LOCUS       NM_009538               5235 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus pleiomorphic adenoma gene-like 1 (Plagl1), transcript
            variant 1, mRNA.
ACCESSION   NM_009538
VERSION     NM_009538.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5235)
  AUTHORS   Li,C., Qiao,L., Ge,J., Hu,S., Yang,H., Hu,C. and Li,T.
  TITLE     PLAGL1 overexpression induces cytoplasmic DNA accumulation that
            triggers cGAS/STING activation
  JOURNAL   J Cell Mol Med 28 (19), e70130 (2024)
   PUBMED   39365284
  REMARK    GeneRIF: PLAGL1 overexpression induces cytoplasmic DNA accumulation
            that triggers cGAS/STING activation.
REFERENCE   2  (bases 1 to 5235)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   3  (bases 1 to 5235)
  AUTHORS   Henry,S., Kokity,L. and Pirity,M.K.
  TITLE     Polycomb protein RYBP activates transcription factor Plagl1 during
            in vitro cardiac differentiation of mouse embryonic stem cells
  JOURNAL   Open Biol 13 (2), 220305 (2023)
   PUBMED   36751888
  REMARK    GeneRIF: Polycomb protein RYBP activates transcription factor
            Plagl1 during in vitro cardiac differentiation of mouse embryonic
            stem cells.
REFERENCE   4  (bases 1 to 5235)
  AUTHORS   Riegl,S.D., Starnes,C., Jima,D.D., Baptissart,M., Diehl,A.M.,
            Belcher,S.M. and Cowley,M.
  TITLE     The imprinted gene Zac1 regulates steatosis in developmental
            cadmium-induced nonalcoholic fatty liver disease
  JOURNAL   Toxicol Sci 191 (1), 34-46 (2023)
   PUBMED   36200916
  REMARK    GeneRIF: The imprinted gene Zac1 regulates steatosis in
            developmental cadmium-induced nonalcoholic fatty liver disease.
REFERENCE   5  (bases 1 to 5235)
  AUTHORS   Baptissart,M., Bradish,C.M., Jones,B.S., Walsh,E., Tehrani,J.,
            Marrero-Colon,V., Mehta,S., Jima,D.D., Oh,S.H., Diehl,A.M.,
            Fougeray,T., Guillou,H. and Cowley,M.
  TITLE     Zac1 and the Imprinted Gene Network program juvenile NAFLD in
            response to maternal metabolic syndrome
  JOURNAL   Hepatology 76 (4), 1090-1104 (2022)
   PUBMED   35083765
  REMARK    GeneRIF: Zac1 and the Imprinted Gene Network program juvenile NAFLD
            in response to maternal metabolic syndrome.
REFERENCE   6  (bases 1 to 5235)
  AUTHORS   Varrault,A., Gueydan,C., Delalbre,A., Bellmann,A., Houssami,S.,
            Aknin,C., Severac,D., Chotard,L., Kahli,M., Le Digarcher,A.,
            Pavlidis,P. and Journot,L.
  TITLE     Zac1 regulates an imprinted gene network critically involved in the
            control of embryonic growth
  JOURNAL   Dev Cell 11 (5), 711-722 (2006)
   PUBMED   17084362
  REMARK    GeneRIF: Plagl1/Zac1 gene is imprinted, with preferential
            expression from the paternal allele, and is one of a network of
            imprinted genes involved in the control of embryonic growth.
REFERENCE   7  (bases 1 to 5235)
  AUTHORS   Huang,S.M. and Stallcup,M.R.
  TITLE     Mouse Zac1, a transcriptional coactivator and repressor for nuclear
            receptors
  JOURNAL   Mol Cell Biol 20 (5), 1855-1867 (2000)
   PUBMED   10669760
REFERENCE   8  (bases 1 to 5235)
  AUTHORS   Abdollahi,A., Bao,R. and Hamilton,T.C.
  TITLE     LOT1 is a growth suppressor gene down-regulated by the epidermal
            growth factor receptor ligands and encodes a nuclear zinc-finger
            protein
  JOURNAL   Oncogene 18 (47), 6477-6487 (1999)
   PUBMED   10597250
REFERENCE   9  (bases 1 to 5235)
  AUTHORS   Pagotto,U., Arzberger,T., Ciani,E., Lezoualc'h,F., Pilon,C.,
            Journot,L., Spengler,D. and Stalla,G.K.
