LOCUS       NM_008867               7112 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus phospholipase A2 receptor 1 (Pla2r1), mRNA.
ACCESSION   NM_008867
VERSION     NM_008867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7112)
  AUTHORS   Massemin,A., Goehrig,D., Flaman,J.M., Jaber,S., Griveau,A.,
            Djebali,S., Marcos,E., Payen,L., Marvel,J., Parent,R., Adnot,S.,
            Bertolino,P., Rieusset,J., Tortereau,A., Vindrieux,D. and
            Bernard,D.
  TITLE     Loss of Pla2r1 decreases cellular senescence and age-related
            alterations caused by aging and Western diets
  JOURNAL   Aging Cell 22 (11), e13971 (2023)
   PUBMED   37667516
  REMARK    GeneRIF: Loss of Pla2r1 decreases cellular senescence and
            age-related alterations caused by aging and Western diets.
REFERENCE   2  (bases 1 to 7112)
  AUTHORS   Abi Nahed,R., Dhellemmes,M., Payre,C., Le Blevec,E., Perrier,J.P.,
            Hennebicq,S., Escoffier,J., Ray,P.F., Loeuillet,C., Lambeau,G. and
            Arnoult,C.
  TITLE     Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10
            Reveals That PLA2G10 Improves In Vitro Fertilization through Both
            Its Enzymatic Activity and as Ligand of PLA2R1
  JOURNAL   Int J Mol Sci 23 (14), 8033 (2022)
   PUBMED   35887380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7112)
  AUTHORS   Huna,A., Griveau,A., Vindrieux,D., Jaber,S., Flaman,J.M.,
            Goehrig,D., Azzi,L., Medard,J.J., Djebali,S., Hernandez-Vargas,H.,
            Dante,R., Payen,L., Marvel,J., Bertolino,P., Aubert,S., Dubus,P.
            and Bernard,D.
  TITLE     PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation
            during aging
  JOURNAL   Cell Death Dis 12 (2), 190 (2021)
   PUBMED   33594040
  REMARK    GeneRIF: PLA2R1 promotes DNA damage and inhibits spontaneous tumor
            formation during aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7112)
  AUTHORS   Kishi,H., Yamaguchi,K., Watanabe,K., Nakamura,K., Fujioka,D. and
            Kugiyama,K.
  TITLE     Deficiency of Phospholipase A2 Receptor Exacerbates Autoimmune
            Myocarditis in Mice
  JOURNAL   Inflammation 43 (3), 1097-1109 (2020)
   PUBMED   32016628
  REMARK    GeneRIF: Deficiency of Phospholipase A2 Receptor Exacerbates
            Autoimmune Myocarditis in Mice.
REFERENCE   5  (bases 1 to 7112)
  AUTHORS   Nicol,B., Grimm,S.A., Chalmel,F., Lecluze,E., Pannetier,M.,
            Pailhoux,E., Dupin-De-Beyssat,E., Guiguen,Y., Capel,B. and Yao,H.H.
  TITLE     RUNX1 maintains the identity of the fetal ovary through an
            interplay with FOXL2
  JOURNAL   Nat Commun 10 (1), 5116 (2019)
   PUBMED   31712577
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7112)
  AUTHORS   Hanasaki,K. and Arita,H.
  TITLE     Biological and pathological functions of phospholipase A(2)
            receptor
  JOURNAL   Arch Biochem Biophys 372 (2), 215-223 (1999)
   PUBMED   10600158
  REMARK    Review article
REFERENCE   7  (bases 1 to 7112)
  AUTHORS   Knopp,E.A., Arndt,T.L., Eng,K.L., Caldwell,M., LeBoeuf,R.C.,
            Deeb,S.S. and O'Brien,K.D.
  TITLE     Murine phospholipid hydroperoxide glutathione peroxidase: cDNA
            sequence, tissue expression, and mapping
  JOURNAL   Mamm Genome 10 (6), 601-605 (1999)
   PUBMED   10341094
REFERENCE   8  (bases 1 to 7112)
  AUTHORS   Hanasaki,K., Yokota,Y., Ishizaki,J., Itoh,T. and Arita,H.
