LOCUS       NM_018807               5407 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus pleiomorphic adenoma gene-like 2 (Plagl2), mRNA.
ACCESSION   NM_018807
VERSION     NM_018807.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5407)
  AUTHORS   Zhu,G., Yang,X., Zhou,W., Lian,X. and Hao,Y.
  TITLE     PLAGL2 induces nucleus pulposus cell apoptosis via regulating
            RASSF5 expression and thus accelerates intervertebral disc
            degeneration
  JOURNAL   Exp Cell Res 430 (1), 113699 (2023)
   PUBMED   37364764
  REMARK    GeneRIF: PLAGL2 induces nucleus pulposus cell apoptosis via
            regulating RASSF5 expression and thus accelerates intervertebral
            disc degeneration.
REFERENCE   2  (bases 1 to 5407)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5407)
  AUTHORS   Adnani,L., Dixit,R., Chen,X., Balakrishnan,A., Modi,H., Touahri,Y.,
            Logan,C. and Schuurmans,C.
  TITLE     Plag1 and Plagl2 have overlapping and distinct functions in
            telencephalic development
  JOURNAL   Biol Open 7 (11) (2018)
   PUBMED   30361413
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5407)
  AUTHORS   Strubberg,A.M., Veronese Paniagua,D.A., Zhao,T., Dublin,L.,
            Pritchard,T., Bayguinov,P.O., Fitzpatrick,J.A.J. and Madison,B.B.
  TITLE     The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate
            and Activates Expression of ASCL2 in Intestinal Epithelial Cells
  JOURNAL   Stem Cell Reports 11 (2), 410-424 (2018)
   PUBMED   30017821
  REMARK    GeneRIF: PLAGL2 expression is strongly associated with an IESC
            signature in colorectal cancer and may be responsible for
            contributing to the aberrant activation of an immature phenotype.
REFERENCE   5  (bases 1 to 5407)
  AUTHORS   Chen,A.C., Donovan,A., Ned-Sykes,R. and Andrews,N.C.
  TITLE     Noncanonical role of transferrin receptor 1 is essential for
            intestinal homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 112 (37), 11714-11719 (2015)
   PUBMED   26324903
REFERENCE   6  (bases 1 to 5407)
  AUTHORS   Alam,S., Zinyk,D., Ma,L. and Schuurmans,C.
  TITLE     Members of the Plag gene family are expressed in complementary and
            overlapping regions in the developing murine nervous system
  JOURNAL   Dev Dyn 234 (3), 772-782 (2005)
   PUBMED   16193498
REFERENCE   7  (bases 1 to 5407)
  AUTHORS   Landrette,S.F., Kuo,Y.H., Hensen,K., Barjesteh van Waalwijk van
            Doorn-Khosrovani,S., Perrat,P.N., Van de Ven,W.J., Delwel,R. and
            Castilla,L.H.
  TITLE     Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia
            in cooperation with Cbfb-MYH11
  JOURNAL   Blood 105 (7), 2900-2907 (2005)
   PUBMED   15585652
REFERENCE   8  (bases 1 to 5407)
  AUTHORS   Yang,M.C., Weissler,J.C., Terada,L.S., Deng,F. and Yang,Y.S.
  TITLE     Pleiomorphic adenoma gene-like-2, a zinc finger protein,
            transactivates the surfactant protein-C promoter
  JOURNAL   Am J Respir Cell Mol Biol 32 (1), 35-43 (2005)
   PUBMED   15361364
REFERENCE   9  (bases 1 to 5407)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 5407)
  AUTHORS   Mizutani,A., Furukawa,T., Adachi,Y., Ikehara,S. and Taketani,S.
  TITLE     A zinc-finger protein, PLAGL2, induces the expression of a
            proapoptotic protein Nip3, leading to cellular apoptosis
  JOURNAL   J Biol Chem 277 (18), 15851-15858 (2002)
   PUBMED   11832486
  REMARK    GeneRIF: induces the expression of a proapoptotic protein Nip3,
            leading to cellular apoptosis.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807380.6.
