LOCUS       NM_019762               2857 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus plakophilin 3 (Pkp3), transcript variant 1, mRNA.
ACCESSION   NM_019762
VERSION     NM_019762.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Elliott,K.H., Balchand,S.K., Bonatto Paese,C.L., Chang,C.F.,
            Yang,Y., Brown,K.M., Rasicci,D.T., He,H., Thorner,K.,
            Chaturvedi,P., Murray,S.A., Chen,J., Porollo,A., Peterson,K.A. and
            Brugmann,S.A.
  TITLE     Identification of a heterogeneous and dynamic ciliome during
            embryonic development and cell differentiation
  JOURNAL   Development 150 (8) (2023)
   PUBMED   36971348
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Muller,L., Keil,R. and Hatzfeld,M.
  TITLE     Plakophilin 3 facilitates G1/S phase transition and enhances
            proliferation by capturing RB protein in the cytoplasm and
            promoting EGFR signaling
  JOURNAL   Cell Rep 42 (1), 112031 (2023)
   PUBMED   36689330
  REMARK    GeneRIF: Plakophilin 3 facilitates G1/S phase transition and
            enhances proliferation by capturing RB protein in the cytoplasm and
            promoting EGFR signaling.
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Raghavan,R., Koyande,N., Beher,R., Chetlangia,N., Ramadwar,M.,
            Pawade,S., Thorat,R., van Hengel,J., Sklyarova,T., van Roy,F. and
            Dalal,S.N.
  TITLE     Plakophilin3 loss leads to increased adenoma formation and rectal
            prolapse in APCmin mice
  JOURNAL   Biochem Biophys Res Commun 586, 14-19 (2022)
   PUBMED   34823217
  REMARK    GeneRIF: Plakophilin3 loss leads to increased adenoma formation and
            rectal prolapse in APC(min) mice.
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Ihrie,R.A., Marques,M.R., Nguyen,B.T., Horner,J.S., Papazoglu,C.,
            Bronson,R.T., Mills,A.A. and Attardi,L.D.
  TITLE     Perp is a p63-regulated gene essential for epithelial integrity
  JOURNAL   Cell 120 (6), 843-856 (2005)
   PUBMED   15797384
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Bonne,S., Gilbert,B., Hatzfeld,M., Chen,X., Green,K.J. and van
            Roy,F.
  TITLE     Defining desmosomal plakophilin-3 interactions
  JOURNAL   J Cell Biol 161 (2), 403-416 (2003)
   PUBMED   12707304
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Vasioukhin,V., Bowers,E., Bauer,C., Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is essential in epidermal sheet formation
  JOURNAL   Nat Cell Biol 3 (12), 1076-1085 (2001)
   PUBMED   11781569
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Bonne,S., van Hengel,J., Nollet,F., Kools,P. and van Roy,F.
  TITLE     Plakophilin-3, a novel armadillo-like protein present in nuclei and
            desmosomes of epithelial cells
  JOURNAL   J Cell Sci 112 (Pt 14), 2265-2276 (1999)
   PUBMED   10381383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109272.20, BC139775.1 and BC090668.1.
            
            On Jun 30, 2009 this sequence version replaced NM_019762.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136719.1, BC139775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC109272.20        53423-53466         c
            45-2754             BC139775.1         1-2710
            2755-2857           BC090668.1         2824-2926
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.34 cM"
     gene            1..2857
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /note="plakophilin 3"
                     /db_xref="GeneID:56460"
                     /db_xref="MGI:MGI:1891830"
     exon            1..333
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2495
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="plakophilin-3 isoform 1"
                     /protein_id="NP_062736.2"
                     /db_xref="CCDS:CCDS21999.1"
                     /db_xref="GeneID:56460"
                     /db_xref="MGI:MGI:1891830"
                     /translation="MQEGNFLLSALQPETGVCSLALPSDLQLDRRGAEGPEADRLRAA
                     RVQEQVRARLLQLGQQSRHNGSAELDGSAESARGMPRGQYHTMQTGFSSRSQGMSGDK
                     TSTFRPIAKPAYSPASWSSRSAVDLTCSRRLSSAHNGGSAFGAVGYGGTQPTPPMPTR
                     PVSFHERGGAASRADYDTLSLRSLRLGPGGLDDRYSVVSEQLEPAAASTYRAYAYERQ
                     ASSGSSRAGGLDWPEATEGPPSRTIRAPAMRTLQRFQSSHRSRGGTGSVSGAGLEPVA
                     RAPSVRSLSLSLADSGHLPDVRGLDSYTGHRTLQRLSSGFDDIDLPSAVKYLMASDPN
                     LQVLGAAYIQHRCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDN
                     VDNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTD
                     LVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVT
                     YINHALDVGKCEDKSVENAVCVLRNLSYRLYDEMPPSALQRLEGRGRRDMAGAPPGEM
                     VGCFTPQSRRLRELPLTADALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHT
