LOCUS       NM_001029838            3550 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus Pbx/knotted 1 homeobox 2 (Pknox2), transcript variant
            2, mRNA.
ACCESSION   NM_001029838
VERSION     NM_001029838.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Trigila AP, Castagna VC, Berasain L, Montini D, Rubinstein M,
            Gomez-Casati ME and Franchini LF.
  TITLE     Accelerated Evolution Analysis Uncovers PKNOX2 as a Key
            Transcription Factor in the Mammalian Cochlea
  JOURNAL   Mol Biol Evol 40 (7) (2023)
   PUBMED   37247388
  REMARK    GeneRIF: Accelerated Evolution Analysis Uncovers PKNOX2 as a Key
            Transcription Factor in the Mammalian Cochlea.
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Miyake Y, Obana M, Nakae T, Yamamoto A, Tanaka S, Maeda M, Okada Y
            and Fujio Y.
  TITLE     PKNOX2 regulates myofibroblast functions and tubular cell survival
            during kidney fibrosis
  JOURNAL   Biochem Biophys Res Commun 571, 88-95 (2021)
   PUBMED   34311199
  REMARK    GeneRIF: PKNOX2 regulates myofibroblast functions and tubular cell
            survival during kidney fibrosis.
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Lopez-Gonzalez L, Alonso A, Garcia-Calero E, de Puelles E and
            Puelles L.
  TITLE     Tangential Intrahypothalamic Migration of the Mouse Ventral
            Premamillary Nucleus and Fgf8 Signaling
  JOURNAL   Front Cell Dev Biol 9, 676121 (2021)
   PUBMED   34095148
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S,
            Rodriguez-Malmierca LM, Pistolic J, Benes V, Tiwari VK and
            Lopez-Bendito G.
  TITLE     Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals
            Putative Sensory-Modality Specific Genes
  JOURNAL   Cereb Cortex 27 (11), 5054-5069 (2017)
   PUBMED   27655933
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Antosova B, Smolikova J, Klimova L, Lachova J, Bendova M, Kozmikova
            I, Machon O and Kozmik Z.
  TITLE     The Gene Regulatory Network of Lens Induction Is Wired through
            Meis-Dependent Shadow Enhancers of Pax6
  JOURNAL   PLoS Genet 12 (12), e1006441 (2016)
   PUBMED   27918583
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L
            and Maas RL.
  TITLE     Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic
            development
  JOURNAL   Dev Biol 300 (2), 748-757 (2006)
   PUBMED   17049510
REFERENCE   7  (bases 1 to 3550)
  AUTHORS   Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC,
            Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G
            and Blasi F.
  TITLE     Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major
            reduction of Pbx and Meis proteins and a pleiotropic embryonic
            phenotype
  JOURNAL   Mol Cell Biol 26 (15), 5650-5662 (2006)
   PUBMED   16847320
REFERENCE   8  (bases 1 to 3550)
  AUTHORS   Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B,
            Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA,
            Hoffman PL, Iyer VR, Koob GF and Bergeson SE.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   9  (bases 1 to 3550)
  AUTHORS   Haller K, Rambaldi I, Daniels E and Featherstone M.
  TITLE     Subcellular localization of multiple PREP2 isoforms is regulated by
            actin, tubulin, and nuclear export
  JOURNAL   J Biol Chem 279 (47), 49384-49394 (2004)
   PUBMED   15339927
  REMARK    GeneRIF: transcriptional regulation by PREP2 is modulated through
            the subcellular distribution of multiple isoforms and by
            interaction with two distinct cytoskeletal systems
REFERENCE   10 (bases 1 to 3550)
  AUTHORS   Haller K, Rambaldi I, Kovacs EN, Daniels E and Featherstone M.
  TITLE     Prep2: cloning and expression of a new prep family member
  JOURNAL   Dev Dyn 225 (3), 358-364 (2002)
   PUBMED   12412021
  REMARK    GeneRIF: Prep2 functions to varying degrees in a broad array of
            tissues and developmental processes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848729.1, AK082952.1 and BB349034.1.
