LOCUS       NM_023196               1561 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus phospholipase A2, group XIIA (Pla2g12a), transcript
            variant 1, mRNA.
ACCESSION   NM_023196
VERSION     NM_023196.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Nakamura,A., Sakai,S., Taketomi,Y., Tsuyama,J., Miki,Y., Hara,Y.,
            Arai,N., Sugiura,Y., Kawaji,H., Murakami,M. and Shichita,T.
  TITLE     PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural
            repair after ischemic stroke
  JOURNAL   Neuron 111 (19), 2995-3010 (2023)
   PUBMED   37490917
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Endo,Y., Kanno,T., Nakajima,T., Ikeda,K., Taketomi,Y., Yokoyama,S.,
            Sasamoto,S., Asou,H.K., Miyako,K., Hasegawa,Y., Kawashima,Y.,
            Ohara,O., Murakami,M. and Nakayama,T.
  TITLE     1-Oleoyl-lysophosphatidylethanolamine stimulates RORgammat activity
            in TH17 cells
  JOURNAL   Sci Immunol 8 (86), eadd4346 (2023)
   PUBMED   37540735
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   Nicolaou,A., Northoff,B.H., Sass,K., Ernst,J., Kohlmaier,A.,
            Krohn,K., Wolfrum,C., Teupser,D. and Holdt,L.M.
  TITLE     Quantitative trait locus mapping in mice identifies phospholipase
            Pla2g12a as novel atherosclerosis modifier
  JOURNAL   Atherosclerosis 265, 197-206 (2017)
   PUBMED   28917158
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Munoz-Sanjuan,I. and Brivanlou,A.H.
  TITLE     Induction of ectopic olfactory structures and bone morphogenetic
            protein inhibition by Rossy, a group XII secreted phospholipase A2
  JOURNAL   Mol Cell Biol 25 (9), 3608-3619 (2005)
   PUBMED   15831466
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Ho,I.C., Arm,J.P., Bingham,C.O. 3rd, Choi,A., Austen,K.F. and
            Glimcher,L.H.
  TITLE     A novel group of phospholipase A2s preferentially expressed in type
            2 helper T cells
  JOURNAL   J Biol Chem 276 (21), 18321-18326 (2001)
   PUBMED   11278438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051117.1 and BB505724.1.
            
            On Nov 23, 2013 this sequence version replaced NM_023196.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051117.1, AK009133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1557              BC051117.1         1-1557
            1558-1561           BB505724.1         257-260
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 59.4 cM"
     gene            1..1561
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /note="phospholipase A2, group XIIA"
                     /db_xref="GeneID:66350"
                     /db_xref="MGI:MGI:1913600"
     exon            1..330
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /inference="alignment:Splign:2.1.0"
     exon            331..407
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /inference="alignment:Splign:2.1.0"
     exon            408..573
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /inference="alignment:Splign:2.1.0"
     exon            574..1561
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /note="hexamer: AATGAA"
     polyA_site      1029
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /note="major polyA site"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /note="hexamer: AATAAA"
     polyA_site      1557
                     /gene="Pla2g12a"
                     /gene_synonym="2310004B05Rik; GXII; GXII-1; GXII-1-PLA2;
                     mGXII-1; Pla2g12; Rossy"
                     /note="major polyA site"
ORIGIN      
        1 gttcggcgca gctcagtgac ggggcgcgag ctcgcgagcg cggaggaggc cgggggcctg
       61 agccggagcc ggagcgcgcg ccgctgccca gccccgccgc gccggccccg cagatggtga
      121 ctccgcggcc cgcgcccgcc cggagccccg cgctcctcct cctcctgctg ctggccactg
      181 cgcgtgggca ggaacaggac cagaccaccg actggagggc caccctcaag accatccgca
      241 acggcatcca caagatagac acgtacctca acgccgcgct ggacctgctg ggcggggagg
      301 acgggctctg ccagtacaag tgcagcgacg gatcgaagcc tgttccacgc tatggatata
      361 aaccatctcc accaaatggc tgtggctcgc cactgtttgg cgttcatctg aacataggta
      421 tcccttccct gaccaagtgc tgcaaccagc acgacagatg ctacgagacc tgcgggaaaa
      481 gcaagaacga ctgtgacgag gagttccagt actgcctctc caagatctgc agagacgtgc
      541 agaagacgct cggactatct cagaacgtcc aggcatgtga gacaacggtg gagctcctct
      601 ttgacagcgt catccattta ggctgcaagc catacctgga cagccagcgg gctgcatgct
      661 ggtgtcgtta tgaagaaaaa acagatctat aaagaccctg actgctggag agcaggcgag
      721 aatggaggac catccttgcc aaagatccga tgctttaaca gcctaatgtt gccttagttt
      781 tgtgttgacg ggtcattttg agacctttct atactgtgtc tttttttaga acctcaaagt
      841 gaaaatggtg gggggccagg cagaaacaga gagcatgctt gggatgggga gcgagcagga
      901 catccaagag catgccttcc tgagactcgc tgtcgtggtg gctcccccaa actgggaaga
      961 aaagcttaag cccgtgtgac ttggtgttca tagttgtact taacaataaa aatgaaagca
     1021 aatgtaaaat tcattgtaag gacttttcag cattatttta ttttgaaata caggccaatc
     1081 ttcccttaga actattattt attttgaaat ttcagatgta catttatacc tggaaaaact
     1141 attaattctc catttttatt atacataacg tgttgtttct ctgaagccca ctaagatagg
     1201 tataaatatg ttactcacaa ctacaaggtt tccaagtgtg catctcttgt acagttggaa
     1261 tcacggttga tacttctctg gagagacgcc ccaggacatc tgagtgttgg gatgtgcaca
     1321 gaattcagaa gcccagcttc ctcaaaccgc ttagagcaaa tgtccttcct ctcctgctgt
     1381 gagctctagg aatgacgggt ttaacgggcc aagccgagct ctgaatctgt gcgctatctg
     1441 ctgctgaggt tgtggttact ccctcatccc cgttttccat cttctatcct ggagtagtgt
     1501 taaaagtctg acattttcta atggaggtct taataaacgc tatttacttc ttagtaatct
     1561 c
//
