LOCUS       NM_008868               1618 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phospholipase A2, group IIC (Pla2g2c), mRNA.
ACCESSION   NM_008868
VERSION     NM_008868.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Song,H., Lim,H., Paria,B.C., Matsumoto,H., Swift,L.L., Morrow,J.,
            Bonventre,J.V. and Dey,S.K.
  TITLE     Cytosolic phospholipase A2alpha is crucial [correction of A2alpha
            deficiency is crucial] for 'on-time' embryo implantation that
            directs subsequent development
  JOURNAL   Development 129 (12), 2879-2889 (2002)
   PUBMED   12050136
  REMARK    Erratum:[Development 2002 Aug;129(15):3761]
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Akilesh,S., Dudley,M.E., Eden,P.A. and Roopenian,D.C.
  TITLE     Efficient chromosomal mapping of a methylcholanthrene-induced tumor
            antigen by CTL immunoselection
  JOURNAL   J Immunol 167 (9), 5143-5149 (2001)
   PUBMED   11673526
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Valentin,E., Ghomashchi,F., Gelb,M.H., Lazdunski,M. and Lambeau,G.
  TITLE     On the diversity of secreted phospholipases A(2). Cloning, tissue
            distribution, and functional expression of two novel mouse group II
            enzymes
  JOURNAL   J Biol Chem 274 (44), 31195-31202 (1999)
   PUBMED   10531313
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Chen,J., Shao,C., Lazar,V., Srivastava,C.H., Lee,W.H. and
            Tischfield,J.A.
  TITLE     Localization of group IIc low molecular weight phospholipase A2
            mRNA to meiotic cells in the mouse
  JOURNAL   J Cell Biochem 64 (3), 369-375 (1997)
   PUBMED   9057094
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Balboa,M.A., Balsinde,J., Winstead,M.V., Tischfield,J.A. and
            Dennis,E.A.
  TITLE     Novel group V phospholipase A2 involved in arachidonic acid
            mobilization in murine P388D1 macrophages
  JOURNAL   J Biol Chem 271 (50), 32381-32384 (1996)
   PUBMED   8943302
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Tischfield,J.A., Xia,Y.R., Shih,D.M., Klisak,I., Chen,J.,
            Engle,S.J., Siakotos,A.N., Winstead,M.V., Seilhamer,J.J.,
            Allamand,V., Gyapay,G. and Lusis,A.J.
  TITLE     Low-molecular-weight, calcium-dependent phospholipase A2 genes are
            linked and map to homologous chromosome regions in mouse and human
  JOURNAL   Genomics 32 (3), 328-333 (1996)
   PUBMED   8838795
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Chen,J., Engle,S.J., Seilhamer,J.J. and Tischfield,J.A.
  TITLE     Cloning and characterization of novel rat and mouse low molecular
            weight Ca(2+)-dependent phospholipase A2s containing 16 cysteines
  JOURNAL   J Biol Chem 269 (37), 23018-23024 (1994)
   PUBMED   8083202
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Dennis,E.A.
  TITLE     Diversity of group types, regulation, and function of phospholipase
            A2
  JOURNAL   J Biol Chem 269 (18), 13057-13060 (1994)
   PUBMED   8175726
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA464794.1, U18119.1 and AL844178.7.
