LOCUS       NM_145378               3859 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phospholipase A2, group IVB (cytosolic) (Pla2g4b),
            mRNA.
ACCESSION   NM_145378 XM_355378 XM_358347 XM_892847 XM_900371 XM_900375
            XM_900391 XM_900400 XM_900408 XM_900416 XM_900430 XM_917664
            XM_925074 XM_925078 XM_925084 XM_925088 XM_925090 XM_925092
            XM_925095 XM_983757 XM_983791 XM_983829 XM_983873 XM_983913
            XM_984017
VERSION     NM_145378.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3859)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3859)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3859)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3859)
  AUTHORS   Gao,Y., Lu,J., Bao,X., Yi,X., Peng,C., Chen,W., Zhen,T., Shi,Y.,
            Xing,K., Zhu,S. and Ding,Y.
  TITLE     Inhibition of phospholipases suppresses progression of psoriasis
            through modulation of inflammation
  JOURNAL   Exp Biol Med (Maywood) 246 (11), 1253-1262 (2021)
   PUBMED   33641447
  REMARK    GeneRIF: Inhibition of phospholipases suppresses progression of
            psoriasis through modulation of inflammation.
REFERENCE   5  (bases 1 to 3859)
  AUTHORS   Choi,J.H., Wang,K.W., Zhang,D., Zhan,X., Wang,T., Bu,C.H.,
            Behrendt,C.L., Zeng,M., Wang,Y., Misawa,T., Li,X., Tang,M.,
            Zhan,X., Scott,L., Hildebrand,S., Murray,A.R., Moresco,E.M.,
            Hooper,L.V. and Beutler,B.
  TITLE     IgD class switching is initiated by microbiota and limited to
            mucosa-associated lymphoid tissue in mice
  JOURNAL   Proc Natl Acad Sci U S A 114 (7), E1196-E1204 (2017)
   PUBMED   28137874
REFERENCE   6  (bases 1 to 3859)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3859)
  AUTHORS   Lee,I.T., Lee,C.W., Tung,W.H., Wang,S.W., Lin,C.C., Shu,J.C. and
            Yang,C.M.
  TITLE     Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic
            acid-induced cPLA2/COX-2-dependent airway inflammatory responses
  JOURNAL   Am J Pathol 176 (4), 1671-1684 (2010)
   PUBMED   20167866
  REMARK    GeneRIF: TLR2 cooperates with MyD88, PI3K, and Rac1 in lipoteichoic
            acid-induced cPLA2/COX-2-dependent airway inflammatory responses
REFERENCE   8  (bases 1 to 3859)
  AUTHORS   Ghosh,M., Loper,R., Ghomashchi,F., Tucker,D.E., Bonventre,J.V.,
            Gelb,M.H. and Leslie,C.C.
  TITLE     Function, activity, and membrane targeting of cytosolic
            phospholipase A(2)zeta in mouse lung fibroblasts
  JOURNAL   J Biol Chem 282 (16), 11676-11686 (2007)
   PUBMED   17293613
REFERENCE   9  (bases 1 to 3859)
  AUTHORS   Ohto,T., Uozumi,N., Hirabayashi,T. and Shimizu,T.
  TITLE     Identification of novel cytosolic phospholipase A(2)s, murine
            cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster
            with cPLA(2){beta}
  JOURNAL   J Biol Chem 280 (26), 24576-24583 (2005)
   PUBMED   15866882
  REMARK    GeneRIF: murine cytosolic phospholipases A2 delta, epsilon, and
            zeta form a gene cluster with cPLA(2)beta
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137721.1, DQ888308.1 and AL833774.4.
