LOCUS       NM_001357092            2980 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus phospholipase A and acyltransferase 1 (Plaat1),
            transcript variant 2, mRNA.
ACCESSION   NM_001357092 XM_006522204
VERSION     NM_001357092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Rahman,S.M.K., Sasaki,S., Uyama,T., Hussain,Z., Sikder,M.M.,
            Saiga,H., Ohmura-Hoshino,M., Ohta,K.I., Miki,Y., Hoshino,K.,
            Ueno,M., Murakami,M. and Ueda,N.
  TITLE     PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid
            accumulation in mice
  JOURNAL   FASEB J 37 (7), e23032 (2023)
   PUBMED   37330992
  REMARK    GeneRIF: PLAAT1 deficiency alleviates high-fat diet-induced hepatic
            lipid accumulation in mice.
REFERENCE   2  (bases 1 to 2980)
  AUTHORS   Bradley,R.M., Hashemi,A., Aristizabal-Henao,J.J., Stark,K.D. and
            Duncan,R.E.
  TITLE     PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin
            Transacylase Activity
  JOURNAL   Int J Mol Sci 23 (12), 6714 (2022)
   PUBMED   35743156
  REMARK    GeneRIF: PLAAT1 Exhibits Phosphatidylcholine:Monolysocardiolipin
            Transacylase Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2980)
  AUTHORS   Hussain,Z., Uyama,T., Kawai,K., Rahman,I.A., Tsuboi,K., Araki,N.
            and Ueda,N.
  TITLE     Comparative analyses of isoforms of the calcium-independent
            phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and
            mice
  JOURNAL   J Lipid Res 57 (11), 2051-2060 (2016)
   PUBMED   27623847
REFERENCE   4  (bases 1 to 2980)
  AUTHORS   Cai,Y., Yoneda,M., Tomita,T., Kurotani,R., Okamoto,M., Kido,T.,
            Abe,H., Mitzner,W., Guha,A. and Kimura,S.
  TITLE     Transgenically-expressed secretoglobin 3A2 accelerates resolution
            of bleomycin-induced pulmonary fibrosis in mice
  JOURNAL   BMC Pulm Med 15, 72 (2015)
   PUBMED   26178733
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2980)
  AUTHORS   Uyama,T., Inoue,M., Okamoto,Y., Shinohara,N., Tai,T., Tsuboi,K.,
            Inoue,T., Tokumura,A. and Ueda,N.
  TITLE     Involvement of phospholipase A/acyltransferase-1 in
            N-acylphosphatidylethanolamine generation
  JOURNAL   Biochim Biophys Acta 1831 (12), 1690-1701 (2013)
   PUBMED   23994608
REFERENCE   6  (bases 1 to 2980)
  AUTHORS   Uyama,T., Ichi,I., Kono,N., Inoue,A., Tsuboi,K., Jin,X.H.,
            Araki,N., Aoki,J., Arai,H. and Ueda,N.
  TITLE     Regulation of peroxisomal lipid metabolism by catalytic activity of
            tumor suppressor H-rev107
  JOURNAL   J Biol Chem 287 (4), 2706-2718 (2012)
   PUBMED   22134920
REFERENCE   7  (bases 1 to 2980)
  AUTHORS   Richard,A.F., Demignon,J., Sakakibara,I., Pujol,J., Favier,M.,
            Strochlic,L., Le Grand,F., Sgarioto,N., Guernec,A., Schmitt,A.,
            Cagnard,N., Huang,R., Legay,C., Guillet-Deniau,I. and Maire,P.
  TITLE     Genesis of muscle fiber-type diversity during mouse embryogenesis
            relies on Six1 and Six4 gene expression
  JOURNAL   Dev Biol 359 (2), 303-320 (2011)
   PUBMED   21884692
REFERENCE   8  (bases 1 to 2980)
  AUTHORS   Shinohara,N., Uyama,T., Jin,X.H., Tsuboi,K., Tonai,T., Houchi,H.
            and Ueda,N.
