tagtggaacc ctggagttct gggtagtaga aagcaaccct ttatatttgg
     4201 ggagttttgt ttgtttgttt gtttgttttt tacatgaata aaagtggact tcagggaaaa
     4261 aaaaaaaaaa aaa
//