  TITLE     Inhibition of Zac1, a new gene differentially expressed in the
            anterior pituitary, increases cell proliferation
  JOURNAL   Endocrinology 140 (2), 987-996 (1999)
   PUBMED   9927333
REFERENCE   10 (bases 1 to 5235)
  AUTHORS   Spengler,D., Villalba,M., Hoffmann,A., Pantaloni,C., Houssami,S.,
            Bockaert,J. and Journot,L.
  TITLE     Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc
            finger protein expressed in the pituitary gland and the brain
  JOURNAL   EMBO J 16 (10), 2814-2825 (1997)
   PUBMED   9184226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065150.1.
            
            On Jun 26, 2018 this sequence version replaced NM_009538.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065150.1, AW106283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17084362
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5235              BC065150.1         45-5279
FEATURES             Location/Qualifiers
     source          1..5235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.72 cM"
     gene            1..5235
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /note="pleiomorphic adenoma gene-like 1"
                     /db_xref="GeneID:22634"
                     /db_xref="MGI:MGI:1100874"
     exon            1..193
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..232
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..264
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..350
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..663
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..2626
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein regulator of apoptosis and cell cycle
                     arrest; zinc finger protein PLAGL1"
                     /codon_start=1
                     /product="zinc finger protein PLAGL1 isoform a"
                     /protein_id="NP_033564.2"
                     /db_xref="CCDS:CCDS48501.1"
                     /db_xref="GeneID:22634"
                     /db_xref="MGI:MGI:1100874"
                     /translation="MAPFRCQKCGKSFVTLEKFTIHNYSHSRERPFKCSKAECGKAFV
                     SKYKLMRHMATHSPQKIHQCTHCEKTFNRKDHLKNHLQTHDPNKISYACDDCGKKYHT
                     MLGYKRHLALHSASNGDLTCGVCTLELGSTEVLLDHLKSHAEEKANQAPREKKYQCDH
                     CDRCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMQENMQA
                     GDYQSNFQLIAPSTSFQIKVDPMPPFQLGAAPENGLDGGLPPEVHGLVLAAPEEAPQP
                     MPPLEPLEPLEPLEPLEPMQSLEPLQPLEPMQPLEPMQPLEPMQPLEPLEPLEPMQPL
                     EPMQPLEPMQPMLPMQPMQPMQPMQPMLPMQPMLPMQPMQPMQPMLPMPEPSFTLHPG
                     VVPTSPPPIILQEHKYNPVPTSYAPFVGMPVKADGKAFCNVGFFEEFPLQEPQAPLKF
                     NPCFEMPMEGFGKVTLSKELLVDAVNIAIPASLEISSLLGFWQLPPPTPQNGFVNSTI
                     PVGPGEPLPHRITCLAQQQPPPLPPPPPLPLPQPLPVPQPLPQPQMQPQFQLQIQPQM
                     QPQMQLQPLQLQLPQLLPQLQPQQQPDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP
                     EEEQEEAEEEAEEGAEEGAEPEAQAEEEEEEEEAEEPQPEEAQIAVSAVNLGQPPLPP
                     TPHIFTAGSNTAILPHFHHAFR"
     exon            664..5216
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5194..5199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /note="hexamer: AATAAA"
     polyA_site      5216
                     /gene="Plagl1"
                     /gene_synonym="2610311E24Rik; Lot1; Zac1"
