LOCUS       NM_023625               3595 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phospholipase B domain containing 2 (Plbd2), mRNA.
ACCESSION   NM_023625
VERSION     NM_023625.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3595)
  AUTHORS   Lakomek,K., Dickmanns,A., Mueller,U., Kollmann,K., Deuschl,F.,
            Berndt,A., Lubke,T. and Ficner,R.
  TITLE     De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from
            mouse
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 3), 220-228 (2009)
   PUBMED   19237744
  REMARK    GeneRIF: A 22-atom substructure of 21 intrinsic S atoms & 1 Xe atom
            with very low occupancy was found & refined at a resolution of
            2.4A. The model was refined to an R(free) factor of 19.8%. The
            contribution of the Xe atom to the anomalous signal was negligible.
REFERENCE   3  (bases 1 to 3595)
  AUTHORS   Jensen,A.G., Chemali,M., Chapel,A., Kieffer-Jaquinod,S., Jadot,M.,
            Garin,J. and Journet,A.
  TITLE     Biochemical characterization and lysosomal localization of the
            mannose-6-phosphate protein p76 (hypothetical protein LOC196463)
  JOURNAL   Biochem J 402 (3), 449-458 (2007)
   PUBMED   17105447
REFERENCE   4  (bases 1 to 3595)
  AUTHORS   Deuschl,F., Kollmann,K., von Figura,K. and Lubke,T.
  TITLE     Molecular characterization of the hypothetical 66.3-kDa protein in
            mouse: lysosomal targeting, glycosylation, processing and tissue
            distribution
  JOURNAL   FEBS Lett 580 (24), 5747-5752 (2006)
   PUBMED   17007843
REFERENCE   5  (bases 1 to 3595)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029813.1, AK043608.1 and AK042089.1.
            
            On Oct 17, 2007 this sequence version replaced NM_023625.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029813.1, AK043608.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1324              AK029813.1         1-1324
            1325-3563           AK043608.1         1315-3553
            3564-3595           AK042089.1         3562-3593
FEATURES             Location/Qualifiers
     source          1..3595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.63 cM"
     gene            1..3595
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="phospholipase B domain containing 2"
                     /db_xref="GeneID:71772"
                     /db_xref="MGI:MGI:1919022"
     exon            1..337
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1817
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="putative phospholipase B-like 2; 76 kDa protein;
                     66.3 kDa protein; LAMA-like protein 2; lamina ancestor
                     homolog 2; phospholipase B domain-containing protein 2"
                     /codon_start=1
                     /product="putative phospholipase B-like 2 precursor"
                     /protein_id="NP_076114.2"
                     /db_xref="CCDS:CCDS19620.1"
                     /db_xref="GeneID:71772"
                     /db_xref="MGI:MGI:1919022"
                     /translation="MAAPVDGSSGGWAARALRRALALTSLTTLALLASLTGLLLSGPA
                     GALPTLGPGWQRQNPDPPVSRTRSLLLDAASGQLRLEDGFHPDAVAWANLTNAIRETG
                     WAYLDLSTNGRYNDSLQAYAAGVVEASVSEELIYMHWMNTVVNYCGPFEYEVGYCEKL
                     KNFLEANLEWMQREMELNPDSPYWHQVRLTLLQLKGLEDSYEGRLTFPTGRFTIKPLG
                     FLLLQISGDLEDLEPALNKTNTKPSLGSGSCSALIKLLPGGHDLLVAHNTWNSYQNML
                     RIIKKYRLQFREGPQEEYPLVAGNNLVFSSYPGTIFSGDDFYILGSGLVTLETTIGNK
                     NPALWKYVQPQGCVLEWIRNVVANRLALDGATWADVFKRFNSGTYNNQWMIVDYKAFL
                     PNGPSPGSRVLTILEQIPGMVVVADKTAELYKTTYWASYNIPYFETVFNASGLQALVA
                     QYGDWFSYTKNPRAKIFQRDQSLVEDMDAMVRLMRYNDFLHDPLSLCEACNPKPNAEN
                     AISARSDLNPANGSYPFQALHQRAHGGIDVKVTSFTLAKYMSMLAASGPTWDQCPPFQ
                     WSKSPFHSMLHMGQPDLWMFSPIRVPWD"
     exon            338..431
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            432..590
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            591..691
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            692..906
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1004
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1165
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1261
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1333
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1486
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1649
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..3595
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="hexamer: AACAAA"
     polyA_site      2241
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="major polyA site"
     polyA_site      2729
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="major polyA site"
