LOCUS       NM_019645               4670 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus plakophilin 1 (Pkp1), transcript variant 1, mRNA.
ACCESSION   NM_019645
VERSION     NM_019645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4670)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 4670)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   3  (bases 1 to 4670)
  AUTHORS   Fuchs,M., Foresti,M., Radeva,M.Y., Kugelmann,D., Keil,R.,
            Hatzfeld,M., Spindler,V., Waschke,J. and Vielmuth,F.
  TITLE     Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering
  JOURNAL   Cell Mol Life Sci 76 (17), 3465-3476 (2019)
   PUBMED   30949721
  REMARK    GeneRIF: Pkp1 regulates desmoglein membrane availability, whereas
            Pkp1 but not Pkp3 is required for desmoglein 3 clustering.
REFERENCE   4  (bases 1 to 4670)
  AUTHORS   Wang,H.Z., Wang,F., Chen,P.F., Zhang,M., Yu,M.X., Wang,H.L.,
            Zhao,Q. and Liu,J.
  TITLE     Coexpression network analysis identified that plakophilin 1 is
            associated with the metastasis in human melanoma
  JOURNAL   Biomed Pharmacother 111, 1234-1242 (2019)
   PUBMED   30841437
  REMARK    GeneRIF: PKP1 was identified as a new potential tumor suppressor in
            human melanoma.
REFERENCE   5  (bases 1 to 4670)
  AUTHORS   Choi,Y.J., Laclef,C., Yang,N., Andreu-Cervera,A., Lewis,J., Mao,X.,
            Li,L., Snedecor,E.R., Takemaru,K.I., Qin,C., Schneider-Maunoury,S.,
            Shroyer,K.R., Hannun,Y.A., Koch,P.J., Clark,R.A., Payne,A.S.,
            Kowalczyk,A.P. and Chen,J.
  TITLE     RPGRIP1L is required for stabilizing epidermal keratinocyte
            adhesion through regulating desmoglein endocytosis
  JOURNAL   PLoS Genet 15 (1), e1007914 (2019)
   PUBMED   30689641
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4670)
  AUTHORS   Vasioukhin,V., Bowers,E., Bauer,C., Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is essential in epidermal sheet formation
  JOURNAL   Nat Cell Biol 3 (12), 1076-1085 (2001)
   PUBMED   11781569
REFERENCE   7  (bases 1 to 4670)
  AUTHORS   Hofmann,I., Mertens,C., Brettel,M., Nimmrich,V., Schnolzer,M. and
            Herrmann,H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   8  (bases 1 to 4670)
  AUTHORS   Bierkamp,C., Schwarz,H., Huber,O. and Kemler,R.
  TITLE     Desmosomal localization of beta-catenin in the skin of plakoglobin
            null-mutant mice
  JOURNAL   Development 126 (2), 371-381 (1999)
   PUBMED   9847250
REFERENCE   9  (bases 1 to 4670)
  AUTHORS   Schmidt,A., Langbein,L., Rode,M., Pratzel,S., Zimbelmann,R. and
            Franke,W.W.
  TITLE     Plakophilins 1a and 1b: widespread nuclear proteins recruited in
            specific epithelial cells as desmosomal plaque components
  JOURNAL   Cell Tissue Res 290 (3), 481-499 (1997)
   PUBMED   9369526
REFERENCE   10 (bases 1 to 4670)
  AUTHORS   Hatzfeld,M., Kristjansson,G.I., Plessmann,U. and Weber,K.
  TITLE     Band 6 protein, a major constituent of desmosomes from stratified
            epithelia, is a novel member of the armadillo multigene family
  JOURNAL   J Cell Sci 107 (Pt 8), 2259-2270 (1994)
   PUBMED   7527055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036856.1, AK079429.1, BC139042.1, Y07941.1 and AC162441.11.
