LOCUS       NM_011113               1508 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus plasminogen activator, urokinase receptor (Plaur),
            mRNA.
ACCESSION   NM_011113
VERSION     NM_011113.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Kim,E.Y. and Dryer,S.E.
  TITLE     Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR
            Signal Transduction in Mouse Podocytes: Interactions with
            alphaVbeta3-Integrin
  JOURNAL   Cells 13 (2), 172 (2024)
   PUBMED   38247863
  REMARK    GeneRIF: Role of Formyl Peptide Receptors and beta-Arrestin-1 in
            suPAR Signal Transduction in Mouse Podocytes: Interactions with
            alphaVbeta3-Integrin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Dergilev,K., Tsokolaeva,Z., Goltseva,Y., Beloglazova,I., Ratner,E.
            and Parfyonova,Y.
  TITLE     Urokinase-Type Plasminogen Activator Receptor Regulates Prosurvival
            and Angiogenic Properties of Cardiac Mesenchymal Stromal Cells
  JOURNAL   Int J Mol Sci 24 (21), 15554 (2023)
   PUBMED   37958542
  REMARK    GeneRIF: Urokinase-Type Plasminogen Activator Receptor Regulates
            Prosurvival and Angiogenic Properties of Cardiac Mesenchymal
            Stromal Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Zhu,K., Mukherjee,K., Wei,C., Hayek,S.S., Collins,A., Gu,C.,
            Corapi,K., Altintas,M.M., Wang,Y., Waikar,S.S., Bianco,A.C.,
            Koch,A., Tacke,F., Reiser,J. and Sever,S.
  TITLE     The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes
            and kidney disease
  JOURNAL   Sci Transl Med 15 (714), eabq6492 (2023)
   PUBMED   37729431
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Wei,C., Datta,P.K., Siegerist,F., Li,J., Yashwanth,S., Koh,K.H.,
            Kriho,N.W., Ismail,A., Luo,S., Fischer,T., Amber,K.T., Cimbaluk,D.,
            Landay,A., Endlich,N., Rappaport,J., Hayek,S.S. and Reiser,J.
  CONSRTM   Michigan Medicine COVID-19 Investigators
  TITLE     SuPAR mediates viral response proteinuria by rapidly changing
            podocyte function
  JOURNAL   Nat Commun 14 (1), 4414 (2023)
   PUBMED   37479685
  REMARK    GeneRIF: SuPAR mediates viral response proteinuria by rapidly
            changing podocyte function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Bugge,T.H., Suh,T.T., Flick,M.J., Daugherty,C.C., Romer,J.,
            Solberg,H., Ellis,V., Dano,K. and Degen,J.L.
  TITLE     The receptor for urokinase-type plasminogen activator is not
            essential for mouse development or fertility
  JOURNAL   J Biol Chem 270 (28), 16886-16894 (1995)
   PUBMED   7622505
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Solberg,H., Lober,D., Eriksen,J., Ploug,M., Ronne,E., Behrendt,N.,
            Dano,K. and Hoyer-Hansen,G.
  TITLE     Identification and characterization of the murine cell surface
            receptor for the urokinase-type plasminogen activator
  JOURNAL   Eur J Biochem 205 (2), 451-458 (1992)
   PUBMED   1374026
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Kristensen,P., Eriksen,J., Blasi,F. and Dano,K.
  TITLE     Two alternatively spliced mouse urokinase receptor mRNAs with
            different histological localization in the gastrointestinal tract
  JOURNAL   J Cell Biol 115 (6), 1763-1771 (1991)
   PUBMED   1661735
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Roldan,A.L., Cubellis,M.V., Masucci,M.T., Behrendt,N., Lund,L.R.,
            Dano,K., Appella,E. and Blasi,F.
  TITLE     Cloning and expression of the receptor for human urokinase
            plasminogen activator, a central molecule in cell surface, plasmin
            dependent proteolysis
  JOURNAL   EMBO J 9 (2), 467-474 (1990)
   PUBMED   1689240
  REMARK    Erratum:[EMBO J 1990 May;9(5):1674]
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Miles,L.A. and Plow,E.F.
  TITLE     Binding and activation of plasminogen on the platelet surface
  JOURNAL   J Biol Chem 260 (7), 4303-4311 (1985)
   PUBMED   3920216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002580.1, AK131951.1 and AC161166.7.
