LOCUS       NM_026361               4642 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus plakophilin 4 (Pkp4), transcript variant 1, mRNA.
ACCESSION   NM_026361 XM_130277
VERSION     NM_026361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Muller,L., Gutschner,T. and Hatzfeld,M.
  TITLE     A feedback loop between plakophilin 4 and YAP signaling regulates
            keratinocyte differentiation
  JOURNAL   iScience 27 (9), 110762 (2024)
   PUBMED   39286493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Muller,L., Keil,R., Glass,M. and Hatzfeld,M.
  TITLE     Plakophilin 4 controls the spatio-temporal activity of RhoA at
            adherens junctions to promote cortical actin ring formation and
            tissue tension
  JOURNAL   Cell Mol Life Sci 81 (1), 291 (2024)
   PUBMED   38970683
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
REFERENCE   10 (bases 1 to 4642)
  AUTHORS   Hatzfeld,M. and Nachtsheim,C.
  TITLE     Cloning and characterization of a new armadillo family member,
            p0071, associated with the junctional plaque: evidence for a
            subfamily of closely related proteins
  JOURNAL   J Cell Sci 109 (Pt 11), 2767-2778 (1996)
   PUBMED   8937994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146720.1, BC079848.1 and AA266974.1.
            
            On May 23, 2007 this sequence version replaced NM_026361.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079848.1, SRR1660811.215811.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AK146720.1         2-171
            171-4610            BC079848.1         1-4440
            4611-4642           AA266974.1         286-317
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.52 cM"
     gene            1..4642
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="plakophilin 4"
                     /db_xref="GeneID:227937"
                     /db_xref="MGI:MGI:109281"
     exon            1..279
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            280..416
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..3857
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="isoform 1 is encoded by transcript variant 1;
                     armadillo-related protein"
                     /codon_start=1
                     /product="plakophilin-4 isoform 1"
                     /protein_id="NP_080637.1"
                     /db_xref="CCDS:CCDS16052.1"
                     /db_xref="GeneID:227937"
                     /db_xref="MGI:MGI:109281"
                     /translation="MPAPEQGSLVEEGQPQTHQEAVSTGPGMEPETTATTILASVKEQ
                     ELQFQRLTRELEVERQIVASQLERCRLGAESPSIASTSSTEKSFPWRSTDVPNPGVSK
                     PRVSDTIHPNNYLIRTEPEQGTLYSPEQTSLHESEGSLGNSRSSTQMNSYSDSGYQEA
                     GSFHNSQTVNKADSRQHPFTGSTSNHVVRTSRAEGQTLVQPSVANRAMRRVSSVPSRA
                     QSPSYVTSTGVSPSRGSLRTSLGSGFGSPSVTDSRPLNPSAYSSSTLPAQRAASPYSQ
                     RPASPTAVRRVGSVTSRQTSNPNGPVPQYQTTTRVGSPLTLTDAQTRVASPSQGQVGS
                     SSPKRSGMTAVPQHLGPSLQRTVHDMDQFGQQQYDIYERMVPPRPDSLTGLRSSYASQ
                     HSQLGQELRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYRTGSVGIG
                     NLQRTSSQRSTLTYQRNNYALNTAATYAEPYRPVQYRVQECSYNRLQHTGPADDGATR
                     SPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVY
                     RLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRK
                     SIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSFDDDHKIK
                     FQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVEN
                     CVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQE
                     DQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGN
                     WKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMR
