LOCUS       NM_026163               2891 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus plakophilin 2 (Pkp2), mRNA.
ACCESSION   NM_026163 NM_027894
VERSION     NM_026163.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Lluch,A., Latorre,J., Serena-Maione,A., Espadas,I.,
            Caballano-Infantes,E., Moreno-Navarrete,J.M., Oliveras-Canellas,N.,
            Ricart,W., Malagon,M.M., Martin-Montalvo,A., Birchmeier,W.,
            Szymanski,W., Graumann,J., Gomez-Serrano,M., Sommariva,E.,
            Fernandez-Real,J.M. and Ortega,F.J.
  TITLE     Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to
            breed adipocyte senescence
  JOURNAL   Nat Commun 14 (1), 5106 (2023)
   PUBMED   37607954
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2891)
  AUTHORS   Karatsai,O., Lehka,L., Wojton,D., Grabowska,A.I., Duda,M.K.,
            Lenartowski,R. and Redowicz,M.J.
  TITLE     Unconventional myosin VI in the heart: Involvement in cardiac
            dysfunction progressing with age
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (6), 166748 (2023)
   PUBMED   37169038
REFERENCE   4  (bases 1 to 2891)
  AUTHORS   Tsui,H., van Kampen,S.J., Han,S.J., Meraviglia,V., van Ham,W.B.,
            Casini,S., van der Kraak,P., Vink,A., Yin,X., Mayr,M., Bossu,A.,
            Marchal,G.A., Monshouwer-Kloots,J., Eding,J., Versteeg,D., de
            Ruiter,H., Bezstarosti,K., Groeneweg,J., Klaasen,S.J., van
            Laake,L.W., Demmers,J.A.A., Kops,G.J.P.L., Mummery,C.L., van
            Veen,T.A.B., Remme,C.A., Bellin,M. and van Rooij,E.
  TITLE     Desmosomal protein degradation as an underlying cause of
            arrhythmogenic cardiomyopathy
  JOURNAL   Sci Transl Med 15 (688), eadd4248 (2023)
   PUBMED   36947592
REFERENCE   5  (bases 1 to 2891)
  AUTHORS   Feng,S., Wen,H., Liu,K., Xiong,M., Li,J., Gui,Y., Lv,C., Zhang,J.,
            Ma,X., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation
            with PTBP1 and AR, and is essential for male fertility in mice
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36718792
REFERENCE   6  (bases 1 to 2891)
  AUTHORS   Seeger,T.S., Frank,D., Rohr,C., Will,R., Just,S., Grund,C.,
            Lyon,R., Luedde,M., Koegl,M., Sheikh,F., Rottbauer,W., Franke,W.W.,
            Katus,H.A., Olson,E.N. and Frey,N.
  TITLE     Myozap, a novel intercalated disc protein, activates serum response
            factor-dependent signaling and is required to maintain cardiac
            function in vivo
  JOURNAL   Circ Res 106 (5), 880-890 (2010)
   PUBMED   20093627
REFERENCE   7  (bases 1 to 2891)
  AUTHORS   Goossens,S., Janssens,B., Bonne,S., De Rycke,R., Braet,F., van
            Hengel,J. and van Roy,F.
  TITLE     A unique and specific interaction between alphaT-catenin and
            plakophilin-2 in the area composita, the mixed-type junctional
            structure of cardiac intercalated discs
  JOURNAL   J Cell Sci 120 (Pt 12), 2126-2136 (2007)
   PUBMED   17535849
  REMARK    GeneRIF: By providing an extra link between the cadherin-catenin
            complex and intermediate filaments, the binding of alphaT-catenin
            to plakophilin-2 is proposed to be a means of modulating and
            strengthening cell-cell adhesion between cardiac muscle cells.
REFERENCE   8  (bases 1 to 2891)
  AUTHORS   Yang,Z., Bowles,N.E., Scherer,S.E., Taylor,M.D., Kearney,D.L.,
            Ge,S., Nadvoretskiy,V.V., DeFreitas,G., Carabello,B., Brandon,L.I.,
            Godsel,L.M., Green,K.J., Saffitz,J.E., Li,H., Danieli,G.A.,
            Calkins,H., Marcus,F. and Towbin,J.A.
