LOCUS       NM_172791               2642 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus phospholipase A2, group III (Pla2g3), mRNA.
ACCESSION   NM_172791
VERSION     NM_172791.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2642)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 2642)
  AUTHORS   Tanaka,K., Dozono,N., Neyama,H., Nagai,J., Tsukahara,R.,
            Nagayasu,K., Kaneko,S. and Ueda,H.
  TITLE     Secreted PLA2-III is a possible therapeutic target to treat
            neuropathic pain
  JOURNAL   Biochem Biophys Res Commun 568, 167-173 (2021)
   PUBMED   34237486
  REMARK    GeneRIF: Secreted PLA2-III is a possible therapeutic target to
            treat neuropathic pain.
REFERENCE   3  (bases 1 to 2642)
  AUTHORS   Taketomi,Y., Endo,Y., Higashi,T., Murase,R., Ono,T., Taya,C.,
            Kobayashi,T. and Murakami,M.
  TITLE     Mast Cell-Specific Deletion of Group III Secreted Phospholipase A2
            Impairs Mast Cell Maturation and Functions
  JOURNAL   Cells 10 (7), 1691 (2021)
   PUBMED   34359862
  REMARK    GeneRIF: Mast Cell-Specific Deletion of Group III Secreted
            Phospholipase A2 Impairs Mast Cell Maturation and Functions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2642)
  AUTHORS   Watanabe,K., Taketomi,Y., Miki,Y., Kugiyama,K. and Murakami,M.
  TITLE     Group V secreted phospholipase A2 plays a protective role against
            aortic dissection
  JOURNAL   J Biol Chem 295 (30), 10092-10111 (2020)
   PUBMED   32482892
REFERENCE   5  (bases 1 to 2642)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2642)
  AUTHORS   Taketomi,Y., Ueno,N., Kojima,T., Sato,H., Murase,R., Yamamoto,K.,
            Tanaka,S., Sakanaka,M., Nakamura,M., Nishito,Y., Kawana,M.,
            Kambe,N., Ikeda,K., Taguchi,R., Nakamizo,S., Kabashima,K.,
            Gelb,M.H., Arita,M., Yokomizo,T., Nakamura,M., Watanabe,K.,
            Hirai,H., Nakamura,M., Okayama,Y., Ra,C., Aritake,K., Urade,Y.,
            Morimoto,K., Sugimoto,Y., Shimizu,T., Narumiya,S., Hara,S. and
            Murakami,M.
  TITLE     Mast cell maturation is driven via a group III phospholipase
            A2-prostaglandin D2-DP1 receptor paracrine axis
  JOURNAL   Nat Immunol 14 (6), 554-563 (2013)
   PUBMED   23624557
  REMARK    GeneRIF: Data indicate a PLA2G3-lipocalin-type PGD2 synthase
            (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation.
REFERENCE   7  (bases 1 to 2642)
  AUTHORS   Sato,H., Taketomi,Y., Isogai,Y., Miki,Y., Yamamoto,K., Masuda,S.,
            Hosono,T., Arata,S., Ishikawa,Y., Ishii,T., Kobayashi,T.,
            Nakanishi,H., Ikeda,K., Taguchi,R., Hara,S., Kudo,I. and
            Murakami,M.
  TITLE     Group III secreted phospholipase A2 regulates epididymal sperm
            maturation and fertility in mice
  JOURNAL   J Clin Invest 120 (5), 1400-1414 (2010)
   PUBMED   20424323
  REMARK    GeneRIF: the atypical sPLA2 family member sPLA2-III has a role in
            epididymal lipid homeostasis and its perturbation may lead to sperm
            dysfunction
REFERENCE   8  (bases 1 to 2642)
  AUTHORS   Sato,H., Taketomi,Y., Isogai,Y., Masuda,S., Kobayashi,T.,
            Yamamoto,K. and Murakami,M.
  TITLE     Group III secreted phospholipase A2 transgenic mice spontaneously
            develop inflammation
  JOURNAL   Biochem J 421 (1), 17-27 (2009)
   PUBMED   19371233
  REMARK    GeneRIF: This study showed that endogenous group III sPLA2 (PLA2G3)
            is expressed in mouse skin and that transgenic mice overexpressing
            human PLA2G3 spontaneously develop skin inflammation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2642)
  AUTHORS   Masuda,S., Yamamoto,K., Hirabayashi,T., Ishikawa,Y., Ishii,T.,
            Kudo,I. and Murakami,M.