  TITLE     Resistance to endotoxic shock in phospholipase A2
            receptor-deficient mice
  JOURNAL   J Biol Chem 272 (52), 32792-32797 (1997)
   PUBMED   9407054
REFERENCE   9  (bases 1 to 7112)
  AUTHORS   Zvaritch,E., Lambeau,G. and Lazdunski,M.
  TITLE     Endocytic properties of the M-type 180-kDa receptor for secretory
            phospholipases A2
  JOURNAL   J Biol Chem 271 (1), 250-257 (1996)
   PUBMED   8550569
REFERENCE   10 (bases 1 to 7112)
  AUTHORS   Higashino,K., Ishizaki,J., Kishino,J., Ohara,O. and Arita,H.
  TITLE     Structural comparison of phospholipase-A2-binding regions in
            phospholipase-A2 receptors from various mammals
  JOURNAL   Eur J Biochem 225 (1), 375-382 (1994)
   PUBMED   7925459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY772059.1, BC141356.1, AK036808.1 and BX679662.5.
            
            On Sep 22, 2011 this sequence version replaced NM_008867.1.
            
            Sequence Note: An in-frame AUG is located 35 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it would disrupt the signal peptide on
            NP_032893.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D30779.1, BC141356.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               BY772059.1         2-120
            120-4772            BC141356.1         1-4653
            4773-6357           AK036808.1         1746-3330
            6358-6358           BX679662.5         31370-31370         c
            6359-7112           AK036808.1         3332-4085
FEATURES             Location/Qualifiers
     source          1..7112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 34.65 cM"
     gene            1..7112
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /note="phospholipase A2 receptor 1"
                     /db_xref="GeneID:18779"
                     /db_xref="MGI:MGI:102468"
     exon            1..299
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..4642
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /note="secretory phospholipase A2 receptor; 180 kDa
                     secretory phospholipase A2 receptor; phospholipase A2,
                     group IB, pancreas, receptor; PLA2-I receptor; M-type
                     receptor"
                     /codon_start=1
                     /product="secretory phospholipase A2 receptor precursor"
                     /protein_id="NP_032893.1"
                     /db_xref="CCDS:CCDS16059.1"
                     /db_xref="GeneID:18779"
                     /db_xref="MGI:MGI:102468"
                     /translation="MVQWLAMLQLLWLQQLLLLGIHQGIAQDLTHIQEPSLEWRDKGI
                     FIIQSESLKTCIQAGKSVLTLENCKQPNEHMLWKWVSDDHLFNVGGSGCLGLNISALE
                     QPLKLYECDSTLISLRWHCDRKMIEGPLQYKVQVKSDNTVVARKQIHRWIAYTSSGGD
                     ICEHPSRDLYTLKGNAHGMPCVFPFQFKGHWHHDCIREGQKEHLLWCATTSRYEEDEK
                     WGFCPDPTSMKVFCDATWQRNGSSRICYQFNLLSSLSWNQAHSSCLMQGGALLSIADE
                     DEEDFIRKHLSKVVKEVWIGLNQLDEKAGWQWSDGTPLSYLNWSQEITPGPFVEHHCG
                     TLEVVSAAWRSRDCESTLPYICKRDLNHTAQGILEKDSWKYHATHCDPDWTPFNRKCY
                     KLKKDRKSWLGALHSCQSNDSVLMDVASLAEVEFLVSLLRDENASETWIGLSSNKIPV