                     DLVNRLPGGNGPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRG
                     DRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSHPSLST
                     TNQQMSPIIQSVGSTSSSPALLGIREPRSEYDRTQPPMQYYNSQGDTTHKGLYPGSSK
                     PSPIYISSYSSPAREQNRRLQHQQLYYQDDSTRKTLDAYRLYLQSPRSYEDPYCDDRV
                     HFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV"
     exon            417..529
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            530..564
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            565..696
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            697..884
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1434
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1623
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1843
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1976
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2190
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2374
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2492
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2684
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2858
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..3009
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3205
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3290
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3408
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3537
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3611
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..4614
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4589..4594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="hexamer: AATAAA"
     polyA_site      4614
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggcgg cctctgagca gtctagaggg ctccggggct gagtgcgcgt ggacgccggc
       61 cgcggcggcg gcactatggg cacggggtag aggcgagctg ccgccgccac cggggtggtg
      121 ggagagcctc ttcgggggag ggggcgggag gggagggagg ggagggcagc ggcgaggctg
      181 ccgcacttcg gccagtttgc tccggtgccg cagcggcgac ccttcggcgt ggatgtccct
      241 ggtccctgga gcgacgacgg cctccgcctg agctggaaag aggaatgccc gcccctgaac
      301 agggctcact ggtggaggag gggcaaccac agacccacca ggaagctgtc tccactggcc
      361 caggcatgga acccgagacc acagccacca ctattctagc ttccgtgaag gagcaggagc
      421 ttcagtttca acgactcacc cgagaactgg aagtggaaag gcagattgtt gccagtcagc
      481 tagaaagatg taggcttgga gcagaatcgc caagcatcgc cagcaccagc tcaactgaaa
      541 agtcatttcc ttggagatca acagatgtgc caaatcctgg tgtgagcaaa cctagagttt
      601 ctgacactat tcatcccaac aactatctca tcaggacaga gccagaacag gggaccctct
      661 actcaccaga acagacttct ctccatgaaa gtgagggatc gttgggaaac tcaagaagtt
      721 caacacagat gaattcttac tctgacagtg ggtaccagga agcagggagt ttccacaaca
      781 gccaaaccgt gaacaaggca gacagcagac agcatccatt cacaggatca acaagtaacc
      841 atgtggtgag gacttcaaga gctgaaggac aaacactggt tcagccatca gtagccaatc
      901 gggccatgcg gagagttagt tcagttccat ctagagcaca gtctccttct tatgttacca
      961 gcacaggcgt gtctccttca agggggtcac tgagaacttc tctgggtagt ggatttggct
     1021 ctccatcagt gacggactcc cgacctctga accccagtgc ttactcctcc agcacgctcc
     1081 ctgcacagcg ggccgcctct ccatactcac agagacccgc ctccccaaca gccgtgcgcc
     1141 gggtcgggtc tgtcacctcc cggcagacct ccaatcccaa cggaccagtc cctcagtacc
     1201 agaccaccac cagggtgggg tccccactga ccctgactga tgcccagact cgagtagctt
     1261 ccccatccca aggccaggtg gggtcatcgt ccccgaaacg ctctgggatg accgccgtac
     1321 cacagcacct gggaccttca ctgcaaagga ctgttcatga catggaccaa tttggacagc
     1381 agcagtatga catttatgaa aggatggttc cacctcggcc agacagcctg acaggcttac
     1441 ggagttccta tgccagtcag catagtcagc ttgggcaaga gctccgttca gctgtgtctc
     1501 ctgacttgca catcactcct atctatgaag ggaggaccta ctacagtcca gtgtaccgca
     1561 gcccaaacca cgggaccgtg gagctccagg ggtcacagac agcattgtat cgcacaggct
