LOCUS       NM_001024137            3311 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus phospholipase A2, group IVD (Pla2g4d), mRNA.
ACCESSION   NM_001024137 XM_355379
VERSION     NM_001024137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3311)
  AUTHORS   Breithofer,J., Bulfon,D., Fawzy,N., Tischitz,M., Zitta,C.,
            Hartig,L., Grabner,G.F., Pirchheim,A., Hackl,H., Taschler,U.,
            Lass,A., Tam-Amersdorfer,C., Strobl,H., Kratky,D. and Zimmermann,R.
  TITLE     Phospholipase A2 group IVD mediates the transacylation of
            glycerophospholipids and acylglycerols
  JOURNAL   J Lipid Res 65 (12), 100685 (2024)
   PUBMED   39490928
REFERENCE   2  (bases 1 to 3311)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3311)
  AUTHORS   MacKnight,H.P., Stephenson,D.J., Hoeferlin,L.A., Benusa,S.D.,
            DeLigio,J.T., Maus,K.D., Ali,A.N., Wayne,J.S., Park,M.A.,
            Hinchcliffe,E.H., Brown,R.E., Ryan,J.J., Diegelmann,R.F. and
            Chalfant,C.E.
  TITLE     The interaction of ceramide 1-phosphate with group IVA cytosolic
            phospholipase A2 coordinates acute wound healing and repair
  JOURNAL   Sci Signal 12 (610) (2019)
   PUBMED   31796632
  REMARK    GeneRIF: The interaction of ceramide 1-phosphate with group IVA
            cytosolic phospholipase A2 coordinates acute wound healing and
            repair.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3311)
  AUTHORS   Ohto,T., Uozumi,N., Hirabayashi,T. and Shimizu,T.
  TITLE     Identification of novel cytosolic phospholipase A(2)s, murine
            cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster
            with cPLA(2){beta}
  JOURNAL   J Biol Chem 280 (26), 24576-24583 (2005)
   PUBMED   15866882
  REMARK    GeneRIF: murine cytosolic phospholipases A2 delta, epsilon, and
            zeta form a gene cluster with cPLA(2)beta
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB195276.1.
            
            On Jun 18, 2005 this sequence version replaced XM_355379.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB195276.1, AK145985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3311
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.31 cM"
     gene            1..3311
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /note="phospholipase A2, group IVD"
                     /db_xref="GeneID:78390"
                     /db_xref="MGI:MGI:1925640"
     exon            1..110
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2516
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /EC_number="3.1.1.4"
                     /note="cPLA2-delta"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 delta"
                     /protein_id="NP_001019308.1"
                     /db_xref="CCDS:CCDS16617.1"
                     /db_xref="GeneID:78390"
                     /db_xref="MGI:MGI:1925640"
                     /translation="MWSGDRRVGMESLSPERLHGHPYQEEASVFCRLTVKILEARSLP
                     RADLLSQADPYVTVQLPTASGMKFKTQTVTNSSHPVWNETFSFLIQSQVKNILELTIY
                     DEDVITKDDICFKVSYDVSEILPGQLLQKTFSLNPQGPEELDVELLMERTWDPPENLI
                     TNNVLVARELSHLDVSLDRAGNTAMAAGQDKLELELMLKGSYEDTQTFFPDTAFTFSF
                     HYMRGQDTELNGYLRGPRNSGWNSDTSVTPFNVPLMSLAAGKEMTIDIPAMKAPEGKL
