LOCUS       NM_001122954            2140 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus phospholipase A2, group V (Pla2g5), transcript variant
            1, mRNA.
ACCESSION   NM_001122954
VERSION     NM_001122954.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Htwe YM, Wang H, Belvitch P, Meliton L, Bandela M, Letsiou E and
            Dudek SM.
  TITLE     Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute
            Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus
  JOURNAL   Cells 10 (7), 1731 (2021)
   PUBMED   34359901
  REMARK    GeneRIF: Group V Phospholipase A2 Mediates Endothelial Dysfunction
            and Acute Lung Injury Caused by Methicillin-Resistant
            Staphylococcus Aureus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Koganesawa M, Yamaguchi M, Samuchiwal SK and Balestrieri B.
  TITLE     Lipid Profile of Activated Macrophages and Contribution of Group V
            Phospholipase A2
  JOURNAL   Biomolecules 11 (1), 25 (2020)
   PUBMED   33383652
  REMARK    GeneRIF: Lipid Profile of Activated Macrophages and Contribution of
            Group V Phospholipase A2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Watanabe K, Taketomi Y, Miki Y, Kugiyama K and Murakami M.
  TITLE     Group V secreted phospholipase A2 plays a protective role against
            aortic dissection
  JOURNAL   J Biol Chem 295 (30), 10092-10111 (2020)
   PUBMED   32482892
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Meliton LN, Zhu X, Brown M, Epshtein Y, Kawasaki T, Letsiou E and
            Dudek SM.
  TITLE     Degradation of group V secretory phospholipase A2 in lung
            endothelium is mediated by autophagy
  JOURNAL   Microvasc Res 129, 103954 (2020)
   PUBMED   31730773
  REMARK    GeneRIF: Lysosome-mediated autophagy pathway contributes to gVPLA2
            clearance from lung endothelial cells.
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M,
            Kimura Y, Matsumoto Y, Kimura Y, Maruno T, Kanda K, Nishi K,
            Takaori K, Uemoto S, Takaishi S, Chiba T, Nishi E and Seno H.
  TITLE     Nardilysin inhibits pancreatitis and suppresses pancreatic ductal
            adenocarcinoma initiation in mice
  JOURNAL   Gut 68 (5), 882-892 (2019)
   PUBMED   29798841
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Balboa MA, Balsinde J, Winstead MV, Tischfield JA and Dennis EA.
  TITLE     Novel group V phospholipase A2 involved in arachidonic acid
            mobilization in murine P388D1 macrophages
  JOURNAL   J Biol Chem 271 (50), 32381-32384 (1996)
   PUBMED   8943302
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Bingham CO 3rd, Murakami M, Fujishima H, Hunt JE, Austen KF and Arm
            JP.
  TITLE     A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide
            synthase-2 are functionally linked in the delayed phase of
            prostaglandin D2 generation in mouse bone marrow-derived mast cells
  JOURNAL   J Biol Chem 271 (42), 25936-25944 (1996)
   PUBMED   8824228
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Welch CL, Xia YR, Shechter I, Farese R, Mehrabian M, Mehdizadeh S,
            Warden CH and Lusis AJ.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ,
            Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G and
            Lusis AJ.
  TITLE     Low-molecular-weight, calcium-dependent phospholipase A2 genes are
            linked and map to homologous chromosome regions in mouse and human
  JOURNAL   Genomics 32 (3), 328-333 (1996)
   PUBMED   8838795
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Dennis EA.