     1621 cagtaggtat tggaaatcta caaaggacat ccagccagcg aagcaccctt acataccaaa
     1681 gaaataacta tgccctgaac acagcagcta cctatgcgga gccctacagg ccagttcagt
     1741 accgagtcca agagtgcagc tataacaggc tgcagcacac agggccagct gatgacggtg
     1801 ccacaagatc cccatcaata gacagcattc agaaggaccc cagggagttt gcctggcgtg
     1861 accctgagct gccagaagtc attcacatgc tgcagcacca gttcccatcg gtccaggcaa
     1921 atgccgcagc ctacctgcag catctgtgct ttggtgacaa caaagtgaag atggaggtgt
     1981 acaggctagg gggaatcaag catctggtcg acctgttgga ccacagggtg ttggaagttc
     2041 agaagaatgc ttgtggcgcc cttcgaaacc ttgtgtttgg caagtcaaca gacgaaaata
     2101 aaatagcaat gaagaacgtt ggtggaatcc ctgccttgct gcgactgtta agaaaatcca
     2161 ttgatgcaga agtaagggag cttgttacag gggttctttg gaatctatct tcgtgtgatg
     2221 ctgtaaagat gacaatcatt cgagacgcgc tctcaacctt aaccaacact gtgatagttc
     2281 cacattctgg ttggaataac tcttcctttg atgatgatca taaaattaaa tttcagacct
     2341 cactggttct tcggaacaca acaggttgcc tgaggaacct cagctctgcc ggggaggaag
     2401 cacgaaaaca aatgcgctcc tgcgaggggc tggtggactc gctgttgtat gtgatccaca
     2461 cgtgtgtgaa cacttctgac tacgacagca agacagtgga gaactgtgtg tgtaccctga
     2521 ggaacctgtc ataccggctg gagctggaag tccctcaggc ccggctgctc ggactgaacg
     2581 agctagatga cttactagga aaagagtctc ccagcaaaga ctcggaacca agctgctggg
     2641 gaaagaagaa gaaaaagaaa aagagaacgc cacaagagga ccaatgggat ggagtcgggc
     2701 ctatccctgg actgtccaag tcccccaagg gagtcgagat gctgtggcat ccatcagtgg
     2761 taaagccgta cctgactctg ttagcagaaa gttccaaccc tgccaccttg gaaggctctg
     2821 ccggatccct gcagaacctc tctgctggca actggaagtt tgcagcatac atccgggcag
     2881 ctgtccggaa ggaaaaaggg cttcctatcc ttgtcgagct tctaaggatg gataatgaca
     2941 gagttgtctc ttctgtggcc actgccttga ggaacatggc gctggacgtt cgcaacaagg
     3001 agctcatagg taaatacgcc atgcgagacc tggtgaacag gcttccaggt ggcaacggcc
     3061 ccagcatcct gtccgatgaa accgtggcag ccatctgctg tgctctgcac gaggtcacca
     3121 gcaaaaacat ggagaatgcc aaagctctgg ccgactcggg aggtatagag aagctggtga
     3181 acataaccaa aggcagagga gacagatcct ctctgaaagt ggtgaaggcg gcagcccagg
     3241 tcttgaatac attatggcag taccgggacc tccggagcat ttacaaaaag gatgggtgga
     3301 atcagaacca ttttattaca cctgtgtcca cgctagagcg agaccgattc aaatcacacc
     3361 cttctctgtc caccaccaac caacagatgt cgcccatcat tcagtcagtt ggcagcacct
     3421 cttcctcacc agcactgtta ggaatcagag agcctcgctc tgaatacgat aggacccagc
     3481 cacctatgca gtattacaat agccaagggg acaccacaca taaaggcctg taccctggct
     3541 ccagcaaacc ttcaccaata tacatcagtt cctattcctc accagcaaga gaacaaaata
     3601 gacggctaca gcatcagcag ctgtactatc aagatgactc caccaggaag accttggatg
     3661 catacagact gtacctgcag tctcctcgaa gctatgaaga cccttattgt gatgaccgag
     3721 ttcacttccc agcttctact gattactcaa cgcagtacgg actgaaatca accacgaatt
     3781 atgtagactt ttattccact aaacgacctt cttatagagc cgaacagtac cctgggtccc
     3841 cggactcctg ggtgtagcat caagacggct gcctgctgag gggcgctttc cttctgactc
     3901 tgtttggatt gaggggaagt ccgtcttgct gatgatggtg accgtgaaag tgaaatggaa
     3961 gggatgagtg aagaggtttt ggtttgtttg tttgtttttt ctttttttga ggaattttca
     4021 gggaagtgag gaaacccttg ggagaggact ttgtacgcgc tgtgtaggtg ttagatctaa
     4081 ttacttgtag agtctagtgg tgaaggtgtg ggtgacgtgc tgggaggctt gagacgtggg
     4141 tgagatgaga tgggtatgtg taggtcaaat caaatgacag atgatttttt taatgtgaat
     4201 aaagttatgt tcagatagtt tgtacagaaa aaataataat aaaatggatg cccttcatgt
     4261 tttattgcta ttactaaatg tcaagattgt atgctattat gtcttgtaaa aattccttct
     4321 gttggtgtaa atatggaaat gccacattgg ttaagtgcca tcaattgtaa tgcagtgtgt
     4381 catttgaaaa gagatttgaa gaactgacag cttaaagccc aagcgggaaa cccgcccggg
     4441 aactgttcgc agttgacaac aaactctgac gccctctgtt ttcagtgagt agtgaactcc
     4501 ggaagcacaa aggccagcgt gacagcagcg ccatgctcat ccccctcaca ggacacttca
     4561 ctgccatttt ctatgcacat ggaagaataa taaatgtgga aatttcatcc tggaaaaaaa
     4621 aaaaaaaaaa aaaaaaaaaa aa
//
