LOCUS       NM_001168504            3390 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus phospholipase A2, group IVC (cytosolic,
            calcium-independent) (Pla2g4c), transcript variant 1, mRNA.
ACCESSION   NM_001168504
VERSION     NM_001168504.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Chiba,Y., Suto,W. and Sakai,H.
  TITLE     Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle
            tissues of experimental asthma
  JOURNAL   PLoS One 13 (8), e0202623 (2018)
   PUBMED   30161143
  REMARK    GeneRIF: Validation of differentially expressed genes (DEGs) by
            quantitative RT-PCR showed a significant increase in PLA2 group 4c
            (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in
            bronchoalveolar fluids of the OA-challenged mice was significantly
            increased. A 24-h incubation of BSM tissues with PGD2 caused a
            hyperresponsiveness to acetylcholine in naive control mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Bickford,J.S., Newsom,K.J., Herlihy,J.D., Mueller,C., Keeler,B.,
            Qiu,X., Walters,J.N., Su,N., Wallet,S.M., Flotte,T.R. and Nick,H.S.
  TITLE     Induction of group IVC phospholipase A2 in allergic asthma:
            transcriptional regulation by TNFalpha in bronchoepithelial cells
  JOURNAL   Biochem J 442 (1), 127-137 (2012)
   PUBMED   22082005
  REMARK    GeneRIF: results link cytokine-mediated alterations in cPLA2gamma
            gene expression with allergic asthma and outline a complex
            regulatory mechanism
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Mancuso,D.J., Sims,H.F., Yang,K., Kiebish,M.A., Su,X.,
            Jenkins,C.M., Guan,S., Moon,S.H., Pietka,T., Nassir,F., Schappe,T.,
            Moore,K., Han,X., Abumrad,N.A. and Gross,R.W.
  TITLE     Genetic ablation of calcium-independent phospholipase A2gamma
            prevents obesity and insulin resistance during high fat feeding by
            mitochondrial uncoupling and increased adipocyte fatty acid
            oxidation
  JOURNAL   J Biol Chem 285 (47), 36495-36510 (2010)
   PUBMED   20817734
  REMARK    GeneRIF: Genetic ablation of calcium-independent phospholipase
            A2gamma prevents obesity and insulin resistance during high fat
            feeding by mitochondrial uncoupling and increased adipocyte fatty
            acid oxidation.
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Vignola,M.J., Kashatus,D.F., Taylor,G.A., Counter,C.M. and
            Valdivia,R.H.
  TITLE     cPLA2 regulates the expression of type I interferons and
            intracellular immunity to Chlamydia trachomatis
  JOURNAL   J Biol Chem 285 (28), 21625-21635 (2010)
   PUBMED   20452986
  REMARK    GeneRIF: cPLA(2) has a role in the induction of cell autonomous
            cellular immunity to Chlamydia
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Mancuso,D.J., Han,X., Jenkins,C.M., Lehman,J.J., Sambandam,N.,
            Sims,H.F., Yang,J., Yan,W., Yang,K., Green,K., Abendschein,D.R.,
            Saffitz,J.E. and Gross,R.W.
  TITLE     Dramatic accumulation of triglycerides and precipitation of cardiac
            hemodynamic dysfunction during brief caloric restriction in
            transgenic myocardium expressing human calcium-independent
            phospholipase A2gamma
  JOURNAL   J Biol Chem 282 (12), 9216-9227 (2007)
   PUBMED   17213206
  REMARK    GeneRIF: iPLA2gamma has roles in the lipid plasticity of
            myocardium, in generating signaling metabolites, and in modulating
            energy storage and utilization in myocardium in different metabolic
            contexts
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Vitale,A., Perlin,J., Leonelli,L., Herr,J., Wright,P., Digilio,L.
            and Coonrod,S.
