LOCUS       NM_133792               2754 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus phospholipase A2, group XV (Pla2g15), transcript
            variant 1, mRNA.
ACCESSION   NM_133792
VERSION     NM_133792.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Abe,A., Hiraoka,M., Matsuzawa,F., Aikawa,S.I. and Niimura,Y.
  TITLE     Esterification of side-chain oxysterols by lysosomal phospholipase
            A2
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (10), 158787 (2020)
   PUBMED   32777483
  REMARK    GeneRIF: Esterification of side-chain oxysterols by lysosomal
            phospholipase A2.
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Paduraru,C., Bezbradica,J.S., Kunte,A., Kelly,R., Shayman,J.A.,
            Veerapen,N., Cox,L.R., Besra,G.S. and Cresswell,P.
  TITLE     Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d
            recognition
  JOURNAL   Proc Natl Acad Sci U S A 110 (13), 5097-5102 (2013)
   PUBMED   23493550
  REMARK    GeneRIF: LPLA2 plays a role in the generation of CD1d complexes
            with thymic lipids required for the normal selection and maturation
            of iNKT cells.
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Abe,A., Kelly,R. and Shayman,J.A.
  TITLE     The measurement of lysosomal phospholipase A2 activity in plasma
  JOURNAL   J Lipid Res 51 (8), 2464-2470 (2010)
   PUBMED   20410020
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Abe,A., Kelly,R., Kollmeyer,J., Hiraoka,M., Lu,Y. and Shayman,J.A.
  TITLE     The secretion and uptake of lysosomal phospholipase A2 by alveolar
            macrophages
  JOURNAL   J Immunol 181 (11), 7873-7881 (2008)
   PUBMED   19017977
  REMARK    GeneRIF: The secretion and uptake of lysosomal phospholipase A2 by
            alveolar macrophages
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Hiraoka,M., Abe,A. and Shayman,J.A.
  TITLE     Structure and function of lysosomal phospholipase A2:
            identification of the catalytic triad and the role of cysteine
            residues
  JOURNAL   J Lipid Res 46 (11), 2441-2447 (2005)
   PUBMED   16106046
  REMARK    GeneRIF: identification of the catalytic triad and the role of
            cysteine residues in lysosomal phospholipase A2
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Taniyama,Y., Fuse,H., Satomi,T., Tozawa,R., Yasuhara,Y.,
            Shimakawa,K., Shibata,S., Hattori,M., Nakata,M. and Taketomi,S.
  TITLE     Loss of lysophospholipase 3 increases atherosclerosis in
            apolipoprotein E-deficient mice
  JOURNAL   Biochem Biophys Res Commun 330 (1), 104-110 (2005)
   PUBMED   15781238
  REMARK    GeneRIF: activity is anti-atherogenic and indicate that the
            regulation of this enzyme might be a novel drug target for the
            treatment of atherosclerosis
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Abe,A., Hiraoka,M., Wild,S., Wilcoxen,S.E., Paine,R. 3rd and
            Shayman,J.A.
  TITLE     Lysosomal phospholipase A2 is selectively expressed in alveolar
            macrophages
  JOURNAL   J Biol Chem 279 (41), 42605-42611 (2004)
   PUBMED   15294901
  REMARK    GeneRIF: LPLA2 may be a major enzyme of pulmonary surfactant
            phospholipid degradation by alveolar macrophages
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Hiraoka,M., Abe,A. and Shayman,J.A.
  TITLE     Cloning and characterization of a lysosomal phospholipase A2,
            1-O-acylceramide synthase
  JOURNAL   J Biol Chem 277 (12), 10090-10099 (2002)
   PUBMED   11790796
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133195.4, AK085194.1 and BM226964.2.
            
            On Oct 25, 2017 this sequence version replaced NM_133792.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019373.1, AK155004.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC133195.4         77010-77066         c
            58-2211             AK085194.1         2-2155
            2212-2750           BM226964.2         3-541               c
            2751-2754           AC133195.4         62702-62705         c
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.1 cM"
     gene            1..2754
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /note="phospholipase A2, group XV"
                     /db_xref="GeneID:192654"
                     /db_xref="MGI:MGI:2178076"
     exon            1..260
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1372
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; group XV phospholipase A2; lysosomal
                     phospholipase A2; 1-O-acylceramide synthase; LCAT-like
                     lysophospholipase; lysophospholipase 3; lysosomal
                     phospholipase A and acyltransferase"
                     /codon_start=1
                     /product="lysosomal phospholipase A and acyltransferase
                     isoform 1 precursor"