                     QLKTDCCPKELSVRLSYGLCPEEQAFLSRRKKVVAAALKQALQLDEDLNEDEVPVVGI
                     NAEGGGMRAMISLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYRDPEWSQRDLEG
                     PISHAREHVAKTLLKEFLPEHLASYRQTLKLREEQGYTVTVADLWGLVLESKLHGQVT
                     DQKLSGQRAALERGQNPLPLYLSLNVKENHLETLHFKEWVEFSPYEVGFLKYGGFVPS
                     ELFGSEFFMGRLMKRLPESQICFLEGIWSNLFSVNLMDIWYDITYGKDSNNFPVDVRN
                     SEKEFSGSAGTSSGVEAPWLESGTALAQALKGFLTGRPFHQRSANFLHGLQLHRDYCN
                     QRHFSTWADCNLDDTPNQLTPQDPQLCLIDAGCFMNSSCPSLFRPGRQVDLIISFNYN
                     QSLPFKGLQQSEKYSRARGLPFPRVEPSPEDHSQPQECYLFSDPTCPEAPVVLHFPLV
                     NDSFRDHSAPGVRRSPDELKAGQVNLTGAASPYFMYNMTYKNEDFDRLLQLSDYNVQN
                     NQGTILQALRTVLKRRASETRPLGVKT"
     exon            111..183
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            184..320
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            453..493
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            494..536
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            537..600
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            601..737
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            738..848
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            849..886
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1022
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1159
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1382
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1500
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1638
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1740
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1935
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2102
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2289
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..3286
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2997..3002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /note="hexamer: AAGAAA"
     polyA_site      3017
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /note="major polyA site"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /note="hexamer: CATAAA"
     polyA_site      3280
                     /gene="Pla2g4d"
                     /gene_synonym="2610311B01Rik; cPLA2delta; Pla2delta"
                     /note="major polyA site"
ORIGIN      
        1 agagtcacag ccggacttcg catccagcca ggagttggat gtggagtgga gatagaagag
       61 taggcatgga gagcctgtca cccgagagac tacatggcca tccttaccag gaggaggcct
      121 ctgtcttctg ccggctcact gtgaaaatcc tggaggctcg gagtctgccc agggctgacc
      181 tgttgagtca ggcagatccc tatgtgactg tgcagctgcc aacagcttct ggaatgaaat
      241 tcaagaccca aacagtcact aactccagtc atcctgtgtg gaacgagacc ttcagtttcc
      301 tcatccagag tcaggtcaag aacattctag aactaactat ctatgacgaa gacgtaatta
      361 cgaaagatga catctgcttc aaggtttctt atgatgtctc agaaatcctt cctggacagc
      421 tgctccagaa aaccttcagc ctgaatcctc agggaccaga agagttagat gtggagctcc
      481 taatggaaag aacgtgggac cctccagaaa acctcatcac caacaatgtt cttgtggccc
      541 gagaactgtc acacctggat gtctccctgg acagagccgg gaacaccgcc atggcagcag
      601 gccaggacaa actagagctg gagcttatgc tgaaggggtc atatgaggac acacagacat
      661 ttttcccgga cacagctttt accttcagct tccactacat gaggggccaa gacacagaac
