LOCUS       NM_001362997            4532 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus plakophilin 4 (Pkp4), transcript variant 10, mRNA.
ACCESSION   NM_001362997
VERSION     NM_001362997.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4532)
  AUTHORS   Muller,L., Gutschner,T. and Hatzfeld,M.
  TITLE     A feedback loop between plakophilin 4 and YAP signaling regulates
            keratinocyte differentiation
  JOURNAL   iScience 27 (9), 110762 (2024)
   PUBMED   39286493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4532)
  AUTHORS   Muller,L., Keil,R., Glass,M. and Hatzfeld,M.
  TITLE     Plakophilin 4 controls the spatio-temporal activity of RhoA at
            adherens junctions to promote cortical actin ring formation and
            tissue tension
  JOURNAL   Cell Mol Life Sci 81 (1), 291 (2024)
   PUBMED   38970683
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4532)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4532)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   5  (bases 1 to 4532)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 4532)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   7  (bases 1 to 4532)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4532)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 4532)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
REFERENCE   10 (bases 1 to 4532)
  AUTHORS   Hatzfeld,M. and Nachtsheim,C.
  TITLE     Cloning and characterization of a new armadillo family member,
            p0071, associated with the junctional plaque: evidence for a
            subfamily of closely related proteins
  JOURNAL   J Cell Sci 109 (Pt 11), 2767-2778 (1996)
   PUBMED   8937994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX649232.1 and AL845536.8.
            
            Transcript Variant: This variant (10), as well as variants 11 and
            12, encodes isoform 7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.163045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               BX649232.1         28514-28792
            280-416             AL845536.8         13047-13183
            417-529             AL845536.8         64757-64869
            530-564             AL845536.8         87587-87621
            565-696             AL845536.8         103435-103566
            697-884             AL845536.8         103674-103861
            885-1352            AL845536.8         106459-106926
            1353-1541           AL845536.8         108471-108659
            1542-1761           AL845536.8         110063-110282
            1762-1894           AL845536.8         116881-117013
            1895-2108           AL845536.8         120871-121084
            2109-2292           AL845536.8         133117-133300
            2293-2410           AL845536.8         135953-136070
            2411-2602           AL845536.8         137088-137279
            2603-2776           AL845536.8         137450-137623
            2777-2927           AL845536.8         140462-140612
            2928-3123           AL845536.8         143167-143362
            3124-3208           AL845536.8         146089-146173
            3209-3326           AL845536.8         146293-146410
            3327-3455           AL845536.8         148863-148991
            3456-3529           AL845536.8         150631-150704
            3530-4532           AL845536.8         152572-153574
FEATURES             Location/Qualifiers
     source          1..4532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.52 cM"
     gene            1..4532
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="plakophilin 4"
                     /db_xref="GeneID:227937"
                     /db_xref="MGI:MGI:109281"
     exon            1..279
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            280..416
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            417..529
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            530..564
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            565..696
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            697..884
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1352
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     CDS             1226..3775