                     SFEWSSGSSVIFTNWYPLEPRILPNRRQLCVSAEESDGRWKVKDCKERLFYICKKAGQ
                     VPADEQSGCPAGWERHGRFCYKIDTVLRSFEEASSGYYCSPALLTITSRFEQAFITSL
                     ISSVAEKDSYFWIALQDQNNTGEYTWKTVGQREPVQYTYWNTRQPSNRGGCVVVRGGS
                     SLGRWEVKDCSDFKAMSLCKTPVKIWEKTELEERWPFHPCYMDWESATGLASCFKVFH
                     SEKVLMKRSWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTQERQFWIGFNR
                     RNPLNAGSWAWSDGSPVVSSFLDNAYFEEDAKNCAVYKANKTLLPSNCASKHEWICRI
                     PRDVRPKFPDWYQYDAPWLFYQNAEYLFHTHPAEWATFEFVCGWLRSDFLTIYSAQEQ
                     EFIHSKIKGLTKYGVKWWIGLEEGGARDQIQWSNGSPVIFQNWDKGREERVDSQRKRC
                     VFISSITGLWGTENCSVPLPSICKRVKIWVIEKEKPPTQPGTCPKGWLYFNYKCFLVT
                     IPKDPRELKTWTGAQEFCVAKGGTLVSIKSELEQAFITMNLFGQTTNVWIGLQSTNHE
                     KWVNGKPLVYSNWSPSDIINIPSYNTTEFQKHIPLCALMSSNPNFHFTGKWYFDDCGK
                     EGYGFVCEKMQDTLEHHVNVSDTSAIPSTLEYGNRTYKIIRGNMTWYAAGKSCRMHRA
                     ELASIPDAFHQAFLTVLLSRLGHTHWIGLSTTDNGQTFDWSDGTKSPFTYWKDEESAF
                     LGDCAFADTNGRWHSTACESFLQGAICHVVTETKAFEHPGLCSETSVPWIKFKGNCYS
                     FSTVLDSRSFEDAHEFCKSEGSNLLAIRDAAENSFLLEELLAFGSSVQMVWLNAQFDN
                     NNKTLRWFDGTPTEQSNWGLRKPDMDHLKPHPCVVLRIPEGIWHFTPCEDKKGFICKM
                     EAGIPAVTAQPEKGLSHSIVPVTVTLTLIIALGIFMLCFWIYKQKSDIFQRLTGSRGS
                     YYPTLNFSTAHLEENILISDLEKNTNDEEVRDAPATESKRGHKGRPICISP"
     exon            300..680
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            681..854
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1028
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1142
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1283
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1478
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1636
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1735
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1848
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2012
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2215
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2361
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2446
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2579
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2615
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2773
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2838
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2942
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3079
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3197
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3328
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3476
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3715
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3884
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..4025
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4142
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            4143..4319
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4352
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..7112