     regulatory      3538..3543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="hexamer: AACAAA"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /note="hexamer: AATATA"
     polyA_site      3568
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
     polyA_site      3592
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
ORIGIN      
        1 gacgcagtca cgtggcccgg ctgcggctcg cgatggcggc ccccgtggat gggagctccg
       61 gcggctgggc ggcccgggcg ctacggcggg cactggcgct gacctccctg accacactgg
      121 ccttgctggc ctcgctgacc gggctgttgc tgagcggccc ggcgggcgct ctccctaccc
      181 tggggcccgg ctggcagcgc caaaatccgg acccgccggt ctcccgcacc cgctcgctgc
      241 tgctggacgc cgcgtcgggc cagctgcgcc tggaggatgg cttccacccc gacgcggtgg
      301 cctgggccaa cctcaccaac gccatccgcg agaccgggtg ggcctatctg gacctgagca
      361 caaatggcag gtacaatgac agcctgcagg cctatgcagc tggtgtggtg gaggcctctg
      421 tgtctgagga gctcatctac atgcactgga tgaacacggt ggtcaactac tgcggcccct
      481 tcgaatacga agtcggctac tgtgagaagc ttaagaactt cctggaggcc aacctggagt
      541 ggatgcagag ggaaatggag cttaacccgg actctccgta ctggcaccag gtgcggctga
      601 ccctcctgca gctgaaaggc ctggaggaca gctatgaagg ccgtttaacc ttcccaactg
      661 ggaggttcac catcaaaccc ttggggttcc tcctgctgca gatctctgga gacctggaag
      721 acctagagcc agccctgaat aagaccaaca ccaagccttc cctgggctcc ggttcatgct
      781 ctgccctcat caagctgctg cctggcgggc atgacctcct ggtggcgcac aacacgtgga
      841 actcctacca gaacatgtta cgcatcatca agaagtacag gctgcagttc cgggaggggc
      901 cgcaagagga gtaccccctg gttgctggca acaacttggt tttctcgtcc tacccgggca
      961 ccatcttctc cggagatgac ttctacatcc tgggcagtgg cctggtcacc ctggagacca
     1021 ccattggcaa caagaaccca gccctgtgga agtacgtgca gccccagggc tgtgtgctgg
     1081 agtggatacg aaatgtcgtg gccaaccgcc tggccttgga cggggccacc tgggcagacg
     1141 tcttcaagcg gttcaacagc ggcacgtaca ataaccagtg gatgattgtg gactacaagg
     1201 cattcctccc caacggaccc agccctggaa gccgggtgct cactatccta gaacagatcc
     1261 cgggcatggt ggtggtggct gacaagactg cagagctcta caaaacgacc tactgggcta
     1321 gctacaacat cccgtacttt gagactgtat tcaacgctag tgggctgcag gccctggtgg
     1381 cccagtatgg agattggttc tcttacacta agaaccctcg agccaagatc ttccagaggg
     1441 accagtcact ggtggaggac atggacgcca tggtccggct catgaggtac aatgatttcc
     1501 tccatgaccc tctgtcattg tgtgaagcct gcaacccaaa gcctaatgcg gagaatgcca
     1561 tctctgcccg ctctgacctc aaccccgcca atggctccta cccatttcag gccctgcatc
     1621 agcgcgccca tggtggcatt gatgtgaagg tgaccagctt taccctggcc aagtacatga
     1681 gcatgctggc ggccagtggc cccacgtggg accagtgtcc tccgttccag tggagcaaat
     1741 cgccattcca cagcatgctg cacatgggcc agcccgacct ctggatgttc tcacccatca
     1801 gggtgccatg ggactgagag agagtccgcc tccgcctagc tgccttcatt ttgtgtggcc
     1861 agtgggtcat acacctgccg tccacccctc gggcttctgt cttcactaga ctctggtcct
     1921 agcggcttcc ttcgcaagga cacaacccag tgggctcaga gttgcctctg tctctgagcc
     1981 ctctgcccct tcatggctca tcctccctgt ccctgtcacc agcaggctgg ggcttatgct
     2041 tggctgtggg cctggtggga tccggggcac acattctcct agtgctggtc cctcagcata
     2101 tgtgtgaact gacaggggac attatggttg tcactgctgg cctgtgggcc catcgcctca
     2161 ggaggcagcc ctgtgccctt ctgggcagct cttctaagtg caggagcttg agaacaaaac
     2221 caaagtttct ggctgcttgt agctggaggg ccttgagtct tctttcagca ggaggaatgg
     2281 accgtcaccc cacacttcta cccctactcc cagccaagcc tgcccctggc ctcctggtag
     2341 gtgtctctgg ctgtgtgctc cggtcagcga agcccaggct gtgcttctgt taaacaagcc
     2401 ttgtggggcg gcaccacacc ctgtctgtcc atggctgtct ccttccatct gtcctttctc
     2461 tagtccacgt acctactgtt cacctgcatc accagccccc tgcccgtcca tcccctctcc
     2521 tgtccaccct accgtctttt cactcagtca gcggtccaca cacctacccg tccacttgcc
     2581 tgccttttca tctgaacgtc ctcacctctc acccacccat ccacctgccc gtccgtcagt
     2641 ctgtccaccc agaactgcac atcccttttc attttggttt tgctctgtaa ctcagtgtgg
     2701 ccttgaactt gaatgccttg tagtccacag tcatcctctg gttattgtat ctgctggccg
     2761 ccttcaccct cacatgctgg gtttccatgt acaggccgcc gtgccttgat tctgcttttc
     2821 atcagcccac tcatctctct gtccatttat ccctgttagt ccttctgctc agcatctgtc
     2881 tcaagtgctg tattctgggt cctagcctgg cccaacctgc tgaccactaa gaccctaaat
     2941 cctagaccca gagacccaca tgaaaccaag tcccctgtgt ggggcccaga gagctcacag
     3001 cctgtgaacc agaggcccta agatgtgtgg gtagctttac ccgagccagt ccgggcctgc
     3061 catgtgttct gagtttcgtt ggtagtcagg ggttggtttc ctgtcaggtt cactccacct
     3121 tccctgctct gcagatgcct gcacggggtt ggttttccag acaccagggt ggggccgctg
     3181 gtgtctcagg atggccttgt cctgtcccta aggacttcat attagcatgt ggtggccttg
     3241 cctgtgcatc tcccagctgc tttgcgaccc caccctagat ccctgtgtgg cttagctctg
     3301 gtcctctctc ctgacttacg gatgtgtggg ttccaccagt caatccactg ggagacccaa
     3361 gaccccagag gggagcacca cttctctgag agccagggac gatgtggctg ggtgtagagg
     3421 gagactgaac aaggcaagga agctaacgcc tgtctgcccg gcactcagaa gatgaggcag
     3481 gaggatctcc agtttgagac cagcctgggc tgcacataga ccctcatgtc aagaacaaac
     3541 aaagctcaaa agatctttgc tctataaata tatatttatt ttttatttac aatgg
//
