LOCUS       NM_172695               6815 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus phospholipase A2, activating protein (Plaa), mRNA.
ACCESSION   NM_172695
VERSION     NM_172695.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6815)
  AUTHORS   Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake
            KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali
            GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N,
            Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA,
            Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester
            RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER and Mill P.
  TITLE     PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by
            Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic
            Proteins
  JOURNAL   Am J Hum Genet 100 (5), 706-724 (2017)
   PUBMED   28413018
  REMARK    GeneRIF: We demonstrate that PLAA is essential for neural function,
            through dual roles of (1) regulating post-endocytic trafficking of
            signaling receptors necessary for neural development and (2)
            directing sorting of synaptic vesicle (SV) components during
            recycling, essential for synaptic function.
REFERENCE   2  (bases 1 to 6815)
  AUTHORS   Falik Zaccai TC, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC,
            Shoval Y, Kalfon L, Samra N, Keren Z, Gross B, Chasnyk N,
            Straussberg R, Mullikin JC, Teer JK, Geiger D, Kornitzer D,
            Bitterman-Deutsch O, Samson AO, Wakamiya M, Peterson JW, Kirtley
            ML, Pinchuk IV, Baze WB, Gahl WA, Kleta R, Anikster Y and Chopra
            AK.
  TITLE     Phospholipase A2-activating protein is associated with a novel form
            of leukoencephalopathy
  JOURNAL   Brain 140 (2), 370-386 (2017)
   PUBMED   28007986
REFERENCE   3  (bases 1 to 6815)
  AUTHORS   Doroudi M, Schwartz Z and Boyan BD.
  TITLE     Phospholipase A2 activating protein is required for
            1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein
            kinase C via Pdia3
  JOURNAL   J Steroid Biochem Mol Biol 132 (1-2), 48-56 (2012)
   PUBMED   22484374
  REMARK    GeneRIF: Phospholipase A2 activating protein is required for
            1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein
            kinase C via Pdia3
REFERENCE   4  (bases 1 to 6815)
  AUTHORS   Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, Liang DY and Clark JD.
  TITLE     miR-203 regulates nociceptive sensitization after incision by
            controlling phospholipase A2 activating protein expression
  JOURNAL   Anesthesiology 117 (3), 626-638 (2012)
   PUBMED   22846677
  REMARK    GeneRIF: miR-203 may regulate expression of the novel nociceptive
            mediator PLAA after incision.
REFERENCE   5  (bases 1 to 6815)
  AUTHORS   Zhao G, Li G, Schindelin H and Lennarz WJ.
  TITLE     An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in
            ubiquitin homeostasis and protein degradation
  JOURNAL   Proc Natl Acad Sci U S A 106 (38), 16197-16202 (2009)
   PUBMED   19805280
REFERENCE   6  (bases 1 to 6815)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 6815)
  AUTHORS   Seigneurin-Berny D, Verdel A, Curtet S, Lemercier C, Garin J,
            Rousseaux S and Khochbin S.
  TITLE     Identification of components of the murine histone deacetylase 6
            complex: link between acetylation and ubiquitination signaling
            pathways
  JOURNAL   Mol Cell Biol 21 (23), 8035-8044 (2001)
   PUBMED   11689694
REFERENCE   8  (bases 1 to 6815)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 6815)
  AUTHORS   Wang H, Lemasters JJ and Herman B.
  TITLE     Cloning of a rat cDNA encoding a protein with high homology to
            mouse phospholipase A2-activating protein
  JOURNAL   Gene 161 (2), 237-241 (1995)
   PUBMED   7665086
REFERENCE   10 (bases 1 to 6815)
  AUTHORS   Clark MA, Ozgur LE, Conway TM, Dispoto J, Crooke ST and Bomalaski
            JS.
  TITLE     Cloning of a phospholipase A2-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5418-5422 (1991)
   PUBMED   2052621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA490654.1, AK075934.1, DV646766.1 and AL732597.10.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_172695.3.