  TITLE     Human group III secreted phospholipase A2 promotes neuronal
            outgrowth and survival
  JOURNAL   Biochem J 409 (2), 429-438 (2008)
   PUBMED   17868035
REFERENCE   10 (bases 1 to 2642)
  AUTHORS   Murakami,M., Masuda,S., Shimbara,S., Ishikawa,Y., Ishii,T. and
            Kudo,I.
  TITLE     Cellular distribution, post-translational modification, and
            tumorigenic potential of human group III secreted phospholipase
            A(2)
  JOURNAL   J Biol Chem 280 (26), 24987-24998 (2005)
   PUBMED   15863501
  REMARK    GeneRIF: sPLA(2)-III may have a role in cancer development by
            stimulating tumor cell growth and angiogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079556.1 and AK033572.1.
            
            On Apr 13, 2007 this sequence version replaced NM_172791.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079556.1, AK033572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BC079556.1         1-57
            58-2616             AK033572.1         2-2560
            2617-2642           BC079556.1         2617-2642
FEATURES             Location/Qualifiers
     source          1..2642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.45 cM"
     gene            1..2642
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /note="phospholipase A2, group III"
                     /db_xref="GeneID:237625"
                     /db_xref="MGI:MGI:2444945"
     exon            1..627
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1640
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /EC_number="3.1.1.4"
                     /note="GIII sPLA2; group III secretory phospholipase A2;
                     phosphatidylcholine 2-acylhydrolase 3; group 3 secretory
                     phospholipase A2"
                     /codon_start=1
                     /product="group 3 secretory phospholipase A2 precursor"
                     /protein_id="NP_766379.2"
                     /db_xref="CCDS:CCDS48740.1"
                     /db_xref="GeneID:237625"
                     /db_xref="MGI:MGI:2444945"
                     /translation="MGVLGVLLGVLAFLEGSHTRHWDSTSCHLVQPIPGNPLGSLSFL
                     GKDAQGLALFQAFWDTHHRLQVCIRQDESELITAFRALCAHEPLQHSFIQTPGPALQR
                     ALATLQSQWEACQRSQDSPTGAREKRAIEQSGAPDREHRRRRRGWTIPGTLWCGVGNS
                     AENASELGVFHGPDLCCREHDQCPQTISPLQYNYGIRNFRFHTISHCDCDARFQQCLR
                     SQGDSISDIMGVAFFNVLEIPCFVLKEQEACVAWNWWGGCRAYGSTPLAHLRPRTYYN
                     ASWKAEATSYTPSPQSPAPSKHPQKRGPQQTQARRHSTTTTTPFQTPAISSRPDMIPR
                     GQPGVPHLGFQDGPKHQSAHRVCRSLRHLDQCEHQIKPQETKFHLLNSAQMPLFHCDC
                     TRRLARFLRLHSPPAGTDKVWDLLGTTCFKLAPQLDCAEGKGCSRDHRAIKVSARHLQ
                     RLHKSRLHFRDKGTGGALAQPVEPPGSTMSFYSQCLQVTQAIWRRRGQKKFWSS"
     exon            628..760
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     exon            761..895
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1179
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1309
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1426
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..2623
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /note="hexamer: AGTAAA"
     polyA_site      2623
                     /gene="Pla2g3"
                     /gene_synonym="sPLA2-III"
                     /note="major polyA site"