  TITLE     Diversity of group types, regulation, and function of phospholipase
            A2
  JOURNAL   J Biol Chem 269 (18), 13057-13060 (1994)
   PUBMED   8175726
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY015217.1, BY012884.1, BC030899.1 and CK384107.1.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_001122954.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090021.1, SRR12282455.6381053.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY015217.1         14-50
            38-411              BY012884.1         1-374
            412-2126            BC030899.1         214-1928
            2127-2140           CK384107.1         304-317
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..2140
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /note="phospholipase A2, group V"
                     /db_xref="GeneID:18784"
                     /db_xref="MGI:MGI:101899"
     exon            1..300
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            301..416
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..466
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..611
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..718
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..2133
                     /gene="Pla2g5"
                     /gene_synonym="PLA2; sPLA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctgatgtg actagccagc ggccatgctt ccccaccgtg atgaactaca aggagtcaga
       61 gtaacccctt ctttaacctg cttttgtcag gtgtcttgtc agcccaggga cctatagaaa
      121 tgcagattct taagccccac ccagacctgc tggatcagaa actctgtgga ttgggtcctg
      181 gaagtaaaac ttactggctc ttttttggta gttctgatgc tccctcaagt gtcaagacca
      241 ctgctttaaa gagaaagatt gatgtactag gggtgtcaag gaagaagagg aaatgaggtg
      301 cttgtagacc ctgatgcttg tgctgccggc cataaacgca gggatccaga ctctgtctac
      361 tgaggctgct cctaggaacg ggccctggga acaggcgctg agaccaggct acaaagaacc
      421 caagagatga agggtctcct cacactggct tggttcctgg cttgcagtgt gcctgcagtc
      481 ccagggggct tgctagaact caagtccatg attgagaagg tgaccaggaa gaatgccttt
      541 aagaactatg gcttctacgg ctgctactgt ggctggggcg gtcgcgggac acccaaggat
      601 ggcactgatt ggtgctgtca gatgcacgac cgttgttatg ggcaactgga ggaaaaagac
      661 tgtgccattc ggacccagtc ctatgactac agatacacaa atggcctagt catctgcgaa
      721 cacgactcct tctgtccaat gaggctctgt gcctgtgacc ggaagctggt ctactgcctg
      781 cggagaaacc tctggactta caaccctctt taccagtatt accccaactt cctctgctaa
      841 tgtccgctgt gcgctctgcc ctgggggcac ctcccacggt ggcagtctcc ctctgctgta
      901 ttcctgatgt gtcccgcctc ccccacaagg tcttggatct gccttcctct gtgcaccagt
      961 ggactggaca gagccccccc ccccccccag ggctacactc ttccctccag agtccgagga
     1021 agggactttg atctagagtt ggcagactct caggatggct gagcctgcac ttgctaagtt
     1081 ggctctgggc cctgaagctc ccccggctca ggccagccgt gttgactttt ctttcaattt
     1141 ctggaaccca actgtcatta gcaccctcca gagacctttt actggaggag aagccaaatt
     1201 aactctataa atctgctatg tagatattaa ataaaaccca ttctcaaggc tagaaaaaca
     1261 ccaccccagc acttcctctg acggggctgg ggtgggattg cccacgcttt tccaaccccc
     1321 cccccccccc gaggcatctg tatgctctcg gggatggagg tcaggaaaca ggtgggagcc
     1381 ttgacgcctt gatgcctttc atggtttgtc ttgagttcat tttcttcaac cttaggctcc
     1441 ttcaagccag acctggggtt tatgtttctt ctggaggaag atgagacaca gccctatgcc
     1501 accttgagct cctggctaga gagggcaaca atcagctccc agccctggct tctggcagct
     1561 gtatggtctt ttaaaccttt ggatagtccg aatctctctg gctctcctca aaatataaaa
     1621 caaggctcct tccaggagta tactggtgca caccccaatc ccagcacctg gaaggtggag
     1681 gcaagagaat cgggagttca aggccagcct ctgctcccta gcagggatag tagcctagac
     1741 tatgtgagac tgtgtttcag aaaggaccct ggtacagata caggggagct ggggttctga
     1801 gatgtcactc agtgagaaaa atggtttaaa taagattcgg gggggggggg tagagatata
     1861 tcaatggcgg aatgtctgtc tatttttcac cgagttaggg gctctgaaaa tctcaagtca
     1921 tctatcgctt tataaaagac agaactttct catagcaaca agacaggagg aagagatgta
     1981 ttcaacagta aagcagtgtc cttccggagg aagggtctag gcttcttcaa atggagctcc
     2041 agaatgtgca cgggacacat ccgatctata tttagagacc tttagtgttc aaacattttc
     2101 taaataaagc taattatatg agactaccct gaaaaaaaaa
//