            
            On Nov 17, 2006 this sequence version replaced NM_018807.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078453.1, AK133833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL807380.6         96072-96154         c
            84-456              AL807380.6         90596-90968         c
            457-5407            AL807380.6         82565-87515         c
FEATURES             Location/Qualifiers
     source          1..5407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..5407
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /note="pleiomorphic adenoma gene-like 2"
                     /db_xref="GeneID:54711"
                     /db_xref="MGI:MGI:1933165"
     exon            1..83
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /inference="alignment:Splign:2.1.0"
     exon            84..456
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1687
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /note="pleomorphic adenoma gene like 2"
                     /codon_start=1
                     /product="zinc finger protein PLAGL2"
                     /protein_id="NP_061277.2"
                     /db_xref="CCDS:CCDS16908.1"
                     /db_xref="GeneID:54711"
                     /db_xref="MGI:MGI:1933165"
                     /translation="MTTFFTSVPPWIQDAKQEEEVGWKLVPRPRGREAESQVKCQCEI
                     SGTPFSNGEKLRPHSLPHPEQRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPHQCMY
                     CDKMFHRKDHLRNHLQTHDPNKEALHCSECGKNYNTKLGYRRHLAMHAASSGDLSCKV
                     CLQTFESTQALLEHLKAHSRRVAGGAKEKKHPCDHCDRRFYTRKDVRRHLVVHTGRKD
                     FLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPVDMLGLLSCSSTVSVKEELSPVL
                     CMASRDVMGAKAFPGMLPMGMYGAHIPTMPSAGMPHSLVHNTLPMGMSYPLESSPISS
                     SAQLPPKYQLGSTSYLPDKLPKVEVDSFLAELPGSLSLSSAEPQPASPQPAAAAALLD
                     EALLAKSPANLSEALCAANVDFSHLLGFLPLNLPPCNPPGATGGLVMGYSQAEAQPLL
                     TTLQAQPQDSAGAGGPLNFGPLHSLPPVFTSGLSTTTLPRFHQAFQ"
     exon            457..5407
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5389..5394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /note="hexamer: ATTAAA"
     polyA_site      5407
                     /gene="Plagl2"
                     /gene_synonym="mKIAA0198"
                     /note="major polyA site"
ORIGIN      
        1 ccgaccgccg ccactaccgg ggcctgagcg ggcctggcgg agcccgagcg cggcccggcc
       61 cgcagcgcgg ggtcccgagc gcagtgaaga gactgttttc tgaaggctgc gttggaggct
      121 gtgaccgagc agagagccca tgtgaactga tggggaggct ttctgaataa catggccttt
      181 tgccattagc cttgccatga ccacattttt caccagcgtc cctccctgga ttcaagatgc
      241 aaagcaggag gaggaagtgg gctggaaact agttcccagg cctcggggcc gggaggcaga
      301 gagtcaagtg aagtgccaat gtgaaatctc ggggacacca ttttcaaatg gggagaagct
      361 aaggcctcac agccttcccc atccggagca gagaccatat agctgtcctc agctgcactg
      421 cggcaaggct tttgcctcca agtacaagct gtataggcac atggccaccc actcggccca
      481 gaaaccccac cagtgcatgt actgtgacaa gatgtttcac cgaaaggacc atctgcggaa
