LOCUS       NM_139269               3523 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus phospholipase A and acyltransferase 3 (Plaat3),
            transcript variant 1, mRNA.
ACCESSION   NM_139269
VERSION     NM_139269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3523)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3523)
  AUTHORS   Schuermans,N., El Chehadeh,S., Hemelsoet,D., Gautheron,J.,
            Vantyghem,M.C., Nouioua,S., Tazir,M., Vigouroux,C., Auclair,M.,
            Bogaert,E., Dufour,S., Okawa,F., Hilbert,P., Van Doninck,N.,
            Taquet,M.C., Rosseel,T., De Clercq,G., Debackere,E., Van
            Haverbeke,C., Cherif,F.R., Urtizberea,J.A., Chanson,J.B.,
            Funalot,B., Authier,F.J., Kaya,S., Terryn,W., Callens,S.,
            Depypere,B., Van Dorpe,J., Poppe,B., Impens,F., Mizushima,N.,
            Depienne,C., Jeru,I. and Dermaut,B.
  CONSRTM   Program for Undiagnosed Diseases (UD-PrOZA)
  TITLE     Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and
            neurological syndrome due to impaired PPARgamma signaling
  JOURNAL   Nat Genet 55 (11), 1929-1940 (2023)
   PUBMED   37919452
REFERENCE   3  (bases 1 to 3523)
  AUTHORS   Rahman,S.M.K., Sasaki,S., Uyama,T., Hussain,Z., Sikder,M.M.,
            Saiga,H., Ohmura-Hoshino,M., Ohta,K.I., Miki,Y., Hoshino,K.,
            Ueno,M., Murakami,M. and Ueda,N.
  TITLE     PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid
            accumulation in mice
  JOURNAL   FASEB J 37 (7), e23032 (2023)
   PUBMED   37330992
REFERENCE   4  (bases 1 to 3523)
  AUTHORS   Morishita,H., Eguchi,T., Tsukamoto,S., Sakamaki,Y., Takahashi,S.,
            Saito,C., Koyama-Honda,I. and Mizushima,N.
  TITLE     Organelle degradation in the lens by PLAAT phospholipases
  JOURNAL   Nature 592 (7855), 634-638 (2021)
   PUBMED   33854238
  REMARK    GeneRIF: Organelle degradation in the lens by PLAAT phospholipases.
REFERENCE   5  (bases 1 to 3523)
  AUTHORS   Parmer,C., De Sousa-Coelho,A.L., Cheng,H.S., Daher,G., Burkart,A.,
            Dreyfuss,J.M., Pan,H., Prenner,J.C., Keilson,J.M., Pande,R.,
            Henkin,S., Feinberg,M.W., Patti,M.E. and Creager,M.A.
  TITLE     Skeletal muscle expression of adipose-specific phospholipase in
            peripheral artery disease
  JOURNAL   Vasc Med 25 (5), 401-410 (2020)
   PUBMED   32853041
  REMARK    GeneRIF: Skeletal muscle expression of adipose-specific
            phospholipase in peripheral artery disease.
REFERENCE   6  (bases 1 to 3523)
  AUTHORS   Hummasti,S., Hong,C., Bensinger,S.J. and Tontonoz,P.
  TITLE     HRASLS3 is a PPARgamma-selective target gene that promotes
            adipocyte differentiation
  JOURNAL   J Lipid Res 49 (12), 2535-2544 (2008)
   PUBMED   18664718
  REMARK    GeneRIF: HRASLS3 as one of the downstream effectors of PPARgamma
            action in adipogenesis.
REFERENCE   7  (bases 1 to 3523)
  AUTHORS   Duncan,R.E., Sarkadi-Nagy,E., Jaworski,K., Ahmadian,M. and Sul,H.S.
  TITLE     Identification and functional characterization of adipose-specific
            phospholipase A2 (AdPLA)
  JOURNAL   J Biol Chem 283 (37), 25428-25436 (2008)
   PUBMED   18614531
  REMARK    GeneRIF: study found that AdPLA that was previously known as
            H-Rev-107/HRASLS3 is an adipose-specific, calcium-dependent
            histidine PLA2
REFERENCE   8  (bases 1 to 3523)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   9  (bases 1 to 3523)
  AUTHORS   Roder,K., Latasa,M.J. and Sul,H.S.
