LOCUS       NM_019969               4635 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus pleiomorphic adenoma gene 1 (Plag1), mRNA.
ACCESSION   NM_019969
VERSION     NM_019969.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4635)
  AUTHORS   Gasperoni,J.G., Tran,S.C., Grommen,S.V.H., De Groef,B. and
            Dworkin,S.
  TITLE     The Role of PLAG1 in Mouse Brain Development and Neurogenesis
  JOURNAL   Mol Neurobiol 61 (8), 5851-5867 (2024)
   PUBMED   38240991
  REMARK    GeneRIF: The Role of PLAG1 in Mouse Brain Development and
            Neurogenesis.
REFERENCE   2  (bases 1 to 4635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4635)
  AUTHORS   Tran,S.C., Jaehne,E.J., Dye,L.E., Wong,J., Bakas,J.S.,
            Gasperoni,J.G., Hale,M.W., van den Buuse,M., Dworkin,S.,
            Grommen,S.V.H. and De Groef,B.
  TITLE     Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected
            Behaviours in Adult Mice
  JOURNAL   Neuroscience 455, 30-38 (2021)
   PUBMED   33346119
  REMARK    GeneRIF: Effect of Pleomorphic Adenoma Gene 1 Deficiency on
            Selected Behaviours in Adult Mice.
REFERENCE   4  (bases 1 to 4635)
  AUTHORS   Wong,J., Damdimopoulos,A., Damdimopoulou,P., Gasperoni,J.G.,
            Tran,S.C., Grommen,S.V.H., De Groef,B. and Dworkin,S.
  TITLE     Transcriptome analysis of the epididymis from Plag1 deficient mice
            suggests dysregulation of sperm maturation and extracellular matrix
            genes
  JOURNAL   Dev Dyn 249 (12), 1500-1513 (2020)
   PUBMED   32959928
  REMARK    GeneRIF: Transcriptome analysis of the epididymis from Plag1
            deficient mice suggests dysregulation of sperm maturation and
            extracellular matrix genes.
REFERENCE   5  (bases 1 to 4635)
  AUTHORS   Wong,J., Juma,A.R., Tran,S.C., Gasperoni,J.G., Grommen,S.V.H. and
            De Groef,B.
  TITLE     Deficiency of the transcription factor PLAG1 results in aberrant
            coiling and morphology of the epididymis
  JOURNAL   Asian J Androl 22 (4), 342-347 (2020)
   PUBMED   31464202
  REMARK    GeneRIF: Deficiency of the transcription factor PLAG1 results in
            aberrant coiling and morphology of the epididymis.
REFERENCE   6  (bases 1 to 4635)
  AUTHORS   Alam,S., Zinyk,D., Ma,L. and Schuurmans,C.
  TITLE     Members of the Plag gene family are expressed in complementary and
            overlapping regions in the developing murine nervous system
  JOURNAL   Dev Dyn 234 (3), 772-782 (2005)
   PUBMED   16193498
REFERENCE   7  (bases 1 to 4635)
  AUTHORS   Landrette,S.F., Kuo,Y.H., Hensen,K., Barjesteh van Waalwijk van
            Doorn-Khosrovani,S., Perrat,P.N., Van de Ven,W.J., Delwel,R. and
            Castilla,L.H.
  TITLE     Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia
            in cooperation with Cbfb-MYH11
  JOURNAL   Blood 105 (7), 2900-2907 (2005)
   PUBMED   15585652
REFERENCE   8  (bases 1 to 4635)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
  REMARK    GeneRIF: Plag1 disruption in mouse differentially affects pre- and
            postnatal growth and development of organs, with reproductive
            repercussions
REFERENCE   9  (bases 1 to 4635)
  AUTHORS   Gaikwad,J.S., Cavender,A. and D'Souza,R.N.
  TITLE     Identification of tooth-specific downstream targets of Runx2
  JOURNAL   Gene 279 (1), 91-97 (2001)
   PUBMED   11722849
REFERENCE   10 (bases 1 to 4635)
  AUTHORS   Kas,K., Voz,M.L., Roijer,E., Astrom,A.K., Meyen,E., Stenman,G. and
            Van de Ven,W.J.
  TITLE     Promoter swapping between the genes for a novel zinc finger protein
            and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12)
            translocations
  JOURNAL   Nat Genet 15 (2), 170-174 (1997)
   PUBMED   9020842
  REMARK    Erratum:[Nat Genet 1997 Apr;15(4):411]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ178210.1, BC139283.1 and AL807387.10.