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="isoform 7 is encoded by transcript variant 10;
                     armadillo-related protein"
                     /codon_start=1
                     /product="plakophilin-4 isoform 7"
                     /protein_id="NP_001349926.1"
                     /db_xref="CCDS:CCDS89490.1"
                     /db_xref="GeneID:227937"
                     /db_xref="MGI:MGI:109281"
                     /translation="MTAVPQHLGPSLQRTVHDMDQFGQQQYDIYERMVPPRPDSLTGL
                     RSSYASQHSQLGQELRSAVSPDLHITPIYEGRTYYSPVYRSPNHGTVELQGSQTALYR
                     TGSVGIGNLQRTSSQRSTLTYQRNNYALNTAATYAEPYRPVQYRVQECSYNRLQHTGP
                     ADDGATRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDN
                     KVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPA
                     LLRLLRKSIDAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWNNSSF
                     DDDHKIKFQTSLVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDY
                     DSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLGKESPSKDSEPSCWGKKKKK
                     KKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSL
                     QNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKEL
                     IGKYAMRDLVNRLPGGNGPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLV
                     NITKGRGDRSSLKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFK
                     SHPSLSTTNQQMSPIIQSVGSTSSSPALLGIREPRSEYDRTQPPMQYYNSQGDTTHKG
                     LYPGSSKPSPIYISSYSSPAREQNRRLQHQQLYYQDDSTRKTLDAYRLYLQSPRSYED
                     PYCDDRVHFPASTDYSTQYGLKSTTNYVDFYSTKRPSYRAEQYPGSPDSWV"
     exon            1353..1541
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1761
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1894
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2108
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2292
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2410
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2602
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2776
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2927
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3123
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3208
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3326
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3455
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3529
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..4532
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="hexamer: AATAAA"
     polyA_site      4532
                     /gene="Pkp4"
                     /gene_synonym="5031422I09Rik; 9430019K17Rik; Armrp; p0071"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggcgg cctctgagca gtctagaggg ctccggggct gagtgcgcgt ggacgccggc
       61 cgcggcggcg gcactatggg cacggggtag aggcgagctg ccgccgccac cggggtggtg
      121 ggagagcctc ttcgggggag ggggcgggag gggagggagg ggagggcagc ggcgaggctg
      181 ccgcacttcg gccagtttgc tccggtgccg cagcggcgac ccttcggcgt ggatgtccct
      241 ggtccctgga gcgacgacgg cctccgcctg agctggaaag aggaatgccc gcccctgaac
      301 agggctcact ggtggaggag gggcaaccac agacccacca ggaagctgtc tccactggcc
      361 caggcatgga acccgagacc acagccacca ctattctagc ttccgtgaag gagcaggagc
      421 ttcagtttca acgactcacc cgagaactgg aagtggaaag gcagattgtt gccagtcagc
      481 tagaaagatg taggcttgga gcagaatcgc caagcatcgc cagcaccagc tcaactgaaa
      541 agtcatttcc ttggagatca acagatgtgc caaatcctgg tgtgagcaaa cctagagttt
      601 ctgacactat tcatcccaac aactatctca tcaggacaga gccagaacag gggaccctct
      661 actcaccaga acagacttct ctccatgaaa gtgagggatc gttgggaaac tcaagaagtt
      721 caacacagat gaattcttac tctgacagtg ggtaccagga agcagggagt ttccacaaca
      781 gccaaaccgt gaacaaggca gacagcagac agcatccatt cacaggatca acaagtaacc
      841 atgtggtgag gacttcaaga gctgaaggac aaacactggt tcaggcgtgt ctccttcaag
      901 ggggtcactg agaacttctc tgggtagtgg atttggctct ccatcagtga cggactcccg
      961 acctctgaac cccagtgctt actcctccag cacgctccct gcacagcggg ccgcctctcc
     1021 atactcacag agacccgcct ccccaacagc cgtgcgccgg gtcgggtctg tcacctcccg
     1081 gcagacctcc aatcccaacg gaccagtccc tcagtaccag accaccacca gggtggggtc
