LOCUS       NM_011107                681 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus phospholipase A2, group IB, pancreas (Pla2g1b),
            transcript variant 1, mRNA.
ACCESSION   NM_011107
VERSION     NM_011107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 681)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 681)
  AUTHORS   Haller,A.M., Wolfkiel,P.R., Jaeschke,A. and Hui,D.Y.
  TITLE     Inactivation of Group 1B Phospholipase A2 Enhances Disease Recovery
            and Reduces Experimental Colitis in Mice
  JOURNAL   Int J Mol Sci 24 (22), 16155 (2023)
   PUBMED   38003345
  REMARK    GeneRIF: Inactivation of Group 1B Phospholipase A2 Enhances Disease
            Recovery and Reduces Experimental Colitis in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 681)
  AUTHORS   Garvin,S.E., Kyathanahalli,C., Soha,S., Condon,J.C. and
            Jeyasuria,P.
  TITLE     Preimplantation apoptotic endometrial caspase-3-mediated
            phospholipase A2 activation: a potential component in programming
            uterine receptivity
  JOURNAL   F S Sci 4 (2), 141-150 (2023)
   PUBMED   36603702
  REMARK    GeneRIF: Preimplantation apoptotic endometrial caspase-3-mediated
            phospholipase A2 activation: a potential component in programming
            uterine receptivity.
REFERENCE   4  (bases 1 to 681)
  AUTHORS   Hollie,N.I., Konaniah,E.S., Goodin,C. and Hui,D.Y.
  TITLE     Group 1B phospholipase A inactivation suppresses atherosclerosis
            and metabolic diseases in LDL receptor-deficient mice
  JOURNAL   Atherosclerosis 234 (2), 377-380 (2014)
   PUBMED   24747111
  REMARK    GeneRIF: Pla2g1b inactivation suppressed diet-induced body weight
            gain and reduced diabetes and atherosclerosis in LDL
            receptor-deficient mice.
REFERENCE   5  (bases 1 to 681)
  AUTHORS   Qu,B.X., Gong,Y., Sinclair,D., Fu,M., Perl,D. and Diaz-Arrastia,R.
  TITLE     cPLA2alpha knockout mice exhibit abnormalities in the architecture
            and synapses of cortical neurons
  JOURNAL   Brain Res 1497, 101-105 (2013)
   PUBMED   23266724
REFERENCE   6  (bases 1 to 681)
  AUTHORS   Zvaritch,E., Lambeau,G. and Lazdunski,M.
  TITLE     Endocytic properties of the M-type 180-kDa receptor for secretory
            phospholipases A2
  JOURNAL   J Biol Chem 271 (1), 250-257 (1996)
   PUBMED   8550569
REFERENCE   7  (bases 1 to 681)
  AUTHORS   Higashino,K., Ishizaki,J., Kishino,J., Ohara,O. and Arita,H.
  TITLE     Structural comparison of phospholipase-A2-binding regions in
            phospholipase-A2 receptors from various mammals
  JOURNAL   Eur J Biochem 225 (1), 375-382 (1994)
   PUBMED   7925459
REFERENCE   8  (bases 1 to 681)
  AUTHORS   Chepenik,K.P., Diaz,A. and Jimenez,S.A.
  TITLE     Epidermal growth factor coordinately regulates the expression of
            prostaglandin G/H synthase and cytosolic phospholipase A2 genes in
            embryonic mouse cells
  JOURNAL   J Biol Chem 269 (34), 21786-21792 (1994)
   PUBMED   8063822
REFERENCE   9  (bases 1 to 681)
  AUTHORS   Mukherjee,A.B., Miele,L. and Pattabiraman,N.
  TITLE     Phospholipase A2 enzymes: regulation and physiological role
  JOURNAL   Biochem Pharmacol 48 (1), 1-10 (1994)
   PUBMED   8043009
  REMARK    Review article
REFERENCE   10 (bases 1 to 681)
  AUTHORS   Dennis,E.A.
  TITLE     Diversity of group types, regulation, and function of phospholipase
            A2
  JOURNAL   J Biol Chem 269 (18), 13057-13060 (1994)
   PUBMED   8175726
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117735.8 and AK008668.1.
            
            On Oct 11, 2017 this sequence version replaced NM_011107.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF162712.1, BY708819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC117735.8         13975-14103         c
            130-673             AK008668.1         2-545
            674-681             AC117735.8         5523-5530           c
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 56.1 cM"
     gene            1..681
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /note="phospholipase A2, group IB, pancreas"
                     /db_xref="GeneID:18778"
                     /db_xref="MGI:MGI:101842"
     exon            1..179
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /inference="alignment:Splign:2.1.0"
     exon            180..339
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /inference="alignment:Splign:2.1.0"
     exon            340..467
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /inference="alignment:Splign:2.1.0"
     exon            468..681
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /note="hexamer: AATAAA"
     polyA_site      676
                     /gene="Pla2g1b"
                     /gene_synonym="Pla2a; sPLA2IB"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatccct ctgtgttgtt cccccgatag accaaggcca gcccagagtg gctaagagca
       61 aagcaaacag ccttatcttg ggagcgtggg gccccatgta taaaagaggg aagtcactgg
      121 agttctcccc tcactccttc tgaagatgaa actccttctg ctggctgctc tgctcacagc
      181 aggcgctgct gcacacagca tcagccctcg ggctgtgtgg cagttccgca atatgatcaa
      241 gtgcaccatc cccgggagtg atcccctgaa ggattacaac aactatggct gctactgtgg
      301 cttgggcggc tggggcaccc cagtggacga cttagacagg tgctgccaga ctcatgacca
      361 ctgctacagt caggccaaga agctggaaag ctgtaaattc ctcatagaca acccctacac
      421 caacacttac tcctactcat gctccgggag cgagatcacc tgcagcgcca aaaacaacaa
      481 atgcgaggac ttcatctgca actgtgaccg tgaggccgcc atctgcttct ccaaggtccc
      541 gtacaacaag gaatacaaaa accttgacac cgggaaattc tgttagcctg tcacctcact
      601 tcctgcccac gccgaccccg cccaccttgc tgtcttattt caccctgcgc cctctaataa
      661 agtacctgct gtcagagcct g
//