            
            [WARNING] On Oct 4, 2023 this sequence was replaced by
            NM_001029838.3.
            
            On Nov 8, 2013 this sequence version replaced NM_001029838.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082952.1, SRR6116558.189060.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BB848729.1         2-57
            57-3544             AK082952.1         2-3489
            3545-3550           BB349034.1         281-286
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.7 cM"
     gene            1..3550
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /note="Pbx/knotted 1 homeobox 2"
                     /db_xref="GeneID:208076"
                     /db_xref="MGI:MGI:2445415"
     exon            1..82
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..152
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            153..257
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..366
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1704
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /note="PBX/knotted homeobox 2; homeobox protein PREP-2;
                     homeodomain containing transcription factor PREP2"
                     /codon_start=1
                     /product="homeobox protein PKNOX2"
                     /protein_id="NP_001025009.1"
                     /db_xref="CCDS:CCDS22974.1"
                     /db_xref="GeneID:208076"
                     /db_xref="MGI:MGI:2445415"
                     /translation="MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVH
                     ISAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITS
                     ASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCN
                     RYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVV
                     PASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLD
                     LTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQ
                     VNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTP
                     GTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEEL
                     EEEADELQTTNVSDLGLEHSDSLE"
     exon            367..506
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..678
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..867
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..997
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1095
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1215
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1292
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1471
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..3550
                     /gene="Pknox2"
                     /gene_synonym="D230005H23Rik; Prep2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccgctga cgtcccgagc agtgctggga agtataggct gtgttgtcac gccggtgtca
       61 gtctgatgaa gattggcatc aggtgaacct agaagaagac tttaaggggt tctggttttc
      121 catgctgctc actagaaaag aagccctgaa ctgtactctc tctatagctg actagaggtg
      181 tttctggccc agctggaagt gagaagaggg ggcagacccc ctgaagacca tcccagaggc
      241 agtgggatcc tccaacaatc ctccatgtga atcaatccca tgatgcaaca tgcctcccca
      301 gccccagctc tgacaatgat ggccacgcag aatgtccctc ccccacccta ccaggacagc
      361 ccccagatga cagcaactgc ccagccacct tccaaggccc aggctgtcca catctcagca
      421 ccctcagcta ccgccagcac acctgtgccc agtgccccca ttgatcccca agcccagctg
      481 gaggctgaca agcgagctgt gtacaggcac cctcttttcc cgctcctgac gctgctgttt
      541 gagaaatgtg aacaggccac ccagggctcc gagtgcatca cctccgccag ctttgatgtg
      601 gacatcgaga actttgtcca ccagcaggag caggaacaca aacccttctt cagcgatgac
