LOCUS       NM_012045               2437 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus phospholipase A2, group IIF (Pla2g2f), transcript
            variant 1, mRNA.
ACCESSION   NM_012045
VERSION     NM_012045.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2437)
  AUTHORS   Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y and
            Murakami M.
  TITLE     Expression and Function of Group IIE Phospholipase A2 in Mouse Skin
  JOURNAL   J Biol Chem 291 (30), 15602-15613 (2016)
   PUBMED   27226633
REFERENCE   2  (bases 1 to 2437)
  AUTHORS   Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, Gelb
            MH, Yamamoto K and Murakami M.
  TITLE     Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer
  JOURNAL   J Biol Chem 291 (30), 15588-15601 (2016)
   PUBMED   27226632
REFERENCE   3  (bases 1 to 2437)
  AUTHORS   Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K,
            Kobayashi T, Yamamoto T, Taketomi Y and Murakami M.
  TITLE     Group X Secreted Phospholipase A2 Releases omega3 Polyunsaturated
            Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility
  JOURNAL   J Biol Chem 291 (13), 6895-6911 (2016)
   PUBMED   26828067
REFERENCE   4  (bases 1 to 2437)
  AUTHORS   Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C,
            Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K,
            Lambeau G, Gelb MH and Murakami M.
  TITLE     The role of group IIF-secreted phospholipase A2 in epidermal
            homeostasis and hyperplasia
  JOURNAL   J Exp Med 212 (11), 1901-1919 (2015)
   PUBMED   26438362
  REMARK    GeneRIF: Ethanolamine lysoplasmalogen, a PLA2G2F-derived marker
            product, rescued defective activation of Pla2g2f(-/-) keratinocytes
            both in vitro and in vivo
REFERENCE   5  (bases 1 to 2437)
  AUTHORS   Man MQ, Lin TK, Santiago JL, Celli A, Zhong L, Huang ZM, Roelandt
            T, Hupe M, Sundberg JP, Silva KA, Crumrine D, Martin-Ezquerra G,
            Trullas C, Sun R, Wakefield JS, Wei ML, Feingold KR, Mauro TM and
            Elias PM.
  TITLE     Basis for enhanced barrier function of pigmented skin
  JOURNAL   J Invest Dermatol 134 (9), 2399-2407 (2014)
   PUBMED   24732399
  REMARK    GeneRIF: SKH2/J pigmented mice display enhanced expression of the
            stratum corneum acidifying enzyme, secretory phospholipase A2f
            (sPLA2f).
REFERENCE   6  (bases 1 to 2437)
  AUTHORS   Cankaya M, Hernandez AM, Ciftci M, Beydemir S, Ozdemir H, Budak H,
            Gulcin I, Comakli V, Emircupani T, Ekinci D, Kuzu M, Jiang Q,
            Eichele G and Kufrevioglu OI.
  TITLE     An analysis of expression patterns of genes encoding proteins with
            catalytic activities
  JOURNAL   BMC Genomics 8, 232 (2007)
   PUBMED   17626619
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2437)
  AUTHORS   Wijewickrama GT, Albanese A, Kim YJ, Oh YS, Murray PS, Takayanagi
            R, Tobe T, Masuda S, Murakami M, Kudo I, Ucker DS, Murray D and Cho
            W.
  TITLE     Unique membrane interaction mode of group IIF phospholipase A2
  JOURNAL   J Biol Chem 281 (43), 32741-32754 (2006)
   PUBMED   16931517
REFERENCE   8  (bases 1 to 2437)
  AUTHORS   Murakami M, Yoshihara K, Shimbara S, Lambeau G, Gelb MH, Singer AG,
            Sawada M, Inagaki N, Nagai H, Ishihara M, Ishikawa Y, Ishii T and
            Kudo I.
  TITLE     Cellular arachidonate-releasing function and
            inflammation-associated expression of group IIF secretory
            phospholipase A2
  JOURNAL   J Biol Chem 277 (21), 19145-19155 (2002)
   PUBMED   11877435
REFERENCE   9  (bases 1 to 2437)
  AUTHORS   Cormier RT, Bilger A, Lillich AJ, Halberg RB, Hong KH, Gould KA,
            Borenstein N, Lander ES and Dove WF.
  TITLE     The Mom1AKR intestinal tumor resistance region consists of Pla2g2a
            and a locus distal to D4Mit64
  JOURNAL   Oncogene 19 (28), 3182-3192 (2000)
   PUBMED   10918573
REFERENCE   10 (bases 1 to 2437)
  AUTHORS   Valentin E, Ghomashchi F, Gelb MH, Lazdunski M and Lambeau G.
  TITLE     On the diversity of secreted phospholipases A(2). Cloning, tissue
            distribution, and functional expression of two novel mouse group II
            enzymes
  JOURNAL   J Biol Chem 274 (44), 31195-31202 (1999)
   PUBMED   10531313
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY146964.1, AK029254.1 and BM942827.1.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_012045.5.
            
            On Jul 29, 2009 this sequence version replaced NM_012045.3.