                     /note="major polyA site"
ORIGIN      
        1 aacctcactc gcctggcagg cgggagaacg ctcggggagt tgcggccgcg ggcaccgggc
       61 tcgcggctat cgggactgga gagcaagcgg gcatctcctg ggcgccgtca tggctgctta
      121 ggctgcgcct gcctgcggat cgcggatccg ggatcggaga tctgacggcg acgcctgagt
      181 ccggctaggg taggttgttc ctgcttgatt gcttcagcgt gccatcggct tcgtatttgc
      241 ataggagtca gaggagttaa tcttgtctct tctcacaggt ttgagtcttc agacttctac
      301 agaactccat aatatctgcc tcacagctgg ctttcctgct ctcacagaag atacccagct
      361 attgtgctct ggatctctcc tggctgctag gctgtagcgc tgcctttctg gagtcaggct
      421 gtagtgactc cccaccttct ttctgtctgg gcttaaatgg cacagcagtt cctcagcaca
      481 tctgaagaag aaagtgtgag aaccaaaggc catggctcca ttccgctgtc aaaaatgtgg
      541 caagtccttc gtcaccctgg agaagttcac cattcacaat tattcccact ccagggagcg
      601 cccattcaag tgctcgaagg ctgagtgtgg caaagccttc gtctccaagt ataagctgat
      661 gagacacatg gccacacact cgccacagaa gattcaccag tgtactcact gtgagaagac
      721 attcaaccgg aaggaccacc tgaagaacca cctccagacc cacgatccca acaagatctc
      781 ctacgcgtgt gacgattgcg gcaagaagta ccacaccatg ctgggctaca agaggcacct
      841 ggccctgcac tcggcgagca atggcgatct cacctgtggg gtgtgcaccc tggagctggg
      901 gagcaccgag gtcctgctgg accacctcaa gtctcacgcg gaagaaaagg ccaaccaggc
      961 acccagggag aagaaatacc agtgcgacca ctgtgataga tgcttctaca cccggaaaga
     1021 tgtgcgtcgc cacctggtgg tccacacagg atgcaaggac ttcctgtgtc agttctgtgc
     1081 ccagagattt gggcgcaaag accacctcac tcgtcacacc aagaagaccc actcccagga
     1141 gctgatgcaa gagaatatgc aggcaggaga ttaccagagc aatttccaac tcattgcgcc
     1201 ttcaacttcg ttccagataa aggttgatcc catgcctcct ttccagctag gagcggctcc
     1261 cgagaacggg cttgatggtg gcttgccacc cgaggttcat ggtctagtgc ttgctgcccc
     1321 agaagaagct ccccaaccca tgccgccctt ggagcctttg gagcctttgg agcctttgga
     1381 gcctttggag ccgatgcagt ctttggagcc tttgcagcct ttggagccga tgcagccttt
     1441 ggagccaatg cagcctttgg agccgatgca gcctttagag cctttggagc ctctggagcc
     1501 gatgcagcct ttggagccga tgcagccttt ggagcctatg cagccaatgc tgccaatgca
     1561 gccaatgcag ccaatgcagc caatgcagcc aatgctgcca atgcagccaa tgctgccaat
     1621 gcagccaatg cagccaatgc agccaatgct gccaatgcca gagccgtctt tcactctgca
     1681 ccctggcgta gttcccacct ctcctccccc aattattctt caggagcata agtataatcc
     1741 tgttcctacc tcatatgccc catttgtagg catgcccgtc aaagcagatg gcaaggcctt
     1801 ttgcaacgtg ggtttctttg aggaatttcc tctgcaagag cctcaggcgc ctctcaagtt
     1861 caacccatgt tttgagatgc ctatggaggg gtttgggaaa gtcaccctgt ccaaagagct
     1921 gctggtagat gctgtgaata tagccattcc tgcctctctg gagatttcct ccctattggg
     1981 gttttggcag ctcccccctc ctactcccca gaatggcttt gtgaatagca ccatccctgt
     2041 ggggcctggg gagccactgc cccataggat aacctgtctg gcgcagcagc agccaccgcc
     2101 actgccgccg ccaccaccgc tgccactgcc acagccactg ccagtgccac agccactacc
     2161 acagccacag atgcagccac agtttcagtt gcagatccag ccccagatgc agccccagat
     2221 gcagctgcag ccactgcagc tgcagctacc acagctgctg ccgcaactgc aacctcagca
     2281 gcagcctgat cctgagccag agccagagcc agagccagag ccagagccag agccagagcc
     2341 ggaaccggaa ccggagccag agccagagcc agaaccagag ccagaggaag aacaggaaga
     2401 ggcagaagaa gaggcagagg aaggagcaga ggaaggagca gaaccagagg cacaggcaga
     2461 agaagaggaa gaggaagagg aagcggaaga gccacagcca gaagaagccc aaatagcagt
     2521 gagtgctgtg aatctgggcc agccccccct acccccaact ccccatattt tcacagctgg