            
            On Sep 15, 2006 this sequence version replaced NM_172695.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139355.1, AK075934.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-587               CA490654.1         38-624
            588-1803            AK075934.1         520-1735
            1804-2214           DV646766.1         290-700
            2215-6815           AL732597.10        5867-10467          c
FEATURES             Location/Qualifiers
     source          1..6815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.34 cM"
     gene            1..6815
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /note="phospholipase A2, activating protein"
                     /db_xref="GeneID:18786"
                     /db_xref="MGI:MGI:104810"
     exon            1..371
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            372..565
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..666
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..787
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..955
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1091
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1261
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1419
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1639
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1708
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1777
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1879
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2044
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..6815
                     /gene="Plaa"
                     /gene_synonym="2410007N06; D4Ertd618e; PLA2P; PLAP; Ufd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgatgaat tccggcgtgt gtgttagggt tgctgtgtca ctcaggcggc tcggcgcgcc
       61 ccttcccccg cggtccttcc gcaccggctg actggctctt ccggtctccg gcgcccctct
      121 cctgcaggcg ggtctcgggc cgcagcctgg cgcacgccgg ctcgggcctg tggacgagtc
      181 tcgcgctgtg cccgggggcc gggctccgga tccacgctgg ccatggcgag cggcgcctcc
      241 agataccggc tgagctgctc gctcccgggc cacgaactgg acgtgagggg cctggtgtgc
      301 tgcctctacc cgccgggagc ctttgtgtct gtgtcccggg atcggaccac ccgcctctgg
      361 gctccagaca gtcctaacag gggctttaca gaaatgcact gtatgagcgg ccactctaat
      421 tttgtgtctt gtgtgtgtat cataccctca agtgacatat atcctcatgg actgattgcc
      481 actggaggaa atgaccacaa tatttgcatt ttctcgctgg acagtccaat gccactttat
      541 attttaaagg gtcacaaaga tactgtttgt agtctttctt ctggaaaatt tgggacatta
      601 cttagtggct catgggacac cactgctaaa gtctggctga atgacaaatg catgatgaca
      661 ttacagggtc atacagccgc agtatgggca gtaaagattt tacctgaaca gggcttaatg
      721 ctaactggat cagcagacaa gaccattaaa ctatggaagg ctggaagatg tgagaggact
      781 tttttagggc atgaagactg tgtaagaggc ttggcaatct tgagtgagac agaatttctt
      841 tcctgtgcaa acgatgctag tattagaagg tggcagatca ctggcgagtg tctggaagta
      901 tactttggac atacaaatta tatttatagc atatctgtct ttccaaactc caaagatttt
      961 gtgaccactg cagaagacag atctctaaga atatggaaac atggtgaatg cgcccaaaca
     1021 atccgacttc cagctcagtc tatatggtgt tgctgcgtac tggaaaatgg tgacattgtg
     1081 gttggtgcga gtgatggtat tattagggtg tttacagagt cagaggagcg gacagcaagt
     1141 gctgaggaaa tcaaagcttt tgagagagag ctctctcagg caactatcga ttccaaaact
     1201 ggtgacttgg gggatattaa tgcggagcag cttcctggga gggaacatct cagtgagcca
     1261 ggtactagag aaggacagac tcgtctaatc agagatggag agagagttga agcctatcag
     1321 tggagtgtta gtgacgggag gtggataaaa attggtgatg ttgttggctc atctggtgct
