LOCUS       NM_011109               2173 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus phospholipase A2, group IID (Pla2g2d), transcript
            variant 1, mRNA.
ACCESSION   NM_011109
VERSION     NM_011109.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2173)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 2173)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2173)
  AUTHORS   Zheng,J., Meyerholz,D., Wong,L.R., Gelb,M., Murakami,M. and
            Perlman,S.
  TITLE     Coronavirus-specific antibody production in middle-aged mice
            requires phospholipase A2G2D
  JOURNAL   J Clin Invest 131 (11) (2021)
   PUBMED   34060490
  REMARK    GeneRIF: Coronavirus-specific antibody production in middle-aged
            mice requires phospholipase A2G2D.
REFERENCE   4  (bases 1 to 2173)
  AUTHORS   Watanabe,K., Taketomi,Y., Miki,Y., Kugiyama,K. and Murakami,M.
  TITLE     Group V secreted phospholipase A2 plays a protective role against
            aortic dissection
  JOURNAL   J Biol Chem 295 (30), 10092-10111 (2020)
   PUBMED   32482892
REFERENCE   5  (bases 1 to 2173)
  AUTHORS   Sato,H., Taketomi,Y., Miki,Y., Murase,R., Yamamoto,K. and
            Murakami,M.
  TITLE     Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by
            Mobilizing omega3 Polyunsaturated Fatty Acids in WAT
  JOURNAL   Cell Rep 31 (5), 107579 (2020)
   PUBMED   32375030
  REMARK    GeneRIF: Secreted Phospholipase PLA2G2D Contributes to Metabolic
            Health by Mobilizing omega3 Polyunsaturated Fatty Acids in WAT.
REFERENCE   6  (bases 1 to 2173)
  AUTHORS   Cormier,R.T., Bilger,A., Lillich,A.J., Halberg,R.B., Hong,K.H.,
            Gould,K.A., Borenstein,N., Lander,E.S. and Dove,W.F.
  TITLE     The Mom1AKR intestinal tumor resistance region consists of Pla2g2a
            and a locus distal to D4Mit64
  JOURNAL   Oncogene 19 (28), 3182-3192 (2000)
   PUBMED   10918573
REFERENCE   7  (bases 1 to 2173)
  AUTHORS   Shakhov,A.N., Rubtsov,A.V., Lyakhov,I.G., Tumanov,A.V. and
            Nedospasov,S.A.
  TITLE     SPLASH (PLA2IID), a novel member of phospholipase A2 family, is
            associated with lymphotoxin deficiency
  JOURNAL   Genes Immun 1 (3), 191-199 (2000)
   PUBMED   11196711
REFERENCE   8  (bases 1 to 2173)
  AUTHORS   Valentin,E., Ghomashchi,F., Gelb,M.H., Lazdunski,M. and Lambeau,G.
  TITLE     On the diversity of secreted phospholipases A(2). Cloning, tissue
            distribution, and functional expression of two novel mouse group II
            enzymes
  JOURNAL   J Biol Chem 274 (44), 31195-31202 (1999)
   PUBMED   10531313
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
REFERENCE   9  (bases 1 to 2173)
  AUTHORS   Ishizaki,J., Suzuki,N., Higashino,K., Yokota,Y., Ono,T.,
            Kawamoto,K., Fujii,N., Arita,H. and Hanasaki,K.
  TITLE     Cloning and characterization of novel mouse and human secretory
            phospholipase A(2)s
  JOURNAL   J Biol Chem 274 (35), 24973-24979 (1999)
   PUBMED   10455175
REFERENCE   10 (bases 1 to 2173)
  AUTHORS   Valentin,E., Koduri,R.S., Scimeca,J.C., Carle,G., Gelb,M.H.,
            Lazdunski,M. and Lambeau,G.
  TITLE     Cloning and recombinant expression of a novel mouse-secreted
            phospholipase A2
  JOURNAL   J Biol Chem 274 (27), 19152-19160 (1999)
   PUBMED   10383420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844178.7.
