LOCUS       NM_013737               1923 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus phospholipase A2, group VII (platelet-activating
            factor acetylhydrolase, plasma) (Pla2g7), mRNA.
ACCESSION   NM_013737 XM_915078 XM_923555 XM_923566 XM_923573 XM_923580
VERSION     NM_013737.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Yao J and Zhao Y.
  TITLE     Lp-PLA2 silencing ameliorates inflammation and autophagy in
            nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3
            pathway
  JOURNAL   PeerJ 11, e15639 (2023)
   PUBMED   37397012
  REMARK    GeneRIF: Lp-PLA2 silencing ameliorates inflammation and autophagy
            in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo
            MM, Trowe MO and Kispert A.
  TITLE     Permissive ureter specification by TBX18-mediated repression of
            metanephric gene expression
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960826
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Wang J, Jiang M, Xiong A, Zhang L, Luo L, Liu Y, Liu S, Ran Q, Wu
            D, Xiong Y, He X, Leung EL and Li G.
  TITLE     Integrated analysis of single-cell and bulk RNA sequencing reveals
            pro-fibrotic PLA2G7high macrophages in pulmonary fibrosis
  JOURNAL   Pharmacol Res 182, 106286 (2022)
   PUBMED   35662628
  REMARK    GeneRIF: Integrated analysis of single-cell and bulk RNA sequencing
            reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary
            fibrosis.
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Moriyama H, Endo J, Kataoka M, Shimanaka Y, Kono N, Sugiura Y, Goto
            S, Kitakata H, Hiraide T, Yoshida N, Isobe S, Yamamoto T, Shirakawa
            K, Anzai A, Katsumata Y, Suematsu M, Kosaki K, Fukuda K, Arai H and
            Sano M.
  TITLE     Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells
            regulate pulmonary vascular remodeling
  JOURNAL   Nat Commun 13 (1), 3013 (2022)
   PUBMED   35641514
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A,
            Nguyen K, Aladyeva E, Predeus AN, Smith SR, Ravussin E, Galban C,
            Artyomov MN and Dixit VD.
  TITLE     Caloric restriction in humans reveals immunometabolic regulators of
            health span
  JOURNAL   Science 375 (6581), 671-677 (2022)
   PUBMED   35143297
  REMARK    GeneRIF: Caloric restriction in humans reveals immunometabolic
            regulators of health span.
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Stafforini DM, Sheller JR, Blackwell TS, Sapirstein A, Yull FE,
            McIntyre TM, Bonventre JV, Prescott SM and Roberts LJ 2nd.
  TITLE     Release of free F2-isoprostanes from esterified phospholipids is
            catalyzed by intracellular and plasma platelet-activating factor
            acetylhydrolases
  JOURNAL   J Biol Chem 281 (8), 4616-4623 (2006)
   PUBMED   16371369
  REMARK    GeneRIF: PAF acetylhydrolases play key roles in the hydrolysis of
            F2-isoprostanes esterified on phospholipids in vivo
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Koizumi H, Yamaguchi N, Hattori M, Ishikawa TO, Aoki J, Taketo MM,
            Inoue K and Arai H.
  TITLE     Targeted disruption of intracellular type I platelet activating
            factor-acetylhydrolase catalytic subunits causes severe impairment
            in spermatogenesis
  JOURNAL   J Biol Chem 278 (14), 12489-12494 (2003)
   PUBMED   12551946
  REMARK    GeneRIF: deletion of both subunits induces a marked loss of germ
            cells at an early spermatogenic stage.
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Chami O and O'Neill C.
  TITLE     Identification and regulation of the platelet-activating factor
            acetylhydrolase activity in the mouse uterus in early pregnancy
  JOURNAL   Reprod Fertil Dev 13 (5-6), 367-376 (2001)
   PUBMED   11833932
  REMARK    GeneRIF: PAF acetylhydrolase activity in the uterus in early
            pregnancy was not produced locally but probably resulted from the
            influx of the plasma form of the enzyme
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Tjoelker LW, Eberhardt C, Unger J, Trong HL, Zimmerman GA, McIntyre
            TM, Stafforini DM, Prescott SM and Gray PW.
  TITLE     Plasma platelet-activating factor acetylhydrolase is a secreted
            phospholipase A2 with a catalytic triad
  JOURNAL   J Biol Chem 270 (43), 25481-25487 (1995)
   PUBMED   7592717
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Tjoelker LW, Wilder C, Eberhardt C, Stafforini DM, Dietsch G,
            Schimpf B, Hooper S, Le Trong H, Cousens LS, Zimmerman GA, Yamada
            Y, McIntyre TM, Prescott SM and Gray PW.