  TITLE     Silencing of the mouse H-rev107 gene encoding a class II tumor
            suppressor by CpG methylation
  JOURNAL   J Biol Chem 277 (34), 30543-30550 (2002)
   PUBMED   12055182
REFERENCE   10 (bases 1 to 3523)
  AUTHORS   Roder,K., Latasa,M.J. and Sul,H.S.
  TITLE     Murine H-rev107 gene encoding a class II tumor suppressor: gene
            organization and identification of an Sp1/Sp3-binding GC-box
            required for its transcription
  JOURNAL   Biochem Biophys Res Commun 293 (2), 793-799 (2002)
   PUBMED   12054540
  REMARK    GeneRIF: identification of an Sp1/Sp3-binding GC-box required for
            the transcription of H-rev107 (H-rev107)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163505.1 and AK038809.1.
            
            On Jan 11, 2006 this sequence version replaced NM_139269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163505.1, SRR1660819.60819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1872              AK163505.1         2-1873
            1873-2896           AK038809.1         280-1303
            2897-3523           AK163505.1         2899-3525
FEATURES             Location/Qualifiers
     source          1..3523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.33 cM"
     gene            1..3523
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /note="phospholipase A and acyltransferase 3"
                     /db_xref="GeneID:225845"
                     /db_xref="MGI:MGI:2179715"
     exon            1..106
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /inference="alignment:Splign:2.1.0"
     exon            107..170
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /inference="alignment:Splign:2.1.0"
     exon            171..273
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /inference="alignment:Splign:2.1.0"
     exon            274..542
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /inference="alignment:Splign:2.1.0"
     exon            543..3523
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      748..753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /note="hexamer: AATAAA"
     polyA_site      767
                     /gene="Plaat3"
                     /gene_synonym="AdPLA; Hrasls3; Hrev107; HRSL3; MLP-3;
                     Pla2g16"
                     /note="major polyA site"
ORIGIN      
        1 agcctggact ctgcggccat taaaccagtc cccattgcgc tggcctccac ttgcctactt
       61 ggggcgcgag gaggttggag agtttttttc tgggacccaa gcaaaggcat ccacgctgct
      121 gctaagctga aattgaagct cacacatcct ggaaaatgct agcacccata ccagaaccca
      181 agcctggaga cctgattgag attttccgcc ctatgtacag acactgggcc atctatgttg
      241 gtgatggata cgtgatccac ctggctcctc caagtgaaat cgcaggagct ggggcagcca
      301 gcatcatgtc tgctttgact gacaaggcca tagtgaagaa agaactgctg tgccatgtgg
      361 ccgggaagga caagtaccag gtcaataaca aacatgacga ggagtacacc ccactgcctc
      421 tgagcaagat catccagcgg gctgagagac tggtggggca ggaggtgctc tacaggctga
      481 ccagcgagaa ctgtgagcac tttgtgaatg aactacgcta tggagttcct cggagtgatc
      541 aggtcagaga tgcggtcaag gcggtaggca tcgctggagt gggcttggcg gccttgggcc
      601 tcgttggagt catgctctcc agaaacaaga aacagaagca atgagctgaa tgactgccca
      661 gtttttgggc tcttcttttg ctagagggtt tggagtttga tttatagatt ctattgcttt
      721 ataattaggt ttattttcac aacatacaat aaaccacaag aaaggaattt ttgtgaggat
      781 actgcagtag ctacctggtg tgaagtctct ggagggaagc tcggggctct gttctggata