            
            On Apr 22, 2009 this sequence version replaced NM_019969.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY574219.1, BC139285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                CJ178210.1         2-51
            51-588              BC139283.1         1-538
            589-589             AL807387.10        75958-75958         c
            590-2154            BC139283.1         540-2104
            2155-4635           AL807387.10        71413-73893         c
FEATURES             Location/Qualifiers
     source          1..4635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 2.18 cM"
     gene            1..4635
                     /gene="Plag1"
                     /note="pleiomorphic adenoma gene 1"
                     /db_xref="GeneID:56711"
                     /db_xref="MGI:MGI:1891916"
     exon            1..192
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..297
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..389
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..486
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..845
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             604..2103
                     /gene="Plag1"
                     /note="C2H2 zinc finger protein PLAG1; pleiomorphic
                     adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1"
                     /protein_id="NP_064353.2"
                     /db_xref="CCDS:CCDS17941.1"
                     /db_xref="GeneID:56711"
                     /db_xref="MGI:MGI:1891916"
                     /translation="MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFN
                     SVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQNFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLGMTCPIDMDAVHPSHHLAFKC
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSPASSSKLGLEPQSGSPDD
                     GAGDLSLSKSSISISDPLSTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQEEAHS
                     SVSQLPTQTQDLQDPANTVGLSSLHSLSAAFTSSLSSSTTLPRFHQAFQ"
     exon            846..4635
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4375..4380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plag1"
                     /note="hexamer: AATAAA"
     polyA_site      4397
                     /gene="Plag1"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcagctgcaa gttgagctgc aggggcagcg catacactac aatggctgct
       61 ggaaagaggc gtaaggaaac aatttccagg cccgccgcgt ccagcccgaa atatgagaaa
      121 aaaattatta gaaattccgc gggcggtgta aaggcggcgg acgggccgga gggaggatgt
      181 taaagctccg cggttgcctg tcagtgctgc ctgggtggta ttgggcaccc agaatgcttc
      241 agtctgtgat gatctattaa taaggtggcc ttactagagt ttggaacagg gcttcagtta
      301 ctttactgtc atttatggga aacagcagtg aataaaactg gcctgagcct gccctgagct
      361 gcctacagtt gactgcttat tctctgaaga ttggccaaaa tgggaaggac tggattctgc
      421 tctctcccac gaagagttag tggactggct aagatcaaag tctgaggctt ctccatcacc
      481 aatcagtccc tttttgcttt cttttacgac cacatgaaac ttgagaagcc acctaaagct
      541 atatcactta gtggagttgg gcagttccca ggtgtccaac aagaaggcct ggtttaggct
      601 gcgatggcca ctgtcattcc tggtgatttg tcagaagtaa gagataccca gaaagcccct
      661 tcagggaaac gtaagcgtgg tgaaagcaaa ccaagaaaaa actttccttg ccaactgtgt
      721 gacaaggcct ttaacagtgt tgagaaatta aaggttcact ccttctctca cacgggagag
      781 aggccctaca agtgcacaca ccaagactgc accaaggcct ttgtttctaa gtacaaatta
      841 caaaggcaca tggctactca ctctcctgag aaaacccaca agtgtaatta ctgtgagaaa
      901 atgtttcacc ggaaagacca tctgaagaat cacctccata cacatgaccc caacaaagag
      961 acctttaaat gcgaagagtg tggcaagagc tacaatacca agcttggttt taagcgacac
     1021 ttggccttgc atgctgccac cagtggtgac ctcacctgca aggtgtgttt gcagaatttt
     1081 gagagcacag gtgtgctcct agagcacctg aaatctcacg cgggcaagtc atctgggggt
     1141 gtgaaggaga aaaagcacca atgtgagcac tgcgaacgca ggttctacac ccggaaggat
     1201 gtccggagac acatggtggt acacacagga agaaaggact tcctctgtca gtactgcgca
     1261 cagagatttg gacgaaagga tcacctcact cgacacatga agaagagtca caatcaggag
     1321 cttctgaagg tcaaaacgga accagtagat ttcctggacc catttacctg caacatgtct