            
            On Nov 20, 2015 this sequence version replaced NM_011113.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144796.1, AK131951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK002580.1         55-57
            4-1507              AK131951.1         3-1506
            1508-1508           AC161166.7         195590-195590       c
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.92 cM"
     gene            1..1508
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /note="plasminogen activator, urokinase receptor"
                     /db_xref="GeneID:18793"
                     /db_xref="MGI:MGI:97612"
     exon            1..85
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1011
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /note="urokinase plasminogen activator surface receptor;
                     urokinase plasminogen activator receptor"
                     /codon_start=1
                     /product="urokinase plasminogen activator surface receptor
                     precursor"
                     /protein_id="NP_035243.1"
                     /db_xref="CCDS:CCDS20950.1"
                     /db_xref="GeneID:18793"
                     /db_xref="MGI:MGI:97612"
                     /translation="MGLPRRLLLLLLLATTCVPASQGLQCMQCESNQSCLVEECALGQ
                     DLCRTTVLREWQDDRELEVVTRGCAHSEKTNRTMSYRMGSMIISLTETVCATNLCNRP
                     RPGARGRAFPQGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSLK
                     DEDYTRGCGSLPGCPGTAGFHSNQTFHFLKCCNYTHCNGGPVLDLQSFPPNGFQCYSC
                     EGNNTLGCSSEEASLINCRGPMNQCLVATGLDVLGNRSYTVRGCATASWCQGSHVADS
                     FPTHLNVSVSCCHGSGCNSPTGGAPRPGPAQLSLIASLLLTLGLWGVLLWT"
     exon            86..196
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            197..340
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            341..496
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            497..631
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            632..778
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1508
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1489..1494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /note="hexamer: ATTAAA"
     polyA_site      1508
                     /gene="Plaur"
                     /gene_synonym="Cd87; u-PAR; uPAR"
                     /note="major polyA site"
ORIGIN      
        1 tctagagcag aggtgaagga agaacccatg ggactcccaa ggcggctgct gctgctgctg
       61 ttgctggcga ctacctgtgt cccagcctcc cagggcctgc agtgcatgca gtgtgagagt
      121 aaccagagct gcctggtaga ggagtgtgct ctgggccagg acctctgcag gactaccgtg
      181 cttcgggaat ggcaagatga tagagagctg gaggtggtga caagaggctg tgcccacagc
      241 gaaaagacca acaggaccat gagttaccgc atgggctcca tgatcatcag cctgacagag
      301 accgtgtgcg ccacaaacct ctgcaacagg cccagacccg gagcccgagg ccgtgctttc
      361 ccccagggcc gttacctcga gtgtgcgtcc tgcacctctt tggaccagag ctgtgagagg
      421 ggccgggagc aaagcctgca atgccgctat cctacagagc actgtattga agtggtgacc
      481 ctccagagca cagaaaggag cttgaaggat gaggactaca cccgaggctg tggcagtctt
      541 cccggatgcc caggcacagc aggtttccat agcaaccaga cctttcactt cctgaagtgt
      601 tgcaactaca cccactgcaa tggtggccca gttctggatc ttcagagctt tccaccgaat
      661 ggcttccagt gttacagctg tgaggggaac aatacccttg ggtgttcctc cgaagaggcg
      721 tctctcatca actgccgggg accaatgaat cagtgcctgg tggctacagg cttagatgtg
      781 ctgggaaacc ggagttatac cgtaagaggc tgcgccacgg cttcctggtg ccaaggctcc
      841 cacgtggcag actccttccc gacccacctc aacgtctctg tctcctgctg ccacggcagc
      901 ggctgtaaca gccccacagg gggcgccccc aggccaggcc ctgctcaact cagcctcatt
      961 gcctctctgc tcctgaccct cggactatgg ggcgtcctcc tctggacctg actcctgagc
     1021 cggcagccct ggctggaccc agggtctttt gactccctcc cccctgctcc atctttgagg
     1081 atgtgtgtgc cctcgtgttg tcttctttgg acctcagttt ttccatgaac cagaagagaa
     1141 ttggaacaag ggctgcgggc agcaggggcc tcttagttga gataatattg ttgctgttat
     1201 tattattatt atcattgtta ttgctctaat ttattatata aatatatata taaaagattt
     1261 ttgtaccagt gaacaaggtt gggtctcccc actgtcacat ttagcttggg aagatgagag
     1321 cagcagggaa ttgttttttt gtttgtttgt ttgtttgatt gattgattga tttttgcttt
     1381 gagacaggat ctcaccatgt agccctagct gccctggaac ttactttata gaccaggcta
     1441 gcctaaaact cacagagacc cacctgcctc tacctcctca gtgctttgat taaaggtgtg
     1501 taccacca
//