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5596..5601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /note="hexamer: AATAAA"
     polyA_site      5619
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /note="major polyA site"
     regulatory      6062..6067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
                     /note="hexamer: AATAAA"
     polyA_site      6090
                     /gene="Pla2r1"
                     /gene_synonym="Pla2-r; Pla2g1br; Pla2r"
ORIGIN      
        1 gtctccacgc ccagagtccc aagtgtacac gctgtggcga caagggaggc gagttcatct
       61 ccagggctct gggatggcgt ggtcctcaag aagagtggta gcttctcttg cctcctgcag
      121 cctagtccag agcaggggac acggttctga ttcccgtggg tgtcacctag cgtgcctgat
      181 ggtgcaatgg ttagcgatgc tgcagctgct ctggctgcaa cagctgctgc tgctggggat
      241 tcaccagggc atcgcccaag atttgactca catccaggaa ccgtccctcg agtggcgtga
      301 taaaggaatt ttcattatcc agagcgagag cctgaagaca tgcattcagg caggtaaatc
      361 tgtactgacc ctggagaact gcaagcagcc aaacgagcac atgctgtgga aatgggtttc
      421 cgacgaccac ctctttaatg tgggaggcag tggctgccta ggcctgaaca tatctgctct
      481 ggagcaacca ttaaagctct atgaatgtga ttccaccctc atttccctga gatggcactg
      541 tgacaggaag atgatcgagg gcccactcca gtacaaggtc caggtgaagt ctgacaacac
      601 agtggtggca agaaaacaga tccataggtg gatcgcctac acgtccagtg gtggggacat
      661 ttgtgagcat cctagcagag atttatatac gttaaaaggg aatgcccatg ggatgccttg
      721 cgtgtttcct ttccagttca aaggtcactg gcaccatgac tgtatccgag aagggcagaa
      781 agagcacctg ctgtggtgtg ccaccacaag ccgatacgaa gaagacgaga agtggggatt
      841 ctgcccagat cctacctcta tgaaggtgtt ctgtgatgct acgtggcaaa ggaatggcag
      901 ttcacgcatt tgctaccagt tcaacctgct ttcgtctctg tcttggaacc aggcccattc
      961 ttcatgcctg atgcaaggag gtgctttgct aagtattgca gatgaagatg aagaagattt
     1021 cataaggaag cacttgagca aggtagtcaa ggaagtgtgg attggtttga accagctgga
     1081 tgagaaggct ggctggcagt ggtctgatgg aacaccactc agctacctga actggagcca
     1141 agagataact cctgggccat ttgttgagca tcactgtgga accctggagg ttgtttcagc
     1201 tgcctggagg agcagggact gcgagtccac cttgccttat atatgcaaac gggatctaaa
     1261 ccacactgcg cagggaatcc tggaaaagga ctcctggaaa taccatgcca ctcactgtga
     1321 tcctgactgg actcccttca atcgtaaatg ctacaaactt aagaaagaca gaaagagctg
     1381 gcttggggct ctgcactctt gccaatcgaa tgacagcgtg ttgatggatg tagcttcgtt
     1441 ggcagaggtg gagtttcttg taagcctcct tagggatgaa aatgcatcag aaacgtggat
     1501 tggtttgagt agcaataaaa tcccagtctc ctttgagtgg tccagtggct cctctgtcat
     1561 ctttactaac tggtaccctc tggagcctcg aattcttcca aacagaagac aactgtgtgt
     1621 ctcagccgag gaatctgacg gacgctggaa agtgaaagat tgtaaagaaa gactctttta
     1681 tatttgtaag aaagcagggc aagtccctgc tgatgagcag tccggatgtc cagcgggctg
     1741 ggagagacac ggcagatttt gttacaaaat cgacacagtc ctgcgaagct ttgaggaggc
     1801 ttcgagtggc tattactgct ctcctgcgct cctgaccatc accagccgat ttgaacaagc
     1861 ttttattacc agtttgatca gtagtgtggc agaaaaggac agttattttt ggattgctct
     1921 tcaagaccaa aacaatacag gagagtacac ttggaagacc gtggggcaga gggagccggt
     1981 gcagtacaca tactggaaca cgcgtcaacc cagcaatcgt ggtggctgcg ttgttgtacg
     2041 aggaggaagt tcacttggtc gctgggaagt gaaggattgt agcgacttta aggcaatgtc