                     TEAAAGALQNITAGDRRWAGVLSRLALEQERILNPLLDRVRTADHNQLRSLTGLIRNL
                     SRNARNKDEMSTKVVSHLIEKLPGSVGEKCPPAEVLVNIIAVLNNLVVASPIAARDLL
                     YFDGLRKLVFIKKKRDSPDSEKSSRAASSLLANLWQYSKLHRDFRAKGYRKEDFLGP"
     exon            334..413
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..1045
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1169
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1374
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1549
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1667
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1838
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2024
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2178
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2371
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2459
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2839
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2818..2823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2839
                     /gene="Pkp3"
                     /gene_synonym="2310056L12Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtctatgaga gccagccagg aagagactct ggaaccgggc ctcgagggac aagaccggga
       61 gaggcccagg acaggtgggc tggctagtcg cccctgtcac tatgcaggaa ggtaacttcc
      121 tgctgtctgc cctgcagcct gagactggtg tttgctccct ggctctgcct tcggacctac
      181 agctggatcg ccggggtgcg gagggaccgg aggctgatcg acttagagct gccagagtcc
      241 aggagcaagt ccgagcccgc ctcctgcagc tgggccagca gtcgcggcac aatgggtctg
      301 ctgagcttga tggctccgcg gagagcgcca gaggcatgcc cagaggtcaa tatcacacta
      361 tgcagactgg cttcagctcc cgatcccagg gcatgagtgg agacaagacc tcgaccttcc
      421 ggcccatcgc caagccggcc tacagcccag cttcctggtc ctcccgctca gccgtggatc
      481 tgacgtgcag tcggaggctg agttctgccc acaatggggg cagtgccttt ggggctgtgg
      541 gatatggggg tacccagccc actccaccta tgcccacccg gccagtgtcc ttccatgagc
      601 gaggtggggc agccagcaga gctgactatg acacattatc cctgcgctca ctgaggctgg
      661 ggccaggggg cctggatgac cgttacagcg tggtatctga gcaactggag cctgcagccg
      721 cctctaccta cagggcctat gcttacgagc gccaggctag ctccggctct agccgagcag
      781 ggggcctgga ctggccagag gccacagagg gaccacccag caggaccatc cgtgcacctg
      841 ccatgcgaac cctgcaaaga tttcagagca gccaccgaag ccgtgggggt accgggtcag
      901 tgtcaggtgc cggcttggag ccagtggccc gagccccatc tgtgcgcagc ctcagtctta
      961 gcctggctga ctcaggccac ctgccagatg tacgcgggct ggacagctac acgggccatc
     1021 gaaccctgca gaggctcagc agtggctttg atgacattga cctgccttca gcagtcaagt
     1081 acctcatggc ctcagacccc aacctgcagg tgctgggagc agcttacatc cagcacaggt
     1141 gttacagtga tgccgccgcc aagaagcagg ctcgcagcct tcaggcagtg cctagactgg
     1201 tgaagctctt caaccacgcc aaccaggagg tgcagcgcca cgccacaggt gccatgcgca
     1261 acctcatcta cgacaatgta gacaacaagc tggcgttggt agaggagaat ggcatttttg
     1321 agctgttgcg gacacttcga gagcaggatg atgagctacg caaaaatgtt acagggatcc
     1381 tatggaacct gtcctccagt gaccacctaa aggaccgcct cgcccgggat acactggagc
     1441 agctcacaga tctggtgctg agccccctgt caggggcagg tgggcctccc ctcatccagc
     1501 agaatgcctc agaggcagag atcttctaca atgctactgg cttcctcagg aacctcagct
     1561 cagcctccca ggccactcgg cagaagatgc gcgagtgcca tgggctagtg gatgctctgg
     1621 tcacctacat caaccatgcc ctggacgttg gcaagtgtga ggacaagagt gtggaaaatg
     1681 ctgtgtgtgt gctgaggaac ctgtcctacc gcctctacga cgagatgccg ccatcagcct
     1741 tgcagcggct tgaaggccgg ggccgcaggg acatggcagg ggctccgcct ggtgaaatgg
     1801 taggctgctt cacacctcag agtcggcggc tgcgagagct tcctctcaca gctgatgcac
     1861 tcacctttgc cgaagtatct aaggatccca agggcctcga atggctgtgg agcccccaga
     1921 ttgtggggtt gtacaaccga ctgctgcagc gctgtgaact aaatcggcat acaacggagg
     1981 cggccgcagg ggcgctacag aatatcaccg cgggcgaccg caggtgggca ggtgtgctga
     2041 gccgcctggc cctggaacag gagcgaatcc tgaacccctt gctggaccgc gttcgcaccg
     2101 ctgaccacaa ccaactgcgc tcactgactg gcctcatccg aaacctgtct cggaatgcca
     2161 ggaacaagga cgagatgtcc acaaaggtag tgagccacct gattgagaag cttcctggta
     2221 gtgtgggtga gaagtgtccc ccagctgagg tgctggtcaa catcatagcc gtgctcaaca
     2281 acctggtggt agccagcccc attgctgccc gggacctgct ctactttgat ggcctccgaa
     2341 agctggtctt catcaaaaag aagagggata gccccgacag tgagaagtct tcccgggcag
     2401 cctccagcct cttggccaac ctctggcagt acagcaagct ccaccgtgac ttccgggcga
     2461 aaggctaccg gaaagaggac ttcctgggtc cataggtgaa gcctcctgga gatgaagtga
     2521 ttcagcttcc aagagatagg ctcagctcct gctgtcccac agcacataga agaggagctg
     2581 atgccacagg acctctctct ctctctctct ctcctctctg gagtcctgtg tgtgtgccct
     2641 tgaggggcca gggccaccag aaaagaacag gcgcttgcaa ctggggattg attggcttct
     2701 gcagggcagg gaaagggggt agagcttgag ctgctctggt gtactgggtg gcgattagtc
     2761 acaatggcaa gggcggggcc accctcggcc tgacagcttt gtgacggcaa cattgggatt
     2821 aaaggtggtt ttgaacacaa aaaaaaaaaa aaaaaaa
//