  TITLE     Desmosomal dysfunction due to mutations in desmoplakin causes
            arrhythmogenic right ventricular dysplasia/cardiomyopathy
  JOURNAL   Circ Res 99 (6), 646-655 (2006)
   PUBMED   16917092
REFERENCE   9  (bases 1 to 2891)
  AUTHORS   Grossmann,K.S., Grund,C., Huelsken,J., Behrend,M., Erdmann,B.,
            Franke,W.W. and Birchmeier,W.
  TITLE     Requirement of plakophilin 2 for heart morphogenesis and cardiac
            junction formation
  JOURNAL   J Cell Biol 167 (1), 149-160 (2004)
   PUBMED   15479741
  REMARK    GeneRIF: plakophilin 2 is important for the assembly of junctional
            proteins and represents an essential morphogenic factor and
            architectural component of the heart
REFERENCE   10 (bases 1 to 2891)
  AUTHORS   Gallicano,G.I., Kouklis,P., Bauer,C., Yin,M., Vasioukhin,V.,
            Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is required early in development for assembly of
            desmosomes and cytoskeletal linkage
  JOURNAL   J Cell Biol 143 (7), 2009-2022 (1998)
   PUBMED   9864371
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004650.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026163.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004650.1, AK049481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2891              AK004650.1         2-2892
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.09 cM"
     gene            1..2891
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /note="plakophilin 2"
                     /db_xref="GeneID:67451"
                     /db_xref="MGI:MGI:1914701"
     exon            1..251
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2416
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /codon_start=1
                     /product="plakophilin-2"
                     /protein_id="NP_080439.1"
                     /db_xref="CCDS:CCDS27981.1"
                     /db_xref="GeneID:67451"
                     /db_xref="MGI:MGI:1914701"
                     /translation="MAVPGSLAECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSS
                     GRGDPAARSQRIQEQVQQTLARRGRSSAVSGNLHRTSSVPEYVYKLHVVENDFVGRQS
                     PVTRDYDMLKAGMTATYGSRWGRAAAQYSSQKSVEERSWRQPLRRLEISPDSSPERAH
                     YGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQAGTARRPPGCGSFSDAVFDNGPL
                     KPTMPTHPPGTSHSAGSLLEETTVRVSQARLQSTQSRTARSSWPRSSVRSSLREPGRM
                     LTTAGQAAVGSGDAHGDRSVFADAQLGNADIEMTLERAVNMLDADHVPVSKISAAATF
                     IQHESFQKSEARKRVNQLRGIPKLLQLLKLQNEDVQRAACGALRNLVFEDNDNKLEVA
                     ELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFS
                     GWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKMMRRCDGLIDSLVHYVRGTI
                     ADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRS
                     RKLKEQYQDLQMPEERSNPHGIEWLWHSIVIRMYLSLIAKSTRNYTQEASLGALQNLT
                     AGGGPIPTLVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAK
                     ETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTIS
                     IGEGYAPNKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD"
     exon            252..364
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            365..936
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1072
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1280
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1458
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1576
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1741
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1915
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2069
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2259
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2347
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2891