            
            Transcript Variant: This variant (1) encodes a longer protein
            (isoform 1), which lacks a signal peptide. With the available data,
            it is not clear which start codon is most likely used.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029254.1, BC125567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BY146964.1         2-12
            12-991              AK029254.1         2-981
            992-992             BM942827.1         255-255
            993-2437            AK029254.1         982-2426
FEATURES             Location/Qualifiers
     source          1..2437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.56 cM"
     gene            1..2437
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /note="phospholipase A2, group IIF"
                     /db_xref="GeneID:26971"
                     /db_xref="MGI:MGI:1349661"
     exon            1..238
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            239..291
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            292..436
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            437..546
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
     exon            547..2437
                     /gene="Pla2g2f"
                     /gene_synonym="GIIFsPLA2; sPLA2-IIF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgccccgg cactaccctg cttgttgtgc gtgacagcgt gaagctgggg cctgctctcc
       61 agagactttt gggcatatta aggacctctc aagctctatg tcggtggcct tccaaaatcc
      121 acgacatggc agatggggca caggccaacc ccaaagggtt caggaagaag gcgctggtta
      181 aacactccac tggacggaag agcccaagcc tcagggcctc tccctctaaa acctccaggt
      241 ccagcctggg tatgaagaaa ttctttgcca tcgcagtcct ggccggcagt gtggtaacca
      301 cggcccacag cagcctgctg aacctgaagt ccatggtgga ggccatcaca cacagaaact
      361 ccatcctgtc ctttgtgggc tacggctgct actgcgggct ggggggacgc ggccatccca
      421 tggatgaggt agactggtgc tgccatgccc acgactgttg ctatgagaag ctctttgagc
      481 agggctgccg cccctacgtg gaccactatg accacaggat cgagaatggc accatgattg
      541 tctgcactga gctcaatgag acggagtgtg acaagcagac atgcgagtgt gacaagagcc
      601 tgactctgtg cctcaaggat cacccataca ggaacaagta ccgaggctac ttcaacgtct
      661 actgccaggg ccccacaccc aactgcagca tctatgaccc gtacccagag gaagtcacct
      721 gtgggcatgg cctccctgcg acccctgtct caacctagcc tgactgaggt ccgagagaag
      781 agacggtggg atgtcccgct ggggtctaca tctgatgtgt ggggccagat agggtgcaga
      841 actgtcctgt ggctccgtcc cagtcctgta gtgagctcag tactagaaga ttctagaagg
      901 ccagggcttg ttagtggtat cactctgtca gtcttacact aagcatctgg ggatctctcc
      961 tggatatgga aagaaatgat gacccccccc ccagctcaac tccaagaacc tttgagacct
     1021 ttcacaggcc tgaaaatcca ctcccaggca ggcaaagtgc caggttgagg cctgggttct
     1081 gggggggacc ctggagtccc acaagctgac ataaagagtc atctctactt ttcagacttg
     1141 tggctctcta gagtctcatt cacagagtgg gtgaccccat ccagtcctta gtcaacagga
     1201 tgcatctagg cccaaagcct gacctctctt acccagagtg cctccgggca ggcttcgagg
     1261 gcacagggac cccatataca cagtagctgc acatacaggg actggctgga ggtggtcaca
     1321 cctccacagt tcttcctgcc cctctgactc ctgcccagaa gtggtgggta cccccccacc
     1381 ccgtgccatt cattgtccca cccacattca gagcagcagg ccagggctgc tgggagctta
     1441 ctctctctct atgcagggag agcctagttc agactgtcac tggggaagac actaaggtct
     1501 gggttgaaat gtggaaggga gggtcaaatc aggagattga aaggaaaact caggtggaga
     1561 gggaacgggg tagtaaggaa aggagctggg ggagaggtag aggcaagttg tgatgaggct
     1621 caggccagtt gccagacatg tcagtgggaa cagcaaggga agggatggta aagggctagt
     1681 gttactgagg gtactgggcc ccacagctct ggggaatctt gggcagaggt gagggctcct
     1741 gctggcaggt cacctctgct atccccagcc tcatatttct tcaggtgtac ctttccctgt
     1801 cccctgcctc tccttccatc tcagggtcaa cagtgtctag ccctacctca tatctgtctt
     1861 ctgcctccat ccaatgtcaa cactgaggac ccagccttgt ccggatgctg acaatattca
     1921 ccgggaggct tagcttgtgt ggctacatgg gacactgtca ctggagacag agagccaagc
     1981 agggtggtat agaggcaggg aagggtgttt atgtagatag cggtgtctat aatggcagca
     2041 catgtgtgag aggggccact ctctgaagct tgcctcatgc tggttgtggt gtgacacagt
     2101 ggtcacttat gtgcactgac ccagcttgcc ccagccttgt gatcttcctc atttaccctc
     2161 tcagaggctc agccaacaag cctccctggt cttccctgcc tcactgctcc catcaagcca
     2221 ggggtggcgt tgggatgggc gcccagagag ttcctgctga gttttgacac cagacgtgtg
     2281 ggctcctgca tgggtatatt cctatagagt aggctgggcc aatgagactc tactgttgta
     2341 ggacccagct cacctgtacc tcaacccccc tccccctgtc tccacagaat acaacatctc
     2401 ttccccaaac taataaaaac cctcctgtct tggctgc
//
