LOCUS       NM_023530               1080 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus phospholipase A2, group XIIB (Pla2g12b), mRNA.
ACCESSION   NM_023530
VERSION     NM_023530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Thierer,J.H., Foresti,O., Yadav,P.K., Wilson,M.H., Moll,T.O.C.,
            Shen,M.C., Busch-Nentwich,E.M., Morash,M., Mohlke,K.L., Rawls,J.F.,
            Malhotra,V., Hussain,M.M. and Farber,S.A.
  TITLE     Pla2g12b drives expansion of triglyceride-rich lipoproteins
  JOURNAL   Nat Commun 15 (1), 2095 (2024)
   PUBMED   38453914
  REMARK    GeneRIF: Pla2g12b drives expansion of triglyceride-rich
            lipoproteins.
            Erratum:[Nat Commun. 2024 Mar 22;15(1):2572. doi:
            10.1038/s41467-024-46847-y. PMID: 38519494]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Fu,L., Ping,J., Guo,F., Song,J., Luo,M. and Chen,L.
  TITLE     PLA2G12B Mediates Arachidonic Acid Metabolism through Activation of
            the NF-kappaB Pathway to Promote Membrane Nephropathy
  JOURNAL   Kidney Blood Press Res 48 (1), 652-665 (2023)
   PUBMED   37757774
  REMARK    GeneRIF: PLA2G12B Mediates Arachidonic Acid Metabolism through
            Activation of the NF-kappaB Pathway to Promote Membrane
            Nephropathy.
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Chen,L., Wu,M., Zhang,S., Tan,W., Guan,M., Feng,L., Chen,C.,
            Tao,J., Chen,L. and Qu,L.
  TITLE     Estrogen-related receptor gamma regulates hepatic triglyceride
            metabolism through phospholipase A2 G12B
  JOURNAL   FASEB J 33 (7), 7942-7952 (2019)
   PUBMED   30922124
  REMARK    GeneRIF: ERRgamma transcriptionally regulates the expression of
            PLA2G12B by binding to its promoter region. In Pla2g12b-null mice,
            ERRgamma fails to regulate hepatic VLDL-TG secretion and lipid
            droplets accumulate in the liver. ERRgamma is a novel regulator of
            hepatic VLDL-TG secretion, which is mediated through the action on
            PLA2G12B.
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Liu,Q., Yang,M., Fu,X., Liu,R., Sun,C., Pan,H., Wong,C.W. and
            Guan,M.
  TITLE     Activation of farnesoid X receptor promotes triglycerides lowering
            by suppressing phospholipase A2 G12B expression
  JOURNAL   Mol Cell Endocrinol 436, 93-101 (2016)
   PUBMED   27471003
  REMARK    GeneRIF: FXR regulates serum triglyceride level in part through
            PLA2G12B.
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Aljakna,A., Choi,S., Savage,H., Hageman Blair,R., Gu,T.,
            Svenson,K.L., Churchill,G.A., Hibbs,M. and Korstanje,R.
  TITLE     Pla2g12b and Hpn are genes identified by mouse ENU mutagenesis that
            affect HDL cholesterol
  JOURNAL   PLoS One 7 (8), e43139 (2012)
   PUBMED   22912808
  REMARK    GeneRIF: Low HDL Cholesterol Levels in strain Hlb218 Is Caused by a
            Mutation at amino acid position 129 in the third exon of Pla2g12b.
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Guan,M., Qu,L., Tan,W., Chen,L. and Wong,C.W.
  TITLE     Hepatocyte nuclear factor-4 alpha regulates liver triglyceride
            metabolism in part through secreted phospholipase A GXIIB
  JOURNAL   Hepatology 53 (2), 458-466 (2011)
   PUBMED   21274867
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Rouault,M., Bollinger,J.G., Lazdunski,M., Gelb,M.H. and Lambeau,G.
  TITLE     Novel mammalian group XII secreted phospholipase A2 lacking
            enzymatic activity
  JOURNAL   Biochemistry 42 (39), 11494-11503 (2003)
   PUBMED   14516201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021592.1.
            
            On Jun 19, 2003 this sequence version replaced NM_023530.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021592.1, AK008035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.54 cM"
     gene            1..1080
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /note="phospholipase A2, group XIIB"
                     /db_xref="GeneID:69836"
                     /db_xref="MGI:MGI:1917086"
     exon            1..297
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /inference="alignment:Splign:2.1.0"
     exon            298..386
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /inference="alignment:Splign:2.1.0"
     exon            387..552
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1066
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /note="hexamer: AATAAA"
     polyA_site      1066
                     /gene="Pla2g12b"
                     /gene_synonym="2010002E04Rik; Fksg71; hlb218; Pla2g13"
                     /note="major polyA site"
ORIGIN      
        1 gggctgtgta tgtccccagg gcttcctggg accctggctg gggttgggga cgagagcagc
       61 cgcgagggtc tacttgtgcg tgcaaaatga agctgctctg cggcttcttc ctcctgtggc
      121 ttggcctggt agggaacctg gctcagagtg accccagccc caaggaagag gagtcctact
      181 ctgactgggg cctgaggcag ctgcggggca gcttcgagtc tgtcaacagc tacgtggatt
      241 ccttcatgga gctgctggga gggaagaatg gagtctgtca gtaccggtgt cgatatggaa
      301 aggcgccgat gcccagacct ggttacaaag cccaggagcc caatggttgc agttcctatt
      361 tcctgggtat caaggtacca ggaagtatgg acctgggcat cccagcaatg accaagtgtt
      421 gcaaccagct ggacgtctgc tacgacacct gcggtgccaa caaataccgc tgtgacgcaa
      481 aattccgatg gtgcctccac tcaatctgct ccgacctcaa gcggagcctg ggctttgtct
      541 ccaacgtgga agcagcctgt gattctctgg ctgataccgt gttcaacacc gtgtggacct
      601 tgggctgccg accctttatg aacagtcagc gggcagcctg catctgtgca gaggaggaga
      661 aagaagagct atgaagagaa ggtggctctt ccaggctttg aggcacgtcg gggctgtttc
      721 agagacagct gtgtgacaag agagccgtcc tttcttcaaa cccttcggaa atcacgagct
      781 ggaaaaggga ggcagcaggc cttgtccttt gaggaaagtt aagaaaaaga cacgcagagt
      841 ctgaagaccg ctctccccag ccgagaacca cgtgcctgga aattcagttc ttcgctgaag
      901 gaccgctaca agtagatctt gctattccta gatctggtca tgacagtcat aagcgaaatc
      961 tgggggagcc caaacatttg ggacataatg acttttcatt ggcccatgtt tcagttgcca
     1021 gttgacacct cacatttaat aaagcacact ttttagaaaa ctgtaaaaaa aaaaaaaaaa
//