  TITLE     Mouse cPLA2gamma, a novel oocyte and early embryo-abundant
            phospholipase A2 gamma-like protein, is targeted to the nuclear
            envelope during germinal vesicle breakdown
  JOURNAL   Dev Biol 282 (2), 374-384 (2005)
   PUBMED   15950603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC117808.1 and AC161792.9.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117808.1, SRR9219380.91833.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2072              BC117808.1         1-2072
            2073-3390           AC161792.9         161108-162425
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.84 cM"
     gene            1..3390
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /note="phospholipase A2, group IVC (cytosolic,
                     calcium-independent)"
                     /db_xref="GeneID:232889"
                     /db_xref="MGI:MGI:1196403"
     exon            1..111
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1897
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 is encoded by transcript variant 1; egg
                     and early embryo abundant protein; CPLA2-gamma; cytosolic
                     phospholipase A2 gamma; cytosolic lysophospholipase;
                     cytosolic lysophospholipid O-acyltransferase"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 gamma isoform 1"
                     /protein_id="NP_001161976.1"
                     /db_xref="CCDS:CCDS52027.1"
                     /db_xref="GeneID:232889"
                     /db_xref="MGI:MGI:1196403"
                     /translation="MSCAESPKSLHKRSSGVCPATRLQEAEKAAVHKRSPKVLEALRK
                     LNIQADQAPVIAVLGSGGGLRAHIACLGVLSELKELGLLDAVTYLAGVSGSTWALSSL
                     YTKNGNMEGIEEELKHRYEKNEWDFHESLEKAIQASKRENYSLTDFWAYLIVSRQIRE
                     LQDSNLSSLKKQVEEGVLPYPIFAAIDEDLLADWRERKTQNSWFEFTPHHAGYPALGA
                     YVPITEFGSRFENGKLVKSEPERDLTFLRGLWGSAFADIKEIKNYILNYFRNPFGKLK
                     FIEGPVTYSEAPRMNVDAMLLDLVMAYFTDMNDPSIKDKLCALQQALGTETDEFGIEM
                     AEIIQNWNETSAEKKEQFLDHLLDRFKKTQEDTTTYSLMNWNTGLVWDRCVFVNETRK
                     CVSKWQWGTVYNFLYKHGKIADETMCSRELLHLVDAGFAINTPYPLVLPPVRETHLIL
                     SFDFSAGDPLETIRATADYCQRHEIPFPEVSEDQLKEWAKAPASCYVLRGETGPVVMH
                     FTLFNKDNCGDDIETWRKKYGTVKLSDSYTPDLVRDLLRVSKENVKKNKINILSEMRK
                     VAGNPGNIPRVNKEACLGDRVKDPQGSQTVEFKKSHNISKD"
     exon            112..226
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            227..363
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            364..553
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            554..674
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            675..815
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            816..869
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            870..911
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1055
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1205
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1301
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1456
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1628
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1779
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1906
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..3390
                     /gene="Pla2g4c"
                     /gene_synonym="D7Ertd445e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatcccacg acaaagctgg tcgtgattgt gccacaggag aaagcaactt tgaaagtagt
       61 agaagtcagg aagatgagct gtgccgagtc tcccaaatca ctacataagc gaagctctgg
      121 ggtctgccct gccactagac tccaggaagc agaaaaggca gctgtgcaca aacgcagtcc
      181 caaggttttg gaggctctac gaaagctcaa catccaagct gaccaggctc cagtcattgc
      241 tgtcttgggc tctggcgggg ggctgcgggc ccacatcgct tgtcttggtg tgctgagtga