            
            On Mar 21, 2009 this sequence version replaced NM_008868.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA464794.1, SRR5189685.151387.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               CA464794.1         4-183
            181-668             U18119.1           7-494
            669-1618            AL844178.7         142617-143566       c
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.54 cM"
     gene            1..1618
                     /gene="Pla2g2c"
                     /note="phospholipase A2, group IIC"
                     /db_xref="GeneID:18781"
                     /db_xref="MGI:MGI:106638"
     exon            1..164
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     exon            165..291
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     exon            292..392
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..805
                     /gene="Pla2g2c"
                     /EC_number="3.1.1.4"
                     /note="group IIC secretory phospholipase A2; PLA2-8;
                     sPLA2-IIC; GIIC sPLA2; 14 kDa phospholipase A2;
                     phosphatidylcholine 2-acylhydrolase 2C"
                     /codon_start=1
                     /product="group IIC secretory phospholipase A2 precursor"
                     /protein_id="NP_032894.2"
                     /db_xref="CCDS:CCDS18831.1"
                     /db_xref="GeneID:18781"
                     /db_xref="MGI:MGI:106638"
                     /translation="MKGIAIFLVFIFYWTTSTLSSFWQFQRMVKHVTGRSAFFSYYGY
                     GCYCGLGGKGLPVDATDRCCWAHDCCYHKLKEYGCQPILNAYQFTIVNGTVTCGCTVA
                     SSCLCGQKACECDKQSVYCFKENLATYEKAFKQLFPTRPQCGRDKLQC"
     exon            393..537
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     exon            538..641
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     exon            642..1618
                     /gene="Pla2g2c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1599..1604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g2c"
                     /note="hexamer: AGTAAA"
     polyA_site      1618
                     /gene="Pla2g2c"
                     /note="major polyA site"
ORIGIN      
        1 ggactagggc acggagggcg gaggggcaga ggtggttcac ggattccagg ctcaggacct
       61 tggtgtggcc ctgccccatg gaggccacag ggccctgggc ctggacccct gccattggaa
      121 ctcttcttcc tgacctggcc tgactcttgt gtctcctggg gaatggtcta actatataca
      181 gtcagcaact ccagccactt caccgcgttt cccaacagct ttgagttttg gaggccggca
      241 gcctgactgc tttctcagaa gctatggtcc actacctcag ccattctgtt ggagccaaac
      301 tggcaaatga aggtgaaatc cccgaaccgt ggacctcctg gtcacctcgg gaatgaaggg
      361 cattgccatc ttccttgtct tcatcttcta ctggacaacc tccaccctca gcagtttctg
      421 gcagttccag aggatggtca aacacgtcac agggcgcagc gccttcttct cctattacgg
      481 atatggctgc tactgtgggc ttgggggcaa agggctccct gtggatgcca cagacaggtg
      541 ctgctgggct catgactgct gctaccacaa gcttaaggaa tatggctgcc aacccatctt
      601 gaatgcctac cagttcacca ttgtcaatgg gacggtgacc tgtggatgca ccgtggccag
      661 cagctgcctc tgcgggcaga aggcctgtga gtgtgacaaa cagtctgtgt actgcttcaa
      721 ggagaacctg gccacctacg agaaggcctt caagcagctc ttcccgacca ggcctcagtg
      781 tggcagggac aaactccagt gctaggaagg ccaccctcat ccctccatca cctgctctag
      841 tcccgagccc cttctgaaga gctttgctgt ctggggagtg tcttttcagt cattaaggga
      901 ctggaggtgg agaattcctg ccctggaaac aaaccgtggg tatctggcca ttaagagata
      961 cagtctgtca gtaggaaaca aggacataag ggagcaggga tggggggcat cctgcaatcc
     1021 cagcatttga gacatggagg caggagagga aggagaggca ggaggccagg ggcaacctcc
     1081 actatacggt aagttcaagg ctagcctgag ctactttaga ccctgccttg aaaaattttt
     1141 taaacatttt ttaaaggaaa ataaaacagg ggaacacagg ggttgagctg aaaggtgctc
     1201 tcaaaccctt ctccccagaa gagcagagag ccccaggatc cagcctaaac tcccctgtac
     1261 cctctatcct ggtcaggatg tgtgtctgac tggggaacca agtcatctac ccaggtcagg
     1321 ctgggaagtg agccgggatc ctagaaaaca cagcccagga gcctcgcctg gaatctcctc
     1381 atttgcacca ggtctgacct ctccagcagg atgcaggatg cacccctgtc tcagaaggtg
     1441 gggcactatc agaaaaatgg tgtgcaccag tgccacaaag atgtcactgg ttaagatggc
     1501 atcaagaaat ggaaagagga tgttcgggac agggggtcca aggcacccaa aatccttacc
     1561 ccaatttaga agcctttggt cctgtaagac ttaattctag taaacgagga aggtctaa
//