                     /protein_id="NP_598553.1"
                     /db_xref="CCDS:CCDS22630.1"
                     /db_xref="GeneID:192654"
                     /db_xref="MGI:MGI:2178076"
                     /translation="MDRHLCTCRETQLRSGLLLPLFLLMMLADLTLPAQRHPPVVLVP
                     GDLGNQLEAKLDKPKVVHYLCSKKTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTS
                     RATQFPDGVDVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAP
                     YDWRRAPNENGPYFLALREMIEEMYQMYGGPVVLVAHSMGNVYMLYFLQRQPQVWKDK
                     YIHAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTW
                     SHEKVFVYTPTTNYTLRDYHRFFRDIGFEDGWFMRQDTEGLVEAMTPPGVELHCLYGT
                     GVPTPNSFYYESFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVSLQELPGSEH
                     IEMLANATTLAYLKRVLLEP"
     exon            261..417
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..536
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..635
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..860
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..2754
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2727..2732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /note="hexamer: AATAAA"
     polyA_site      2751
                     /gene="Pla2g15"
                     /gene_synonym="ACS; LLPL; Lpla2; Lypla3"
                     /note="major polyA site"
ORIGIN      
        1 ttagcaagag gcgggtctta attgactggt atctgcgagc ggtggggtta actagctgag
       61 ctgcggcccg ggcctaggca cgatccctaa tctctaaagc agccccttgg acctgcgacc
      121 acagtctcac gccatggatc gccatctctg cacctgtcgc gagacccagc tccggagtgg
      181 cctcctgtta cctctgtttc tactaatgat gctggcagac ctgacgctcc cggcccaacg
      241 tcaccccccg gtggtgctgg tgcctggtga tttgggtaac cagttggaag caaagctgga
      301 taagccaaag gttgtacact acctttgctc caagaagacg gacagctact tcacactctg
      361 gctgaatctg gaactgcttc tgcctgttat cattgactgc tggattgaca atatcaggct
      421 ggtttacaac agaacatctc gggccaccca gtttcccgat ggtgtggacg tgcgtgtccc
      481 tggctttggg gaaacatttt ctatggaatt cctagacccc agcaagagga atgtgggttc
      541 ctatttctac actatggtgg agagccttgt gggctggggc tacacacggg gtgaagacgt
      601 tcgaggtgct ccctatgatt ggcggcgagc cccaaatgaa aacgggccct acttcttggc
      661 cctgcgagag atgatcgagg agatgtacca gatgtatggg ggccccgtgg tgctggtcgc
      721 ccacagcatg ggcaacgtgt acatgctcta ctttctgcag cggcagccac aagtctggaa
      781 ggacaaatat atccatgcct tcgtctcact gggggcgccc tgggggggcg tggccaagac
      841 gctgcgtgtc ctggcctcag gagacaacaa tcgcattccc gtcattgggc cactgaagat
      901 ccgggaacag cagcgatctg ccgtctctac cagctggcta ctgccataca accacacttg
      961 gtcacatgaa aaggtatttg tatacacacc cacgactaac tacacgctcc gggactatca
     1021 ccggttcttc cgggacatcg gtttcgaaga tggctggttc atgcggcagg acacagaagg
     1081 gctggttgaa gccatgacgc cacccggggt ggagctgcac tgcttgtatg gcactggtgt
     1141 tcccacgcca aactctttct actacgagag ctttcctgat cgggacccca aaatctgctt
     1201 cggcgatggt gacggcacgg tgaacctgga gagcgtcctg cagtgccaag cctggcagag
     1261 ccgccaagag cacagagtat cattgcagga gctgccggga agcgagcaca ttgagatgct
     1321 agccaatgcc accaccttgg cttatctgaa acgtgtgctt ctggaacctt gatgtcctcc
     1381 gccaggcagg gctgctggat ggctggacca cggagctttt cttggcctct gactctttca
     1441 cggtctacaa gcttggcaga gtttgtgacc atcattcaag tcccaggagg catctgcctc
     1501 ggaggaatgc tatttctcaa cctttcttct gtagaatggc catgaagaag gaagaagtga
     1561 gtgtggacat ttgaaggaga ctgctgctgc tgctgctgct gaattgtgac ctcacgctgg
     1621 ctctggaggc tggcttgttt ggcccctcac cccagtccct aacttggacc gtgcaatcct
     1681 cttagctctc tggtctttct actctagctc actgggccct aaccttccct tttgagggat
     1741 gttagttact gagctgatgt cctgccatga aagattccac agagatcccc gggtgacctt
     1801 cccacgcact ggcctcaggt tgcccactac actggccaca ggtggctaga gctgctggct
     1861 tccctgtgac ctcgctggtg gacattctga gtgtggggtc tcctggaggc agtcgggtaa
     1921 gcccctgcag gcaggccagt tgctcgtatt gtctccgtga tccctccagg ctgggttctt
     1981 tacagtctgc tcctacctct catttagcag catcctagtt ctggactgga cagcagagga
     2041 cctctcaatt cttgggggcc atgtcctaag attcctgatg tcccagcttg tgacggaggt
     2101 cccggtactg aagctggctc tgttggttct gggacctgta gtttaagggg aggggatggg
     2161 gcttctttga aggttcctag aaagaaagtg agctcaaggg aacagccacg gttgcttaga
     2221 gcttcccatg agtcaccttc ttgagaactc taccatcatg gtgcaccccg ctgtggggta
     2281 tttctactat ccacttgggc tggcacaggg ttgagaggtg gtagagttcc tgcccaacac
     2341 taccaccagg cagctgaatg ggttttggtt tgcaggaaaa cagtccagag ctttgaaaag
     2401 gctcctaaga gagctaggaa cttagagtcc cagcttgggg gtgggggggg attgtttgtt
     2461 tgccccaggg atgccacatg gtctctgtgt gacagcaggg atggggaatc tgggactgcc
     2521 ttagggacag tgtacctgac tatgggcttg ggtacagctt ttaagttggg gtctcaaaac
     2581 cacttagaag ctggaccaca ctgccttccc atatcgtttc tgatgctgga cttcccttgt
     2641 taagcacatt cctatcatct gtccctcacc tgagtgttgg gaccccccca cttggggccc
     2701 tgagcaaact gtacctcgat tttggcaata aaagtattct ggatgttgta aggt
//
