LOCUS       NM_011987                926 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus phospholipase A2, group X (Pla2g10), transcript
            variant 1, mRNA.
ACCESSION   NM_011987
VERSION     NM_011987.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 926)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 926)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 926)
  AUTHORS   Nakamura,A., Sakai,S., Taketomi,Y., Tsuyama,J., Miki,Y., Hara,Y.,
            Arai,N., Sugiura,Y., Kawaji,H., Murakami,M. and Shichita,T.
  TITLE     PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural
            repair after ischemic stroke
  JOURNAL   Neuron 111 (19), 2995-3010 (2023)
   PUBMED   37490917
REFERENCE   4  (bases 1 to 926)
  AUTHORS   Ogden,H.L., Lai,Y., Nolin,J.D., An,D., Frevert,C.W., Gelb,M.H.,
            Altemeier,W.A. and Hallstrand,T.S.
  TITLE     Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2
            Inflammation, Leading to an Allergen-Specific Immune Response in
            the Lung
  JOURNAL   J Immunol 204 (12), 3097-3107 (2020)
   PUBMED   32341057
REFERENCE   5  (bases 1 to 926)
  AUTHORS   Nolin,J.D., Lai,Y., Ogden,H.L., Manicone,A.M., Murphy,R.C., An,D.,
            Frevert,C.W., Ghomashchi,F., Naika,G.S., Gelb,M.H., Gauvreau,G.M.,
            Piliponsky,A.M., Altemeier,W.A. and Hallstrand,T.S.
  TITLE     Secreted PLA2 group X orchestrates innate and adaptive immune
            responses to inhaled allergen
  JOURNAL   JCI Insight 2 (21), 94929 (2017)
   PUBMED   29093264
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 926)
  AUTHORS   Hanasaki,K., Yamada,K., Yamamoto,S., Ishimoto,Y., Saiga,A., Ono,T.,
            Ikeda,M., Notoya,M., Kamitani,S. and Arita,H.
  TITLE     Potent modification of low density lipoprotein by group X secretory
            phospholipase A2 is linked to macrophage foam cell formation
  JOURNAL   J Biol Chem 277 (32), 29116-29124 (2002)
   PUBMED   12021277
  REMARK    GeneRIF: LDL modification by GXPLA2 [GXPLA2]
REFERENCE   7  (bases 1 to 926)
  AUTHORS   Yokota,Y., Notoya,M., Higashino,K., Ishimoto,Y., Nakano,K.,
            Arita,H. and Hanasaki,K.
  TITLE     Clearance of group X secretory phospholipase A(2) via mouse
            phospholipase A(2) receptor
  JOURNAL   FEBS Lett 509 (2), 250-254 (2001)
   PUBMED   11741598
REFERENCE   8  (bases 1 to 926)
  AUTHORS   Morioka,Y., Saiga,A., Yokota,Y., Suzuki,N., Ikeda,M., Ono,T.,
            Nakano,K., Fujii,N., Ishizaki,J., Arita,H. and Hanasaki,K.
  TITLE     Mouse group X secretory phospholipase A2 induces a potent release
            of arachidonic acid from spleen cells and acts as a ligand for the
            phospholipase A2 receptor
  JOURNAL   Arch Biochem Biophys 381 (1), 31-42 (2000)
   PUBMED   11019817
REFERENCE   9  (bases 1 to 926)
  AUTHORS   Valentin,E., Ghomashchi,F., Gelb,M.H., Lazdunski,M. and Lambeau,G.
  TITLE     On the diversity of secreted phospholipases A(2). Cloning, tissue
            distribution, and functional expression of two novel mouse group II
            enzymes
  JOURNAL   J Biol Chem 274 (44), 31195-31202 (1999)
   PUBMED   10531313
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
REFERENCE   10 (bases 1 to 926)
  AUTHORS   Cupillard,L., Koumanov,K., Mattei,M.G., Lazdunski,M. and Lambeau,G.
  TITLE     Cloning, chromosomal mapping, and expression of a novel human
            secretory phospholipase A2
  JOURNAL   J Biol Chem 272 (25), 15745-15752 (1997)
   PUBMED   9188469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC154607.2, AK076921.1 and
            AV075661.1.
            
            On Jul 21, 2015 this sequence version replaced NM_011987.3.
            
            Summary: This gene encodes a member of the phospholipase A2 family
            of lipolytic enzymes that hydrolyzes glycerophospholipids to
            produce free fatty acids and lysophospholipids. The encoded protein
            undergoes proteolytic processing to generate a calcium-dependent
            enzyme that plays pivotal roles in the liberation of arachidonic
            acid from membrane phospholipids leading to the production of
            various inflammatory lipid mediators, such as prostaglandins. In
            response to myocardial ischemia/reperfusion, mice lacking the
            encoded protein display a reduction in myocardial infarct size
            partly through the suppression of neutorphil cytotoxic activities.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. All of these isoforms may undergo
            similar processing to generate the mature protein. [provided by
            RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF892392.1, CF892916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC154607.2         124346-124447       c
            103-924             AK076921.1         2-823
            925-926             AV075661.1         313-314
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.5 cM"
     gene            1..926
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /note="phospholipase A2, group X"
                     /db_xref="GeneID:26565"
                     /db_xref="MGI:MGI:1347522"
     exon            1..128
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            129..279
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            280..386
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            387..926
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /note="hexamer: AATAAA"
     polyA_site      926
                     /gene="Pla2g10"
                     /gene_synonym="GX sPLA2; PLA2GX; sPLA2-X"
                     /note="major polyA site"
ORIGIN      
        1 gtatactggc ccttctggtc agtcctacac ctgtcactct cctatgtgtg ggccacctct
       61 gtgacgggca ataatgctgc tgctactgct gctgttgctg ctgggacctg gacccggatt
      121 cagcgaagca accaggaggt cacatgtata caagcgtgga ctcctggagc tggcagggac
      181 cttggattgt gttgggcctc gatctccgat ggcttacatg aactatggct gttattgtgg
      241 ccttggtggc catggagagc cacgtgacgc cattgactgg tgctgctacc accacgactg
      301 ctgctactct cgggctcagg acgctggctg cagccctaag ttagaccgct acccatggaa
      361 gtgcatggac catcacatcc tgtgtggacc agcagagaac aaatgccaag aacttttgtg
      421 caggtgtgac gaggagctgg cttactgcct ggcagggacc gagtaccacc tgaaatacct
      481 cttcttcccc tccattttat gtgagaagga ctctcccaag tgcaattgac aggctcacat
      541 gtccctttgc acatggaaac gcacttcact ttcagtgatc accaacagca tgcaatttgt
      601 gcaggagagt caccggaggc caagtgctaa agccacctgc gtttgctttc tccttccatt
      661 caggaactca caactatgag cctgtggagt tgccagtctg atgaaggttc aaagtcctgg
      721 gcctgtttta tacaaatagc gctgtgttgg gcgtggtata ctttttgaaa ttcagccttt
      781 atgagaagct gtactatctt gtacctgctg cagggctgct ggtcagatgt gggtgaacac
      841 ctgcttaggc ttggctgtgg taataacatt gccacatgat acatctaaga attgtaactg
      901 taataaaaaa atgttcccta actggc
//