            
            On Oct 22, 2013 this sequence version replaced NM_145378.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849376,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AK137721.1         2-93
            93-2441             DQ888308.1         1-2349
            2442-3859           AL833774.4         144998-146415       c
FEATURES             Location/Qualifiers
     source          1..3859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.09 cM"
     gene            1..3859
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="phospholipase A2, group IVB (cytosolic)"
                     /db_xref="GeneID:211429"
                     /db_xref="MGI:MGI:2384819"
     exon            1..74
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2441
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2 group IVB; lysophospholipase A1
                     group IVB"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 beta"
                     /protein_id="NP_663353.3"
                     /db_xref="CCDS:CCDS38209.2"
                     /db_xref="GeneID:211429"
                     /db_xref="MGI:MGI:2384819"
                     /translation="MALQTCPVYMQAKVPETCLLTVRVLRASGLPSKDLVTSSDCYVT
                     LNLPTASSHTLQTRTVKNSRNPVWNQNFHFRIHRQLKNVMELKVFDHDLVTRDDPVLS
                     VLFDVGTLQIGTQRQSFSLGTQEKGCLEVEFRLQTLTDCEEQLISNGIVVARELSCLH
                     VELKRTGDPKRSERKVQLVVAGACEGPQDASAGTGSFHFHYPACWEQELNVHLQDDPH
                     EQLKVPLRTLPSSQLVRLVFPTSQEPLMRLELKKEEGPKELAVRLGCGPCPEEQAFLS
                     KRKQVVAAALKKALQLDQDLHEDEIPVIAVMATGGGIRAMTSLYGQLAGLQELGLLDC
                     ISYITGASGSTWALANLYEDPEWSQKDLAGPTEVLKTQVTKSKLGALAPSQLWRYRQE
                     LAERARLGHPTCFTNLWALINEALLHDKPHEHKLSDQREALSRGQNPLPIYCALNSKE
                     QGLSTFDFGEWCEFSPYEVGFPKYGAFISSELFGSEFFMGRLVKQLPESRICFLEGIW
                     SNLFAASLQDSLYWSSEPSQFWDRWAQDQANLDKEQVPHLKIAEPPTMAGRIAELFTD
                     LLTKRPLAHATHNFTRGLHFHKDYFQNSHFSAWKASKLDRLPNQLTPTEPHLCLLDVG
                     YLINTSCPPLLQPTRDVDLILSLDYNLYGAFQQLQLLSRFCQEQGIPFPSISPSPEEQ
                     RQPQECHLFCDPAQPEAPAVLHFPLVNDSFQDYSAPGVPRTSEEKAAGEVNLSSSDSP
                     YHYTKVTYSQEDVDKLLRLTHYNICNNQDRLREAMHQAVQRRRKRKQFRPE"
     exon            75..171
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            172..308
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            309..437
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            438..478
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            479..521
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            522..576
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            577..707
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            708..791
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            792..829
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            830..965
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1102
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1325
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1443
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1581
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1686
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1866
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2033
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2220
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3859
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2755..2760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="hexamer: TATAAA"
     polyA_site      2792
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="major polyA site"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="hexamer: AATAAA"
     polyA_site      3651
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
     regulatory      3818..3823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="hexamer: CATAAA"
     regulatory      3822..3827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="hexamer: AATAAA"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
                     /note="hexamer: AATAAA"
     polyA_site      3835
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
     polyA_site      3839
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
     polyA_site      3859
                     /gene="Pla2g4b"
                     /gene_synonym="A030011C02Rik; cPLA2-beta; Gm1013"
ORIGIN      
        1 aaagctgaca gttgttggtt ctgtggccac tacgccatca ttcctgttcc tgtggacttg
       61 gtctcatggc tctgcaaacc tgcccagtct acatgcaggc aaaggtgcca gagacatgcc
      121 tgctcactgt acgcgtcctc cgggccagtg gcttgccttc caaggaccta gtaacctcct