            
            On Aug 27, 2015 this sequence version replaced NM_019645.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036856.1, Y07941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AK036856.1         2-93
            93-701              AK079429.1         94-702
            702-756             BC139042.1         615-669
            757-3448            AK079429.1         759-3450
            3449-4666           Y07941.1           3267-4484
            4667-4670           AC162441.11        6580-6583
FEATURES             Location/Qualifiers
     source          1..4670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.35 cM"
     gene            1..4670
                     /gene="Pkp1"
                     /note="plakophilin 1"
                     /db_xref="GeneID:18772"
                     /db_xref="MGI:MGI:1328359"
     exon            1..397
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2382
                     /gene="Pkp1"
                     /codon_start=1
                     /product="plakophilin-1"
                     /protein_id="NP_062619.1"
                     /db_xref="CCDS:CCDS15322.1"
                     /db_xref="GeneID:18772"
                     /db_xref="MGI:MGI:1328359"
                     /translation="MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQ
                     VMMTVKRQKSKSSQSSTLSHSNRGSMYDGLADNYNNYGTTSRSSYFSKFQAGNGSWGY
                     PIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCATPGAGSDICFMQKIKASRSEPDL
                     YCDPRGTLRKGTLGSKGHKTTQNRCSFYSTCSGQKAVKKCPVRPPSCTSKQDPVYVPP
                     ISCNKDLSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDEKYQAIGAYYIQHTCFQ
                     DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTPNKLETRRQNGIRE
                     AVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDGNS
                     NMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDK
                     SVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGDKMMNNNYDC
                     PLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSNGM
                     SQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLL
                     TSHTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNTASSPKAA
                     EAARLLLSDMWASKELQSVLRQQGFDRNMMGNIAGANNLRNFTSRF"
     exon            398..504
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..899
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1044
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1252
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1430
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1545
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1701
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1878
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2032
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2219
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2307
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2414
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..4670
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4641..4646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pkp1"
                     /note="hexamer: AATAAA"
     polyA_site      4665
                     /gene="Pkp1"
                     /note="major polyA site"
ORIGIN      
        1 cagtgcctac tgagggacga gccggggcgg aggcgccagg agcagcagcc gggagccctc
       61 acgcggacca gcgctctatg gccaaaggga gccgctgaga ggagaacagg cgctcgctcg
      121 caccccggct cgcactctcg ctcccctggc ccgcactcgc accctcggct cccctggccc
      181 gcgcctcccg ccaccatgaa ccactctccg ctcaagaccg cgctggcgta cgaatgcttc
      241 caggaccagg acaactccac gctggctttg ccctctgacc aaaagatgaa gaccggcacg
      301 tcgggcaggc agcgcgtgca ggagcaagtg atgatgaccg tcaaacggca gaagtccaag
      361 tcttcccagt cgtccacctt gagtcactcc aaccgaggtt ccatgtatga tgggctggct
      421 gacaattaca acaactacgg caccacgagc agaagcagct acttctccaa gttccaggca
      481 gggaatggct cgtggggata tccgatctac aatgggaccc tcaagcggga gcccgacaac
      541 agacgcttca gctcctatag ccagatggag aactggagcc ggcactatcc ccgaggcagc
      601 tgtgccaccc cgggcgctgg cagtgacatc tgcttcatgc agaaaatcaa ggcaagccgc
      661 agtgagcctg acctctactg tgacccaagg ggcacactgc gcaagggcac cctgggcagc
      721 aagggccaca agaccaccca gaaccgatgc agcttctaca gcacttgcag tggtcagaag
      781 gctgtcaaga agtgtcccgt gcggccgccc tcctgcacct ccaagcaaga cccggtgtat
      841 gtgccgccta tctcctgcaa caaggacctg tccttcggcc actcgagggc cagttccaag
      901 atctgcagtg aggacattga gtgtagtggg ctgaccatcc ccaaggctgt gcagtacctg
      961 tgctcccagg atgagaagta ccaggccatc ggagcctatt acatccagca cacctgcttc
