LOCUS       NM_019538               1089 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus placental specific protein 1 (Plac1), transcript
            variant 1, mRNA.
ACCESSION   NM_019538
VERSION     NM_019538.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1089)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 1089)
  AUTHORS   Rahdan,S., Razavi,S.A., Shojaeian,S., Shokri,F., Amiri,M.M. and
            Zarnani,A.H.
  TITLE     Immunization with placenta-specific 1 (plac1) induces potent
            anti-tumor responses and prolongs survival in a mouse model of
            melanoma
  JOURNAL   Adv Med Sci 67 (2), 338-345 (2022)
   PUBMED   36084365
  REMARK    GeneRIF: Immunization with placenta-specific 1 (plac1) induces
            potent anti-tumor responses and prolongs survival in a mouse model
            of melanoma.
REFERENCE   3  (bases 1 to 1089)
  AUTHORS   George,M.R., Duan,Q., Nagle,A., Kathiriya,I.S., Huang,Y., Rao,K.,
            Haldar,S.M. and Bruneau,B.G.
  TITLE     Minimal in vivo requirements for developmentally regulated cardiac
            long intergenic non-coding RNAs
  JOURNAL   Development 146 (23) (2019)
   PUBMED   31784461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1089)
  AUTHORS   Shi,L.Y., Ma,Y., Zhu,G.Y., Liu,J.W., Zhou,C.X., Chen,L.J., Wang,Y.,
            Li,R.C., Yang,Z.X. and Zhang,D.
  TITLE     Placenta-specific 1 regulates oocyte meiosis and fertilization
            through furin
  JOURNAL   FASEB J 32 (10), 5483-5494 (2018)
   PUBMED   29723063
  REMARK    GeneRIF: Upon meiosis onset, active furin/IGF-1 receptor relocates
            into the cytoplasm to activate (phosphorylate) Akt to promote
            meiosis. In summary, our finding suggests that Plac1, a protein
            that is crucial for placentation, is also essential for oocyte
            meiosis and fertilization.
REFERENCE   5  (bases 1 to 1089)
  AUTHORS   Yuan,H., Wang,X., Shi,C., Jin,L., Hu,J., Zhang,A., Li,J.,
            Vijayendra,N., Doodala,V., Weiss,S., Tang,Y., Weiner,L.M. and
            Glazer,R.I.
  TITLE     Plac1 Is a Key Regulator of the Inflammatory Response and Immune
            Tolerance In Mammary Tumorigenesis
  JOURNAL   Sci Rep 8 (1), 5717 (2018)
   PUBMED   29632317
  REMARK    GeneRIF: Results provide evidence that Plac1 modulates a
            tolerogenic tumor microenvironment in part by modulating the
            chemokine axis in mammary tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1089)
  AUTHORS   Yan,C., Pendola,F.L., Jacob,R., Lau,A.L., Eppig,J.J. and
            Matzuk,M.M.
  TITLE     Oosp1 encodes a novel mouse oocyte-secreted protein
  JOURNAL   Genesis 31 (3), 105-110 (2001)
   PUBMED   11747200
REFERENCE   7  (bases 1 to 1089)
  AUTHORS   Elliott,R.W., Miller,D.R., Pearsall,R.S., Hohman,C., Zhang,Y.,
            Poslinski,D., Tabaczynski,D.A. and Chapman,V.M.
  TITLE     Genetic analysis of testis weight and fertility in an interspecies
            hybrid congenic strain for Chromosome X
  JOURNAL   Mamm Genome 12 (1), 45-51 (2001)
   PUBMED   11178743
REFERENCE   8  (bases 1 to 1089)
  AUTHORS   Cocchia,M., Huber,R., Pantano,S., Chen,E.Y., Ma,P., Forabosco,A.,
            Ko,M.S. and Schlessinger,D.