     1381 aatcagcaaa catctggaaa agttttatat gaagggaaag aatttgatta tgttttctca
     1441 atcgatgtga atgaaggtgg accatcgtat aaattaccat ataatgtcag tgacgatccc
     1501 tggctagttg catacaactt cttgcagaaa aatgatttga atcccatgtt tctggatcag
     1561 gtggctaaat ttattattga taacacaaaa ggtcaaacac tgggacttgg gaataccagt
     1621 ttttcagatc cgtttacagg tggtggtcgc tatgttccag gaacttcagg accttccaac
     1681 acagtgcaga cagcagatcc tttcacaggt gctgggcgtt acatgccagg ttctgcaggt
     1741 atggacacca ccatgactgg agttgatcca tttacaggga acagtgccta ccgatcagct
     1801 gcatctaaaa cagtgaacat ttatttcccc aaaaaagaag ctcttacctt tgaccaagca
     1861 aaccctacac aaatattagg aaaactgaag gaacttaatg gaactgcacc tgaagagaag
     1921 aagctaactg aagacgactt agtacttctt gaaaagatac tgtccctgat ttgtaataat
     1981 tcctcagaaa agccaacggc ccagcaactt cagattttgt ggaaagctat caactggcct
     2041 gaagacattg tctttcctgc acttgacatt cttcgcctat cgattaagca tcccaatgtg
     2101 aatgagaatt tctgcaatga aaaaggagac cagttcagca gccatcttat caaccttctg
     2161 aaccccaaag gaaagccagc aaaccagctg cttgctctta ggactttttg caattgcttt
     2221 gttagtcagg caggacaaaa gctcatgatg tcccagaggg agtcactgat gtcacatgca
     2281 atagaactga aatccgggag taataagaac attcatattg ctctggctac attgaccttg
     2341 aactattctg tttgtttcca taaagaccat aacattgaag ggaaagctca atgcctctca
     2401 gtaattagca caatcttgga agttgtgcaa gacctagaag ccacgtttag actccttgtg
     2461 gctcttggga cacttatcag tgatgattca aatgctatac aattagccaa atctttaggt
     2521 gttgattctc aaataaaaaa gtatgtctcc gtatcagagc cagctaaagt gagtgaatgc
     2581 tgtagacttg tcttacattt gctgtagcag tggggaaaag acgctgaggg gttttctttt
     2641 tttgttttgt tttgttttgt ttttttccac attttacatg actgattgca gatgtttaaa
     2701 aagaaagaaa ggaaaattgg attaagttca gatcttgtaa agttgtgttg aggagaaaca
     2761 aattataaat aaagtttttg cactgatggt tgtgaggttt tcctgtgtaa tggagtagat
     2821 tttcaagggt gtagaaatgt taaaaactat aaccaataac agcacaatta taacagcatt
     2881 ttcttcctta ccttcaccac tcaggagaac acagaggttc tataacctgt ttctgatcta
     2941 tgacatcttg ttcagttgac tgttctcttt tgtacattag cttctccact ttcactgttg
     3001 tattctttca atagcactga tgcatttcaa ggtcttcttt taggatttac ttgaaaaatc
     3061 atttcaatta agtttgttat aaattgtaaa ttgataaata acaataattt cttgagccat
     3121 ttgtaaatag aaagtatcat ctttcatggt tcaattttac atgaagaaag cacattggta
     3181 agctgttata ttacatatca tttcagacaa ctgaggcctt aaatgagtat ggcttaggag
     3241 tttctttcac tatatgaggt aacttcattt tttctagttt tgatatctta caagttaaat
     3301 catttctttt atccttcacc atttgaagta gtagtgtcat ctttcatttc agttttgtac
     3361 atgttgatca tattcattat ttcaaagaga atatttggaa tttttttact tttactaggc
     3421 aattgtgtaa gcaacattta tcagacttta aagtaaaaaa acctgtcatg tgaaattagt
     3481 atttttagtc cctggaatgg tccaggtctt acattgctat ctaattctca aatcagcttt
     3541 ctttgaaaag tggttattgt gcttctgttt tcaaaaggaa aggtaataga ataaattata
     3601 ataggaaggt taaacatgaa cataaaggca tgagtactcc atgtagtcta gtctacacag
     3661 agcacttgcc atgatgcagc ttcctggaaa gccacaggtt tgtttctaaa cagcccagca
     3721 actaaaacaa aggagacatc ctttaattga acaattcatt atgtctatga cagtgctgtt
     3781 tcttctttct ttttttggtt tctccagaca aggtttcatt agcagctgtt ctggcactca
     3841 ctttataaac caggttggcc ttgaaccccg aaacctgtct gcctctgcct cctgagtact
     3901 aggattaaag ccaccactcc cagctcagtc ccttttctta agaagtgtac ttatattggt
     3961 atgtgtatgt gtgtgccttt tggttttatt tgtttttcgg tactagggac caaacctggt
     4021 tgcatgttgg ggaaggtcta ctcactggat tacattccca gttccaggct ttcgtcttga