     2101 tctgtgcaag acaccagtca aaatctggga gaaaacagag cttgaagaga gatggccgtt
     2161 tcacccctgc tatatggatt gggaatcagc cactggtctg gccagttgct tcaaggtgtt
     2221 tcatagcgaa aaggtcctga tgaaaagatc gtggagagaa gcagaagcat tctgtgagga
     2281 gtttggggct cacctcgcaa gctttgccca tatagaggaa gaaaatttcg tgaatgagct
     2341 tctacattca aaatttaatt ggacacagga aaggcagttc tggattggat ttaatagaag
     2401 gaacccactg aatgctggtt cttgggcgtg gtctgacggg tcacctgttg tctcttcatt
     2461 tttagacaat gcttattttg aagaagatgc aaaaaattgt gctgtgtata aggcaaacaa
     2521 aacattgttg ccctcgaact gtgcctccaa acacgagtgg atatgcagaa ttccaagaga
     2581 tgtgagaccc aagtttccag actggtacca gtacgatgcg ccgtggctct tctatcagaa
     2641 cgccgagtac ctcttccaca cccacccagc ggagtgggcc acctttgagt ttgtctgcgg
     2701 ctggctgcga agtgacttcc tcacaattta ttctgctcag gagcaagaat tcatccacag
     2761 caaaatcaaa gggctgacaa agtatggtgt gaagtggtgg atcggacttg aagaaggagg
     2821 agccagagat caaattcagt ggagtaacgg gtcgcccgtg atattccaga actgggacaa
     2881 aggaagagaa gaaagagtgg atagccagag aaagcgatgt gtcttcatat cttccataac
     2941 agggctctgg gggactgaga actgctctgt tcctttgccc agcatctgta agcgagtgaa
     3001 gatatgggtc atcgagaagg agaagccgcc gacacagcct gggacatgcc ccaaggggtg
     3061 gctgtatttt aactataagt gcttcctggt gacaattccc aaggaccctc gggagctgaa
     3121 gacctggaca ggtgctcagg aattctgtgt cgccaagggt gggacgctgg tctccatcaa
     3181 aagtgaattg gaacaagctt ttattactat gaatcttttt ggccagacca cgaatgtgtg
     3241 gatagggtta caaagtacta atcatgagaa atgggtaaat gggaagcctc tggtgtactc
     3301 taactggtct ccatcggata taataaatat accaagttat aacaccactg aatttcaaaa
     3361 gcatattcct ctctgtgccc tcatgtcaag taatcctaat ttccatttta ctggaaaatg
     3421 gtatttcgat gactgtggga aagaaggcta tggatttgtc tgtgaaaaaa tgcaagacac
     3481 ccttgaacac catgtaaacg tgtctgatac gtctgcaatc cccagtacgt tagaatatgg
     3541 aaacagaact tataagataa tccgtggtaa tatgacttgg tatgcagccg gaaagtcctg
     3601 ccggatgcac agagcagaac tggccagcat tccagatgcg tttcaccagg ccttcctcac
     3661 ggttctcctc agcaggctgg gacacaccca ctggattgga ctctccacca cagacaatgg
     3721 tcagactttt gactggtcgg acggcaccaa atcccctttc acctattgga aggatgagga
     3781 gtcggccttt cttggtgact gcgcttttgc tgacaccaac ggacgctggc atagcacagc
     3841 ctgcgagtca tttctgcaag gcgccatttg tcacgtagtc actgaaacaa aggcatttga
     3901 gcacccaggg ctgtgctcag aaacatcagt tccctggata aaatttaaag gtaactgcta
     3961 cagtttttcc acagtcctgg acagcaggag ttttgaagat gctcatgaat tttgcaaaag
     4021 tgaaggatct aatctgttgg caatcaggga tgcggctgaa aattcatttc tcctggaaga
     4081 gcttcttgcg tttgggtctt ctgtgcagat ggtttggttg aatgctcagt ttgataataa
     4141 caacaaaacc ttaaggtggt ttgacggaac acccacagag cagtccaact ggggccttcg
     4201 gaagccagac atggaccacc tcaagccaca tccgtgtgtt gtcctgagga tcccggaagg
     4261 aatatggcac tttaccccat gcgaggacaa aaaggggttc atatgtaaaa tggaagcagg
     4321 catcccagct gtaacggcgc agccagagaa aggactaagc cacagcatcg ttcctgtcac
     4381 agtaacgctg acgttgataa tagccctggg cattttcatg ctttgcttct ggatatataa
     4441 gcagaaaagt gacatcttcc agagactcac ggggtctcgg ggttcttact accccacact
     4501 caacttcagc acagcacatt tagaagagaa cattctcatt tctgatcttg agaagaacac
     4561 caatgatgaa gaagttagag atgctccagc tacagagagc aaaagaggcc acaaagggcg