     1141 cccactgacc ctgactgatg cccagactcg agtagcttcc ccatcccaag gccaggtggg
     1201 gtcatcgtcc ccgaaacgct ctgggatgac cgccgtacca cagcacctgg gaccttcact
     1261 gcaaaggact gttcatgaca tggaccaatt tggacagcag cagtatgaca tttatgaaag
     1321 gatggttcca cctcggccag acagcctgac aggcttacgg agttcctatg ccagtcagca
     1381 tagtcagctt gggcaagagc tccgttcagc tgtgtctcct gacttgcaca tcactcctat
     1441 ctatgaaggg aggacctact acagtccagt gtaccgcagc ccaaaccacg ggaccgtgga
     1501 gctccagggg tcacagacag cattgtatcg cacaggctca gtaggtattg gaaatctaca
     1561 aaggacatcc agccagcgaa gcacccttac ataccaaaga aataactatg ccctgaacac
     1621 agcagctacc tatgcggagc cctacaggcc agttcagtac cgagtccaag agtgcagcta
     1681 taacaggctg cagcacacag ggccagctga tgacggtgcc acaagatccc catcaataga
     1741 cagcattcag aaggacccca gggagtttgc ctggcgtgac cctgagctgc cagaagtcat
     1801 tcacatgctg cagcaccagt tcccatcggt ccaggcaaat gccgcagcct acctgcagca
     1861 tctgtgcttt ggtgacaaca aagtgaagat ggaggtgtac aggctagggg gaatcaagca
     1921 tctggtcgac ctgttggacc acagggtgtt ggaagttcag aagaatgctt gtggcgccct
     1981 tcgaaacctt gtgtttggca agtcaacaga cgaaaataaa atagcaatga agaacgttgg
     2041 tggaatccct gccttgctgc gactgttaag aaaatccatt gatgcagaag taagggagct
     2101 tgttacaggg gttctttgga atctatcttc gtgtgatgct gtaaagatga caatcattcg
     2161 agacgcgctc tcaaccttaa ccaacactgt gatagttcca cattctggtt ggaataactc
     2221 ttcctttgat gatgatcata aaattaaatt tcagacctca ctggttcttc ggaacacaac
     2281 aggttgcctg aggaacctca gctctgccgg ggaggaagca cgaaaacaaa tgcgctcctg
     2341 cgaggggctg gtggactcgc tgttgtatgt gatccacacg tgtgtgaaca cttctgacta
     2401 cgacagcaag acagtggaga actgtgtgtg taccctgagg aacctgtcat accggctgga
     2461 gctggaagtc cctcaggccc ggctgctcgg actgaacgag ctagatgact tactaggaaa
     2521 agagtctccc agcaaagact cggaaccaag ctgctgggga aagaagaaga aaaagaaaaa
     2581 gagaacgcca caagaggacc aatgggatgg agtcgggcct atccctggac tgtccaagtc
     2641 ccccaaggga gtcgagatgc tgtggcatcc atcagtggta aagccgtacc tgactctgtt
     2701 agcagaaagt tccaaccctg ccaccttgga aggctctgcc ggatccctgc agaacctctc
     2761 tgctggcaac tggaagtttg cagcatacat ccgggcagct gtccggaagg aaaaagggct
     2821 tcctatcctt gtcgagcttc taaggatgga taatgacaga gttgtctctt ctgtggccac
     2881 tgccttgagg aacatggcgc tggacgttcg caacaaggag ctcataggta aatacgccat
     2941 gcgagacctg gtgaacaggc ttccaggtgg caacggcccc agcatcctgt ccgatgaaac
     3001 cgtggcagcc atctgctgtg ctctgcacga ggtcaccagc aaaaacatgg agaatgccaa
     3061 agctctggcc gactcgggag gtatagagaa gctggtgaac ataaccaaag gcagaggaga
     3121 cagatcctct ctgaaagtgg tgaaggcggc agcccaggtc ttgaatacat tatggcagta
     3181 ccgggacctc cggagcattt acaaaaagga tgggtggaat cagaaccatt ttattacacc
     3241 tgtgtccacg ctagagcgag accgattcaa atcacaccct tctctgtcca ccaccaacca
     3301 acagatgtcg cccatcattc agtcagttgg cagcacctct tcctcaccag cactgttagg
     3361 aatcagagag cctcgctctg aatacgatag gacccagcca cctatgcagt attacaatag
     3421 ccaaggggac accacacata aaggcctgta ccctggctcc agcaaacctt caccaatata
     3481 catcagttcc tattcctcac cagcaagaga acaaaataga cggctacagc atcagcagct
     3541 gtactatcaa gatgactcca ccaggaagac cttggatgca tacagactgt acctgcagtc
     3601 tcctcgaagc tatgaagacc cttattgtga tgaccgagtt cacttcccag cttctactga
     3661 ttactcaacg cagtacggac tgaaatcaac cacgaattat gtagactttt attccactaa
     3721 acgaccttct tatagagccg aacagtaccc tgggtccccg gactcctggg tgtagcatca
     3781 agacggctgc ctgctgaggg gcgctttcct tctgactctg tttggattga ggggaagtcc
     3841 gtcttgctga tgatggtgac cgtgaaagtg aaatggaagg gatgagtgaa gaggttttgg
     3901 tttgtttgtt tgttttttct ttttttgagg aattttcagg gaagtgagga aacccttggg
     3961 agaggacttt gtacgcgctg tgtaggtgtt agatctaatt acttgtagag tctagtggtg
     4021 aaggtgtggg tgacgtgctg ggaggcttga gacgtgggtg agatgagatg ggtatgtgta
     4081 ggtcaaatca aatgacagat gattttttta atgtgaataa agttatgttc agatagtttg
     4141 tacagaaaaa ataataataa aatggatgcc cttcatgttt tattgctatt actaaatgtc
     4201 aagattgtat gctattatgt cttgtaaaaa ttccttctgt tggtgtaaat atggaaatgc
     4261 cacattggtt aagtgccatc aattgtaatg cagtgtgtca tttgaaaaga gatttgaaga
     4321 actgacagct taaagcccaa gcgggaaacc cgcccgggaa ctgttcgcag ttgacaacaa
     4381 actctgacgc cctctgtttt cagtgagtag tgaactccgg aagcacaaag gccagcgtga
     4441 cagcagcgcc atgctcatcc ccctcacagg acacttcact gccattttct atgcacatgg
     4501 aagaataata aatgtggaaa tttcatcctg ga
//