      841 acagtctttc ctggctggcc tttctgtttg ctgtggtacc ctttgtattg cagaaaacag
      901 agtccaacac tgttatctca agtgaagcgc attactgcgt gccagatact atggtatgcc
      961 aaaggagaca gcctgggtac acagaaatgg aaacatcaga tagccaggga tcttggccta
     1021 gaacttgttt caacgtggcg ctttgagact caggcgctgg agtttatgga tattcagtgg
     1081 tgtgagaagg acaaatcctg gagtgttggg gctttagctc agtgatagag tgctttcctg
     1141 gcgagcatgc agttttaggt tcaatccctc gtgtcatcct aaaaccttcc gatttccttc
     1201 tgcagtacag ctctgttcta gtcaggtttc tattgctaag ataaagactt gaaacccctt
     1261 gggggaggaa atggtttatt ggcttacata tccctggcca cagtccattg agagacgctc
     1321 aaaggaactc aaggcaggaa ccgaagcaga aaccatgatg ggtgctgctt attggcttgc
     1381 tcgccgtgac atacatcttg tctgttggag ccctggtcag gattgaaacg ttgctctgta
     1441 aaagctttct cccgacttat gcgcatcttg cacagaatac acatgtgctc gctgagttcc
     1501 agcactgaga gaatagtttt ctttggctca ggttccttag ggcttcacgt cagtgctcaa
     1561 ggtccccaaa cccaaaggac ctagacctaa gttcaaaggg caggtgtccc gatgctcacc
     1621 ctcccacaca atattcataa tatttagata atattaattt atacctaaac taatagtgag
     1681 tggggcaaga gaaagaagga gaaaaaacaa atacaagaga actaaatgaa acttaactgt
     1741 caaatgagga aaagcaatct ggggccgtgg agagggctca gaaagtggag ctgtttgctg
     1801 ccaattctgt ggacccgagt ttagtccatg ggatgcacac agtggaagga acaagccaac
     1861 tcccaaaagt tgtctcctga cctccactta tgtaccataa tattggtgca catatatctg
     1921 catgcaatac ataagtaagc actataaaaa gtttttaaaa actggaagaa aatacagact
     1981 ttaaggcaaa aataatttac tacacagaga ttgtgtgtag tatataattg aacaaaatga
     2041 ttactacaca gagataataa aacaatcttg attaaagttt caactcaatt aaagtatata
     2101 ctaattctaa attcatttgc atttaatagt ctcaaagtag atcgtgaatt cttggccagt
     2161 aaattgacaa tttaccattg tagtcggaga tcaaaatgtt atggggtctg cttaaatcca
     2221 actcgactca aacaccagat caatgcaaag gacaaaactg tgtcgtgacc aagctgctac
     2281 tgattgacca gggctgcagg acagacttgg gagctgaact gtgacctgga gccagagtgc
     2341 tacagagctt taaagcttga aaatcaccaa catctgggcc aagttacagt tacattttcc
     2401 accaatcagg atttagggac agtggatttc cttaggaact tgtctttgtg ctacacttat
     2461 cctgttccca ttggttgggc tattcaacta tggcaggacc actaacctaa cattcatgtc
     2521 tgaacttgtc aaccaggatg tcagttacct atgtgtatct ctctctgcca aacaggatga
     2581 caggcaccca gtacccagta cccagggagg tcttgggaac ttaaatttta tttgactcct
     2641 atttaaaatg aaagttttac ttaaaatggc ttcattttgg ttccttctta gaaaaataaa
     2701 tattttttga ggctggaaag atggcttagt ggttatgagc actggctgct tttccaggga
     2761 gcctgagttt tgtttcccaa cacacgtggt tcttcacaac catctgtaac ttcagctcca
     2821 gaggatccag caactttttc taccctccac cagcactgca cacacagaca tacgtgcagg
     2881 caaagcaccc acacacatat aaaaactaaa aaaaagtata acttctagga cctggtaaag
     2941 caacataaag atgtagaaaa gtttaaaaag ttgtcaagaa acagtttcaa tagacatgca
     3001 gtataagtgt gagacacaaa gtctaacgac atacataaca catttataaa aaattgatga
     3061 tatactagta cagtggtttg aacaagaacg gcctccatag gctcagacag gatttctctg
     3121 tgtaccgttg gctgtcctgg aacttgctct gtaggccagg ctggctctga gctcacagag
     3181 atctgcctgt ttctgcctcc tgagtgctag gattaaggcc tgcgctactt ctacctggct
     3241 cttacatttt aatgcttggt tatcaaagag tagcactact ttagagggat ttggaggtgt
     3301 ggcctcgttg gaggaagcgt gtcactggga gtgggcttta aaggttcaaa agctcaacca
     3361 agcccagtgt tgctctcttc ctgctgccta tggatcaaga tgtagagctc tcagctatct
     3421 cttcagcacc atgtctgcct gtatgctgcc atgctttggg catgataaca atggactaga
     3481 ccttcaaact gtaagccagc cccaattaaa tgttttcctg tat
//