     1381 gtgcctataa aagatgaact cctgccggtc atgtccttac cttccagtga actcttgtca
     1441 aagccattca caaacacttt gcagttaaac ctctataaca ctccatttca gtccatgcag
     1501 agctctgggt ctgctcacca aatgataaca actttacctt tgggaatgac atgccccata
     1561 gatatggatg ctgttcaccc ctctcatcat cttgctttca aatgcccatt cagttctacc
     1621 tcatacgcaa tctctattcc tgaaaaagaa cagccattaa agggggaaat tgagagttac
     1681 ctgatggagc tacaaggtgg tgcaccatct tcatcccagg attctccagc atcgtcatct
     1741 aagctagggt tagagcctca gagtgggtcg ccagatgatg gtgctgggga cctctccctg
     1801 tcaaagagct ctatctctat cagtgacccc ctcagcacac cagcattgga tttctctcag
     1861 ttgttcaatt tcataccatt gaatggtccc ccttataacc cactttcagt gggaagcctt
     1921 gggatgagct attcccagga ggaagcacac tcttctgtct ctcagctgcc cacacaaaca
     1981 caggatcttc aggaccctgc aaacactgtg ggtctaagtt ctctgcactc actgtcggca
     2041 gcgttcacca gcagcctgag ctcaagcact accttgcccc gtttccacca ggcgtttcag
     2101 tagagtctgg gccgagggac tcacccgagg tgcttgtgta gccctgcctg caatgaccat
     2161 ttatattcta gtgcctactt ttaacataat acaaaaactt ctgcttttgt ataatatcag
     2221 gttttatgaa gccagtaaat aataggaact agcctcttcg ataagctttg aaatcgttcg
     2281 tgtttaacta cgtttgctat ttctcctgat ttcctgccag ttgtcatagt ctcagagttt
     2341 aatttcatat aggagcgcca ttattatcac taaattttac aagtcctatg ttcaaattac
     2401 tgttagatct taaatttttc atttttgtct aatagcaatg ggcattggac tttttttttt
     2461 tttgcaaata ttcagtacag tgtaaatctt atgaagtgtg ttgtgtgaat aactgaagtg
     2521 tttcacattt ttttactagc cactaaatgg attcataatt aagtgtgttt taaatgagtt
     2581 aagaatccag tttggggaga gtatagtggt ttcttaaata taccatcatt tcagatcaat
     2641 atattttgag gactgctatt gtctggctaa aatattttaa gtttcagtat ctatctaaaa
     2701 gaaacctaga gaggtagcag ggtgttgtgt gttagtacta gccctcaggc tggtttgccg
     2761 catttcaatc atctttccat aaacagtgtg tggcatcgaa gtcatcagga tcagtgtaga
     2821 aaggttttgt tatatgcctg tcacctttca taccccagga tggcttcagt ataccagcgt
     2881 tctcattttg catggtggac cacagttatt ccagagtctt agagccattg tgggacaata
     2941 gacagtaaat atgtgaaacc tacaatggct gggctgcctc aatcgtcggg gtgatagact
     3001 cctcaacagg aagatggatg taaaacagcc aaaccccaga acttgtccag agaattccac
     3061 tgttgccaga gctgaaaact gaactccttg ggtgcagagt aaaagcctat cacatcactt
     3121 ctaaagcagt cttgcccggt gagctcttgc tcagtgcgta tccatcttgc cctgctgttt
     3181 ttggatggag aacttaacaa ttagacccat cagaaagcaa cttgaggagt tctacagttt
     3241 tacacaacca gaagttgtaa gaccctactt ttactctggg aatcaggagg aatgttagaa
     3301 acaagttgaa tctatagtgg aaacagagga aaataaagca aacaccaaac gcatatgagt
     3361 gcacctagga tgtggaatgc actgagtgag gtagcgatgg acttcctctt gtcagacagc
     3421 caccaggaat gcgatcgatg gttccatgta tatcttccta agggttattt gtggcatcaa
     3481 cttatgaaat gtatctatta agcacttgtt aacaccttat tttgggaccc cttctgttgg
     3541 ggcaggggtg aagggaggtt tatagaaggc tatgtatctc ttttttaaaa gaaagaagaa
     3601 gaagaaacta tattttaatt tctgagcact cattagccct gtatggggaa actctttccc
     3661 ttctgtaagg gccagttatc actgcatatt gcattgttta cccatcatcc taaatgtaat
     3721 tacagattac tgacgataat gcattattta caatgcctgg gaatagtcta aattgaggag
     3781 aagtgtaaac tgtcatttga atggggcttt cactctatgt catacacaca cctagtgcac
     3841 ttcgtagaat cagagttgct ctctagaggg ttcaagctcc tggttctaac cctagagcag
     3901 tagtttttat acttatgtat ttaaatttta ttgtgaaaaa tacattttat taaaaagttt
     3961 tccaaaggca ttaaaattat atatgttaat aaggaaatac atgtttaact cttcaagctg
     4021 ctcctaagct atgagtggga gtgcactcac tctgaaagtg ggctcttagc tctgcttcat
     4081 gaccgcttcc ttagtttcta tgaaacagat cacttaccta atgttctagt tggatggtta
     4141 gtgttcaata ttgctttaat caccacttaa aaaggagggg acatttggtg acagagcaca
     4201 agtaaataaa aaaacctatt tttatgtaga gttcacaagc accacatatg aaagcactag
     4261 tttattctat ctaaaatttg cttaagaagt cacattaatg acctgagacg ttggccttca
     4321 taggctgtat gtatttcact gctaattgaa aaaagggagt accaggatat atgaaataaa
     4381 gcattttgaa atgggaatgg cgccatatat gtgtgtgtgt atatatatat atatatatat
     4441 atacacatat atatgtgtat gtatatgtat atatatgtgt gtatatgtgt gtgtgtatat
     4501 atatatatat aacaaatata tttttatcct aactcttacc ctgcacggaa ctctagtaca
     4561 catcttccag ggaaccagtg ttaaaatgta gagtcttaat tttcttgtat gtacacctct
     4621 ttgcctgttg ctgcc
//
