LOCUS       NM_008873               2343 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus plasminogen activator, urokinase (Plau), mRNA.
ACCESSION   NM_008873
VERSION     NM_008873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Torres-Paris,C., Song,H.J., Engelberger,F., Ramirez-Sarmiento,C.A.
            and Komives,E.A.
  TITLE     The Light Chain Allosterically Enhances the Protease Activity of
            Murine Urokinase-Type Plasminogen Activator
  JOURNAL   Biochemistry 63 (11), 1434-1444 (2024)
   PUBMED   38780522
  REMARK    GeneRIF: The Light Chain Allosterically Enhances the Protease
            Activity of Murine Urokinase-Type Plasminogen Activator.
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Laurenzi,G., Fedeli,V. and Canipari,R.
  TITLE     Decreased fertility in female mice lacking urokinase plasminogen
            activator
  JOURNAL   Reprod Biol 24 (1), 100840 (2024)
   PUBMED   38113659
  REMARK    GeneRIF: Decreased fertility in female mice lacking urokinase
            plasminogen activator.
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Sugioka,K., Nishida,T., Kodama-Takahashi,A., Murakami,J.,
            Fukuda,M., Matsuo,O. and Kusaka,S.
  TITLE     Urokinase-type plasminogen activator promotes corneal epithelial
            migration and nerve regeneration
  JOURNAL   Exp Eye Res 233, 109559 (2023)
   PUBMED   37385532
  REMARK    GeneRIF: Urokinase-type plasminogen activator promotes corneal
            epithelial migration and nerve regeneration.
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Kida,Y., Okahisa,T., Sato,Y., Bando,M., Fujimoto,S., Ma,B.,
            Nakagawa,T., Kawaguchi,T., Nakamura,F., Okamoto,K., Miyamoto,H.,
            Sogabe,M., Tsuneyama,K. and Takayama,T.
  TITLE     Urokinase-type plasminogen activator blockade ameliorates
            experimental colitis in mice
  JOURNAL   Sci Rep 13 (1), 2899 (2023)
   PUBMED   36806262
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2343)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 2343)
  AUTHORS   Dietrich,W., Katz,H., Lincoln,S.E., Shin,H.S., Friedman,J.,
            Dracopoli,N.C. and Lander,E.S.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   8  (bases 1 to 2343)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   9  (bases 1 to 2343)
  AUTHORS   Gleditsch,L. and Bogen,B.
  TITLE     A Tcra congenic mouse: V alpha epitope expression is influenced by
            both Tcra haplotypes and background genes
  JOURNAL   Immunogenetics 35 (3), 153-160 (1992)
   PUBMED   1371498
REFERENCE   10 (bases 1 to 2343)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA10 homologous loci in cattle
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 123-126 (1991)
   PUBMED   1655359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY320655.1 and X02389.1.
            
            On Dec 8, 2009 this sequence version replaced NM_008873.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X02389.1, BC120709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY320655.1         2-46
            46-2192             X02389.1           1-2147
            2193-2343           X02389.1           2149-2299
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.53 cM"
     gene            1..2343
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /note="plasminogen activator, urokinase"
                     /db_xref="GeneID:18792"
                     /db_xref="MGI:MGI:97611"
     exon            1..73
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            74..160
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1405
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /EC_number="3.4.21.73"
                     /note="U-plasminogen activator; urokinase-type plasminogen
                     activator"
                     /codon_start=1
                     /product="urokinase-type plasminogen activator precursor"
                     /protein_id="NP_032899.1"
                     /db_xref="CCDS:CCDS26858.1"
                     /db_xref="GeneID:18792"
                     /db_xref="MGI:MGI:97611"
                     /translation="MKVWLASLFLCALVVKNSEGGSVLGAPDESNCGCQNGGVCVSYK