  TITLE     Enzymological analysis of the tumor suppressor A-C1 reveals a novel
            group of phospholipid-metabolizing enzymes
  JOURNAL   J Lipid Res 52 (11), 1927-1935 (2011)
   PUBMED   21880860
  REMARK    GeneRIF: a possible enzyme activity of A-C1
REFERENCE   9  (bases 1 to 2980)
  AUTHORS   Akiyama,H., Hiraki,Y., Noda,M., Shigeno,C., Ito,H. and Nakamura,T.
  TITLE     Molecular cloning and biological activity of a novel Ha-Ras
            suppressor gene predominantly expressed in skeletal muscle, heart,
            brain, and bone marrow by differential display using clonal mouse
            EC cells, ATDC5
  JOURNAL   J Biol Chem 274 (45), 32192-32197 (1999)
   PUBMED   10542256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154421.2.
            
            On Jan 23, 2023 this sequence version replaced NM_001357092.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4421453.1,
                                           SRR17784651.1013978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC154421.2         143833-144011       c
            180-318             AC154421.2         136392-136530       c
            319-584             AC154421.2         133568-133833       c
            585-2980            AC154421.2         123611-126006       c
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 20.01 cM"
     gene            1..2980
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /note="phospholipase A and acyltransferase 1"
                     /db_xref="GeneID:27281"
                     /db_xref="MGI:MGI:1351473"
     exon            1..179
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..683
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="Harvey rat sarcoma virus oncogene related
                     suppressor; phospholipid-metabolizing enzyme A-C1;
                     HRAS-like suppressor 1"
                     /codon_start=1
                     /product="phospholipase A and acyltransferase 1"
                     /protein_id="NP_001344021.1"
                     /db_xref="CCDS:CCDS28094.1"
                     /db_xref="GeneID:27281"
                     /db_xref="MGI:MGI:1351473"
                     /translation="MAVNDCFSLTYPHNPHPGDLIEVFRPCYQHWALYLGDGYVINIA
                     PIDGIRSSFTSAKSVFSTKALVKMQLLKDVVGNDTYRINNKYDTTYPPLPVEEVIQRS
                     EFAIGQEVAYDLLVNNCEHFVTLLRYGEGVSEQANRAIGTIGLVAAGIDIFTFLGLFP
                     KRQRTKY"
     exon            180..318
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..584
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..2980
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /note="hexamer: AATAAA"
     polyA_site      832
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /note="major polyA site"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
                     /note="hexamer: AATAAA"
     polyA_site      2980
                     /gene="Plaat1"
                     /gene_synonym="2810012B06Rik; A-C1; Hrasls; Hrasrs; HRSL1"
ORIGIN      
        1 gacgctggcg ttgacgcagc ggagggaggc tgtggtggcc ttggctgtgg ccttggcctc
       61 agggcgatgc ggatggagtc acccagggtc tgctagcggc accgcagcga gcccgtggag
      121 aacccgggaa gcccgtcact gcctccaggg cactaagaca acccagcttg agcagggaga
      181 tggcggtaaa tgattgcttc agtctgacct atcctcacaa cccacaccca ggagacttga
      241 ttgaagtgtt ccgtccttgc tatcagcact gggcactgta cttgggtgat ggctacgtga