      541 ccacttgcag acccatgacc ccaacaaaga ggccctccac tgctctgagt gtggtaagaa
      601 ttataataca aagctgggat accgtcgtca cctggccatg catgctgcca gcagtggtga
      661 tctcagctgc aaggtgtgcc tgcagacctt tgagagtacc caggccctat tggagcacct
      721 gaaggctcac tcacgccggg tagcaggagg tgctaaggag aagaagcacc cctgtgacca
      781 ttgtgacagg cggttctata ctcggaagga tgtccgacgg cacctagtgg tgcacacagg
      841 tcgtaaggac ttcctgtgtc agtactgtgc ccagagattt ggccgcaagg atcacctgac
      901 acgccatgtc aagaagagcc actcacagga actgctcaag atcaagacag agccagtgga
      961 tatgttaggc ttgctcagct gtagctctac agtcagtgta aaggaagagc tgagccctgt
     1021 gctttgcatg gcctctcggg acgtgatggg ggctaaggcc tttcctggca tgttgcccat
     1081 gggtatgtat ggtgcccaca tccctaccat gcccagtgcg ggcatgccac actccctggt
     1141 gcacaacaca ctgcccatgg gtatgagtta ccctctggaa tcttctccta tctcctcctc
     1201 agctcagctc cctccaaaat accagcttgg atctacctca tacttgcccg acaaactgcc
     1261 caaagtggag gtggatagtt ttctggcaga gcttcctgga agcctgtctc tctcctcggc
     1321 tgaacctcag cccgcctcac ctcagccggc ggcagctgca gccctcctgg atgaagcact
     1381 gctcgccaag agtcccgcca acctctccga ggccctctgc gctgctaatg tggacttttc
     1441 ccacttactg ggctttcttc cgctcaacct acccccatgt aacccaccag gggccacagg
     1501 aggcttggtt atgggctact cccaagctga ggcacagcct ttgctcacca ctttgcaggc
     1561 tcagcctcaa gattccgctg gagctggggg acccctgaac tttgggcctc tgcactcctt
     1621 acctcctgtc ttcacctctg gcctgagtac caccaccctg cctcgtttcc accaagcatt
     1681 ccagtagccc ccatgaaggt cccccaactc agttttttgc ttctgccagg gagcctaagt
     1741 acccaccccg tccacctccc ccatgaaggc agctgagctt tcagagctgg gttcaaaaag
     1801 aaaattctag tgtctatatg gagcacttgg tttgggggtt caggctccag gatcaattta
     1861 gagggatcct tgaacccagc cccgtgaaca atctatcata ggactttcag gtatttttac
     1921 ttttattttt tgatctgaac tgggagctat atttagccct ctgcctctcc aaagcatcag
     1981 aaccaccttc agtctggaga aggggaagcc tcttggagac agagggtttc accttatatg
     2041 acctcaagag aaacagccta agaagcccgc cttctggtcc caatctgcag accctccagc
     2101 agttggctgt tgagtccctg ctgtggaagt tctcttgact atcacctgct tccagctacc
     2161 aggcaagaaa gagggcctct gttctcaacc atcccacccc accccaccca cagctcccct
     2221 tcagtcagtg ttgtccagca acggtaccgt ttacacattc acctccgaca cgccatttca
     2281 cctccctcgc cacactgtta gccttagtga ttgcagtgaa cactgtttac acaccgtgaa
     2341 tccattccca ccagtccatt tcagttgcca ccagcctgaa ccactcggta cctggtgtta
     2401 actggagccc tgtttacaag gcggagtcgg gtcttgctga cttctcttca cttgaggtca
     2461 catttttccc ccgtggggaa ataaactgac tttggactgc ttcagtttct gccatcttcc
     2521 atgactgctt ctattcctgc cttccatggc agtgtccaca ggagataggc aagaagattg
     2581 gagcagcttt ctcacaggtc tgcaatttgg attttctcca agtacatcat gacaccttcg
     2641 tcctcctgaa ctggagaggg gaagaaatga aaggcatccc atatcaacca tttcctcagt
     2701 ccctgacccc accctggaca tcatgagcag ttatccgtct tggcaggagg ggttctgggg
     2761 ttcgggctgg atagcagagg agagggatga gccctgcgtt tatttccctt ctgctcgtcc
     2821 ttttccagga cacaatggaa ctgtcggaag aagagtttct agaaagttag gattgggcag
     2881 atagttgagt cctaatctat caaatcattg ttgcctctca taccaaaatg ttcttaccca
     2941 ctgtccttcc cccttctctg ctttgcagtc cccatggact ctgggcatgg tgcactgtcg