            
            On Mar 26, 2018 this sequence version replaced NM_011109.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF169408.1, AF169407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL844178.7         111342-111457       c
            117-261             AL844178.7         108407-108551       c
            262-368             AL844178.7         107737-107843       c
            369-2173            AL844178.7         105140-106944       c
FEATURES             Location/Qualifiers
     source          1..2173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..2173
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /note="phospholipase A2, group IID"
                     /db_xref="GeneID:18782"
                     /db_xref="MGI:MGI:1341796"
     exon            1..116
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /inference="alignment:Splign:2.1.0"
     exon            117..261
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /inference="alignment:Splign:2.1.0"
     exon            262..368
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /inference="alignment:Splign:2.1.0"
     exon            369..2173
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1231..1236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /note="hexamer: AATAAA"
     polyA_site      1250
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /note="major polyA site"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /note="hexamer: AATAAA"
     polyA_site      2171
                     /gene="Pla2g2d"
                     /gene_synonym="GIID; GIID sPLA2; mGIID; PLA2IID;
                     sPLA2-IID; Splash"
                     /note="major polyA site"
ORIGIN      
        1 agcaggaggc gcgtgggttg ggtaggattc gcagggggac taacataagg ggctgcctgc
       61 cttgctctgg gctggaacta tgagactcgc cctgctgtgt gggctgctgc tggccggtat
      121 aactgcaacc cagggagggc tcctgaacct gaacaagatg gtcacacaca tgacggggaa
      181 gaaagccttc ttcagctact ggccctacgg ctgtcactgt ggacttggtg gcaaagggca
      241 acccaaagat gccacagact ggtgctgtca gaagcatgat tgttgctatg cccacctgaa
      301 gatcgatgga tgcaagagcc tgacagacaa ctacaaatac agcatctccc agggcactat
      361 ccagtgctct gacaacggga gctggtgtga aaggcaactg tgtgcttgtg acaaggaggt
      421 ggccttgtgc ttgaagcaaa acctggatag ctacaataag cgcctgcgtt actactggcg
      481 gccccgttgc aaaggcaaga ctccagcatg ctaagggagt ccactctgtc tgtcccctgg
      541 attccaccct gtcctgggac atctcaagca ttgaagtcct gcagcttgct gcctcccact
      601 ctggtgtcta gtctcctgga ccagctggct tttcaaggtc tccttgcaaa agggcctggc
      661 cttgaggact tcctcttggt gcctttctac tgtaaaggac ccttttgatc tttctaacgg
      721 tgacactcct ctcccttcaa actctggtct ttctggacca aggtcagagc tcagccctct
      781 gatgctgtgt tctcccccaa ctaagctatg agacctctag gttcagccct gccccatttc
      841 agattcagtg gtaccctctg gtggtacctt gattcaggag tcccctagaa ccaagcccat
      901 tatgggctcc aacaacaacg ggatttaagg gtgggggaag ttgcagtctt gttgcactcg
      961 gtgggtcctg gagcttggcc tgctgtttct tgcccgttgt gctttcgctg ggatctcttg
     1021 ctgcataata gctcaggctc cggggccgtc ctttggaagc ctctcttggc tagccattct
     1081 ccccagcgct aaggacatca ttgggctgga ctgtctgggt ggcatcacag cccacatttc
     1141 tcctgagacc aggatgatag atgttccagt actttgtctc atcccaggcc tggtttcttt
     1201 ctctggaaac tttctccaaa gagccctctt aataaacaac tttcacaaga gcccctgact
     1261 caggctccac ctctggggaa acacgtttta gcaacattta taaattccat gacctctctc
     1321 cctcccagaa ccaccggcct aattacaaac ctcagaactt tccttagctg ctgcagctaa
     1381 ggaaagtgtg ttcattagtg gcagattcag gagccagaat tcttggaaga tcagcttccc
     1441 atatgaacat ggaaggggga ctagggtttg agggatagct ttgctgagta tcctttctgg
     1501 ctcaaactga cccagcctac cttcatccct gcagctattg gcattgaagg gactctagct
     1561 agcctagacc tggcaagcat ggctctggca ggccttcccc ttttccccaa ttctctctgc
     1621 cttgctaaaa caaaacaaaa caaaacaaaa caaaacaaaa caaaacaaaa caacaacaaa
     1681 acattagatt gcattcctaa agctagcccc caaagtctct tcccttattt ggccagtttc
     1741 tcctccttag gctgactacc aaggtcccct atcaaagtat tgaagtccag caatcaaagg
     1801 ccctctttga ggccgggcag tggtggtgaa tgcctttaat cccagcattt gggaggcaga
     1861 ggcaggagga tttctgagtt caaggccagc ctggtctaca gagtgagttc caggacagcc
     1921 agggctacaa cagagaaatc ctgtctcgaa aatcaaaaaa aaaaaaaaaa aaaaaaggcc
     1981 ctctttggtt cacccaatac gcccaatcaa aacataccaa ggcacccagc ccattctaac
     2041 acagacctcc ccttttcccg attcttataa attacacctg caaggtcatt tgctgctgtt
     2101 tttctgtctg agtcagaaaa tagccacttt aacttttctt caccgcttaa taaaaggtct
     2161 ctctgtgaaa acc
//
