LOCUS       NM_134102               1994 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus phospholipase A1 member A (Pla1a), mRNA.
ACCESSION   NM_134102
VERSION     NM_134102.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Tam,H., Xu,Y., An,J., Schoneberg,T., Schulz,A., Muppidi,J.R. and
            Cyster,J.G.
  TITLE     Phosphatidylserine phospholipase A1 enables GPR34-dependent immune
            cell accumulation in the peritoneal cavity
  JOURNAL   J Exp Med 221 (11) (2024)
   PUBMED   39412501
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Zhao,Y., Aoudjit,F. and Bourgoin,S.G.
  TITLE     Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced
            Psoriatic Arthritis in Mice Model
  JOURNAL   Int J Mol Sci 23 (15), 8559 (2022)
   PUBMED   35955693
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Asano,A., Nelson-Harrington,J.L. and Travis,A.J.
  TITLE     Phospholipase B is activated in response to sterol removal and
            stimulates acrosome exocytosis in murine sperm
  JOURNAL   J Biol Chem 288 (39), 28104-28115 (2013)
   PUBMED   23943622
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Inoue,A., Arima,N., Ishiguro,J., Prestwich,G.D., Arai,H. and
            Aoki,J.
  TITLE     LPA-producing enzyme PA-PLAalpha regulates hair follicle
            development by modulating EGFR signalling
  JOURNAL   EMBO J 30 (20), 4248-4260 (2011)
   PUBMED   21857648
  REMARK    GeneRIF: A phosphatidic acid-phospholipase A1alpha-lysophosphatidic
            acid-P2Y5 axis regulates differentiation of hair follicles via a
            tumour necrosis factor alpha converting enzyme-transforming growth
            factor alpha-epidermal growth factor receptor pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Wen,X.Y., Stewart,A.K., Skaug,J., Wei,E. and Tsui,L.C.
  TITLE     Murine phosphatidylserine-specific phospholipase A1 (Ps-pla1) maps
            to chromosome 16 but is distinct from the lpd (lipid defect) locus
  JOURNAL   Mamm Genome 12 (2), 129-132 (2001)
   PUBMED   11210182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF063498.1 and BC030670.1.
            
            On Jan 9, 2008 this sequence version replaced NM_134102.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF063498.1, BC030670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1364              AF063498.1         2-1365
            1365-1994           BC030670.1         1364-1993
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.83 cM"
     gene            1..1994
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /note="phospholipase A1 member A"
                     /db_xref="GeneID:85031"
                     /db_xref="MGI:MGI:1934677"
     exon            1..342
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1640
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /EC_number="3.1.1.111"
                     /note="phosphatidylserine-specific phospholipase A1"
                     /codon_start=1
                     /product="phospholipase A1 member A precursor"
                     /protein_id="NP_598863.3"
                     /db_xref="CCDS:CCDS28166.1"
                     /db_xref="GeneID:85031"
                     /db_xref="MGI:MGI:1934677"
                     /translation="MRPGLWETCFWLWGPLLWLSIGSSGNVPPTTQPKCTDFQSANLL
                     RGTNLKVQFLLFTPSDPSCGQLVEEGSDIRSSEFNASLGTKVIIHGFRALGTKPSWID
                     KFISAVLRAADANVIAVDWVYGSTGVYYSAVENVVKLSLEISRFLSKLLELGVSESSI
                     HIIGVSLGAHVGGMVGHFYKGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHT
                     DTDNLGIRIPVGHVDYFVNGGQDQPGCPAFFHAGYNYLICDHMRAVHLYISALENTCP