     3001 tctttgctct tcattgagga tcttccaccc accatggtcc cctcagttgc acctagtgtc
     3061 tagcaatgtg tcttgcaaga aattcctaat tcttctgctg acttggagct cgctgccaca
     3121 gacagcacag cccttgccca gaagcagctg aacaattcct aacccatttc atctcggttc
     3181 tgtatgggtt tttcccgtgc atggaaggga ggcagctcag ggaccaccat tgtggagcct
     3241 ttgagacctc tctgattcag aaacacactt ctacctcttt actgttaact ccaacagatg
     3301 tagccagcag cctgggcact tgtgttagtg gtgccgtttg ctggcttctc cactagggtt
     3361 tcaggacaga ctacctagga actgcctcaa cctcccacca gttcttccct gcccctccct
     3421 tctgtctaga ttcacttcag tttattgttg ggaactgtgc aggtccaaga cctggactcc
     3481 tgcttcagcc caggccagta ctccttgtct gaggtgaaag ccttcagttt agctccctgg
     3541 cccttgtgtg gaagcaatgt ggagtgaatg agcatatttt gatttaagca aggtagcttg
     3601 gaataccttt tttaaaaaca actggatata aatatgtctg acaggattgg aatcagacta
     3661 tgtgatttgc ttgtaaagat tagtttcagt gagtcccagg gactaattaa ggtttatttt
     3721 taaaagcgtc tgccttggtg cgcaaccacc tcctgcatgc tatgcatgct gttgggactc
     3781 gtattacagg gaatggcatt gagaagccaa gtgggactca ctgctgccat tctccttgtg
     3841 cttggtcttc actagacccc agccccctct acccttctta ccacctccct atagcctcag
     3901 cttcagaagc cagtagcctc cagccacaga gtatcgtgtt gtgggctgtt tgagaagacc
     3961 tgtcctcctg agctgctcct tcccatggtg ctcacaggcc agcagagcac ctcttgtaga
     4021 tcttgttcca cctctaatct ttcctcgttg tctgttctta tgtattcttc agttttccca
     4081 cttctcagtg tcttcactct aaggactttt cctgtcactg tgaactttgc tggttatctg
     4141 ccttcaattt ttggaccaca aaccaccctg cagcttctta aacctttccc caacctacca
     4201 cccaaaagaa ccttttggcc agttgttaaa aggacaggaa tgattttatt ctgtagttgg
     4261 agcccaaact cattaaggta ccctttatga ggccaagaga gccagagggg catgcgccca
     4321 ggacaggagc catggcatgt ggcacagacc aatcagggac cagaaaagaa tgatgtccct
     4381 ttccttgcca tgtccttgag cctgtcagta atgaactggc tgcaagggga cagcacctct
     4441 cagcctgcac agcagcttgt cagagtgaga actgtcctgg ggccagagac taacatgccc
     4501 aggtggtgtc ggctcagagg atcctagcac catcttaagc aggtgggagg cagggaaggg
     4561 tgcaccagcg tgtctttccc tgactttaca tggtgttttg ttaatgcaaa tccgggaagc
     4621 aggtgtgatt gctttttgct cgtagatatt atcctaagtt gaaatcccct aaatctccct
     4681 tagtagcctt taagttcccc cttccctttt tggtagctgt tttctctacc cctcctccat
     4741 aattaaaaaa acaaaaaaca gaaaaacaaa caaaaaaagt tgtattatac aggatcaata
     4801 ttttgctttt taacaaggat atttatgtaa taagaaactt tgccttaggt aggtgttggc
     4861 cagaaaagtc cagatttctc tgtgacctca ccctggcctc tcctggagct ctgaacctgc
     4921 tgtggaagga agtggctgtg actttaacca ctggagagcg gagtctgtgg tgtggagagg
     4981 gtgttcactg tgtaatcttg ggctgtgtgg agttgttctt atcaccttgc ttcagatgtt
     5041 actttggcgt cctccaccag ttctccatgc gcacctctgc atgtccggca ctagaatccc
     5101 tgaacactac ttcacacctc ccccactgcc agttggttga tgctctagag ccactctttc
     5161 ttaatgccag attatttaaa gaaaaataca agacaaaaac cttctagcac tttgtaaaca
     5221 cagtgaataa cctcttggag tatttttggc tttatataaa acaaggtttt taattgtaaa
     5281 atataagtgc cattagaaaa tgcacagggc atatctttgt taaagtagat tttttcaatg
     5341 ttttacagaa ttaattttca aaaaaaagtt tttataatga agttgtttat taaaaacttc
     5401 tgaatga
//