      721 tgaatgggta cctgaggggc cccagaaaca gtggctggaa ctcagatacc tcggtgacac
      781 ctttcaatgt acccctgatg tcgttggccg cagggaagga gatgaccata gacattcctg
      841 ctatgaaggc tccagaaggg aagctgcagc ttaagacaga ctgttgcccc aaagagctgt
      901 ctgtgaggct gagctatggg ctctgtcccg aggagcaggc cttcctaagc aggaggaaga
      961 aggtggtggc tgccgccctg aagcaggctc tgcaactgga tgaagacttg aacgaagatg
     1021 aggtccctgt tgtgggcatc aatgctgagg gaggaggtat gcgggctatg atctcactct
     1081 acggccacct actggcgctt cagaagttgg gcctcctgga ctgtgtgacc tacttcagtg
     1141 gcatctcagg ctctacatgg acaatggccc acctgtacag ggacccagag tggtcacaga
     1201 gggacctcga aggacccatc agtcatgcta gggagcatgt ggctaaaacc ctgctgaagg
     1261 aattcctccc cgaacacttg gcaagctacc gccagacact gaagcttcgg gaagagcagg
     1321 gctacaccgt cacggtagca gacctgtggg gcctggtgct ggagtccaag ctgcatgggc
     1381 aggtgacaga tcagaagctg tcaggacaga gagctgcact ggagaggggt cagaaccctt
     1441 tgcctctcta cttgagcctc aatgtcaaag agaaccatct ggaaaccctc cacttcaagg
     1501 aatgggtaga gttctctccc tatgaagttg ggtttctgaa atatggaggc tttgtccctt
     1561 ctgagctctt cggctctgag ttcttcatgg gacggctgat gaagagactt cccgagtccc
     1621 agatttgctt tctggaaggt atctggagca accttttctc tgtgaacctg atggatatct
     1681 ggtatgacat cacctatggg aaagactcaa acaatttccc tgtggatgtc cggaactcag
     1741 agaaggagtt ctcaggctca gcaggaacct cctctggtgt ggaggcccca tggctggagt
     1801 ctggaacagc tctggcccag gcacttaagg gctttctgac tggcaggcca ttccaccagc
     1861 gtagcgccaa cttcctccat ggcctccagc tgcaccggga ctactgtaac cagagacact
     1921 tctccacctg ggcggattgc aacctagatg acaccccgaa tcagctgacc ccacaggacc
     1981 ctcagctctg cctaattgat gctggctgct tcatgaacag cagctgtccc tccctgttcc
     2041 gcccaggtcg ccaagtggac ctcataatct ccttcaatta caaccaatcc cttcccttta
     2101 aggggctgca gcaatctgag aaatacagca gagctcgggg cctgcccttc ccccgtgtgg
     2161 agcccagccc agaggaccac agccagcccc aggaatgtta cctcttctca gaccccacct
     2221 gcccggaagc acccgttgtg ctgcacttcc cgctggtcaa tgactccttc agggatcact
     2281 cagcccctgg tgtcaggcgc agccctgatg agctcaaggc tgggcaggtg aatctcacag
     2341 gggctgcctc cccctacttc atgtacaaca tgacctacaa gaacgaagat ttcgaccggt
     2401 tgcttcagct ctctgactac aatgttcaga acaaccaggg cactatcctg caggccctga
     2461 ggacagttct gaaacggagg gcttcagaga ccaggccatt gggagtgaag acgtgaggct
     2521 tctcaggggg tctctgaggc tctgaagacc acactatgat cctccaactt ccaagggctt
     2581 aactcagcct gcatctaggc acagtggcag tgcctttggc tggagcttcc agttctccac
     2641 ccacatttgt atttctggct ggagggaaag gaccccttcc atggggctca gcttcctcag
     2701 ggcctggctg agcgacagtc ttgcacacct atggaagcca ctgcagctgg cctcactgcc
     2761 cagagggcgt accccaccct ccatccttcc ctgtgtttcc agttggtcct agaggaattg
     2821 aatacctcct gtgacacgta cataagacac ctgatggcag cagactgttc actgctaatg
     2881 gacatctcct tagtttttgt agtttgaact tgaatcctgc aatcttcagt tcaccagctt
     2941 gaatactttt tggtggattc tggagggaat tcagttatgg atcttgcgat ctatgaaaga
     3001 aatggtcttc cttcctcctt cctggttcga atgtgtttta tttcttgttc tgactgaatt
     3061 gccctgacta gaatcctgga cattgtgctc cacggacacg gcaagagtag ccatccttgg
     3121 ttttatttct gatatggaag gacagcatca aggcttccta ccgttttgct gttcaatctt
     3181 aagtgggttt gggttttgtc agattgaaaa cattctgttc tgtccctagt ttgttgagtg
     3241 gttttgttgt tagtgatatc ataaaaaggt attgaatgtt gtcgcgaaaa aaaaaaaaaa
     3301 aaaaaaaaaa a
//