  TITLE     Anti-inflammatory properties of a platelet-activating factor
            acetylhydrolase
  JOURNAL   Nature 374 (6522), 549-553 (1995)
   PUBMED   7700381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051454.1 and BF020830.1.
            
            [WARNING] On Oct 26, 2023 this sequence was replaced by
            NM_013737.6.
            
            On Oct 25, 2007 this sequence version replaced NM_013737.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010726.1, SRR1660817.154013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1754              AK051454.1         2-1755
            1755-1923           BF020830.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.74 cM"
     gene            1..1923
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /note="phospholipase A2, group VII (platelet-activating
                     factor acetylhydrolase, plasma)"
                     /db_xref="GeneID:27226"
                     /db_xref="MGI:MGI:1351327"
     exon            1..336
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            337..476
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            477..598
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            599..743
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            744..837
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            838..906
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1030
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1144
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1236
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1407
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1556
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1915
                     /gene="Pla2g7"
                     /gene_synonym="PAF-AH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcagga tccacgcatg ggcgctcgaa gaggtccaag tggtggctgt ccctggagct
       61 agtgttgtgt gagcctgagt cgcagcagct tggagctgtc aggaggctgg gccacacgct
      121 cctcccctgt ccctcttgca cagcaaccgg aggaggggag ggtcgagcct aaaggtagat
      181 tttacgagga ggctgtatgc tcaacccacc tctgagttat tctatccccg ggggtaaaaa
      241 gactgtctgg aagcctgccg tgctaggatc tgactcgctc tggtggcatt gctgcgctca
      301 gggttctggg tatccgggag tcagtgcagt gaccagaaca tcaaactgaa gccactgctc
      361 agctcctaag atggtaccac tcaaactgca ggcgcttttc tgcctcctct gctgcctccc
      421 atgggtccat ccttttcact ggcaagacac atcttctttt gacttcaggc cgtcagtaat
      481 gtttcacaag ctccaatcgg tgatgtctgc tgccggctct ggccatagta aaatccccaa
      541 aggaaatgga tcgtaccccg tcggttgtac agatctgatg ttcggttatg ggaatgagag
      601 cgtcttcgtg cgtttgtact acccagctca agatcaaggt cgcctcgaca ctgtttggat
      661 cccaaacaaa gaatattttt tgggtcttag tatatttctt ggaacaccca gtattgtagg
      721 caatatttta cacctcttat atggttctct gacaactcct gcaagctgga attctccttt
      781 gaggactgga gaaaaatacc cactcattgt cttttctcat ggtctcggag ccttcaggac
      841 gatttattct gctattggca ttggcttggc atctaatggg tttatagtgg ccactgtcga
      901 acacagagac agatctgcat cggcaactta cttttttgaa gaccaggtgg ctgcaaaagt
      961 ggaaaacagg tcttggcttt acctgagaaa agtaaaacaa gaggagtcgg aaagtgtccg
     1021 gaaagaacag gttcagcaaa gagcaataga atgttcccgg gctctcagtg cgattcttga
     1081 cattgaacat ggagacccaa aagagaatgt actaggttca gcttttgaca tgaaacagct
     1141 gaaggatgct attgatgaga ctaaaatagc tttgatggga cattcttttg gaggagcaac
     1201 agttcttcaa gcccttagtg aggaccagag attcagatgt ggagttgctc ttgatccatg
     1261 gatgtatccg gtgaacgaag agctgtactc cagaaccctc cagcctctcc tctttatcaa
     1321 ctctgccaaa ttccagactc caaaggacat cgcaaaaatg aaaaagttct accagcctga
     1381 caaggaaagg aaaatgatta caatcaaggg ctcagtgcac cagaactttg acgactttac
     1441 ttttgtaact ggcaaaataa ttggaaacaa gctgacactg aaaggagaaa tcgattccag
     1501 agtagccatc gacctcacca acaaagcttc gatggctttc ttacaaaagc atttagggct
     1561 tcagaaagac tttgatcagt gggaccctct ggtggaagga gatgatgaga acctgattcc
     1621 tgggtcaccc tttgacgcag tcacccaggt cccggctcag caacactctc caggatcaca
     1681 gacccagaat tagaagaact tgcttgttac acagttgcct tttaaaagta gagtgacatg
     1741 agagagagag agagagagag cgcacgcgcg cgcgcgcgcg cgcgcgagca atgtatttac
     1801 ccaaataagc attttttaaa tatacactgt actgtaggat agtgatgaac gcctagccta
     1861 agattttttt ccccctgtaa atgtaacgaa tataaaatag agaatacaaa aatgaaaaaa
     1921 aaa
//
