LOCUS       NP_076114                594 aa            linear   ROD 30-APR-2024
DEFINITION  putative phospholipase B-like 2 precursor [Mus musculus].
ACCESSION   NP_076114
VERSION     NP_076114.2
DBSOURCE    REFSEQ: accession NM_023625.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 594)
  AUTHORS   Lakomek,K., Dickmanns,A., Mueller,U., Kollmann,K., Deuschl,F.,
            Berndt,A., Lubke,T. and Ficner,R.
  TITLE     De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from
            mouse
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 3), 220-228 (2009)
   PUBMED   19237744
  REMARK    GeneRIF: A 22-atom substructure of 21 intrinsic S atoms & 1 Xe atom
            with very low occupancy was found & refined at a resolution of
            2.4A. The model was refined to an R(free) factor of 19.8%. The
            contribution of the Xe atom to the anomalous signal was negligible.
REFERENCE   3  (residues 1 to 594)
  AUTHORS   Jensen,A.G., Chemali,M., Chapel,A., Kieffer-Jaquinod,S., Jadot,M.,
            Garin,J. and Journet,A.
  TITLE     Biochemical characterization and lysosomal localization of the
            mannose-6-phosphate protein p76 (hypothetical protein LOC196463)
  JOURNAL   Biochem J 402 (3), 449-458 (2007)
   PUBMED   17105447
REFERENCE   4  (residues 1 to 594)
  AUTHORS   Deuschl,F., Kollmann,K., von Figura,K. and Lubke,T.
  TITLE     Molecular characterization of the hypothetical 66.3-kDa protein in
            mouse: lysosomal targeting, glycosylation, processing and tissue
            distribution
  JOURNAL   FEBS Lett 580 (24), 5747-5752 (2006)
   PUBMED   17007843
REFERENCE   5  (residues 1 to 594)
  AUTHORS   Perelygin,A.A., Scherbik,S.V., Zhulin,I.B., Stockman,B.M., Li,Y.
            and Brinton,M.A.
  TITLE     Positional cloning of the murine flavivirus resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9322-9327 (2002)
   PUBMED   12080145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029813.1, AK043608.1 and AK042089.1.
            
            On Jun 10, 2003 this sequence version replaced NP_076114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029813.1, AK043608.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.63 cM"
     Protein         1..594
                     /product="putative phospholipase B-like 2 precursor"
                     /note="putative phospholipase B-like 2; 76 kDa protein;
                     66.3 kDa protein; LAMA-like protein 2; lamina ancestor
                     homolog 2; phospholipase B domain-containing protein 2"
                     /calculated_mol_wt=61887
     sig_peptide     1..46
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4421
     mat_peptide     47..594
                     /product="Putative phospholipase B-like 2.
                     /id=PRO_0000286111"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TCN2.2)"
                     /calculated_mol_wt=61887
     Region          90..589
                     /region_name="Phospholip_B"
                     /note="Phospholipase B; pfam04916"
                     /db_xref="CDD:461479"
     Site            93
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17007843; propagated from
                     UniProtKB/Swiss-Prot (Q3TCN2.2)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17007843,
                     ECO:0000269|PubMed:19237744; propagated from
                     UniProtKB/Swiss-Prot (Q3TCN2.2)"
     Site            236
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17007843,
                     ECO:0000269|PubMed:19237744; propagated from
                     UniProtKB/Swiss-Prot (Q3TCN2.2)"
     Site            441
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17007843,
                     ECO:0000269|PubMed:19237744; propagated from
                     UniProtKB/Swiss-Prot (Q3TCN2.2)"
     Site            520
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17007843,
                     ECO:0000269|PubMed:19237744; propagated from
                     UniProtKB/Swiss-Prot (Q3TCN2.2)"
     CDS             1..594
                     /gene="Plbd2"
                     /gene_synonym="1300012G16Rik; P76"
                     /coded_by="NM_023625.4:33..1817"
                     /db_xref="CCDS:CCDS19620.1"
                     /db_xref="GeneID:71772"
                     /db_xref="MGI:MGI:1919022"
ORIGIN      
        1 maapvdgssg gwaaralrra laltslttla llasltglll sgpagalptl gpgwqrqnpd
       61 ppvsrtrsll ldaasgqlrl edgfhpdava wanltnaire tgwayldlst ngryndslqa
      121 yaagvveasv seeliymhwm ntvvnycgpf eyevgycekl knfleanlew mqremelnpd
      181 spywhqvrlt llqlkgleds yegrltfptg rftikplgfl llqisgdled lepalnktnt
      241 kpslgsgscs alikllpggh dllvahntwn syqnmlriik kyrlqfregp qeeyplvagn
      301 nlvfssypgt ifsgddfyil gsglvtlett ignknpalwk yvqpqgcvle wirnvvanrl
      361 aldgatwadv fkrfnsgtyn nqwmivdyka flpngpspgs rvltileqip gmvvvadkta
      421 elykttywas ynipyfetvf nasglqalva qygdwfsytk nprakifqrd qslvedmdam
      481 vrlmryndfl hdplslceac npkpnaenai sarsdlnpan gsypfqalhq rahggidvkv
      541 tsftlakyms mlaasgptwd qcppfqwsks pfhsmlhmgq pdlwmfspir vpwd
//