                     YFSRIRRCSCPRKFQGEHCEIDASKTCYHGNGDSYRGKANTDTKGRPCLAWNAPAVLQ
                     KPYNAHRPDAISLGLGKHNYCRNPDNQKRPWCYVQIGLRQFVQECMVHDCSLSKKPSS
                     SVDQQGFQCGQKALRPRFKIVGGEFTEVENQPWFAAIYQKNKGGSPPSFKCGGSLISP
                     CWVASAAHCFIQLPKKENYVVYLGQSKESSYNPGEMKFEVEQLILHEYYREDSLAYHN
                     DIALLKIRTSTGQCAQPSRSIQTICLPPRFTDAPFGSDCEITGFGKESESDYLYPKNL
                     KMSVVKLVSHEQCMQPHYYGSEINYKMLCAADPEWKTDSCKGDSGGPLICNIEGRPTL
                     SGIVSWGRGCAEKNKPGVYTRVSHFLDWIQSHIGEEKGLAF"
     exon            161..191
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            192..299
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            300..474
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            475..566
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            567..789
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            790..938
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1079
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1228
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..2343
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="Plau"
                     /gene_synonym="u-PA; uPA"
                     /note="major polyA site"
ORIGIN      
        1 gtagccccag agctctgtct gtcatccatc cagtccttgc gtgtctgcca gcgcccttcc
       61 gctgcagtca ccgaactgct gtctagagcc cagcggcact accatgaaag tctggctggc
      121 gagcctgttc ctctgcgcct tggtggtgaa aaactctgaa ggtggcagtg tacttggagc
      181 tcctgatgaa tcaaactgtg gctgtcagaa cggaggtgta tgcgtgtcct acaagtactt
      241 ctccagaatt cgccgatgca gctgcccaag gaaattccag ggggagcact gtgagataga
      301 tgcatcaaaa acctgctatc atggaaatgg tgactcttac cgaggaaagg ccaacactga
      361 taccaaaggt cggccctgcc tggcctggaa tgcgcctgct gtccttcaga aaccctacaa
      421 tgcccacaga cctgatgcta ttagcctagg cctggggaaa cacaattact gcaggaaccc
      481 tgacaaccag aagcgaccct ggtgctatgt gcagattggc ctaaggcagt ttgtccaaga
      541 atgcatggtg catgactgct ctcttagcaa aaagccttct tcgtctgtag accaacaagg
      601 cttccagtgt ggccagaagg ctctaaggcc ccgctttaag attgttgggg gagaattcac
      661 tgaggtggag aaccagccct ggttcgcagc catctaccag aagaacaagg gaggaagtcc
      721 tccctccttt aaatgtggtg ggagtctcat cagtccttgc tgggtggcca gtgccgcaca
      781 ctgcttcatt caactcccaa agaaggaaaa ctacgttgtc tacctgggtc agtcgaagga
      841 gagctcctat aatcctggag agatgaagtt tgaggtggag cagctcatct tgcacgaata
      901 ctacagggaa gacagcctgg cctaccataa tgatattgcc ttgctgaaga tacgtaccag
      961 cacgggccaa tgtgcacagc catccaggtc catacagacc atctgcctgc ccccaaggtt
     1021 tactgatgct ccgtttggtt cagactgtga gatcactggc tttggaaaag agtctgaaag
     1081 tgactatctc tatccaaaga acctgaaaat gtccgtcgta aagcttgttt ctcatgaaca
     1141 gtgtatgcag ccccactact atggctctga aattaattat aaaatgctgt gtgctgcgga
     1201 cccagagtgg aaaacagatt cctgcaaggg cgattctgga ggaccgctta tctgtaacat
     1261 cgaaggccgc ccaactctga gtgggattgt gagctggggc cgaggatgtg cagagaaaaa
     1321 caagcccggt gtctacacga gggtctcaca cttcctggac tggattcaat cccacattgg
     1381 agaagagaaa ggtctggcct tctgatggcc ctcaggtagc tgagggaaga aacagatggg
     1441 tcacttgttc ccatgctgac cgtcctctct gcaacagagt cgtcaaatgg agggaagaag
     1501 ctgaaaagac aggttttgca ttgatcctct gctgtgctgc ccaccagggt gagcgccaat
     1561 agcattaccc tcagacacag gcctgggtgc tggccatcca gaccctcccg accaggatgg
     1621 aaagttggtc ctgactcagg atgctataga ccaggagttg cctttttatg gactaaagcc
     1681 atctgcagtt tagaaaacat ctcctgggca agtgtaggag gagagctgtt tcccttaatg
     1741 ggtcattcat gagatctgct gttgggaaat aaatgatttc ccaattagga agtgcaacag
     1801 ctgaggtatt gtgagggtgc ttgtccaata tgagaacggt agcttgagga gtagagacac
     1861 taacggcttg agggaacagc tctagcatcc catgaatgga tcaggaaatg ttatatttgt
     1921 gtgtatgttt gttcactctg cacaggctgt gagtataagc ctgagcaaaa gctggtgtat
     1981 ttctgtatct aactgcaagt ctaggtattt ccctaactcc agactgtgat gcggggccat
     2041 ttggtcttcc atgtgatgct ccacgtgaat gtatcattcc cgggcgtgac ccgtgactag
     2101 cactaaatgt cggtttcact ttttatatag atgtccactt cttggccagt tatctttttt
     2161 tttttttttt tttttttttt tttttttttt ttactaatta gcctagttca tccaatcctc
     2221 actgggtggg gtaaggacca cttctacata cttaatattt aataattatg ttctgctatt
     2281 tttatttata tctattttta taattctgag taaaggtgat caataaatgt gatttttctg
     2341 aag
//