      661 ccagaactgg acaatctgat ggtgaaggca atccaggtcc tgaggatcca cctgctagag
      721 ttggagaaag tcaatgagct ctgcaaggac ttttgcaacc gttacatcac ctgcctcaaa
      781 accaagatgc acagtgataa cctgctcagg aatgacctcg gggggcccta ctcccccaac
      841 cagccctcca taaaccttca ctcacaggac ctcctgcaga attcccccaa ttcaatgtct
      901 ggagtctcca ataaccccca ggggattgtg gtcccagcct cagcactcca gcagggcaac
      961 atcgccatga caaccgtcaa ttctcaagtc gtgtcaggtg gagccttata tcagccggtt
     1021 accatggtaa cctcccaagg tcaggtggtc acccaagcaa tcccccaggg agccatccag
     1081 atccagaata cacaggttaa ccttgacctc acctccctcc tggacaatga ggataagaag
     1141 tccaagaaca aacgaggagt cttgcccaag catgccacca atataatgcg ttcttggctc
     1201 ttccagcatc tcatgcaccc ctatcccact gaagatgaga agaggcagat tgccgcgcag
     1261 acaaacctca cccttctgca agtaaacaac tggttcatca atgccaggag gcgcatcctg
     1321 cagcccatgc ttgatgccag caacccagat cctgctccca aagccaagaa aatcaagtct
     1381 cagcaccggc ccacccaaag attctggccc aattccattg ctgctggggt tctgcaacag
     1441 cagggtggca ccccagggac gaaccctgat ggttccatca acttggacaa cctgcagtcc
     1501 ctgtcctcag acaatgccac catggccatg cagcaggcaa tgatggctgc acatgatgat
     1561 tcattggatg gcacggaaga agaggatgaa gatgatatgg aggaggagga agaggaggag
     1621 gaggagctag aggaggaggc tgatgagcta cagacaacga atgtcagcga cctgggcttg
     1681 gaacacagtg actccctgga gtagtcaggc agcccagatt gcgctggtca ccgagcagga
     1741 aaggagtgtc atcaggaggg ttcagggtgg ggggaggaga tatgggcagg cagcactaag
     1801 aaagttgggc cctagcttcc ccgaatcata gcttgaagaa atgcagagga gacaccctgc
     1861 tcctttccaa ccaccaagct tcagtgaaaa cctagtccca gaccctcaga ctacagagca
     1921 ctccattgct ggggccagcc aaacagcctg agaagaaaga cagcgtgaga tctggactca
     1981 ccgaatacca gagatgacac ccatggctcc gcatggaaaa agacttgatt tgtttacaag
     2041 ccactgccct gtgaggtgga caggcgctgc ttgcagagcg aacctttgct aaggggcaga
     2101 cttgggaggg aaggatgaga aagaaggggt ctaacatttt cccccaggag aatctgagct
     2161 cccttgaaag acactcacgg acagaaagga gcccaaatgc ataaccagtg gccagaggag
     2221 tgggagggcc tgagacaaca ccacaccctt catatcagag tggaacgtgg actgcacagg
     2281 gctccaactt accctaccag gaccctgtct cttggcacag cagccatgga ctataaggag
     2341 agggggaagg aaaccaaaga gactccttct tcctctcttg gaaatacatt gtaggtgggt
     2401 ccaacctgaa gaggttaaga gcaactctac atctgggtca gctcgaggac caagcaggta
     2461 gcagaacctg gatcaggagc catattaaga tgactttggg gatcccagca gtccctacgt
     2521 gatcacatag ctcctgtcac aataggacca tagtgtctta ttagatgttc ctaccctcag
     2581 atggagttct tcagagaccc cagccccctc cataaacctt taggggttct ttccactcca
     2641 caggtcttcg tggtatccct ctgctcccaa gctggcacta ccagcttctg gcctcctcct
     2701 tcattctatt ctccagagaa ggcagaagaa acattggaaa gaagcattgt cccaatggga
     2761 agccagggtc tgaagaaggt gctactgctc ttaccttcag gactcaacat ggcaggggat
     2821 atagcgccca gctgatccac acacaccatg cttggcatct gctcctcctg tcccctccca
     2881 ccctgtggct gtgaaagaca ggactgacca cacgtgtgtt ttccgttggg tttaatgtga
     2941 tgggtgtgca gttccttcat ttgtaagtgt gcattggcca tctccttcag tgctaggatg
     3001 tgaatggcta tctggctcaa ccagagggca ctcttgcgac cttctgagcc ttctcctcct
     3061 ctacctggtt gggtggagca aaaggatagt cacttttctg aggtctcccg gaaatgaatg
     3121 tatttctccc ccaaaagagc tgatatttaa tgttttacta gggatttttg agaaacaaat
     3181 aaccttattt ataatctggg cgatccaatc atttttttac tcccttttga tgccatacct
     3241 agaggaaagg caagcttttt ggcgtgagac ttttgcaacc cacaatggga taaaacattt
     3301 cctcttctgg ttcatttttc ttgttaaagt acatacatcc acacataaat tcctccactc
     3361 agcaccgtga caagctccct tcttcagcac ggacatgtgt gcatacgtgc acatggatac
     3421 acatgtctac atctccctcc tagccccttc cacctgccta atgttacgca acctccttct
     3481 gatgtatcca ccaaaccagt actgaatgtg gccacgagtt ttcagtaaac cttatcacct
     3541 accgaaatac
//