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /note="hexamer: AATAAA"
     polyA_site      2887
                     /gene="Pkp2"
                     /gene_synonym="1200008D14Rik; 1200012P04Rik; Pkp2l"
                     /note="major polyA site"
ORIGIN      
        1 agtccctcct ggtcactccg ccgacgcgat ggccgtcccc ggctcactgg ccgagtgtgg
       61 ctacatccgg actgtgctgg gccagcagat cctgggtcac ctggacagct ccagcctggc
      121 cttgccctcc gaggccagac tgaggctggc cggcagcagc ggccgcggcg acccggcggc
      181 ccggagccag cggatccagg agcaggtgca gcagaccctg gcccgccggg gccggagctc
      241 tgcggtcagc gggaaccttc accgaaccag cagtgtccct gagtatgtct acaagctaca
      301 cgtggttgag aatgactttg ttggacggca gtcacctgtc actagggact atgacatgct
      361 taaggctgga atgactgcca cttatggaag tcgctggggg agagcagcag cacagtacag
      421 ttcccagaag tcagtggagg agagatcctg gaggcagcct ctgaggagac ttgagatttc
      481 cccagatagc agcccggaga gagcccacta tgggcacagc gaataccagt atgcctggcg
      541 gagccacgtg gtgcctggtg ggcgcctcac cctgccacgc tatgctcgct cagagatcct
      601 gggcctacgc caggctggca cagcccgcag gccacctggg tgcgggtcat tcagcgatgc
      661 tgtcttcgac aatggcccac tcaagcccac aatgcccacc caccctcctg gcaccagcca
      721 cagtgcgggc agcttgttgg aagagaccac tgtgcgcgtg agccaggctc ggcttcaaag
      781 cacgcagagc agaaccgccc gctcctcctg gcccaggagc tcagtccgca gtagcctgcg
      841 ggagccagga agaatgctga ccaccgcagg ccaggctgcc gtgggcagcg gggatgcaca
      901 tggggacagg agtgtcttcg ctgacgccca gctggggaat gcagacatcg aaatgacctt
      961 ggagagagct gtgaatatgc tggatgcaga ccatgtacca gtatccaaga tctctgccgc
     1021 agctaccttc atacagcatg agagcttcca aaaatctgaa gcacggaaaa gggtcaatca
     1081 acttcgaggc atccctaagc ttctacaact gctcaaactt cagaacgaag atgttcaacg
     1141 ggctgcttgt ggggccttga gaaacttggt atttgaagac aatgataaca agttggaggt
     1201 agctgaactg aatggagtgc ctcggctact gcaggtgctg aagcaaacca gagacttgga
     1261 gacaaaaaag caaataacag gtttgctctg gaacctgtcc tctagtgata aactcaagca
     1321 tctcatgata acagaagcct tgctcacctt gacagagagt gtcatcatcc ccttctccgg
     1381 gtggcctgaa ggcgactacc ccaaagccaa tggcttgctt gattttgata tattctacaa
     1441 tgtcactgga tgcctaagga acatgagctc tgctggcccc gatgggagga agatgatgag
     1501 aaggtgtgat ggtctcattg actcattggt ccactatgtc agaggaacta ttgcagacta
     1561 ccagccagat gataaggcca cagagaactg tgtgtgcatt cttcataacc tctcctacca
     1621 gctggaggca gagctcccag agaaatattc ccagagtatc tacatgcaaa accggaatat
     1681 ccagactaac agtaacaaaa gtattgggtg ttttggcagc cgaagtagga aactaaaaga
     1741 gcaataccaa gacttgcaga tgccagagga aaggagcaat ccacatggca ttgagtggct
     1801 gtggcattcc attgtgataa ggatgtattt gtccttaatt gccaagagta cccgaaacta
     1861 tacccaagag gcatcacttg gggctctcca gaacctcaca gcaggaggcg gcccgatacc
     1921 cacattggtg gctcgaatgg ttgtccaaaa ggaaaatggt cttcagcata cacggaagat
     1981 gctgcacgtg ggtgatccca gtgtgaaaaa gactgcggtc tccctgctga ggaatttgtc
     2041 acggaatctt tccctgcaga atgaaattgc taaagaaact ctaccagatt tggtttctat
     2101 aattcctgac acagtcccaa gtactgacct tctcattgaa accacagcct ctgcttgcta
     2161 tacgttgaac aatttaatgc aaaatagtta ccagaatgca cgagaccttc tgaacaccgg
     2221 aggtctgcag aaaattatga ccatcagcat aggggaaggc tatgccccca acaaggccag
     2281 caaagcagcc tctgtcctcc tttactctct gtgggcacat acagagctgc atcacgccta
     2341 taagaaggct cagtttaaga aaacagactt tgtcaacagc cggactgcca aagcctacca
     2401 ctctcttaaa gactgatgaa gtggggaaaa aaaaacctca ggaattccag tttcacagtt
     2461 ctccacttaa aaataaaata agataaacaa ttaaaaaaac ctcctcaaag aaaacaccta
     2521 tttttctact aactgaccca agaaacctca aaaagcatgc tttgtttata ttcttttcta
     2581 ttttcatccc caaatctaga aaatgaataa tcagaatata attttgttaa gtgtcctgaa
     2641 gacttccacc aggttgcacc agtatggaat cagttttacc ctgtgcagat aatgggcatc
     2701 attattcagg cttatagtat gtgcaaactc gtgtgagtgt gcaccggagg aacacctgag
     2761 aaagagtgtg tgaatgatgt ttctatccta gttgctcatc tgcatgtcac ttccttaatg
     2821 agccagaggt gtgtgttcac tagtgttgga caggacagag atgaaggaat aaagcattga
     2881 tggcaaatcg c
//