      301 gctgaaagaa cttggcctgt tggatgctgt cacatacctc gcaggggtct ctgggtccac
      361 ttgggcactg tcttcactct acaccaagaa tggaaatatg gaagggatag aagaggagct
      421 gaaacatcgg tatgagaaga atgagtggga ctttcatgag agcctggaga aagccatcca
      481 ggcatcaaag agggagaatt actccctgac tgacttttgg gcctatttaa ttgtttccag
      541 gcaaatcaga gaacttcagg attcgaattt gtccagtcta aagaagcaag tggaagaagg
      601 agtgctgccc tatcccatct ttgcagccat tgatgaggac cttctggctg attggaggga
      661 gaggaaaact cagaattcct ggtttgaatt cactcctcat catgctggct accctgcact
      721 tggggcttat gtccccatca cagagtttgg aagcagattt gagaatggga aactggttaa
      781 atctgagcct gagagagatt tgactttcct gagaggttta tggggaagtg cttttgctga
      841 tattaaagaa attaagaatt atattttgaa ctacttcagg aacccctttg gaaaattgaa
      901 gtttatagaa ggaccagtga catactcaga agcaccaagg atgaatgtgg atgcaatgct
      961 cttggattta gtgatggctt atttcacaga tatgaatgac cccagcatca aggataagct
     1021 ctgtgccctt cagcaggctc tgggtactga gacagatgaa tttggcatag agatggctga
     1081 gatcatccag aattggaatg agacctccgc agagaagaag gagcagtttc tcgaccatct
     1141 gttggatcgc ttcaagaaga cacaagaaga caccaccaca tacagtttga tgaactggaa
     1201 cacgggtcta gtttgggacc gttgcgtttt tgtgaatgaa actcgcaagt gtgtctccaa
     1261 atggcagtgg ggaactgttt acaacttcct ctataaacac ggtaaaattg cagatgagac
     1321 catgtgcagc cgagagcttc tccatctggt ggatgctggt tttgccatca acactcccta
     1381 tccacttgtt ctgcctcctg tgcgtgaaac tcacctcatc ctctcatttg acttcagtgc
     1441 tggggaccca ctagagacca tcagggccac agcagactac tgccaacgcc atgaaatccc
     1501 ctttcctgag gtgagcgagg atcagctgaa ggaatgggcc aaagccccag caagctgcta
     1561 tgtcctcaga ggggaaacag gacctgttgt catgcacttt actctgttca acaaagacaa
     1621 ctgtggagat gatattgaga catggagaaa aaaatatggg acagtaaaac tatctgactc
     1681 atacacacca gacctggtga gagatttgct gagggtatcc aaggagaatg tgaagaaaaa
     1741 caaaattaat atcctcagtg agatgaggaa agtggctggg aatcctggga acatcccaag
     1801 agtgaacaag gaggcctgct tgggagacag agtgaaggat ccccaaggct ctcagactgt
     1861 ggagtttaag aaatcccaca acatatctaa ggattaagga tcctttgcac tacttggaga
     1921 gttggcatct attagtggac tcaccacctg tgctctctcc aaagtccacc gtaagctgtc
     1981 tctttgtgaa gaagaactgc agttttcagg gtactgtggg cctactgctt taccagggcc
     2041 caagtgtcaa cctggcctga tgttctctgc cactcataaa attgcatttg ccttagctat
     2101 taccattgag caagtctcca gagacctaga tggtgtcttt gatagcatta tttagggcac
     2161 tgggtcacca gagctaaaag aggcaaagta tgttcttcag atacctcagg ggaccctaaa
     2221 gctagagcac aactccttga tcatcaaagc caccctgtcc aacatccatg tggctaaaat
     2281 gaatgtagtg attgagacca aagcctcata aatttttctc tcattcttta tctgctcatt
     2341 ttatacaccc agtcttacta agttcttttt ttttttttct ataaaaggat agaccttagc
     2401 tcaaatcatg acccatcact tcagagcaat taaaaaaacc cagacaactc tgagaagaca
     2461 tgttctgtat atgcttgcgt atctgctgcc ttagtgcctc cttcctgctt gcctacttcc
     2521 tctcctttcc atcccttcca cctgtaactc ttctctgatt tggattccac aatcttctca
     2581 ttgtaatatc acaggcaagt tccttcacat gaattccttt aatcatctat ggaataaatg
     2641 tgcattgtgg ttgtgccctg gtcttaagac ctttggcctg ctctggtaca aagaaagttt
     2701 gcaagaggca ttactcattt ttccccaagc caatgctggt ttctttttat taaaaattac
     2761 taatttttca atggcattca agattatggg attcatcatg gcattttata cacatacgaa
     2821 tagtttgtta atttgtttcc cattgtttcc ttttagcctt ccttctttct tatgtgggtc
     2881 ttcttcctcc cttcaaatat tttcctcctg ctcttgtatg tatgcacaaa tatgtatttt
     2941 aagttcagca tgtaaaagaa gacatgcaat atttttcctt tttttatctc tcaattttcc
     3001 tcttgccctc catctcttag gattccttcc ttccagcaaa ttgtccccct tgtactttca
     3061 taacttatat aatacattga gatggataag agaaagatag gtcaaaaggt taaaaatagg
     3121 tgagagatag aaggtaatta gataagatac atagttagta gattgatgat agctataagg
     3181 tggatagata agatagatga ttaattgatt acagaaggaa tataataggt tgatagctag
     3241 gtagctatta ttgttatgaa ggagaacatg atacttgtct tttgggggct gatttctttt
     3301 gtttaacatg atgggttcca gatctgtcca tttttctaca aacaatgtaa ttttcctctt
     3361 cccaatgact caataaacat aaaagacttc
//