      301 tcaacattgc acctatagat ggcattcgct catcatttac aagtgctaag tccgtgttca
      361 gcacaaaggc cttggtgaaa atgcagcttt tgaaggatgt tgtgggaaat gacacataca
      421 gaataaataa caagtacgac acaacatacc ctcctcttcc tgtggaggag gtgatacaac
      481 ggtcagagtt cgctattggg caggaagtag cctatgactt gctggtcaac aactgtgagc
      541 attttgtaac cttgctgcgc tatggagaag gagtgtcaga gcaggccaac cgagcaatcg
      601 gcaccatcgg attggtggca gctggtattg atatcttcac attcctcggc ttgtttccca
      661 aaagacaaag aacgaaatat tagcagttta ttgaagagat tggaatgaag aaatttgtga
      721 ggagaaaaaa aaatcctagg gtgaatactt attttgaatg catcattatt gctcatggtc
      781 cccatgatgg atggcagact ctgtaataaa ttgcttgctg attttaatct tatcattgag
      841 ccaagaaaag tttttcccaa ctagcagaga tttgccgtgg cagcttgaac aaaatgcaat
      901 tgccttttga tcgagccagc tgaggatctt aacagaacca agaccacatt ttatcttctg
      961 ctgtaaatat tgttttcctt ttccctaagg acagctgttt tgccagaggt gtggagaacc
     1021 atttgcatac actgctgaga gacagttgtt agggccaaca tctaaattcc ttttgctttc
     1081 tttgtcagaa aaaggagcgt gaacatatcc agtagtttgg atacatggat atatatccat
     1141 gatatatcca agtacttaag gatctctgca tgacaaagca tttgaggtgg tacccccata
     1201 ttgctgcacc tgtgtgggtg gagcatgtaa gaaggagtgg gggacttttg tgtgtgcata
     1261 tgtatggaat tcttatgaat ggtgtgcatg tatagggacg gtcttggtct cacctttttt
     1321 attcttattt tattcttatt cttattttat tttataattt ataaaaggag acagggtatg
     1381 ctgtccttta tagcttatgg caaactagct agcctgtggg catccagaga gtctcctgtc
     1441 tctgcctcca tttcacggta ggagttctgg agttaccgaa gtgaactaac aacccaagct
     1501 ttctgtggac tctggggatc tgagctcaag acatcatgct tatgtttaag atgctttacc
     1561 cactgagccc ctctccaatc tctctctctc tctttctttc tctctctctc tcccttgtac
     1621 gttcagaccc agtgttcaag actcagtgat gaacaatggg ctgtcgtttt attgatttaa
     1681 atggatccct ccacattgtg tagtagctca gtggtttgac ctttggggct tggcaagcaa
     1741 tcattaatat taatgcaaag agctatattt aaaacacaaa attcctcatt cctttaaaga
     1801 tgtgaactgt aaatcaagga atccgcttat tttattcttt tattttactg attatccgtt
     1861 gaattaaact ccttcttaat gccatttctg cagaattctt gatagcaggt caggagaggt
     1921 gggacgttag tctttctaca tgaaggtagt ataagggcat catgacatta cctcataaac
     1981 cacacagcta gcccggcatc cttttgtgcc attatcaaaa gcatgtcaat caataaggaa
     2041 agagtgccag tgaccatggg gatagaacgt gatggagtat ggtaaagtca agtgcacaag
     2101 actcggtgga aagctcagac ctacttaact gatttgacct tggtgctgga aacactcaca
     2161 ctgatgaggg taacagtaat gtgaacagaa ctatgtgctg ccactcccat ccagacagag
     2221 tcccctctgt cccttcttta cttttctaac aggcccttct tgtccgaacc tccagactca
     2281 ttctttagtt gtctcagaag gcacgaggtt acttttatcc tgaatgcagg tctctgttcc
     2341 caaatagtaa agaatattca gttttctaga agtttcctat taaggtaagg gcagctgcag
     2401 cctctgggct actttcccct ggtgtgccac cttctcaata aactatattt gcagggcatt
     2461 tgtctctggc agaattacac cgcctgtcag gaaagggact aggactgaga accaaatgcc
     2521 tcttagggat tcaaatgaaa cctttctaga ggactctgac atctccactc cagaagaaaa
     2581 gcaaaatgtt aaaaggaaaa cgtcagaaat gcacttttta atccatgggt ttatttcctt
     2641 atcagttatg tgaagctttg gcagccttgg tttgctgtaa acatggccaa ccttaaaatg
     2701 ggcagcccta aatagctgtg gttgttttcc tgcaggtact caatacccac acgttcaatg
     2761 caacttatac ttggatcagc tatttcccca acactatgaa atattgtctg ggcatatttt
     2821 cagcagtcag gaatggagtc cacttctatc atgtttcaaa aaatggaatg taaagatcac
     2881 ctgcatcaag tgataggttt ttggtaatac aaggaaagaa atgtctgtat ttttattgaa
     2941 tatgtacata taacaaataa aatatgctat ctaaatgtca
//