     2581 ctccaacact gctatcctgc cccatttcca tcacgcattt agataaattg gtttttaaga
     2641 gggtgcttct cttgtgggag atgttttaaa catcagttac agtttgagga gaagcattgg
     2701 aaaacaggaa tggggtttta gcttatttgt cataagtagc ttgagaaaaa gaattctcta
     2761 actgcatgcg ttgtgccaat atataccctt agtattcatg cttcctacca aatttagtga
     2821 gcgtgtgtgc attctgtaat caaactgcaa atattatcat attatcctat tattaccctt
     2881 gtattattac cctcatatta ttaccctcat attatcctca ttatcttata atcacgtgat
     2941 tacgtgataa gatccaaaac atgagctgct attttgtaaa tatcgtgttg agtgtaagct
     3001 gttgtagtga tgttagctat gtaactgtgt gtagcctagg aaggggatga tggtaaagtt
     3061 tggaattctc caacttggaa ggtgttttta agagaagggg ataatctttg tatggcgttt
     3121 ataactaggc tgtgtgtttc ttttcaggga ctcgtctata agaaatggac agtttagttc
     3181 ctcttcttgt tagcttactc tgtagtttct tcttcttgtt gcccattgtg tagctttata
     3241 gagtgtgacg ctattgatgt ctccattttt taaagtgaat ttaaatgtac tgttcaatat
     3301 ttttcatgtg atgttgttcc aatgtgagtt acgacttcat ttatcttaaa gacaaaactg
     3361 gttgtcagtc atatctgaca gaagaaagaa atcactgtgt aaccaagtca agtggccaac
     3421 taattgaaag aagaatcaat caaaagtgtt ttgtggactg tgatactcat tatgtttttt
     3481 aacaggaatt taagaaaatg tactggaatt taaaaaaagc ataagtatat tagataagaa
     3541 ttttctttgc ctagcttaac ctactactta agctgcttaa gttctgaagt attgtttgta
     3601 atcaccaata gaaaagtgta tctgtagatg atcaatttaa gtcattgtta gtttgtatcc
     3661 caagaggatt gtgttttgca atgtaaccgt acttgtaatc tcccttgata ccttgttaat
     3721 cgattttgaa agtgtaaaac ctaacctttg aagactctgt atttccttct tgagactgta
     3781 tcccccagca tatatctcct aacctttgaa gactctgtat ttcatttttg agactgtatt
     3841 ccccaggatt tatctcctaa cctttgtaga ctctgtattt cgtttttgag actgtctttc
     3901 ccagcatata tctcctgacc tttgacaact ctgtatttcg tttttgagac tgtattcccc
     3961 agcatatatc tcctgacctt tgaagaccct gcattttgtt tttgagatgg aattcaacag
     4021 catatatctc ctaatctttg atgactctgt attttgtttt tgagattgta ttccccagca
     4081 tatatctcct aacctttgaa gactctgtat ttcatttttg agactgtatt ccccaacgtg
     4141 tatctcctaa cctttgaata atctccactt tgtttttgag actgtattcc ccagcatata
     4201 tctcctaacc tttgatgact ctgtactttg tttttgagag tgtattcccc agcatatatc
     4261 tcctaacctt tgatgactct gtactttgtt tttgagactg tattccccag catatatctc
     4321 ctaacctttg atgactatgt actttgtttt tgagactgta ttccccagca tatatctcct
     4381 aacctttgat gactctgtac tttgtttttg agagtgtatt ccccagcata tatctcctaa
     4441 cctttgatga ctctgtactt tgtttttgag actgtattcc ccagcatata tctcctaacc
     4501 tttgaagaat ctccattttg tttttgagac tgtatttccc agcatatatc tcctaacctt
     4561 tgatgactct gtactttgtt tttgagactg tattccccag catatatctc ctgacctttg
     4621 aagacactgc atttgttttt gggactgtat tccccagcac atatctcccg acttttgaag
     4681 acactgcatt tttttgagac tatattcccc agcatatatc tcctaacctt tgaagactcc
     4741 atatttcgtt tttgagactg tattccccag cacatatctc ctaacctttg aagaatctcc
     4801 attttctttt tgagactgta ttcctcagca tatatctcct aacctttgac gactctgtat
     4861 ttcatttttg agactgtatt ccccagcata tatcttctaa cctttgaaga cactacattt
     4921 tgtttttgag actgtattcc ctagcatata tctcctaacc tttgaagact ccatatttcg
     4981 tttttgagac tgtattgccc agtatatatc tcctaacctt tgatgactct gtatttcgtt
     5041 tttgagactg tattccccag catatatctc ctaacctttg aagactccat atttcgtttt
     5101 tgagactgta ttccccagaa tttatctcct atccttttta gactctgtat ttcgtttttg
     5161 agactgtatt ccctggcata tatacctaca tataataaat gctaagcatc tggcaaaaaa
     5221 aaaaaaaaaa aaaaa
//