     4621 tcctatctgc atttcccctt aacgagatgc cgttatagtg tgaattgcgc ctctgtttta
     4681 attaatcttc aagcactggt tttgaatctt aaccaaatca gatgggattt aacgtattca
     4741 tttcctttaa ctgtggccca ttctgaaaag gcccattatt ttaaaagaca agaactatta
     4801 aatagaattc tcaggccagt ctggtaagca ttcagtgtgt aggtacactc gatacattaa
     4861 gagaaagggg gcgtgtcctc tcactccata tgacaggatg gtacttctgc cagtcagtgc
     4921 ttgtttgatt ctaaatcaac catttttaaa tggtgtggtt tgggaaaatc ctaaatttta
     4981 gacttcaggt tctgagctct caactaatac tttgaatgac aaagttatat tagatctgat
     5041 tctcaagtta agtgggagaa ataccacctt ctcctacata tgaagaactc agtaggcagg
     5101 cactctcaag aacaaccata cagtttaaac tgtgccataa accctcacct gttaattgat
     5161 taccttgatt taaagatatc ttttaggtaa gtttaaagaa atgcattgag agtttaatat
     5221 tgtcaaagtt catgggcctt acttattaaa aactaaaatc taaaattata aaatactata
     5281 taacaatctt ttgttattgt tctgttctgt tttgttttca agacacagct tctttgtata
     5341 aacagtcctg gcggtcctag aattcacttt gtatgccaga ctagcctcaa accctctgcc
     5401 tcccaagtgc tgggattaaa ggtgtgtgcc accactacct ggcaatatgt aatctaacca
     5461 gggcttacag aatagatgta actcaaactt aaagagaaaa aaaagtgaag atctgaattg
     5521 tgctcccatt agaaccaaac taaacaagat gttgaaaaaa tactgaataa aacaaccctg
     5581 gagaaggtgt tttaaaataa actgtccatt ctgaccatct ccttttagtc ttggattagt
     5641 tgatgccatt ggttggttaa tgaggattaa gagtatgata tttggggcca ggagacagtt
     5701 cagttggtaa agtatctgct gtgccatctt gaggacctga gttcaaatcc ccagtaccca
     5761 cataaagact aagtgcagtg gtgcacatct gcaaccccag ctctggggtg ggtatgggac
     5821 aaaaccaggc gaatcccaga agctctttca ccagccagtc tcgccaagct gatgaatttc
     5881 aggttcagtg acagacttta tctcaaaaac tatcatggga aaagacacct aatgtcagac
     5941 tttagcctca gtatgcccac acatatatgt gcatgcacac acacacacat taaaatttta
     6001 aagtatattt cctgtgtatt aaaaggtcac aggtttgata ttctgtcatt aatttatgat
     6061 aaataaaagt gtctccataa tcaagagtaa gaggttactt gccgtctgag tgtttactgg
     6121 gtgtctttat taagatagat cttctgttct agcacagtcc tggggtgaac cagtcagggt
     6181 ggcttctatg ctcatgacac gttattccca gggaagcaat ctatacacag acgacaggag
     6241 gtagctatga aaattaagta tggtccctgg gataaacatg ggcactctca ggcttgcctc
     6301 cttgtgtatt tctgccagta caatccatgg ccctggtgct acctgccact cgtcactagg
     6361 gggcgctctg agaaaaagta tgaatgtgtt ctgcacagca aactgggatc cttatcagta
     6421 caacctgaag actagagtcc ctgtagacta ttacaacgac tacagctccc ggtcacagct
     6481 ctttgctact gctgttatgt ggctgacaca ctgggacact tgactctcat tttgttttcc
     6541 aagtcatagg acttaacttt taaaagaaca ttatattagg tagcagttat atatttatga
     6601 ctcaaaagaa ctaaccggat ggtataaaga ctcaatttaa aaaactctca agtgaaatta
     6661 aatttccttt tattttggtg gatttgatga agctgtggtc aattagcctc ccagtaaaag
     6721 tataaaatca cacataacaa gtggacaaaa gtatgccctt gcagccgtgg ccttgctgaa
     6781 agagatgaga ttgctgtcaa ggctctgttt tgaaatcctg tgttgagcct tccctgaagc
     6841 ctgtccccat gaaccaattt gcacttgttc ccactgctga aatttcagaa acatagagta
     6901 ctaagggact cgcttttttc acatatgaac cctttaaaat ccttttcata gatctcttct
     6961 tctttcatta atttaaaaat atttttcata cagtatatct tgaccatatt ccttctcctc
     7021 tcagaccttc cccatctcct tccccacctg acttcatatt ctctctattt ctcaacaaca
     7081 gtacaattaa aataaactaa caaaataata ag
//