                     LMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVMIEPLPKEVKVYLLTTSSA
                     PYCVHHSLVEFYLKEKRKKDTSIEVTFLSNNVTSSVKITIPKQQLEGRGVMAHPNPQC
                     QINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKTVCIPEPVRLQAGVPAFQD
                     LKIACV"
     exon            343..544
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..722
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..831
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..933
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1023
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1191
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1281
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1390
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1555
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1974
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1950..1955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /note="hexamer: AATAAA"
     polyA_site      1974
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagaacgg tatgtttcaa tgtcccctgc ttaaaaaaaa aaaagtggga aggttggctc
       61 attttcattg agaagaggaa actgaaaact ccagaggtta aacaaatagg aaggtttatt
      121 tatttattta tttattttac aagccacaga gccagttaat gattcctaag tcccaagtgg
      181 gtgttacatg tttgcttgaa ggctgggcca tgtgacatcc caggcttggg gactctcctt
      241 cattctggct ccaggactcc agctccacga tgcgtcctgg cctctgggag acatgcttct
      301 ggttgtgggg accactttta tggctcagca ttggaagttc agggaacgta ccccctacca
      361 cccaacccaa gtgcacggac tttcagagtg ccaacctcct ccgaggcacc aacctcaagg
      421 tgcagtttct cctctttacc ccctcggacc ccagctgtgg gcagctagta gaagaaggca
      481 gtgacatccg gagctctgag ttcaatgcca gtctgggaac caaagtaatt attcatggat
      541 tcagggcgct cggaacaaag ccttcttgga tcgacaagtt tatcagcgct gtcctgcggg
      601 ctgcggatgc taatgtaatc gcggtggact gggtttatgg ttctacgggc gtgtactact
      661 cagcagtgga gaatgtggtc aagctgagcc tggagatctc ccgtttcctc agcaaacttt
      721 tggagctggg cgtgtcagag tcctcaatcc acatcattgg tgtcagtctg ggggctcatg
      781 ttggaggcat ggtgggacat ttctacaaag gccagttggg acagatcaca ggtctggatc
      841 ctgctggacc agagtacacc agagccagcc tggaggaacg cttggatgct ggagacgccc
      901 tgtttgtaga agccatccac acagacacgg acaatttggg tatccggatt cctgttggac
      961 atgtggacta ctttgtcaat ggaggccaag accagcctgg atgccctgcc ttctttcacg
     1021 caggttacaa ttacttgatc tgtgatcaca tgagggcagt acacctctac atcagtgccc
     1081 tggagaacac ctgcccactg atggccttcc cctgtgccag ctacaaggcc ttcctcgcag
     1141 gagactgtct ggattgcttt aaccctttcc tgctctcctg tccgaggatt ggactggtgg
     1201 aacgaggtgg tgtcatgatt gagccgctcc ccaaggaagt gaaggtttat ctcctgacta
     1261 catccagtgc cccgtactgt gtgcaccaca gccttgtgga gttttatttg aaggagaaga
     1321 gaaaaaagga taccagcatc gaggtcacgt ttcttagcaa caacgtaacg tcctcggtca
     1381 agatcaccat acctaaacag caactggaag ggagaggggt catggctcat cctaacccac
     1441 agtgccagat aaaccaagtg aagctcaagt tccaagtttc tagccgggtt tggagaaaag
     1501 acagaactcc tgttgttggg actttctgta ctgcccctct gccggtcaat gacagcaaga
     1561 agacggtctg catacctgag ccagtgcgtc tgcaagcagg cgtgcctgct ttccaggacc
     1621 tgaaaatagc ctgcgtgtag cccgagccta tgcaggaggc agtggccgca gttttccgag
     1681 ggcagtgtgc caagagctgt ttgtgagagc cgtatttcac cccatttcta ctaaagggga
     1741 aggccaaatt cttggtggtt ttccctgtaa gcagttactg tggaggggac agatgactca
     1801 tgttacagac cttgatctcc gtcaccaaca tctaacgctt tacataaatg cccttttagc
     1861 ttctctattt cgacacaact gtgattacct cacaccctta agcatctata cttaggattt
     1921 aatagaaatg tacgcagaga aattttttaa ataaactgcc atggaatatc tgaaaaaaaa
     1981 aaaaaaaaaa aaaa
//