     4081 ttatggaaga aatggtttta taaggacttt gttaaaaatg gtgagcagtg atctcaacat
     4141 tgccattatg gagagccatg ggtttcctga cttaatgcca tatcacagtc taagaagaac
     4201 aaattttttt ccactaaggg gaagaagatt ccgagtgttg agattaatac aggaaagaac
     4261 ttctagaata tcaaaaggga gtgaggaaat gtaaatagag gatgtgtgct ttactgagta
     4321 ttaaattcca agttcctgtg tgtacctgaa ctttaaactt catgttgctg tttcatttat
     4381 gtattcatac tttacctgta ttgaattgag agttaaattt ttatatcaga attaaatggt
     4441 aaaaaaatca tcctggtgcc attataacac ttggcttgtt aatacatcca ttctagcatg
     4501 caattttaag tacaatttat gttatatttt gaaaagcagg gtgggtatct ttgaaaaaag
     4561 aatggatgtg gtcttactta aaacatgagt tcactcttca gaatgtaaga ggtggcaaat
     4621 tgtaaatact tttgtttctt atcactggct tttttataac ttttatttgt acagcctaac
     4681 aaaaacataa tctcacttga acctgtcaaa tggtggttta catattttgt ttttctttaa
     4741 acttttttat agacctctta atgttttctt gaatataaaa gaaataaaca ttcatttagt
     4801 aaagcataca cacatcttat tgactgtaat cctactaagt agaaaaccat tcttagtttt
     4861 atactaccat gacatgtatg taaatatgca ttttaatttt tcaaaaaggg atgtattggt
     4921 cagaaacttt aatatcccat tatattaata tacccatttt ctagtatctg aaactttcct
     4981 gcttttgatt atcaagcaat gctattaaag attgcacaac aatcttacca ttcccttagg
     5041 aatatatttt atgcataaaa ttgatggatc aagttaatag gcaattttgg attgatgtct
     5101 gtctaaatca actccactag gacaattaca ggttagtgaa tctcctactg tattttcaac
     5161 tacattatac attcaactac agacatacgt gatgtccctt tcattaacta ttgtttttat
     5221 ctccttataa atgctactgc tgtggttttc ttatgactag ctgcgtttgt tttactggta
     5281 atatatatca accacacagc attatagttt tttttttttt taatccagtg cagtttggta
     5341 gaaacatagc taaagataaa tctttttcaa agataatttt ggagttaaat gtaggttact
     5401 tggtgcttac cacacagcat tttatgaaga agtgataaga tgaatagaca agtgtttgat
     5461 gtgttatttt tccttcaggt ctttaaagga tttcctcctg catgtcttaa gagagaactt
     5521 aactgctcag gattaagact tacccagggg ctggagagat gactcaacgc ttggatactt
     5581 gttggtttac agaggacctg ggttcagttc cctataccta atggtggttc acagccatcc
     5641 ataactccag ttccagagga catggtctct tctgaccttt gtgtgccagg cacaagcatg
     5701 tgggacatac gtcatacatt catagatata tacaggcaaa acctgtagct gcaaaaaata
     5761 tgtaaatttt aaagtgttac ttagttgtat taaaatatac tttctaggga ctggagaaat
     5821 ggctcagtgg ttaagtttgt gtcctgcttt tctacaacct gagttagagt cacagttcac
     5881 agatggctca caactgcctg ctaactccag atccagaaag actggatacc tctggcctct
     5941 gttgtctcag cactcaggtg cctatgtaga cccacatatc tacacataat ttaaaagtaa
     6001 taaatcttta aactttctaa ttttaattcc taatgcattt tctgtaacgt actgaatagt
     6061 ttaagtatga ttatagatat aataccgaag acccttttta acattttccc atgagttttc
     6121 ctttaatgtt cataaaagtt ataaaaaatt cagtgaccct ctacggactt aaagctatac
     6181 agtgctcctt gacatggagt taaatctctt cccaaatcta ccactacctc aagttgaaaa
     6241 cacatgttag tacactgaac ctattaaaca gcagcctgag acactggagt actgatgatt
     6301 cctgtcaggt taatttagct gtcctgcatc gcctctcctt tgtacaaaag ggtatcttaa
     6361 ccagatattg ctatttgaga aaagcttaaa agtctagttt tcttctgagt ggcattactc
     6421 ttgtgccatc ataaagtcta accactgctg tccaagacta gatcctacat tttcaccgtg
     6481 tttgctttct ctatacttta agaccataaa ttgcagattt cacatcaatt aaacatttca
     6541 atataaatcc ctgaatacaa gcatatttat acatttttga aattacttat ttgccctaat
     6601 atcactcttg ctttaaagct acctactcag aaaaacagtc atcaggattt atgagttgta
     6661 ggcatgtatg taatatttct tactctagaa tagtccatct cttaaagata ctgtctttag
     6721 aattctgcct actatagaat ttgaagtacc tcacatgcta aaacatttcc tataaccctt
     6781 ctgtattaca tattgtttaa taaaataccc tacaa
//