     1021 caggatgaat ctgccaagca acaggtctat cagctggggg gcatctgcaa gctggtggac
     1081 ctcctccgca gccccaatca gaatgtccag caggctgctg ccggggccct gcgcaacctg
     1141 gtgttcagga gcacccccaa caagctggag accaggaggc agaacggaat ccgtgaagct
     1201 gtcagcctcc tgaggagaag cgggagcacg gagatccaaa aacagctgac tgggctcctc
     1261 tggaacctgt cttccactga tgagctgaag gaggagctgg tggccgacgc cctgcctgtt
     1321 ctgactgacc gggtcatcat tcctttctct ggctggtgtg atggtaacag caacatgtcc
     1381 cgggaagtag tggaccctga ggtcttcttc aatgctacag gctgcttgag gaacctgagt
     1441 tcagctgatg ctggccgcca gactatgcgg aactactctg ggctcattga ctccctcatg
     1501 gcctatgtcc agaactgcgt ggctgccagc cgctgcgatg acaagtctgt ggagaactgc
     1561 atgtgtatcc tgcataacct ctcctaccgc ctggacgccg aggtgcccac ccgctaccgc
     1621 cagctggagt acaatacccg caatgcctac accgagaagt cctccactgg ctgcttcagc
     1681 aacaggggtg acaagatgat gaacaataac tatgactgcc cacttccgga ggaagagacc
     1741 aaccccaagg gcagcagctg gctgtaccac tcagatgcca tccggaccta cctgaacctc
     1801 atgggaaaga gcaagaaaga tgctaccttg gaggcctgtg ctggggccct gcaaaacctg
     1861 acagccagca aggggctgat gtccaatggt atgagtcagt taattggaat aaaggaaaag
     1921 ggcctgccac aaatcgcccg tctcctgcaa tctggcaatt cggatgtggt gcggtccgga
     1981 gcctctctgc tgagcaacat gtctcgccac cctgtgctgc acagagtgat gggaaaccag
     2041 gtgttcccag aggtaaccag actcctcact agccacaccg gcaataccag caactctgaa
     2101 gatatcttgt cctcagcctg ctacactgtg aggaacctga tgacctcaca gcctcagatg
     2161 gccaagcagt acttctccaa cagcatgctc aacaatgtct tcaacttgtg ccgcaacact
     2221 gcctcctcac ctaaggctgc agaggctgcc cggctactcc tgtctgacat gtgggccagc
     2281 aaggagctgc agagtgtcct caggcagcaa ggtttcgata ggaatatgat gggaaacata
     2341 gctggggcca acaacctcag aaacttcacc tcccggttct aagaagagac tgcccaagca
     2401 agttcaactt gcagaaagac acgacccagc tgagaagacc tcaggccttg aagatgggtt
     2461 acctgctcca tcctgcgtgg tatttggaga cgttcagatg caaccaagag cagcctgaaa
     2521 actgtggatg atggaaataa tttttgattc ttttttttcc ttaggggaac tggcaggcta
     2581 tagggttggg gaggttgggt gggggggctt tcttgagtta aaggggctta catctgatgt
     2641 caatactttc ttctctgaga aacagtatat atatataatg tgtataatgt aagtatgtgt
     2701 gtgtggtgtg cctgtgtggt gtgttcacgc atgtgttcgt gtgtgtgtgt gtgtgtgtgt
     2761 gtgtgcctaa aagcataacc aacaagagaa acaggctggg tgtgacgatc ctttgcagtt
     2821 cacaggcagc acaggggact ctccgtgtct ccctttatag acatgtgggc tgcacccaca
     2881 tgaaagcttt agccagcaga gccccagact tcagacagcc tgcaagcagc tattggtgga
     2941 gaaaggaagt aagaagatca cctgaagcca gaactgtggg gatgtgctca ctcatctcct
     3001 caaggggata gggtaggaac agatgggcac tgggcactgc ctgctcaggc ttctcagaga
     3061 acagagagga agactggaaa ttagttgcaa tgcacctcag acccagcttg ctgagcgtca
     3121 ggtgagggag ttcccagagg ctgaaggaag ggaatttggg tggatagacc aggtaaagga
     3181 agtgtcctgt taaggcatca actagcccac attccagcca tcagcctctt tcttcatgaa
     3241 ctctagctgt tctgtctgcc ctctgtctct gtgaaacaaa actgcctagt ggggtagagg
     3301 cagccaaccc caggacccca gacttcacac tgcagacaga agtaccaaaa gaacatctga
     3361 gaaccccatg agtgagcctg tctatgtgaa gccccctagg acaaatgact gatggacaga
     3421 gctgagcctt cccccagagc cttcatgtct aggctattgc ttctccactg gtgtggttag
     3481 tgctgggtag acatgaatga taagggccat acctctctca aggagggtat agaatgctcc
     3541 ttggcccaac cctcttctta ccccagcagt aagaccgaaa aattcctcta tggctcaggg
     3601 tggcctagta aacgatctgt ccattgagga ttgaggaggt cagctacgtg aggacattgt
     3661 tcctgagagg tgtcctaagc catctacccg gtgtgctctg gcactgtgag tctgcagcat
     3721 ccttccctgt ttggcttgtg tgggattctg cctcctacct cacctcctct ctgataccag
     3781 cgtgggatgc tgtcccacca cactgtcctt gggtaggctt cttgtgatct cctttgccag
     3841 tcactgggat ccagaacaat ctacttcttc aagcatgcca ttgtcacact actctgcacg
     3901 acagtgaggg gagcacttaa ggcaataaca ggaaatcaaa cctacagtac ccctgcccct
     3961 ccatatagtg tatgttcgcc caagaaagga tacccaggtc ctgggcttca gggactatcc
     4021 acttactcag tcaatttgag aaaatcatgt agaacgttca agtcaacaag ggagactgct
     4081 gtaggccctc aagaatgacg ttcccaccca accccccagt atcatcctca cttcctgcag
     4141 ccctcggact cagttttctt ttccctggga ggaaggttgg gtaggttcac catttgcttt
     4201 ggtgatgaag caggtcttaa gatacccaga ggtcaggctc aattgtggga acttcttcca
     4261 tgatctcaag ctggccagat gggctgggcc caacatgtgc ctgtcattcc agggaaaaat
     4321 taaagggact tatgaataaa ttcctagaag caggaggtaa ggggctggct ggactttctg
     4381 tatcccagac ttatcttcat ggtttttttc atcaaatttg cctcctagtt ccatatctaa
     4441 aacaagttac aatttaggac caaatgagaa aggacagagg ccctgtgtct tccttgactt
     4501 ttggacttgc tgcagcgtct gggaccctcc gtccagccct cactgtcctt gctccatctt
     4561 gtatgagaac cttgtgctga acgggcccag tttccttgta tgatacacca tgtatttgct
     4621 ttgtcaaaat ataggaaatc aataaactac tagtatttct ttgaaggttt
//