  TITLE     PLAC1, an Xq26 gene with placenta-specific expression
  JOURNAL   Genomics 68 (3), 305-312 (2000)
   PUBMED   10995572
REFERENCE   9  (bases 1 to 1089)
  AUTHORS   Hemberger,M., Himmelbauer,H., Ruschmann,J., Zeitz,C. and Fundele,R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   10 (bases 1 to 1089)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005501.1 and BC051666.1.
            
            On Nov 10, 2017 this sequence version replaced NM_019538.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF250838.1, AK005501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1070              AK005501.1         2-1071
            1071-1089           BC051666.1         1057-1075
FEATURES             Location/Qualifiers
     source          1..1089
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 29.31 cM"
     gene            1..1089
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /note="placental specific protein 1"
                     /db_xref="GeneID:56096"
                     /db_xref="MGI:MGI:1926287"
     exon            1..111
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            112..183
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            184..1076
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..762
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /note="placenta-specific protein 1; ectoplacental cone,
                     invasive trophoblast giant cells, extraembryonic ectoderm
                     and chorion sequence 26"
                     /codon_start=1
                     /product="placenta-specific protein 1 precursor"
                     /protein_id="NP_062411.1"
                     /db_xref="CCDS:CCDS30128.1"
                     /db_xref="GeneID:56096"
                     /db_xref="MGI:MGI:1926287"
                     /translation="MNLRKFLGGTVLVAFMLFSYSEQNQVNVLCSTDWFMVTVHPFLL
                     NNDVYVHFYEVHLGLGCPPNHVHPHFYQFHYRVTECGIRIKAVSPDVVIYSSEIHYAS
                     KGSSTKYVIPVSCAAPRRSPWLTKPYSAKAPSNNMGATPKNDTSYHVFTLPEPSEQPN
                     CSCPPYVYNQKSM"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /note="hexamer: AATAAA"
     polyA_site      1076
                     /gene="Plac1"
                     /gene_synonym="DXWsu72e; Epcs26; Oosp2l"
                     /note="major polyA site"
ORIGIN      
        1 gaagattgaa ggctaaggga cctgcctcat cttctcgcta ccccttccct cgtgctccac
       61 acggagagaa cagaactaac agaattctca gcccaagatt tcttttttta actgccttca
      121 gcagtgagca caaagccacg tttcaaagga gactgacaaa ttatccccag ctgccagaag
      181 gagaatcctt cctggacgcc ttcttgtctc ctgtgagtct tcacctaacc tgctgcaaga
      241 atgaaccttc gcaagttcct gggaggcact gtcttagtcg ccttcatgct cttcagctac
      301 tcggagcaaa accaagtgaa tgtgctgtgc tcgacagatt ggttcatggt caccgttcac
      361 cccttcttgc tgaataatga tgtgtatgtt catttttacg aggtgcacct gggccttggt
      421 tgccctccca atcatgttca cccacatttc taccagtttc actaccgcgt taccgaatgt
      481 ggcatccgca tcaaggctgt ctctccagat gtcgtcatct atagctctga gattcactat
      541 gcttccaagg gctcatcaac gaaatatgtg attcccgtgt cctgtgctgc ccctcgccgg
      601 tccccttggc tcactaagcc ctactccgcg aaagcaccta gcaacaacat gggtgcgact
      661 ccgaagaatg atacttccta ccacgtgttc accttgccag agcctagcga acaacccaac
      721 tgcagctgcc caccttatgt ctacaatcaa aagagcatgt aaaccctcca tcatgggaca
      781 gagtctttgg aggtccttct tgtgtagtca tctgactgtg caaatgtttc tggggactag
      841 tgtgttcact cagatgatct gaggaaaccc atatagtgcc cagatgtaag ggcttctgaa
      901 aattctgttt ctaaaaatga atatatagca ttttctactg tcagccaaat agatgccatg
      961 atagctcttt taggggaatt ttggaaaggg tcaattcata tatagctgat tgtaactttt
     1021 ttttttacta tttttgtatc ttttaaaaca ataataaaat tctgattggc aataaaaaaa
     1081 aaaaaaaaa
//