ORIGIN      
        1 attcattggc cctgacaccc aggggctgct gggcatcgct tccgctggag cctcagcagc
       61 tgcctcaggg gcagtcaaag gcaggcatcc cggggctttg tctgaccagg ctggactaga
      121 gtagaatggg ggtcctgggg gtacttctag gagtgctggc tttcctagag ggctcccata
      181 cccgtcactg ggacagtacc tcctgccatt tggtccagcc catccctggt aaccctctgg
      241 gctccctgag cttcttgggc aaagatgccc aaggcctggc attattccag gccttctggg
      301 atacacacca caggctgcag gtttgtatca ggcaggatga atctgaactt atcacagcgt
      361 tcagggccct ctgtgctcat gagcctttgc agcactcctt catccaaacc cctggacctg
      421 cgctgcagag agcactggcc actctgcaga gccagtggga ggcatgtcaa aggtctcagg
      481 atagtcctac aggagccagg gagaagcgag caatagagca gagtggagca cctgacagag
      541 agcaccgtcg aaggaggaga ggctggacca ttcctggcac gctgtggtgc ggtgttggga
      601 actctgctga aaatgcctca gaactgggcg tgttccacgg ccctgacctc tgctgccggg
      661 aacacgatca gtgcccacaa accatttcgc ccttgcagta taactatggc atccgaaatt
      721 tccgcttcca caccatctct cactgcgact gtgacgccag gtttcaacag tgcctgagga
      781 gccagggtga ctccatctcc gacatcatgg gcgtggcctt cttcaacgtg ctggagatcc
      841 cctgctttgt gctgaaggag caggaggcct gtgtggcttg gaactggtgg ggcgggtgca
      901 gggcatatgg ctccacgccc cttgctcacc ttcggcccag gacttactat aatgcctcct
      961 ggaaggctga ggccacctca tatactccca gcccccaaag cccagcaccc agcaaacacc
     1021 cacagaagag gggcccacag cagacacaag ccagacgtca cagcacaact accactacac
     1081 ctttccagac ccctgccatc tcctccagac ctgatatgat ccccagaggc cagccaggag
     1141 ttccacatct gggcttccag gatggcccaa aacatcaaag tgcccaccga gtctgtcgaa
     1201 gccttcgcca cctggaccag tgtgagcacc agatcaagcc ccaggaaacc aagttccacc
     1261 tgctcaacag tgcccagatg ccccttttcc actgcgattg cacccgccgt ctggcacgtt
     1321 tcctgaggct ccacagcccg cctgcaggca ccgacaaagt ttgggatctc ctgggtacca
     1381 cctgctttaa gctggccccc caacttgact gtgctgaggg caaaggctgt tccagagacc
     1441 acagggccat taaggtgtca gctcggcact tgcagaggct tcacaagagc cgactccatt
     1501 tcagggataa aggcacaggt ggggctctgg cacagcctgt ggagccccca gggagcacca
     1561 tgtcattcta cagccagtgt ctgcaagtaa cccaggcaat ctggagacgc aggggacaga
     1621 agaaattctg gagctcataa tgacagtaac agcagcttgg gcaccagcct ggacctcctt
     1681 cctggtgttg ctatattctg agagacttgg ttggtctctt ctttgaggaa caacatggct
     1741 ctgatggact gcaggggggt tgatggaagg aacctcaagg tccaaatatt ggaccgcatc
     1801 tcccgctgta cttggtgacc ttgaactggt gacacaaccc ctctgtgccg ggatgtggtg
     1861 ttcagaggct attctgatgc cttgggctta gaccttgcca ggtaacttca tacacagata
     1921 gaaaagggga gtggctgatt ccaggaatcc aggaggtatg ggaaccaggt acttgagtgt
     1981 ccctgttgct agacctgcct ttctgagccc cagcacttta cagtgaggcc taaagccgta
     2041 ggtgggaaac caaggataca agagaaatgc ctgtacctga atccagggtg aggagggtgt
     2101 tcccacgttc tttacaggag accccttctt taaatagttt ctgggtcctt cctggcctga
     2161 actaatcttt ctgttctaat tctaaattga aatcttttct gtgcccatga ggagttaggg
     2221 caagggacct ccctcctcca catgggcctt agtgccctcc tctgaaagag aaggtagagg
     2281 tgggggtcat tattgtttgt ctgtctgagt cagggtttca ctgtagccca ggctagcttc
     2341 cgctatgtat aggagggtaa ccttgaactt ctggcccact ttcctctacc tccaaaatgc
     2401 tggaattgca ggcgtatgac atcacaccaa gttttaggtg atactgggga gagaaaccag
     2461 ggtgtcaacc cttccagcct ggttggagca tgctaccaac taaatcacac ccccagcttg
     2521 aaaaggggac ccgtaaccgt gaactacctc acaggggtgc tgaggagtaa atgaattaat
     2581 caacacacat accacccagt aaacattctt cttctctaac acaaaaaaaa aaaaaaaaaa
     2641 aa
//