      181 ctgactgcta tgtgactctg aacctgccca cggcttccag ccacacgctc cagacacgca
      241 cagtcaagaa cagccgaaac cctgtctgga atcagaactt ccacttccgg atccataggc
      301 agctcaagaa tgttatggaa ctgaaagtct ttgaccatga cctggtgacc agagatgacc
      361 cagtattgtc agtgctgttt gacgtgggga ccctgcaaat tgggactcag cgccagagct
      421 tctccttggg tactcaggag aaagggtgct tagaagttga gtttcggcta cagactctga
      481 cagactgtga ggaacagctc atcagcaatg gcatcgtggt ggcccgggaa ctctcctgct
      541 tgcacgttga actgaagagg acaggagatc caaagaggtc agagcgcaaa gttcaacttg
      601 tggttgctgg ggcctgtgag ggcccacagg atgcctctgc gggcactgga tctttccact
      661 tccattatcc agcctgctgg gagcaagagc tgaatgttca tctgcaggat gacccccatg
      721 agcagctgaa ggtgccacta cgaactctac cctcctcgca gctggtgaga cttgtcttcc
      781 ccacgtccca ggagccactg atgaggctgg aactcaagaa ggaagaagga ccaaaggagc
      841 tggctgtgcg gctgggctgt gggccctgcc ctgaggaaca ggccttccta agcaagagga
      901 agcaggtggt ggctgccgcg ctgaaaaagg ccttacagct ggaccaagac ctgcacgagg
      961 atgagatccc cgtgattgcc gtgatggcca ctggtggtgg gatccgggcc atgacgtctt
     1021 tgtatgggca gctggccggc ctgcaggagc tcggccttct cgactgcatc tcctatatca
     1081 cgggggcttc aggatccacc tgggcactgg ccaacctcta tgaggaccca gagtggtcgc
     1141 agaaggacct ggcagggccc actgaggtgc tgaagacaca ggtgacaaag agcaagctgg
     1201 gtgcgttggc ccctagccaa ctttggcggt accggcaaga gctggctgag cgtgctcgcc
     1261 tgggccaccc aacctgcttc accaacttgt gggccctcat taatgaggcc ttgctgcacg
     1321 acaagcccca tgaacacaaa ctctcagatc aacgagaggc cctgagtcga ggccagaacc
     1381 ctctgcctat ctattgtgcc ctcaacagca aggagcaggg cctgagtacc tttgactttg
     1441 gggagtggtg tgagttctct ccatatgaag tcggcttccc caagtatgga gccttcatct
     1501 cctccgagct ctttggctcg gagttcttta tggggcggct ggtgaagcag cttcccgagt
     1561 cccgcatctg cttcctggaa ggcatctgga gcaatctgtt tgcggccagc ctccaagaca
     1621 gcttgtactg gtcctcagaa cccagccagt tctgggaccg ctgggcgcag gatcaggcca
     1681 acctggacaa agagcaggtc ccccatctga agatagcaga gccaccgaca atggctggca
     1741 ggatcgccga gctcttcact gacctcctga caaagcgtcc cctcgcccac gccacccaca
     1801 acttcacgcg aggcctccat ttccacaagg actatttcca gaactctcac ttctctgcct
     1861 ggaaagcttc caaactggac aggctcccca accagctgac acccactgag ccccacctct
     1921 gcctcctgga tgttggctat ctcatcaata ctagctgccc acccctcctg cagccaacac
     1981 gggatgtgga cctcatcttg tcactggact acaacctcta cggagccttt cagcagctgc
     2041 agcttctgag ccggttctgc caggagcagg gcatcccttt cccatccatc tcacccagcc
     2101 ccgaggagca gcggcagcct caggagtgcc atctgttctg tgacccagcc cagcccgaag
     2161 ccccggctgt gctgcacttc cctttggtca atgactcctt ccaagactac tctgcccctg
     2221 gggtgccacg gacatcggag gagaaggcag ctggggaggt gaatctgtct tcttctgact
     2281 ccccatacca ctacacaaaa gtgacctaca gccaggaaga tgtggacaag ctgttacggc
     2341 tgacgcatta caacatctgc aacaaccagg atcggctgcg ggaggccatg caccaggccg
     2401 tgcagcggcg gagaaagcgc aaacagttta ggccggagtg acagctgagc taccctggct
     2461 gggctcctgc ctgggtcact cttggtcttt aactcctttc cccttctgct ccgagttcaa
     2521 gaccagcatc accaactgct ccagagactc tggaaactct gatgtccagg cacagctcca
     2581 caaaggtgtg tctgggactt ccacaagtga cactaacatg tcagcagccc tgtcacagag
     2641 tctaggctgg aagctgcaag cagaggtgct atggccatca tccatggatg gacttggggc
     2701 tcgttagaga cgggacactg tgacacggaa catttgacat gttacagggg tgcttataaa
     2761 cgggaggtgc ttgtggcact gtcccaagag tatctgctgt accaggctgt tacttccact
     2821 ctgaaagcag gtcccttccc aagaggcctc gagcatggac gttccggtcc tgtcacaggt
     2881 tgccatcttt gcccagagat cttgcaatga agccatggtt catctcaggc atagccagtg
     2941 acttgcgaca tcagttgctt gtcctctgac aggagctgtg ttctgcacac tggtcctgag
     3001 cagccctggg gagggtacct ttgggtcagt agtcgagtgg ttcccaggtg tgtctccact
     3061 ggtagccccg aggattggtg ttgactgagg attcatctta aggtttagac ctgtagggag
     3121 aacagagatt aggaaccaac caccctccct aaacatggtg tctagtcctc tccatacctg
     3181 aacatccctc ctgctcctag ctgaggtgtg agcaggtact agaggctctg agatgagtag
     3241 ggtgtaacaa ctttgattct catgatccag caagctctgt cagccaggca agtgtttgtc
     3301 ccaacaccat tagaagccac tatgagctgg acctggtggc ataggtctct aatcccagct
     3361 acgcaggaga ctaagtcagg aagagtacaa gttcaaagcc agcctgggct acaagagtga
     3421 gttcaaggcc acaatttagc tgtcaagtaa aagataacta aggggggctg gagagatggc
     3481 tcagtggtta agagcactgg ctgctattcc agagatcctg agtacaattc ccaacaacca
     3541 catggtggct cacaaccatc tgtaatggga tctgatgcca ccttctggtg tgcctgaaga
     3601 tagcaacaat gtactcacat gcataaaata aatcaatctt aaaaggctaa atctcaggct
     3661 ggtgggatgg ctcagcggtt aagagtgcca actgctcttc caaaggtcct gagttcaaat
     3721 cacagcaacc acatggtggc tcacaaccat ctgtaatgaa atctgatgcc ctcttctaga
     3781 gtgtctgaag acggctacag tgtacttaca tataatacat aaataaataa ataaataaat
     3841 atttttttaa aaagttaaa
//
